This package produces tables with the level of replication (number of replicates) and the experimental uncoded values of the quantitative factors to be used for rotatable Central Composite Design (CCD) experimentation and a 2-D contour plot of the corresponding variance of the predicted response according to Mead et al. (2012) <doi:10.1017/CBO9781139020879> design_ccd(), and analyzes CCD data with response surface methodology ccd_analysis(). A rotatable CCD provides values of the variance of the predicted response that are concentrically distributed around the average treatment combination used in the experimentation, which with uniform precision (implied by the use of several replicates at the average treatment combination) improves greatly the search and finding of an optimum response. These properties of a rotatable CCD represent undeniable advantages over the classical factorial design, as discussed by Panneton et al. (1999) <doi:10.13031/2013.13267> and Mead et al. (2012) <doi:10.1017/CBO9781139020879.018> among others.

Monocle 3 performs clustering, differential expression and trajectory analysis for single-cell expression experiments. It orders individual cells according to progress through a biological process, without knowing ahead of time which genes define progress through that process. Monocle 3 also performs differential expression analysis, clustering, visualization, and other useful tasks on single-cell expression data. It is designed to work with RNA-Seq data, but could be used with other types as well.

This package is a collection of baseline correction algorithms. Beside those it provides a framework and a Tcl/Tk enabled GUI for optimizing baseline algorithm parameters. Typical use is the removal of the background effects from spectra, which are originating from various types of spectroscopy and spectrometry. Also, there is a possibility of optimizing this with regard to regression or classification results. Correction methods include polynomial fitting, weighted local smoothers and many more.

Tree based algorithms can be improved by introducing boosting frameworks. LightGBM is one such framework, based on Ke, Guolin et al. (2017). This package offers an R interface to work with it. It is designed to be distributed and efficient with the following goals:

1. Faster training speed and higher efficiency;

2. lower memory usage;

3. better accuracy;

4. parallel learning supported; and

5. capable of handling large-scale data.

This package aims to make it easy to use various types of fonts (TrueType, OpenType, Type 1, web fonts, etc.) in R graphs, and supports most output formats of R graphics including PNG, PDF and SVG. Text glyphs will be converted into polygons or raster images, hence after the plot has been created, it no longer relies on the font files. No external software such as Ghostscript is needed to use this package.

cfDNA fragments carry important features for building cancer sample classification ML models, such as fragment size, and fragment end motif etc. Analyzing and visualizing fragment size metrics, as well as other biological features in a curated, standardized, scalable, well-documented, and reproducible way might be time intensive. This package intends to resolve these problems and simplify the process. It offers two sets of functions for cfDNA feature characterization and visualization.

This package provides a backward-pipe operator for magrittr (%<%) or pipeR (%<<%) that allows for a performing operations from right-to-left. This allows writing more legible code where right-to-left ordering is natural. This is common with hierarchies and nested structures such as trees, directories or markup languages (e.g. HTML and XML). The package also includes a R-Studio add-in that can be bound to a keyboard shortcut.

This package provides a method for identifying pattern changes between 2 experimental conditions in correlation networks (e.g., gene co-expression networks), which builds on a commonly used association measure, such as Pearson's correlation coefficient. This package includes functions to calculate correlation matrices for high-dimensional dataset and to test differential correlation, which means the changes in the correlation relationship among variables (e.g., genes and metabolites) between 2 experimental conditions.

This package provides tools to analyse human and mosquito behavioral interactions and to compute exposure to mosquito bites estimates. Using behavioral data for human individuals and biting patterns for mosquitoes, you will be able to compute hourly exposure for bed net users and non-users, and summarize (e.g. proportion indoors and outdoors, proportion per time periods, and proportion prevented by bed nets) or visualize these dynamics across a 24-hour cycle.

This package provides tools for flexible non-linear least squares model fitting using general-purpose optimization techniques. The package supports a variety of optimization algorithms, including those provided by the optimx package, making it suitable for handling complex non-linear models. Features include parallel processing support via the future and foreach packages, comprehensive model diagnostics, and visualization capabilities. Implements methods described in Nash and Varadhan (2011, <doi:10.18637/jss.v043.i09>).

Graphical approach provides a useful framework for multiplicity adjustment in clinical trials with multiple endpoints. This package includes statistical methods to optimize sample size over initial weight and transition probability in a graphical approach under a common setting, which is to use marginal power for each endpoint in a trial design. See Zhang, F. and Gou, J. (2023). Sample size optimization for clinical trials using graphical approaches for multiplicity adjustment, Technical Report.

Scientific journal numeric formatting policies implemented in code. Emphasis on formatting mean/upper/lower sets of values to pasteable text for journal submission. For example c(2e6, 1e6, 3e6) becomes "2.00 million (1.00--3.00)". Lancet and Nature have built-in styles for rounding and punctuation marks. Users may extend journal styles arbitrarily. Four metrics are supported; proportions, percentage points, counts and rates. Magnitudes for all metrics are discovered automatically.

Changes of landscape diversity and structure can be detected soon if relying on landscape class combinations and analysing patterns at multiple scales. LandComp provides such an opportunity, based on Juhász-Nagy's functions (Juhász-Nagy P, Podani J 1983 <doi:10.1007/BF00129432>). Functions can handle multilayered data. Requirements of the input: binary data contained by a regular square or hexagonal grid, and the grid should have projected coordinates.

Estimates group transmission assortativity coefficients from transmission trees. Group transmission assortativity coefficients measure the tendency for individuals to transmit within their own group (e.g. age group, vaccination status, or location) compared to other groups. The package requires information on who infected whom, group membership for all individuals, and the relative sizes of each group in the population. For more details see Geismar et al. (2024) <doi:10.1371/journal.pone.0313037>.

This package provides a toolkit containing statistical analysis models motivated by multivariate forms of the Conway-Maxwell-Poisson (COM-Poisson) distribution for flexible modeling of multivariate count data, especially in the presence of data dispersion. Currently the package only supports bivariate data, via the bivariate COM-Poisson distribution described in Sellers et al. (2016) <doi:10.1016/j.jmva.2016.04.007>. Future development will extend the package to higher-dimensional data.

Publicly available data from Medicare frequently requires extensive initial effort to extract desired variables and merge them; this package formalizes the techniques I've found work best. More information on the Medicare program, as well as guidance for the publicly available data this package targets, can be found on CMS's website covering publicly available data. See <https://www.cms.gov/Research-Statistics-Data-and-Systems/Research-Statistics-Data-and-Systems.html>.

This package provides functions are provided for internal use by the spatial capture-recapture package secr (from version 5.4.0). The idea is to speed up the installation of secr', and possibly reduce its size. Initially the functions are those for area and transect search that use numerical integration code from RcppNumerical and RcppEigen'. The functions are not intended to be user-friendly and require considerable preprocessing of data.

The Vega-Lite JavaScript framework provides a higher-level grammar for visual analysis, akin to ggplot or Tableau', that generates complete Vega specifications. Functions exist which enable building a valid spec from scratch or importing a previously created spec file. Functions also exist to export spec files and to generate code which will enable plots to be embedded in properly configured web pages. The default behavior is to generate an htmlwidget'.

For distributions whose probability density functions are log-concave, the adaptive rejection sampling algorithm can be used to build envelope functions for sampling. For others, the modified adaptive rejection sampling algorithm, the concave-convex adaptive rejection sampling algorithm, and the adaptive slice sampling algorithm can be used. This R package mainly includes these four functions: rARS(), rMARS(), rCCARS(), and rASS(). These functions can realize sampling based on the algorithms above.

This package provides a BiocBook can be created by authors (e.g. R developers, but also scientists, teachers, communicators, ...) who wish to 1) write (compile a body of biological and/or bioinformatics knowledge), 2) containerize (provide Docker images to reproduce the examples illustrated in the compendium), 3) publish (deploy an online book to disseminate the compendium), and 4) version (automatically generate specific online book versions and Docker images for specific Bioconductor releases).

SNPediaR provides some tools for downloading and parsing data from the SNPedia web site <http://www.snpedia.com>. The implemented functions allow users to import the wiki text available in SNPedia pages and to extract the most relevant information out of them. If some information in the downloaded pages is not automatically processed by the library functions, users can easily implement their own parsers to access it in an efficient way.

This package provides a Bayesian data modeling scheme that performs four interconnected tasks: (i) characterizes the uncertainty of the elicited parametric prior; (ii) provides exploratory diagnostic for checking prior-data conflict; (iii) computes the final statistical prior density estimate; and (iv) executes macro- and micro-inference. Primary reference is Mukhopadhyay, S. and Fletcher, D. 2018 paper "Generalized Empirical Bayes via Frequentist Goodness of Fit" (<https://www.nature.com/articles/s41598-018-28130-5 >).

Cluster Evolution Analytics allows us to use exploratory what if questions in the sense that the present information of an object is plugged-in a dataset in a previous time frame so that we can explore its evolution (and of its neighbors) to the present. See the URL for the papers associated with this package, as for instance, Morales-Oñate and Morales-Oñate (2024) <doi:10.1016/j.softx.2024.101921>.

Simulate and fitting exponential multivariate Hawkes model. This package simulates a multivariate Hawkes model, introduced by Hawkes (1971) <doi:10.2307/2334319>, with an exponential kernel and fits the parameters from the data. Models with the constant parameters, as well as complex dependent structures, can also be simulated and estimated. The estimation is based on the maximum likelihood method, introduced by introduced by Ozaki (1979) <doi:10.1007/BF02480272>, with maxLik package.