This package provides a system for querying, retrieving and analyzing protocol- and results-related information on clinical trials from three public registers, the European Union Clinical Trials Register (EUCTR), ClinicalTrials.gov (CTGOV) and the ISRCTN. Trial information is downloaded, converted and stored in a database. Functions are included to identify deduplicated records, to easily find and extract variables (fields) of interest even from complex nesting as used by the registers, and to update previous queries. The package can be used for meta-analysis and trend-analysis of the design and conduct as well as for results of clinical trials.

Package containing example and annotation data for Hipathia package. Hipathia is a method for the computation of signal transduction along signaling pathways from transcriptomic data. The method is based on an iterative algorithm which is able to compute the signal intensity passing through the nodes of a network by taking into account the level of expression of each gene and the intensity of the signal arriving to it. It also provides a new approach to functional analysis allowing to compute the signal arriving to the functions annotated to each pathway. Hipathia depends on this package to be functional.

Reads files exported from QX Manager or QuantaSoft containing amplitude values from a run of ddPCR (96 well plate) and robustly sets thresholds to determine positive droplets for each channel of each individual well. Concentration and normalized concentration in addition to other metrics is then calculated for each well. Results are returned as a table, optionally written to file, as well as optional plots (scatterplot and histogram) for both channels per well written to file. The package includes a shiny application which provides an interactive and user-friendly interface to the full functionality of PoDCall.

This package provides tools for exploration of R package dependencies. The main deepdep() function allows to acquire deep dependencies of any package and plot them in an elegant way. It also adds some popularity measures for the packages e.g. in the form of download count through the cranlogs package. Uses the CRAN metadata database <http://crandb.r-pkg.org> and Bioconductor metadata <https://bioconductor.org>. Other data acquire functions are: get_dependencies(), get_downloads() and get_description(). The deepdep_shiny() function runs shiny application that helps to produce a nice deepdep plot.

This package provides R-implementation of Decision forest algorithm, which combines the predictions of multiple independent decision tree models for a consensus decision. In particular, Decision Forest is a novel pattern-recognition method which can be used to analyze: (1) DNA microarray data; (2) Surface-Enhanced Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (SELDI-TOF-MS) data; and (3) Structure-Activity Relation (SAR) data. In this package, three fundamental functions are provided, as (1)DF_train, (2)DF_pred, and (3)DF_CV. run Dforest() to see more instructions. Weida Tong (2003) <doi:10.1021/ci020058s>.

Analysis of temporal changes (i.e. dynamics) of ecological entities, defined as trajectories on a chosen multivariate space, by providing a set of trajectory metrics and visual representations [De Caceres et al. (2019) <doi:10.1002/ecm.1350>; and Sturbois et al. (2021) <doi:10.1016/j.ecolmodel.2020.109400>]. Includes functions to estimate metrics for individual trajectories (length, directionality, angles, ...) as well as metrics to relate pairs of trajectories (dissimilarity and convergence). Functions are also provided to estimate the ecological quality of ecosystem with respect to reference conditions [Sturbois et al. (2023) <doi:10.1002/ecs2.4726>].

FASTQC is the most widely used tool for evaluating the quality of high throughput sequencing data. It produces, for each sample, an html report and a compressed file containing the raw data. If you have hundreds of samples, you are not going to open up each HTML page. You need some way of looking at these data in aggregate. fastqcr Provides helper functions to easily parse, aggregate and analyze FastQC reports for large numbers of samples. It provides a convenient solution for building a Multi-QC report, as well as, a one-sample report with result interpretations.

This package provides tools to build and work with bilateral generalized-mean price indexes (and by extension quantity indexes), and indexes composed of generalized-mean indexes (e.g., superlative quadratic-mean indexes, GEKS). Covers the core mathematical machinery for making bilateral price indexes, computing price relatives, detecting outliers, and decomposing indexes, with wrappers for all common (and many uncommon) index-number formulas. Implements and extends many of the methods in Balk (2008, <doi:10.1017/CBO9780511720758>), von der Lippe (2007, <doi:10.3726/978-3-653-01120-3>), and the CPI manual (2020, <doi:10.5089/9781484354841.069>).

This package provides a framework to assist creation of marine ecosystem models, generating either R or C++ code which can then be optimised using the TMB package and standard R tools. Principally designed to reproduce gadget2 models in TMB', but can be extended beyond gadget2's capabilities. Kasper Kristensen, Anders Nielsen, Casper W. Berg, Hans Skaug, Bradley M. Bell (2016) <doi:10.18637/jss.v070.i05> "TMB: Automatic Differentiation and Laplace Approximation.". Begley, J., & Howell, D. (2004) <https://core.ac.uk/download/pdf/225936648.pdf> "An overview of Gadget, the globally applicable area-disaggregated general ecosystem toolbox. ICES.".

This package implements random number generation, plotting, and estimation algorithms for the two-parameter one-sided and two-sided M-Wright (Mainardi-Wright) family. The M-Wright distributions naturally generalize the widely used one-sided (Airy and half-normal or half-Gaussian) and symmetric (Airy and Gaussian or normal) models. These are widely studied in time-fractional differential equations. References: Cahoy and Minkabo (2017) <doi:10.3233/MAS-170388>; Cahoy (2012) <doi:10.1007/s00180-011-0269-x>; Cahoy (2012) <doi:10.1080/03610926.2010.543299>; Cahoy (2011); Mainardi, Mura, and Pagnini (2010) <doi:10.1155/2010/104505>.

This package provides a set of tools for likelihood-based estimation, model selection and testing of two- and three-range shift and migration models for animal movement data as described in Gurarie et al. (2017) <doi: 10.1111/1365-2656.12674>. Provided movement data (X, Y and Time), including irregularly sampled data, functions estimate the time, duration and location of one or two range shifts, as well as the ranging area and auto-correlation structure of the movment. Tests assess, for example, whether the shift was "significant", and whether a two-shift migration was a true return migration.

Following the common types of measures of uncertainty for parameter estimation, two measures of uncertainty were proposed for model selection, see Liu, Li and Jiang (2020) <doi:10.1007/s11749-020-00737-9>. The first measure is a kind of model confidence set that relates to the variation of model selection, called Mac. The second measure focuses on error of model selection, called LogP. They are all computed via bootstrapping. This package provides functions to compute these two measures. Furthermore, a similar model confidence set adapted from Bayesian Model Averaging can also be computed using this package.

This package provides a collection of functions for the analysis of archaeological mortality data (on the topic see e.g. Chamberlain 2006 <https://books.google.de/books?id=nG5FoO_becAC&lpg=PA27&ots=LG0b_xrx6O&dq=life%20table%20archaeology&pg=PA27#v=onepage&q&f=false>). It takes demographic data in different formats and displays the result in a standard life table as well as plots the relevant indices (percentage of deaths, survivorship, probability of death, life expectancy, percentage of population). It also checks for possible biases in the age structure and applies corrections to life tables.

Constructs mixed-level and regular fractional factorial designs using coordinate-exchange optimization and automatic generator search. Design quality is evaluated with J2 and balance (H-hat) criteria, alias structures are computed via correlation-based chaining, and deterministic trend-free run orders can be produced following Coster (1993) <doi:10.1214/aos/1176349410>. Mixed-level design construction follows the NONBPA approach of Pantoja-Pacheco et al. (2021) <doi:10.3390/math9131455>. Regular fraction identification follows Guo, Simpson and Pignatiello (2007) <doi:10.1080/00224065.2007.11917691>. Alias structure computation follows Rios-Lira et al.(2021) <doi:10.3390/math9233053>.

This package provides functions to retrieve, process, analyze, and quality-control marine physical, chemical, and biological data. The main focus is on Swedish monitoring data available through the SHARK database <https://shark.smhi.se/en/>, with additional API support for Nordic Microalgae <https://nordicmicroalgae.org/>, Dyntaxa <https://artfakta.se/>, World Register of Marine Species ('WoRMS') <https://www.marinespecies.org>, AlgaeBase <https://www.algaebase.org>, OBIS xylookup web service <https://iobis.github.io/xylookup/> and Intergovernmental Oceanographic Commission (IOC) - UNESCO databases on harmful algae <https://www.marinespecies.org/hab/> and toxins <https://toxins.hais.ioc-unesco.org/>.

This package provides tools to access and manipulate Word and PowerPoint documents from R. The package focuses on tabular and graphical reporting from R; it also provides two functions that let users get document content into data objects. A set of functions lets add and remove images, tables and paragraphs of text in new or existing documents. When working with PowerPoint presentations, slides can be added or removed; shapes inside slides can also be added or removed. When working with Word documents, a cursor can be used to help insert or delete content at a specific location in the document.

CYPRESS is a cell-type-specific power tool. This package aims to perform power analysis for the cell-type-specific data. It calculates FDR, FDC, and power, under various study design parameters, including but not limited to sample size, and effect size. It takes the input of a SummarizeExperimental(SE) object with observed mixture data (feature by sample matrix), and the cell-type mixture proportions (sample by cell-type matrix). It can solve the cell-type mixture proportions from the reference free panel from TOAST and conduct tests to identify cell-type-specific differential expression (csDE) genes.

At the Swiss Federal Statistical Office (SFSO), spatial maps of Switzerland are available free of charge as Cartographic bases for small-scale thematic mapping'. This package contains convenience functions to import ESRI (Environmental Systems Research Institute) shape files using the package sf and to plot them easily and quickly without having to worry too much about the technical details. It contains utilities to combine multiple areas to one single polygon and to find neighbours for single regions. For any point on a map, a special locator can be used to determine to which municipality, district or canton it belongs.

This package performs simulation-based inference as an alternative to the delta method for obtaining valid confidence intervals and p-values for regression post-estimation quantities, such as average marginal effects and predictions at representative values. This framework for simulation-based inference is especially useful when the resulting quantity is not normally distributed and the delta method approximation fails. The methodology is described in Greifer, et al. (2025) <doi:10.32614/RJ-2024-015>. clarify is meant to replace some of the functionality of the archived package Zelig'; see the vignette "Translating Zelig to clarify" for replicating this functionality.

Several web services are available that provide access to elevation data. This package provides access to many of those services and returns elevation data either as an sf simple features object from point elevation services or as a raster object from raster elevation services. In future versions, elevatr will drop support for raster and will instead return terra objects. Currently, the package supports access to the Amazon Web Services Terrain Tiles <https://registry.opendata.aws/terrain-tiles/>, the Open Topography Global Datasets API <https://opentopography.org/developers/>, and the USGS Elevation Point Query Service <https://apps.nationalmap.gov/epqs/>.

This package provides a faster implementation of Bayesian Causal Forests (BCF; Hahn et al. (2020) <doi:10.1214/19-BA1195>), which uses regression tree ensembles to estimate the conditional average treatment effect of a binary treatment on a scalar output as a function of many covariates. This implementation avoids many redundant computations and memory allocations present in the original BCF implementation, allowing the model to be fit to larger datasets. The implementation was originally developed for the 2022 American Causal Inference Conference's Data Challenge. See Kokandakar et al. (2023) <doi:10.1353/obs.2023.0024> for more details.

This package provides a procedure for comparing multivariate samples associated with different groups. It uses principal component analysis to convert multivariate observations into a set of linearly uncorrelated statistical measures, which are then compared using a number of statistical methods. The procedure is independent of the distributional properties of samples and automatically selects features that best explain their differences, avoiding manual selection of specific points or summary statistics. It is appropriate for comparing samples of time series, images, spectrometric measures or similar multivariate observations. This package is described in Fachada et al. (2016) <doi:10.32614/RJ-2016-055>.

The midasml package implements estimation and prediction methods for high-dimensional mixed-frequency (MIDAS) time-series and panel data regression models. The regularized MIDAS models are estimated using orthogonal (e.g. Legendre) polynomials and sparse-group LASSO (sg-LASSO) estimator. For more information on the midasml approach see Babii, Ghysels, and Striaukas (2021, JBES forthcoming) <doi:10.1080/07350015.2021.1899933>. The package is equipped with the fast implementation of the sg-LASSO estimator by means of proximal block coordinate descent. High-dimensional mixed frequency time-series data can also be easily manipulated with functions provided in the package.

This package provides a model designed to be a reliable testbed where various gene drive interventions for mosquito-borne diseases control. It is being developed to accommodate the use of various mosquito-specific gene drive systems within a population dynamics framework that allows migration of individuals between patches in landscape. Previous work developing the population dynamics can be found in Deredec et al. (2001) <doi:10.1073/pnas.1110717108> and Hancock & Godfray (2007) <doi:10.1186/1475-2875-6-98>, and extensions to accommodate CRISPR homing dynamics in Marshall et al. (2017) <doi:10.1038/s41598-017-02744-7>.