This package provides a computationally-efficient leading-eigenvalue approximation to tail probabilities and quantiles of large quadratic forms, in particular for the Sequence Kernel Association Test (SKAT) used in genomics <doi:10.1002/gepi.22136>. Also provides stochastic singular value decomposition for dense or sparse matrices.

This package provides tools to fit Bayesian state-space models to animal tracking data. Models are provided for location filtering, location filtering and behavioural state estimation, and their hierarchical versions. The models are primarily intended for fitting to ARGOS satellite tracking data but options exist to fit to other tracking data types. For Global Positioning System data, consider the moveHMM package. Simplified Markov Chain Monte Carlo convergence diagnostic plotting is provided but users are encouraged to explore tools available in packages such as coda and boa'.

Parse a BibTeX file to a data.frame to make it accessible for further analysis and visualization.

Nuclear magnetic resonance (NMR) is a highly versatile analytical technique for studying molecular configuration, conformation, and dynamics, especially those of biomacromolecules such as proteins. Biological Magnetic Resonance Data Bank ('BMRB') is a repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules. Currently, BMRB offers an R package RBMRB to fetch data, however, it doesn't easily offer individual data file downloading and storing in a local directory. When using RBMRB', the data will stored as an R object, which fundamentally hinders the NMR researches to access the rich information from raw data, for example, the metadata. Here, BMRBr File Downloader ('BMRBr') offers a more fundamental, low level downloader, which will download original deposited .str format file. This type of file contains information such as entry title, authors, citation, protein sequences, and so on. Many factors affect NMR experiment outputs, such as temperature, resonance sensitivity and etc., approximately 40% of the entries in the BMRB have chemical shift accuracy problems [1,2] Unfortunately, current reference correction methods are heavily dependent on the availability of assigned protein chemical shifts or protein structure. This is my current research project is going to solve, which will be included in the future release of the package. The current version of the package is sufficient and robust enough for downloading individual BMRB data file from the BMRB database <http://www.bmrb.wisc.edu>. The functionalities of this package includes but not limited: * To simplifies NMR researches by combine data downloading and results analysis together. * To allows NMR data reaches a broader audience that could utilize more than just chemical shifts but also metadata. * To offer reference corrected data for entries without assignment or structure information (future release). Reference: [1] E.L. Ulrich, H. Akutsu, J.F. Doreleijers, Y. Harano, Y.E. Ioannidis, J. Lin, et al., BioMagResBank, Nucl. Acids Res. 36 (2008) D402â 8. <doi:10.1093/nar/gkm957>. [2] L. Wang, H.R. Eghbalnia, A. Bahrami, J.L. Markley, Linear analysis of carbon-13 chemical shift differences and its application to the detection and correction of errors in referencing and spin system identifications, J. Biomol. NMR. 32 (2005) 13â 22. <doi:10.1007/s10858-005-1717-0>.

Applies Beta Control Charts to defined values. The Beta Chart presents control limits based on the Beta probability distribution, making it suitable for monitoring fraction data from a Binomial distribution as a replacement for p-Charts. The Beta Chart has been applied in three real studies and compared with control limits from three different schemes. The comparative analysis showed that: (i) the Beta approximation to the Binomial distribution is more appropriate for values confined within the [0, 1] interval; and (ii) the proposed charts are more sensitive to the average run length (ARL) in both in-control and out-of-control process monitoring. Overall, the Beta Charts outperform the Shewhart control charts in monitoring fraction data. For more details, see à ngelo Márcio Oliveira Santâ Anna and Carla Schwengber ten Caten (2012) <doi:10.1016/j.eswa.2012.02.146>.

Carry out Bayesian estimation and forecasting for a variety of stochastic mortality models using vague prior distributions. Models supported include numerous well-established approaches introduced in the actuarial and demographic literature, such as the Lee-Carter (1992) <doi:10.1080/01621459.1992.10475265>, the Cairns-Blake-Dowd (2009) <doi:10.1080/10920277.2009.10597538>, the Li-Lee (2005) <doi:10.1353/dem.2005.0021>, and the Plat (2009) <doi:10.1016/j.insmatheco.2009.08.006> models. The package is designed to analyse stratified mortality data structured as a 3-dimensional array of dimensions p à A à T (strata à age à year). Stratification can represent factors such as cause of death, country, deprivation level, sex, geographic region, insurance product, marital status, socioeconomic group, or smoking behavior. While the primary focus is on analysing stratified data (p > 1), the package can also handle mortality data that are not stratified (p = 1). Model selection via the Deviance Information Criterion (DIC) is supported.

From a given data frame, this package learns its Bayesian network structure based on a selected score.

Transforms focal observations data, where different types of social interactions can be recorded by multiple observers, into asymmetric data matrices. Each cell in these matrices provides counts on the number of times a specific type of social interaction was initiated by the row subject and directed to the column subject.

Designed to simplify and streamline the process of reading and processing large volumes of data in R, this package offers a collection of functions tailored for bulk data operations. It enables users to efficiently read multiple sheets from Microsoft Excel and Google Sheets workbooks, as well as various CSV files from a directory. The data is returned as organized data frames, facilitating further analysis and manipulation. Ideal for handling extensive data sets or batch processing tasks, bulkreadr empowers users to manage data in bulk effortlessly, saving time and effort in data preparation workflows. Additionally, the package seamlessly works with labelled data from SPSS and Stata.

Implementation of the bunching estimator for kinks and notches. Allows for flexible estimation of counterfactual (e.g. controlling for round number bunching, accounting for other bunching masses within bunching window, fixing bunching point to be minimum, maximum or median value in its bin, etc.). It produces publication-ready plots in the style followed since Chetty et al. (2011) <doi:10.1093/qje/qjr013>, with lots of functionality to set plot options.

Unified and user-friendly framework for using new distributional representations of biosensors data in different statistical modeling tasks: regression models, hypothesis testing, cluster analysis, visualization, and descriptive analysis. Distributional representations are a functional extension of compositional time-range metrics and we have used them successfully so far in modeling glucose profiles and accelerometer data. However, these functional representations can be used to represent any biosensor data such as ECG or medical imaging such as fMRI. Matabuena M, Petersen A, Vidal JC, Gude F. "Glucodensities: A new representation of glucose profiles using distributional data analysis" (2021) <doi:10.1177/0962280221998064>.

BRIC-seq is a genome-wide approach for determining RNA stability in mammalian cells. This package provides a series of functions for performing quality check of your BRIC-seq data, calculation of RNA half-life for each transcript and comparison of RNA half-lives between two conditions.

This package provides a Bayesian model for examining the association between environmental mixtures and all Taxa measured in a hierarchical microbiome dataset in a single integrated analysis. Compared with analyzing the associations of environmental mixtures with each Taxa individually, BaHZING controls Type 1 error rates and provides more stable effect estimates when dealing with small sample sizes.

Algorithms for computing and generating plots with and without error bars for Bayesian cluster validity index (BCVI) (O. Preedasawakul, and N. Wiroonsri, A Bayesian Cluster Validity Index, Computational Statistics & Data Analysis, 202, 108053, 2025. <doi:10.1016/j.csda.2024.108053>) based on several underlying cluster validity indexes (CVIs) including Calinski-Harabasz, Chou-Su-Lai, Davies-Bouldin, Dunn, Pakhira-Bandyopadhyay-Maulik, Point biserial correlation, the score function, Starczewski, and Wiroonsri indices for hard clustering, and Correlation Cluster Validity, the generalized C, HF, KWON, KWON2, Modified Pakhira-Bandyopadhyay-Maulik, Pakhira-Bandyopadhyay-Maulik, Tang, Wiroonsri-Preedasawakul, Wu-Li, and Xie-Beni indices for soft clustering. The package is compatible with K-means, fuzzy C means, EM clustering, and hierarchical clustering (single, average, and complete linkage). Though BCVI is compatible with any underlying existing CVIs, we recommend users to use either WI or WP as the underlying CVI.

Primarily created as an easy and understanding way to do basic sequences surrounding the central dogma of molecular biology.

Intended to facilitate acoustic analysis of (animal) sound propagation experiments, which typically aim to quantify changes in signal structure when transmitted in a given habitat by broadcasting and re-recording animal sounds at increasing distances. The package offers a workflow with functions to prepare the data set for analysis as well as to calculate and visualize several degradation metrics, including blur ratio, signal-to-noise ratio, excess attenuation and envelope correlation among others (Dabelsteen et al 1993 <doi:10.1121/1.406682>).

This package provides tools for bioinformatics modeling using recursive transformer-inspired architectures, autoencoders, random forests, XGBoost, and stacked ensemble models. Includes utilities for cross-validation, calibration, benchmarking, and threshold optimization in predictive modeling workflows. The methodology builds on ensemble learning (Breiman 2001 <doi:10.1023/A:1010933404324>), gradient boosting (Chen and Guestrin 2016 <doi:10.1145/2939672.2939785>), autoencoders (Hinton and Salakhutdinov 2006 <doi:10.1126/science.1127647>), and recursive transformer efficiency approaches such as Mixture-of-Recursions (Bae et al. 2025 <doi:10.48550/arXiv.2507.10524>).

An automated graphical exploratory data analysis (EDA) tool that introduces: a.) wideplot graphics for exploring the structure of a dataset through a grid of variables and graphic types. b.) longplot graphics, which present the entire catalog of available graphics for representing a particular variable using a grid of graphic types and variations on these types. c.) plotup function, which presents a particular graphic for a specific variable of a dataset. The plotup() function also makes it possible to obtain the code used to generate the graphic, meaning that the user can adjust its properties as needed. d.) matrixplot graphics that is a grid of a particular graphic showing bivariate relationships between all pairs of variables of a certain(s) type(s) in a multivariate data set.

Bayesian kernel machine regression (from the bkmr package) is a Bayesian semi-parametric generalized linear model approach under identity and probit links. There are a number of functions in this package that extend Bayesian kernel machine regression fits to allow multiple-chain inference and diagnostics, which leverage functions from the future', rstan', and coda packages. Reference: Bobb, J. F., Henn, B. C., Valeri, L., & Coull, B. A. (2018). Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression. ; <doi:10.1186/s12940-018-0413-y>.

Fits bootstrap with univariate spatial regression models using Bootstrap for Rapid Inference on Spatial Covariances (BRISC) for large datasets using nearest neighbor Gaussian processes detailed in Saha and Datta (2018) <doi:10.1002/sta4.184>.

Bayesian optimal design with futility and efficacy stopping boundaries (BOP2-FE) is a novel statistical framework for single-arm Phase II clinical trials. It enables early termination for efficacy when interim data are promising, while explicitly controlling Type I and Type II error rates. The design supports a variety of endpoint structures, including single binary endpoints, nested endpoints, co-primary endpoints, and joint monitoring of efficacy and toxicity. The package provides tools for enumerating stopping boundaries prior to trial initiation and for conducting simulation studies to evaluate the designâ s operating characteristics. Users can flexibly specify design parameters to suit their specific applications. For methodological details, refer to Xu et al. (2025) <doi:10.1080/10543406.2025.2558142>.

This package contains several Bayesian models for data analysis of psychological tests. A user friendly interface for these models should enable students and researchers to perform professional level Bayesian data analysis without advanced knowledge in programming and Bayesian statistics. This package is based on the Stan platform (Carpenter et el. 2017 <doi:10.18637/jss.v076.i01>).

This package provides a fast integrative genetic association test for rare diseases based on a model for disease status given allele counts at rare variant sites. Probability of association, mode of inheritance and probability of pathogenicity for individual variants are all inferred in a Bayesian framework - A Fast Association Test for Identifying Pathogenic Variants Involved in Rare Diseases', Greene et al 2017 <doi:10.1016/j.ajhg.2017.05.015>.

Bayesian network structure learning, parameter learning and inference. This package implements constraint-based (PC, GS, IAMB, Inter-IAMB, Fast-IAMB, MMPC, Hiton-PC, HPC), pairwise (ARACNE and Chow-Liu), score-based (Hill-Climbing and Tabu Search) and hybrid (MMHC, RSMAX2, H2PC) structure learning algorithms for discrete, Gaussian and conditional Gaussian networks, along with many score functions and conditional independence tests. The Naive Bayes and the Tree-Augmented Naive Bayes (TAN) classifiers are also implemented. Some utility functions (model comparison and manipulation, random data generation, arc orientation testing, simple and advanced plots) are included, as well as support for parameter estimation (maximum likelihood and Bayesian) and inference, conditional probability queries, cross-validation, bootstrap and model averaging. Development snapshots with the latest bugfixes are available from <https://www.bnlearn.com/>.