Bias- and Uncertainty-Corrected Sample Size. BUCSS implements a method of correcting for publication bias and uncertainty when planning sample sizes in a future study from an original study. See Anderson, Kelley, & Maxwell (2017; Psychological Science, 28, 1547-1562).

Implementations in cpp of the BayesProject algorithm (see G. Hahn, P. Fearnhead, I.A. Eckley (2020) <doi:10.1007/s11222-020-09966-2>) which implements a fast approach to compute a projection direction for multivariate changepoint detection, as well as the sum-cusum and max-cusum methods, and a wild binary segmentation wrapper for all algorithms.

Easily talk to Google's BigQuery Storage API from R (<https://cloud.google.com/bigquery/docs/reference/storage/rpc>).

This package provides a set of functions to help clinical trial researchers calculate power and sample size for two-arm Bayesian randomized clinical trials that do or do not incorporate historical control data. At some point during the design process, a clinical trial researcher who is designing a basic two-arm Bayesian randomized clinical trial needs to make decisions about power and sample size within the context of hypothesized treatment effects. Through simulation, the simple_sim() function will estimate power and other user specified clinical trial characteristics at user specified sample sizes given user defined scenarios about treatment effect,control group characteristics, and outcome. If the clinical trial researcher has access to historical control data, then the researcher can design a two-arm Bayesian randomized clinical trial that incorporates the historical data. In such a case, the researcher needs to work through the potential consequences of historical and randomized control differences on trial characteristics, in addition to working through issues regarding power in the context of sample size, treatment effect size, and outcome. If a researcher designs a clinical trial that will incorporate historical control data, the researcher needs the randomized controls to be from the same population as the historical controls. What if this is not the case when the designed trial is implemented? During the design phase, the researcher needs to investigate the negative effects of possible historic/randomized control differences on power, type one error, and other trial characteristics. Using this information, the researcher should design the trial to mitigate these negative effects. Through simulation, the historic_sim() function will estimate power and other user specified clinical trial characteristics at user specified sample sizes given user defined scenarios about historical and randomized control differences as well as treatment effects and outcomes. The results from historic_sim() and simple_sim() can be printed with print_table() and graphed with plot_table() methods. Outcomes considered are Gaussian, Poisson, Bernoulli, Lognormal, Weibull, and Piecewise Exponential. The methods are described in Eggleston et al. (2021) <doi:10.18637/jss.v100.i21>.

Read and process brand.yml YAML files. brand.yml is a simple, portable YAML file that codifies your company's brand guidelines into a format that can be used by Quarto', Shiny and R tooling to create branded outputs. Maintain unified, branded theming for web applications to printed reports to dashboards and presentations with a consistent look and feel.

This package provides methods for Bayesian parameter estimation and forecasting in epidemiological models. Functions enable model fitting using Bayesian methods and generate forecasts with uncertainty quantification. Implements approaches described in <doi:10.48550/arXiv.2411.05371> and <doi:10.1002/sim.9164>.

This package provides a light-weight object-oriented system with python'-like syntax which supports multiple inheritances and incorporates a python'-like method resolution order.

R bindings for the various functions and statistical distributions provided by the Boost Math library <https://www.boost.org/doc/libs/latest/libs/math/doc/html/index.html>.

Multicenter randomized trials involve the collection and analysis of data from numerous study participants across multiple sites. Outliers may be present. To identify outliers, this package examines data at the individual level (univariate and multivariate) and site-level (with and without covariate adjustment). Methods are outlined in further detail in Rigdon et al (to appear).

This package performs the algorithm for time series clustering described in Nieto-Barajas and Contreras-Cristan (2014).

Complex machine learning models are often difficult to interpret. Shapley values serve as a powerful tool to understand and explain why a model makes a particular prediction. This package computes variable contributions using permutation-based Shapley values for Bayesian Additive Regression Trees (BART) and its extension with Post-Stratification (BARP). The permutation-based SHAP method proposed by Strumbel and Kononenko (2014) <doi:10.1007/s10115-013-0679-x> is grounded in data obtained via MCMC sampling. Similar to the BART model introduced by Chipman, George, and McCulloch (2010) <doi:10.1214/09-AOAS285>, this package leverages Bayesian posterior samples generated during model estimation, allowing variable contributions to be computed without requiring additional sampling. The BART model is designed to work with the following R packages: BART <doi:10.18637/jss.v097.i01>, bartMachine <doi:10.18637/jss.v070.i04>, and dbarts <https://CRAN.R-project.org/package=dbarts>. For XGBoost and baseline adjustments, the approach by Lundberg et al. (2020) <doi:10.1038/s42256-019-0138-9> is also considered. The BARP model proposed by Bisbee (2019) <doi:10.1017/S0003055419000480> was implemented with reference to <https://github.com/jbisbee1/BARP> and is designed to work with modified functions based on that implementation. BARP extends post-stratification by computing variable contributions within each stratum defined by stratifying variables. The resulting Shapley values are visualized through both global and local explanation methods.

This package provides tools for the analysis of replication studies using Bayes factors (Pawel and Held, 2022) <doi:10.1111/rssb.12491>.

This package provides Bayesian methods for comparing groups on multiple binary outcomes. Includes basic tests using multivariate Bernoulli distributions, subgroup analysis via generalized linear models, and multilevel models for clustered data. For statistical underpinnings, see Kavelaars, Mulder, and Kaptein (2020) <doi:10.1177/0962280220922256>, Kavelaars, Mulder, and Kaptein (2024) <doi:10.1080/00273171.2024.2337340>, and Kavelaars, Mulder, and Kaptein (2023) <doi:10.1186/s12874-023-02034-z>. An interactive shiny app to perform sample size computations is available.

Building on the docking layout manager provided by dockViewR', this provides a flexible front-end to blockr.core'. It provides an extension mechanism which allows for providing means to manipulate a board object via panel-based user interface components.

This package provides methods to estimate optimal dynamic treatment regimes using Bayesian likelihood-based regression approach as described in Yu, W., & Bondell, H. D. (2023) <doi:10.1093/jrsssb/qkad016> Uses backward induction and dynamic programming theory for computing expected values. Offers options for future parallel computing.

This package performs CACE (Complier Average Causal Effect analysis) on either a single study or meta-analysis of datasets with binary outcomes, using either complete or incomplete noncompliance information. Our package implements the Bayesian methods proposed in Zhou et al. (2019) <doi:10.1111/biom.13028>, which introduces a Bayesian hierarchical model for estimating CACE in meta-analysis of clinical trials with noncompliance, and Zhou et al. (2021) <doi:10.1080/01621459.2021.1900859>, with an application example on Epidural Analgesia.

Bindings to the blowfish password hashing algorithm <https://www.openbsd.org/papers/bcrypt-paper.pdf> derived from the OpenBSD implementation.

This package provides an interface to data provided by the Bank for International Settlements <https://www.bis.org>, allowing for programmatic retrieval of a large quantity of (central) banking data.

Bayesian power/type I error calculation and model fitting using the power prior and the normalized power prior for proportional hazards models with piecewise constant hazard. The methodology and examples of applying the package are detailed in <doi:10.48550/arXiv.2404.05118>. The Bayesian clinical trial design methodology is described in Chen et al. (2011) <doi:10.1111/j.1541-0420.2011.01561.x>, and Psioda and Ibrahim (2019) <doi:10.1093/biostatistics/kxy009>. The proportional hazards model with piecewise constant hazard is detailed in Ibrahim et al. (2001) <doi:10.1007/978-1-4757-3447-8>.

Enables a user to consume the BambooHR API endpoints using R. The actual URL of the API will depend on your company domain, and will be handled by the package automatically once you setup the config file. The API documentation can be found here <https://documentation.bamboohr.com/docs>.

Enables quick calibration of radiocarbon dates under various calibration curves (including user generated ones); age-depth modelling as per the algorithm of Haslett and Parnell (2008) <DOI:10.1111/j.1467-9876.2008.00623.x>; Relative sea level rate estimation incorporating time uncertainty in polynomial regression models (Parnell and Gehrels 2015) <DOI:10.1002/9781118452547.ch32>; non-parametric phase modelling via Gaussian mixtures as a means to determine the activity of a site (and as an alternative to the Oxcal function SUM(); currently unpublished), and reverse calibration of dates from calibrated into 14C years (also unpublished).

Multivariate tool for analyzing genome-wide association study results in the form of univariate summary statistics. The goal of bmass is to comprehensively test all possible multivariate models given the phenotypes and datasets provided. Multivariate models are determined by assigning each phenotype to being either Unassociated (U), Directly associated (D) or Indirectly associated (I) with the genetic variant of interest. Test results for each model are presented in the form of Bayes factors, thereby allowing direct comparisons between models. The underlying framework implemented here is based on the modeling developed in "A Unified Framework for Association Analysis with Multiple Related Phenotypes", M. Stephens (2013) <doi:10.1371/journal.pone.0065245>.

This package provides methods for the binarization and trinarization of one-dimensional data and some visualization functions.

Design and analysis of two-arm binomial clinical (phase II) trials using Bayes factors. Implements Bayes factors for point-null and directional hypotheses, predictive densities under different hypotheses, and power and sample size calibration with optional frequentist type-I error and power.