This package performs tuning of clustering models, methods and algorithms including the problem of determining an appropriate number of clusters. Validation of cluster analysis results is performed via quadratic scoring using resampling methods, as in Coraggio, L. and Coretto, P. (2023) <doi:10.1016/j.jmva.2023.105181>.

R interface to Apache Spark, a fast and general engine for big data processing, see <https://spark.apache.org/>. This package supports connecting to local and remote Apache Spark clusters, provides a dplyr compatible back-end, and provides an interface to Spark's built-in machine learning algorithms.

Suite of helper functions for data wrangling and visualization. The only theme for these functions is that they tend towards simple, short, and narrowly-scoped. These functions are built for tasks that often recur but are not large enough in scope to warrant an ecosystem of interdependent functions.

Median-of-means is a generic yet powerful framework for scalable and robust estimation. A framework for Bayesian analysis is called M-posterior, which estimates a median of subset posterior measures. For general exposition to the topic, see the paper by Minsker (2015) <doi:10.3150/14-BEJ645>.

Exploratory analysis on any input data describing the structure and the relationships present in the data. The package automatically select the variable and does related descriptive statistics. Analyzing information value, weight of evidence, custom tables, summary statistics, graphical techniques will be performed for both numeric and categorical predictors.

Multiple ways to bin numeric columns with a tidy output. Wraps a variety of existing binning methods into one function, and includes a new method for binning by equal value, which is useful for sales data. Provides a function to automatically summarize the properties of the binned columns.

Allow R users to interact with the Canvas Learning Management System (LMS) API (see <https://canvas.instructure.com/doc/api/all_resources.html> for details). It provides a set of functions to access and manipulate course data, assignments, grades, users, and other resources available through the Canvas API.

This package performs clustering of quantitative variables, assuming that clusters lie in low-dimensional subspaces. Segmentation of variables, number of clusters and their dimensions are selected based on BIC. Candidate models are identified based on many runs of K-means algorithm with different random initializations of cluster centers.

Data driven strategy to find hidden groups of patients with complex diseases using clinical data. ClustAll facilitates the unsupervised identification of multiple robust stratifications. ClustAll, is able to overcome the most common limitations found when dealing with clinical data (missing values, correlated data, mixed data types).

HMP2Data is a Bioconductor package of the Human Microbiome Project 2 (HMP2) 16S rRNA sequencing data. Processed data is provided as phyloseq, SummarizedExperiment, and MultiAssayExperiment class objects. Individual matrices and data.frames used for building these S4 class objects are also provided in the package.

svaRetro contains functions for detecting retrotransposed transcripts (RTs) from structural variant calls. It takes structural variant calls in GRanges of breakend notation and identifies RTs by exon-exon junctions and insertion sites. The candidate RTs are reported by events and annotated with information of the inserted transcripts.

`tomoseqr` is an R package for analyzing Tomo-seq data. Tomo-seq is a genome-wide RNA tomography method that combines combining high-throughput RNA sequencing with cryosectioning for spatially resolved transcriptomics. `tomoseqr` reconstructs 3D expression patterns from tomo-seq data and visualizes the reconstructed 3D expression patterns.

This package provides a enhanced visualization of single-cell data based on gene-weighted density estimation. Nebulosa recovers the signal from dropped-out features and allows the inspection of the joint expression from multiple features (e.g. genes). Seurat and SingleCellExperiment objects can be used within Nebulosa.

MultiBaC is a strategy to correct batch effects from multiomic datasets distributed across different labs or data acquisition events. MultiBaC is able to remove batch effects across different omics generated within separate batches provided that at least one common omic data type is included in all the batches considered.

The fishpond package contains methods for differential transcript and gene expression analysis of RNA-seq data using inferential replicates for uncertainty of abundance quantification, as generated by Gibbs sampling or bootstrap sampling. Also the package contains a number of utilities for working with Salmon and Alevin quantification files.

This package computes fast (relative to other implementations) approximate Shapley values for any supervised learning model. Shapley values help to explain the predictions from any black box model using ideas from game theory; see doi.org/10.1007/s10115-013-0679-x for details.

This package provides well-known outlier detection techniques in the univariate case. Methods to deal with skewed distribution are included too. The Hidiroglou-Berthelot (1986) method to search for outliers in ratios of historical data is implemented as well. When available, survey weights can be used in outliers detection.

This package provides functions for Meta-analysis Burden Test, Sequence Kernel Association Test (SKAT) and Optimal SKAT (SKAT-O) by Lee et al. (2013) <doi:10.1016/j.ajhg.2013.05.010>. These methods use summary-level score statistics to carry out gene-based meta-analysis for rare variants.

This package provides a set of tools for post processing the outcomes of species distribution modeling exercises. It includes novel methods for comparing models and tracking changes in distributions through time. It further includes methods for visualizing outcomes, selecting thresholds, calculating measures of accuracy and landscape fragmentation statistics, etc.

This package provides extra themes and scales for ggplot2 that replicate the look of plots by Edward Tufte and Stephen Few in Fivethirtyeight, The Economist, Stata, Excel, and The Wall Street Journal, among others. This package also provides geoms for Tufte's box plot and range frame.

This package provides an R interface to the dygraphs JavaScript charting library (a copy of which is included in the package). It provides rich facilities for charting time-series data in R, including highly configurable series- and axis-display and interactive features like zoom/pan and series/point highlighting.

We perform linear, logistic, and cox regression using the base functions lm(), glm(), and coxph() in the R software and the survival package. Likewise, we can use ols(), lrm() and cph() from the rms package for the same functionality. Each of these two sets of commands has a different focus. In many cases, we need to use both sets of commands in the same situation, e.g. we need to filter the full subset model using AIC, and we need to build a visualization graph for the final model. base.rms package can help you to switch between the two sets of commands easily.

Three robust marginal integration procedures for additive models based on local polynomial kernel smoothers. As a preliminary estimator of the multivariate function for the marginal integration procedure, a first approach uses local constant M-estimators, a second one uses local polynomials of order 1 over all the components of covariates, and the third one uses M-estimators based on local polynomials but only in the direction of interest. For this last approach, estimators of the derivatives of the additive functions can be obtained. All three procedures can compute predictions for points outside the training set if desired. See Boente and Martinez (2017) <doi:10.1007/s11749-016-0508-0> for details.

Model based simulation of dynamic networks under tie-oriented (Butts, C., 2008, <doi:10.1111/j.1467-9531.2008.00203.x>) and actor-oriented (Stadtfeld, C., & Block, P., 2017, <doi:10.15195/v4.a14>) relational event models. Supports simulation from a variety of relational event model extensions, including temporal variability in effects, heterogeneity through dyadic latent class relational event models (DLC-REM), random effects, blockmodels, and memory decay in relational event models (Lakdawala, R., 2024 <doi:10.48550/arXiv.2403.19329>). The development of this package was supported by a Vidi Grant (452-17-006) awarded by the Netherlands Organization for Scientific Research (NWO) Grant and an ERC Starting Grant (758791).