The Bayesian Adjustment for Confounding (BAC) algorithm (Wang et al., 2012) can be used to estimate the causal effect of a continuous exposure on a continuous outcome. This package provides an approximate sensitivity analysis of BAC with regards to the hyperparameter omega. BACprior also provides functions to guide the user in their choice of an appropriate omega value. The method is based on Lefebvre, Atherton and Talbot (2014).

Conducts conditional random sampling on observed values in sparse matrices. Useful for training and test set splitting sparse matrices prior to model fitting in cross-validation procedures and estimating the predictive accuracy of data imputation methods, such as matrix factorization or singular value decomposition (SVD). Although designed for applications with sparse matrices, CRASSMAT can also be applied to complete matrices, as well as to those containing missing values.

Calculates and visualises cumulative percent decay curves, which are typically calculated from metagenomic taxonomic profiles. These can be used to estimate the level of expected endogenous taxa at different abundance levels retrieved from metagenomic samples, when comparing to samples of known sampling site or source. Method described in Fellows Yates, J. A. et. al. (2021) Proceedings of the National Academy of Sciences USA <doi:10.1073/pnas.2021655118>.

One way to choose the number of principal components is via the reconstruction error. This package is designed mainly for this purpose. Graphical representation is also supported, plus some other principal component analysis related functions. References include: Jolliffe I.T. (2002). Principal Component Analysis. <doi:10.1007/b98835> and Mardia K.V., Kent J.T. and Bibby J.M. (1979). Multivariate Analysis. ISBN: 978-0124712522. London: Academic Press.

This package provides a multi-layered untargeted pipeline for high-throughput LC/HRMS data processing to extract signals of organic small molecules. The package performs ion pairing, peak detection, peak table alignment, retention time correction, aligned peak table gap filling, peak annotation and visualization of extracted ion chromatograms (EICs) and total ion chromatograms (TICs). The IDSL.IPA package was introduced in <doi:10.1021/acs.jproteome.2c00120> .

Fit parametric models for time-to-event data that show an initial incubation period', i.e., a variable delay phase where the hazard is zero. The delayed Weibull distribution serves as foundational data model. The specific method of MPSE (maximum product of spacings estimation) and MLE-based methods are used for parameter estimation. Bootstrap confidence intervals for parameters and significance tests in a two group setting are provided.

This package provides methods to extract information on pathways, genes and various single-nucleotid polymorphisms (SNPs) from online databases. It provides functions for data preparation and evaluation of genetic influence on a binary outcome using the logistic kernel machine test (LKMT). Three different kernel functions are offered to analyze genotype information in this variance component test: A linear kernel, a size-adjusted kernel and a network-based kernel).

Nonparametric kernel distribution function estimation is performed. Three bandwidth selectors are implemented: the plug-in selectors of Altman and Leger and of Polansky and Baker, and the cross-validation selector of Bowman, Hall and Prvan. The exceedance function, the mean return period and the return level are also computed. For details, see Quintela-del-Rà o and Estévez-Pérez (2012) <doi:10.18637/jss.v050.i08>.

This package provides a set of all-cause and cause-specific life expectancy sensitivity and decomposition methods, including Arriaga (1984) <doi:10.2307/2061029>, others documented by Ponnapalli (2005) <doi:10.4054/DemRes.2005.12.7>, lifetable, numerical, and other algorithmic approaches such as Horiuchi et al (2008) <doi:10.1353/dem.0.0033>, or Andreev et al (2002) <doi:10.4054/DemRes.2002.7.14>.

This package provides functions and examples based on the m-out-of-n bootstrap suggested by Politis, D.N. and Romano, J.P. (1994) <doi:10.1214/aos/1176325770>. Additionally there are functions to estimate the scaling factor tau and the subsampling size m. For a detailed description and a full list of references, see Dalitz, C. and Lögler, F. (2025) <doi:10.32614/RJ-2025-031>.

This package performs meta-analysis and meta-regression using standard and robust methods with confidence intervals based on the profile likelihood. Robust methods are based on alternative distributions for the random effect, either the t-distribution (Lee and Thompson, 2008 <doi:10.1002/sim.2897> or Baker and Jackson, 2008 <doi:10.1007/s10729-007-9041-8>) or mixtures of normals (Beath, 2014 <doi:10.1002/jrsm.1114>).

Function pip3d() tests whether a point in 3D space is within, exactly on, or outside an enclosed surface defined by a triangular mesh. Function pip2d() tests whether a point in 2D space is within, exactly on, or outside a polygon. For a reference, see: Liu et al., A new point containment test algorithm based on preprocessing and determining triangles, Computer-Aided Design 42(12):1143-1150.

This package provides functions to estimate a strategic selection estimator. A strategic selection estimator is an agent error model in which the two random components are not assumed to be orthogonal. In addition this package provides generic functions to print and plot objects of its class as well as the necessary functions to create tables for LaTeX. There is also a function to create dyadic data sets.

The goal of safejoin is to guarantee that when performing joins extra rows are not added to your data. safejoin provides a wrapper around dplyr::left_join that will raise an error when extra rows are unexpectedly added to your data. This can be useful when working with data where you expect there to be a many to one relationship but you are not certain the relationship holds.

This package performs parametric synthesis of sounds with harmonic and noise components such as animal vocalizations or human voice. Also offers tools for audio manipulation and acoustic analysis, including pitch tracking, spectral analysis, audio segmentation, pitch and formant shifting, etc. Includes four interactive web apps for synthesizing and annotating audio, manually correcting pitch contours, and measuring formant frequencies. Reference: Anikin (2019) <doi:10.3758/s13428-018-1095-7>.

Species sensitivity distributions are cumulative probability distributions which are fitted to toxicity concentrations for different species as described by Posthuma et al.(2001) <isbn:9781566705783>. The ssdtools package uses Maximum Likelihood to fit distributions such as the gamma, log-logistic, log-normal and log-normal log-normal mixture. Multiple distributions can be averaged using Akaike Information Criteria. Confidence intervals on hazard concentrations and proportions are produced by bootstrapping.

This package performs maximum likelihood based estimation and inference on time to event data, possibly subject to non-informative right censoring. FitParaSurv() provides maximum likelihood estimates of model parameters and distributional characteristics, including the mean, median, variance, and restricted mean. CompParaSurv() compares the mean, median, and restricted mean survival experiences of two treatment groups. Candidate distributions include the exponential, gamma, generalized gamma, log-normal, and Weibull.

This package provides a novel feature-wise normalization method based on a zero-inflated negative binomial model. This method assumes that the effects of sequencing depth vary for each taxon on their mean and also incorporates a rational link of zero probability and taxon dispersion as a function of sequencing depth. Ziyue Wang, Dillon Lloyd, Shanshan Zhao, Alison Motsinger-Reif (2023) <doi:10.1101/2023.10.31.563648>.

This package provides a generic reference Bayesian analysis of unidimensional mixture distributions obtained by a location-scale parameterisation of the model is implemented. The including functions simulate and summarize posterior samples for location-scale mixture models using a weakly informative prior. There is no need to define priors for scale-location parameters except two hyperparameters in which are associated with a Dirichlet prior for weights and a simplex.

MsImpute is a package for imputation of peptide intensity in proteomics experiments. It additionally contains tools for MAR/MNAR diagnosis and assessment of distortions to the probability distribution of the data post imputation. The missing values are imputed by low-rank approximation of the underlying data matrix if they are MAR (method = "v2"), by Barycenter approach if missingness is MNAR ("v2-mnar"), or by Peptide Identity Propagation (PIP).

This package provides next-generation sequencing (NGS) and mass spectrometry (MS) sample data, code snippets and replication material used for developing NestLink. The NestLink approach is a protein binder selection and identification technology able to biophysically characterize thousands of library members at once without handling individual clones at any stage of the process. Data were acquired on NGS and MS platforms at the Functional Genomics Center Zurich.

srnadiff is a package that finds differently expressed regions from RNA-seq data at base-resolution level without relying on existing annotation. To do so, the package implements the identify-then-annotate methodology that builds on the idea of combining two pipelines approachs differential expressed regions detection and differential expression quantification. It reads BAM files as input, and outputs a list differentially regions, together with the adjusted p-values.

Nonparametric data-driven approach to discovering heterogeneous subgroups in a selection-on-observables framework. aggTrees allows researchers to assess whether there exists relevant heterogeneity in treatment effects by generating a sequence of optimal groupings, one for each level of granularity. For each grouping, we obtain point estimation and inference about the group average treatment effects. Please reference the use as Di Francesco (2022) <doi:10.2139/ssrn.4304256>.

With appRiori <doi:10.1177/25152459241293110>, users upload the research variables and the app guides them to the best set of comparisons fitting the hypotheses, for both main and interaction effects. Through a graphical explanation and empirical examples on reproducible data, it is shown that it is possible to understand both the logic behind the planned comparisons and the way to interpret them when a model is tested.