Examine any number of time series data frames to identify instances in which various criteria are met within specified time frames. In clinical medicine, these types of events are often called "constellations of signs and symptoms", because a single condition depends on a series of events occurring within a certain amount of time of each other. This package was written to work with any number of time series data frames and is optimized for speed to work well with data frames with millions of rows.

This package provides functions for classical test theory analysis, following methods presented by Wu et al. (2006) <doi:10.1007/978-981-10-3302-5>.

This package provides tools for working with the International Classification of Diseases ('ICD-10 Chile official MINSAL'/'DEIS v2018). Includes optimized SQL search with SQLite', fuzzy matching of medical terms ('Jaro-Winkler'), Charlson and Elixhauser comorbidity calculation, WHO ICD-11 API integration, and hierarchical code validation. Data from Centro FIC Chile DEIS <https://deis.minsal.cl/centrofic/>.

The Core Microbiome refers to the group of microorganisms that are consistently present in a particular environment, habitat, or host species. These microorganisms play a crucial role in the functioning and stability of that ecosystem. Identifying these microorganisms can contribute to the emerging field of personalized medicine. The CoreMicrobiomeR is designed to facilitate the identification, statistical testing, and visualization of this group of microorganisms.This package offers three key functions to analyze and visualize microbial community data. This package has been developed based on the research papers published by Pereira et al.(2018) <doi:10.1186/s12864-018-4637-6> and Beule L, Karlovsky P. (2020) <doi:10.7717/peerj.9593>.

Assignment of cell type labels to single-cell RNA sequencing (scRNA-seq) clusters is often a time-consuming process that involves manual inspection of the cluster marker genes complemented with a detailed literature search. This is especially challenging when unexpected or poorly described populations are present. The clustermole R package provides methods to query thousands of human and mouse cell identity markers sourced from a variety of databases.

Create cumulative odds ratio plot to visually inspect the proportional odds assumption from the proportional odds model.

This package contains functions for solving commonly encountered problems while programming in R. This package is intended to provide a lightweight supplement to Base R, and will be useful for almost any R user.

An implementation of Fan plots for cytometry data in ggplot2'. For reference see Britton, E.; Fisher, P. & J. Whitley (1998) The Inflation Report Projections: Understanding the Fan Chart <https://www.bankofengland.co.uk/quarterly-bulletin/1998/q1/the-inflation-report-projections-understanding-the-fan-chart>).

Logic game in the style of the early 1980s home computers that can be played in the R console. This game is inspired by Mastermind, a game that became popular in the 1970s. Can you break the code?

This package contains the probability density function, cumulative distribution function, quantile function, and random number generator for composite and discrete composite distributions with Pareto tails. The detailed description of the methods and the applications of the methods can be found in Bowen Liu, Malwane M.A. Ananda (2023) <arXiv:2309.16443>.

Calculate the likelihood ratio test p-value and likelihood confidence intervals for misspecified Cox models, as described in Shao and Guo (2025) <doi:10.48550/arXiv.2508.11851>.

Joint and Individual Variation Explained (JIVE) is a method for decomposing multiple datasets obtained on the same subjects into shared structure, structure unique to each dataset, and noise. The two most common implementations are R.JIVE, an iterative approach, and AJIVE, which uses principal angle analysis. JIVE estimates subspaces but interpreting these subspaces can be challenging with AJIVE or R.JIVE. We expand upon insights into AJIVE as a canonical correlation analysis (CCA) of principal component scores. This reformulation, which we call CJIVE, 1) provides an ordering of joint components by the degree of correlation between corresponding canonical variables; 2) uses a computationally efficient permutation test for the number of joint components, which provides a p-value for each component; and 3) can be used to predict subject scores for out-of-sample observations. Please cite the following article when utilizing this package: Murden, R., Zhang, Z., Guo, Y., & Risk, B. (2022) <doi:10.3389/fnins.2022.969510>.

Psychometrically analyze latent individual differences related to tasks, interventions, or maturational/aging effects in the context of experimental or longitudinal cognitive research using methods first described by Thomas et al. (2020) <doi:10.1177/0013164420919898>.

This package implements Markowitz Critical Line Algorithm ('CLA') for classical mean-variance portfolio optimization, see Markowitz (1952) <doi:10.2307/2975974>. Care has been taken for correctness in light of previous buggy implementations.

Manipulate and analyze 3-D structural geometry of Protein Data Bank (PDB) files.

This package provides functions that format statistical output in a way that can be inserted into R Markdown documents. This is analogous to the apa_print() functions in the papaja package but prints Markdown or LaTeX syntax.

This package provides a set of functions for conducting cognitive diagnostic computerized adaptive testing applications (Chen, 2009) <DOI:10.1007/s11336-009-9123-2>). It includes different item selection rules such us the global discrimination index (Kaplan, de la Torre, and Barrada (2015) <DOI:10.1177/0146621614554650>) and the nonparametric selection method (Chang, Chiu, and Tsai (2019) <DOI:10.1177/0146621618813113>), as well as several stopping rules. Functions for generating item banks and responses are also provided. To guide item bank calibration, model comparison at the item level can be conducted using the two-step likelihood ratio test statistic by Sorrel, de la Torre, Abad and Olea (2017) <DOI:10.1027/1614-2241/a000131>.

The concept of cause-deleted life expectancy improvement is statistic designed to quantify the increase in life expectancy if a certain cause of death is removed. See Adamic, P. (2015) (<https://papers.ssrn.com/sol3/papers.cfm?abstract_id=2689352>).

This package provides simple functions to convert between color names and hexadecimal color codes using an extensive database of over 32,000 colors. Includes all 657 R built-in colors plus the comprehensive color-names database. The package supports bidirectional conversion with backward compatibility, prioritizing R colors when available.

This package provides function declarations and inline function definitions that facilitate communication between R and the Eigen C++ library for linear algebra and scientific computing.

This package provides tools for trial-based economic evaluation of healthcare interventions. Computes and visualizes incremental cost-effectiveness ratios, cost-effectiveness acceptability curves, cost-effectiveness planes, net monetary benefit tables, and one-way deterministic sensitivity analyses. Supports cost-utility analyses using observed summaries and non-parametric bootstrap uncertainty.

The primary motivation of this package is to take the things that are great about the R packages flextable <https://davidgohel.github.io/flextable/> and officer <https://davidgohel.github.io/officer/>, take the standard and complex pieces of formatting clinical tables for regulatory use, and simplify the tedious pieces.

Estimates the causal decompositions of group disparities developed by Yu and Elwert (2025) <doi:10.1214/24-AOAS1990>. For the nuisance functions of the estimators, we provide both parametric and nonparametric options, as well as manual options in case the default models are not satisfying.

Browser cookies are name-value pairs that are saved in a user's browser by a website. Cookies allow websites to persist information about the user and their use of the website. Here we provide tools for working with cookies in shiny apps, in part by wrapping the js-cookie JavaScript library <https://github.com/js-cookie/js-cookie>.