Inference techniques for Fay Herriot Model.

This package provides a set of functions to build a scoring model from beginning to end, leading the user to follow an efficient and organized development process, reducing significantly the time spent on data exploration, variable selection, feature engineering, binning and model selection among other recurrent tasks. The package also incorporates monotonic and customized binning, scaling capabilities that transforms logistic coefficients into points for a better business understanding and calculates and visualizes classic performance metrics of a classification model.

Data practitioners regularly use the R and Python programming languages to prepare data for analyses. Thus, they encode important data preprocessing decisions in R and Python code. The smallsets package subsequently decodes these decisions into a Smallset Timeline, a static, compact visualisation of data preprocessing decisions (Lucchesi et al. (2022) <doi:10.1145/3531146.3533175>). The visualisation consists of small data snapshots of different preprocessing steps. The smallsets package builds this visualisation from a user's dataset and preprocessing code located in an R', R Markdown', Python', or Jupyter Notebook file. Users simply add structured comments with snapshot instructions to the preprocessing code. One optional feature in smallsets requires installation of the Gurobi optimisation software and gurobi R package, available from <https://www.gurobi.com>. More information regarding the optional feature and gurobi installation can be found in the smallsets vignette.

This package provides functions used in courses taught by Dr. Small at Drew University.

Fit univariate right, left or interval censored regression model under the scale mixture of normal distributions.

Visualisation tools for SMITIDstruct package. Allow to visualize host timeline, transmission tree, index diversities and variant graph using HTMLwidgets'. It mainly using D3JS javascript framework.

This package provides a pair of functions that allow for the generation and tracking of coordinate data clouds without a time dimension, primarily for use in super-resolution plant micro-tubule image segmentation.

Some M-estimators for 1-dimensional location (Bisquare, ML for the Cauchy distribution, and the estimators from application of the smoothing principle introduced in Hampel, Hennig and Ronchetti (2011) to the above, the Huber M-estimator, and the median, main function is smoothm), and Pitman estimator.

Contains, as a main contribution, a function to fit a regression model with possibly right, left or interval censored observations and with the error distribution expressed as a mixture of G-splines. Core part of the computation is done in compiled C++ written using the Scythe Statistical Library Version 0.3.

This package provides a set of tools for determining the necessary sample size in order to identify the optimal dynamic treatment regime in a sequential, multiple assignment, randomized trial (SMART). Utilizes multiple comparisons with the best methodology to adjust for multiple comparisons. Designed for an arbitrary SMART design. Please see Artman (2018) <doi:10.1093/biostatistics/kxy064> for more details.

Discovery of spatial patterns with Hidden Markov Random Field. This package is designed for spatial transcriptomic data and single molecule fluorescent in situ hybridization (FISH) data such as sequential fluorescence in situ hybridization (seqFISH) and multiplexed error-robust fluorescence in situ hybridization (MERFISH). The methods implemented in this package are described in Zhu et al. (2018) <doi:10.1038/nbt.4260>.

Given independent and identically distributed observations X(1), ..., X(n) from a Generalized Pareto distribution with shape parameter gamma in [-1,0], offers several estimates to compute estimates of gamma. The estimates are based on the principle of replacing the order statistics by quantiles of a distribution function based on a log--concave density function. This procedure is justified by the fact that the GPD density is log--concave for gamma in [-1,0].

Local Correlation Integral (LOCI) method for outlier identification is implemented here. The LOCI method developed here is invented in Breunig, et al. (2000), see <doi:10.1145/342009.335388>.

Permits determination of a set of optimal dynamic treatment regimes and sample size for a SMART design in the Bayesian setting with binary outcomes. Please see Artman (2020) <arXiv:2008.02341>.

Interact with the Smartsheet platform through the Smartsheet API 2.0. <https://smartsheet.redoc.ly/>. API is an acronym for application programming interface; the Smartsheet API allows users to interact with Smartsheet sheets directly within R.

SMART trial design, as described by He, J., McClish, D., Sabo, R. (2021) <doi:10.1080/19466315.2021.1883472>, includes multiple stages of randomization, where participants are randomized to an initial treatment in the first stage and then subsequently re-randomized between treatments in the following stage.

This package provides a collection of various oversampling techniques developed from SMOTE is provided. SMOTE is a oversampling technique which synthesizes a new minority instance between a pair of one minority instance and one of its K nearest neighbor. Other techniques adopt this concept with other criteria in order to generate balanced dataset for class imbalance problem.

Method for segmentation of spatial domains and spatially-aware clustering in spatial transcriptomics data. The method generates spatial domains with smooth boundaries by smoothing gene expression profiles across neighboring spatial locations, followed by unsupervised clustering. Spatial domains consisting of consistent mixtures of cell types may then be further investigated by applying cell type compositional analyses or differential analyses.

Statistical Methods for Inferring Transmissions of Infectious Diseases from deep sequencing data (SMITID). It allow sequence-space-time host and viral population data storage, indexation and querying.

This package contains the datasets and a few functions for use with the practicals outlined in Appendix A of the book Statistical Models (Davison, 2003, Cambridge University Press). The practicals themselves can be found at http://statwww.epfl.ch/davison/SM/.

Empirical likelihood methods for asymptotically efficient estimation of models based on conditional or unconditional moment restrictions; see Kitamura, Tripathi & Ahn (2004) <doi:10.1111/j.1468-0262.2004.00550.x> and Owen (2013) <doi:10.1002/cjs.11183>. Kernel-based non-parametric methods for density/regression estimation and numerical routines for empirical likelihood maximisation are implemented in Rcpp for speed.

This package provides a list of methods for estimating a smooth tensor with an unknown permutation. It also contains several multi-variate functions for generating permuted signal tensors and corresponding observed tensors. For a detailed introduction for the model and estimation techniques, see the paper by Chanwoo Lee and Miaoyan Wang (2021) "Smooth tensor estimation with unknown permutations" <arXiv:2111.04681>.

Estimation of two-state (survival) models and irreversible illness- death models with possibly interval-censored, left-truncated and right-censored data. Proportional intensities regression models can be specified to allow for covariates effects separately for each transition. We use either a parametric approach with Weibull baseline intensities or a semi-parametric approach with M-splines approximation of baseline intensities in order to obtain smooth estimates of the hazard functions. Parameter estimates are obtained by maximum likelihood in the parametric approach and by penalized maximum likelihood in the semi-parametric approach.

This is an ExperimentHub package that provides access to the data generated and analyzed in the [smoking-nicotine-mouse](https://github.com/LieberInstitute/smoking-nicotine-mouse/) LIBD project. The datasets contain the expression data of mouse genes, transcripts, exons, and exon-exon junctions across 208 samples from pup and adult mouse brain, and adult blood, that were exposed to nicotine, cigarette smoke, or controls. They also contain relevant metadata of these samples and gene expression features, such QC metrics, if they were used after filtering steps and also if the features were differently expressed in the different experiments.