The r-nleqslv package solves a system of nonlinear equations using a Broyden or a Newton method with a choice of global strategies such as line search and trust region. There are options for using a numerical or user supplied Jacobian, for specifying a banded numerical Jacobian and for allowing a singular or ill-conditioned Jacobian.

This package is an R package designed for QC, analysis, and exploration of single cell RNA-seq data. It easily enables widely-used analytical techniques, including the identification of highly variable genes, dimensionality reduction; PCA, ICA, t-SNE, standard unsupervised clustering algorithms; density clustering, hierarchical clustering, k-means, and the discovery of differentially expressed genes and markers.

Generate causally-simulated data to serve as ground truth for evaluating methods in causal discovery and effect estimation. The package provides tools to assist in defining functions based on specified edges, and conversely, defining edges based on functions. It enables the generation of data according to these predefined functions and causal structures. This is particularly useful for researchers in fields such as artificial intelligence, statistics, biology, medicine, epidemiology, economics, and social sciences, who are developing a general or a domain-specific methods to discover causal structures and estimate causal effects. Data simulation adheres to principles of structural causal modeling. Detailed methodologies and examples are documented in our vignette, available at <https://htmlpreview.github.io/?https://github.com/herdiantrisufriyana/rcausim/blob/master/doc/causal_simulation_exemplar.html>.

This package provides functions for Arps decline-curve analysis on oil and gas data. Includes exponential, hyperbolic, harmonic, and hyperbolic-to-exponential models as well as the preceding with initial curtailment or a period of linear rate buildup. Functions included for computing rate, cumulative production, instantaneous decline, EUR, time to economic limit, and performing least-squares best fits.

This package provides a Bayesian model for examining the association between environmental mixtures and all Taxa measured in a hierarchical microbiome dataset in a single integrated analysis. Compared with analyzing the associations of environmental mixtures with each Taxa individually, BaHZING controls Type 1 error rates and provides more stable effect estimates when dealing with small sample sizes.

This package provides a framework for the replicable removal of personally identifiable data (PID) in data sets. The package implements a suite of methods to suit different data types based on the suggestions of Garfinkel (2015) <doi:10.6028/NIST.IR.8053> and the ICO "Guidelines on Anonymization" (2012) <https://ico.org.uk/media/1061/anonymisation-code.pdf>.

Designing experimental plans that involve both discrete and continuous factors with general parametric statistical models using the ForLion algorithm and EW ForLion algorithm. The algorithms will search for locally optimal designs and EW optimal designs under the D-criterion. Reference: Huang, Y., Li, K., Mandal, A., & Yang, J., (2024)<doi:10.1007/s11222-024-10465-x>.

This package provides tools and methods to apply the model Geospatial Regression Equation for European Nutrient losses (GREEN); Grizzetti et al. (2005) <doi:10.1016/j.jhydrol.2004.07.036>; Grizzetti et al. (2008); Grizzetti et al. (2012) <doi:10.1111/j.1365-2486.2011.02576.x>; Grizzetti et al. (2021) <doi:10.1016/j.gloenvcha.2021.102281>.

Develops a General Equilibrium (GE) Model, which estimates key variables such as wages, the number of residents and workers, the prices of the floor space, and its distribution between commercial and residential use, as in Ahlfeldt et al., (2015) <doi:10.3982/ECTA10876>. By doing so, the model allows understanding the economic influence of different urban policies.

This package implements the tree-based approach to joint modeling of time-to-event and longitudinal data. This approach looks for a tree-based partitioning such that within each estimated latent class defined by a terminal node, the time-to-event and longitudinal responses display a lack of association. See Zhang and Simonoff (2018) <arXiv:1812.01774>.

This package provides a comprehensive R interface to access data from the Kraken cryptocurrency exchange REST API <https://docs.kraken.com/api/>. It allows users to retrieve various market data, such as asset information, trading pairs, and price data. The package is designed to facilitate efficient data access for analysis, strategy development, and monitoring of cryptocurrency market trends.

Four measures of linkage disequilibrium are provided: the usual r^2 measure, the r^2_S measure (r^2 corrected by the structure sample), the r^2_V (r^2 corrected by the relatedness of genotyped individuals), the r^2_VS measure (r^2 corrected by both the relatedness of genotyped individuals and the structure of the sample).

This package provides functions to fit finite mixture of scale mixture of skew-normal (FM-SMSN) distributions, details in Prates, Lachos and Cabral (2013) <doi: 10.18637/jss.v054.i12>, Cabral, Lachos and Prates (2012) <doi:10.1016/j.csda.2011.06.026> and Basso, Lachos, Cabral and Ghosh (2010) <doi:10.1016/j.csda.2009.09.031>.

An R wrapper for pulling data from the National Public Transport Access Nodes ('NaPTAN') API (<https://www.api.gov.uk/dft/national-public-transport-access-nodes-naptan-api/#national-public-transport-access-nodes-naptan-api>). This allows users to download NaPTAN transport information, for the full dataset, by ATCO region code, or by name of region.

An implementation of Simultaneous Truth and Performance Level Estimation (STAPLE) <doi:10.1109/TMI.2004.828354>. This method is used when there are multiple raters for an object, typically an image, and this method fuses these ratings into one rating. It uses an expectation-maximization method to estimate this rating and the individual specificity/sensitivity for each rater.

COSMOS (Causal Oriented Search of Multi-Omic Space) is a method that integrates phosphoproteomics, transcriptomics, and metabolomics data sets based on prior knowledge of signaling, metabolic, and gene regulatory networks. It estimated the activities of transcrption factors and kinases and finds a network-level causal reasoning. Thereby, COSMOS provides mechanistic hypotheses for experimental observations across mulit-omics datasets.

Crumblr enables analysis of count ratio data using precision weighted linear (mixed) models. It uses an asymptotic normal approximation of the variance following the centered log ration transform (CLR) that is widely used in compositional data analysis. Crumblr provides a fast, flexible alternative to GLMs and GLMM's while retaining high power and controlling the false positive rate.

High-throughput sequencing experiments followed by differential expression analysis is a widely used approach to detect genomic biomarkers. A fundamental step in differential expression analysis is to model the association between gene counts and covariates of interest. NBAMSeq a flexible statistical model based on the generalized additive model and allows for information sharing across genes in variance estimation.

Filtering of lowly expressed features (e.g. genes) is a common step before performing statistical analysis, but an arbitrary threshold is generally chosen. SeqGate implements a method that rationalize this step by the analysis of the distibution of counts in replicate samples. The gate is the threshold above which sequenced features can be considered as confidently quantified.

This package provides a data-driven test for the assumptions of quantile normalization using raw data such as objects that inherit eSets (e.g. ExpressionSet, MethylSet). Group level information about each sample (such as Tumor / Normal status) must also be provided because the test assesses if there are global differences in the distributions between the user-defined groups.

Sending functions to remote processes can be wasteful of resources because they carry their environments with them. With this package, it is easy to create functions that are isolated from their environment. These isolated functions, also called crates, print to the console with their total size and can be easily tested locally before being sent to a remote.

This package provides a Bayesian credible interval is interpreted with respect to posterior probability, and this interpretation is far more intuitive than that of a frequentist confidence interval. However, standard highest-density intervals can be wide due to between-subjects variability and tends to hide within-subject effects, rendering its relationship with the Bayes factor less clear in within-subject (repeated-measures) designs. This urgent issue can be addressed by using within-subject intervals in within-subject designs, which integrate four methods including the Wei-Nathoo-Masson (2023) <doi:10.3758/s13423-023-02295-1>, the Loftus-Masson (1994) <doi:10.3758/BF03210951>, the Nathoo-Kilshaw-Masson (2018) <doi:10.1016/j.jmp.2018.07.005>, and the Heck (2019) <doi:10.31234/osf.io/whp8t> interval estimates.

R is a language and environment for statistical computing and graphics. It provides a variety of statistical techniques, such as linear and nonlinear modeling, classical statistical tests, time-series analysis, classification and clustering. It also provides robust support for producing publication-quality data plots. A large amount of 3rd-party packages are available, greatly increasing its breadth and scope.

This package provides a collection of Japanese text processing tools for filling Japanese iteration marks, Japanese character type conversions, segmentation by phrase, and text normalization which is based on rules for the Sudachi morphological analyzer and the NEologd (Neologism dictionary for MeCab'). These features are specific to Japanese and are not implemented in ICU (International Components for Unicode).