Implement the statistical test proposed in Weng et al. (2021) to test whether the average treatment effect curve is constant and whether a discrete covariate is a significant effect modifier.

Fit a mixture of Discrete Laplace distributions using plain numerical optimisation. This package has similar applications as the disclapmix package that uses an EM algorithm.

Solves ordinary and delay differential equations, where the objective function is written in either R or C. Suitable only for non-stiff equations, the solver uses a Dormand-Prince method that allows interpolation of the solution at any point. This approach is as described by Hairer, Norsett and Wanner (1993) <ISBN:3540604529>. Support is also included for iterating difference equations.

This package provides an interface between R and the DuckDB (see <https://duckdb.org>) database with spatial extensions. It supports reading, writing, and performing some geometric operations.

Package to fit diffusion-based IRT models to response and response time data. Models are fit using marginal maximum likelihood. Parameter restrictions (fixed value and equality constraints) are possible. In addition, factor scores (person drift rate and person boundary separation) can be estimated. Model fit assessment tools are also available. The traditional diffusion model can be estimated as well.

Exploration of simulation models (apps) of various infectious disease transmission dynamics scenarios. The purpose of the package is to help individuals learn about infectious disease epidemiology (ecology/evolution) from a dynamical systems perspective. All apps include explanations of the underlying models and instructions on what to do with the models.

An implementation by Chen, Li, and Zhang (2022) <doi: 10.1093/bioadv/vbac041> of the Depth Importance in Precision Medicine (DIPM) method in Chen and Zhang (2022) <doi:10.1093/biostatistics/kxaa021> and Chen and Zhang (2020) <doi:10.1007/978-3-030-46161-4_16>. The DIPM method is a classification tree that searches for subgroups with especially poor or strong performance in a given treatment group.

Direction analysis is a set of tools designed to identify combinatorial effects of multiple treatments/conditions on pathways and kinases profiled by microarray, RNA-seq, proteomics, or phosphoproteomics data. See Yang P et al (2014) <doi:10.1093/bioinformatics/btt616>; and Yang P et al. (2016) <doi:10.1002/pmic.201600068>.

The hybrid model is a highly effective forecasting approach that integrates decomposition techniques with machine learning to enhance time series prediction accuracy. Each decomposition technique breaks down a time series into multiple intrinsic mode functions (IMFs), which are then individually modeled and forecasted using machine learning algorithms. The final forecast is obtained by aggregating the predictions of all IMFs, producing an ensemble output for the time series. The performance of the developed models is evaluated using international monthly maize price data, assessed through metrics such as root mean squared error (RMSE), mean absolute percentage error (MAPE), and mean absolute error (MAE). For method details see Choudhary, K. et al. (2023). <https://ssca.org.in/media/14_SA44052022_R3_SA_21032023_Girish_Jha_FINAL_Finally.pdf>.

This package provides tools to apply Ensemble Empirical Mode Decomposition (EEMD) for cyclostratigraphy purposes. Mainly: a new algorithm, extricate, that performs EEMD in seconds, a linear interpolation algorithm using the greatest rational common divisor of depth or time, different algorithms to compute instantaneous amplitude, frequency and ratios of frequencies, and functions to verify and visualise the outputs. The functions were developed during the CRASH project (Checking the Reproducibility of Astrochronology in the Hauterivian). When using for publication please cite Wouters, S., Crucifix, M., Sinnesael, M., Da Silva, A.C., Zeeden, C., Zivanovic, M., Boulvain, F., Devleeschouwer, X., 2022, "A decomposition approach to cyclostratigraphic signal processing". Earth-Science Reviews 225 (103894). <doi:10.1016/j.earscirev.2021.103894>.

Model-based methods for the detection of disease clusters using GLMs, GLMMs and zero-inflated models. These methods are described in V. Gómez-Rubio et al. (2019) <doi:10.18637/jss.v090.i14> and V. Gómez-Rubio et al. (2018) <doi:10.1007/978-3-030-01584-8_1>.

This package provides a multiple testing procedure aims to find the rare-variant association regions. When variants are rare, the single variant association test approach suffers from low power. To improve testing power, the procedure dynamically and hierarchically aggregates smaller genome regions to larger ones and performs multiple testing for disease associations with a controlled node-level false discovery rate. This method are members of the family of ancillary information assisted recursive testing introduced in Pura, Li, Chan and Xie (2021) <arXiv:1906.07757v2> and Li, Sung and Xie (2021) <arXiv:2103.11085v2>.

Computes the ATM (Attractor Transition Matrix) structure and the tree-like structure describing the cell differentiation process (based on the Threshold Ergodic Set concept introduced by Serra and Villani), starting from the Boolean networks with synchronous updating scheme of the BoolNet R package. TESs (Threshold Ergodic Sets) are the mathematical abstractions that represent the different cell types arising during ontogenesis. TESs and the powerful model of biological differentiation based on Boolean networks to which it belongs have been firstly described in "A Dynamical Model of Genetic Networks for Cell Differentiation" Villani M, Barbieri A, Serra R (2011) A Dynamical Model of Genetic Networks for Cell Differentiation. PLOS ONE 6(3): e17703.

This package provides functions providing an easy and intuitive way for fitting and clusters data using the Mixture of Unigrams models by means the Expectation-Maximization algorithm (Nigam, K. et al. (2000). <doi:10.1023/A:1007692713085>), Mixture of Dirichlet-Multinomials estimated by Gradient Descent (Anderlucci, Viroli (2020) <doi:10.1007/s11634-020-00399-3>) and Deep Mixture of Multinomials whose estimates are obtained with Gibbs sampling scheme (Viroli, Anderlucci (2020) <doi:10.1007/s11222-020-09989-9>). There are also functions for graphical representation of clusters obtained.

Measure of agreement delta was originally by Martà n & Femia (2004) <DOI:10.1348/000711004849268>. Since then has been considered as agreement measure for different fields, since their behavior is usually better than the usual kappa index by Cohen (1960) <DOI:10.1177/001316446002000104>. The main issue with delta is that can not be computed by hand contrary to kappa. The current algorithm is based on the Version 5 of the delta windows program that can be found on <https://www.ugr.es/~bioest/software/delta/cmd.php?seccion=downloads>.

This linear model solution is useful when both predictor and response have associated uncertainty. The doubly weights linear model solution is invariant on which quantity is used as predictor or response. Based on the results by Reed(1989) <doi:10.1119/1.15963> and Ripley & Thompson(1987) <doi:10.1039/AN9871200377>.

This package provides a big-data-friendly and memory-efficient difference-in-differences estimator for staggered (and non-staggered) treatment contexts.

Given an initial set of points, this package minimizes the number of elements to discard from this set such that there exists at least one monotonic and convex mapping within pre-specified upper and lower bounds.

Function to test spatial segregation and association based in contingency table analysis of nearest neighbour counts following Dixon (2002) <doi:10.1080/11956860.2002.11682700>. Some Fortran code has been included to the original dixon2002() function of the ecespa package to improve speed.

This package implements the de-biased estimator for low-rank matrix completion and provides confidence intervals for entries of interest. See: by Chen et al. (2019) <doi:10.1073/pnas.1910053116>, Mai (2021) <arXiv:2103.11749>.

This package provides a collection of functions which aim to assist common computational workflow for analysis of matabolomic data..

This package provides a wrapper for Google's diff-match-patch library. It provides basic tools for computing diffs, finding fuzzy matches, and constructing / applying patches to strings.

This MCMC method takes a data numeric vector (Y) and assigns the elements of Y to a (potentially infinite) number of normal distributions. The individual normal distributions from a mixture of normals can be inferred. Following the method described in Escobar (1994) <doi:10.2307/2291223> we use a Dirichlet Process Prior (DPP) to describe stochastically our prior assumptions about the dimensionality of the data.

This package provides a set of functions to quantify the relationship between development rate and temperature and to build phenological models. The package comprises a set of models and estimated parameters borrowed from a literature review in ectotherms. The methods and literature review are described in Rebaudo et al. (2018) <doi:10.1111/2041-210X.12935>, Rebaudo and Rabhi (2018) <doi:10.1111/eea.12693>, and Regnier et al. (2021) <doi:10.1093/ee/nvab115>. An example can be found in Rebaudo et al. (2017) <doi:10.1007/s13355-017-0480-5>.