Allows clinicians and researchers to compute daily dose (and subsequently days supply) for prescription refills using the following methods: Fixed window, fixed tablet, defined daily dose (DDD), and Random Effects Warfarin Days Supply (REWarDS). Daily dose is the computed dose that the patient takes every day. For medications with fixed dosing (e.g. direct oral anticoagulants) this is known and does not need to be estimated. For medications with varying dose such as warfarin, however, the daily dose should be assumed or estimated to allow measurement of drug exposure. Daysâ supply is the number of days that patientsâ supply of medication will last after each prescription fill. Estimating daysâ supply is necessary to calculate drug exposure. The package computes daysâ supply and daily dose at both the prescription and patient levels. Results at the prescription level are denoted with â -Rx-â and those at patient level are denoted with â -Pt-â .

This package provides tools to create and manipulate probability distributions using S3. Generics pdf(), cdf(), quantile(), and random() provide replacements for base R's d/p/q/r style functions. Functions and arguments have been named carefully to minimize confusion for students in intro stats courses. The documentation for each distribution contains detailed mathematical notes.

Fast fitting of generalised linear models on moderately large datasets, by taking an initial sample, fitting in memory, then evaluating the score function for the full data in the database. Thomas Lumley <doi:10.1080/10618600.2019.1610312>.

Based on random forest principle, DynForest is able to include multiple longitudinal predictors to provide individual predictions. Longitudinal predictors are modeled through the random forest. The methodology is fully described for a survival outcome in: Devaux, Helmer, Genuer & Proust-Lima (2023) <doi: 10.1177/09622802231206477>.

Different sample size calculations with different study designs. These techniques are explained by Chow (2007) <doi:10.1201/9781584889830>.

This package contains the normalizing and variance stabilizing Data-Driven Haar-Fisz algorithm. Also contains related algorithms for simulating from certain microarray gene intensity models and evaluation of certain transformations. Contains cDNA and shipping credit flow data.

Compare functional enrichment between two experimentally-derived groups of genes or proteins (Peterson, DR., et al.(2018)) <doi: 10.1371/journal.pone.0198139>. Given a list of gene symbols, diffEnrich will perform differential enrichment analysis using the Kyoto Encyclopedia of Genes and Genomes (KEGG) REST API. This package provides a number of functions that are intended to be used in a pipeline. Briefly, the user provides a KEGG formatted species id for either human, mouse or rat, and the package will download and clean species specific ENTREZ gene IDs and map them to their respective KEGG pathways by accessing KEGG's REST API. KEGG's API is used to guarantee the most up-to-date pathway data from KEGG. Next, the user will identify significantly enriched pathways from two gene sets, and finally, the user will identify pathways that are differentially enriched between the two gene sets. In addition to the analysis pipeline, this package also provides a plotting function.

Various utilities for the Davies distribution.

Designed to support the visualization, numerical computation, qualitative analysis, model-data fusion, and stochastic simulation for autonomous systems of differential equations. Euler and Runge-Kutta methods are implemented, along with tools to visualize the two-dimensional phaseplane. Likelihood surfaces and a simple Markov Chain Monte Carlo parameter estimator can be used for model-data fusion of differential equations and empirical models. The Euler-Maruyama method is provided for simulation of stochastic differential equations. The package was originally written for internal use to support teaching by Zobitz, and refined to support the text "Exploring modeling with data and differential equations using R" by John Zobitz (2021) <https://jmzobitz.github.io/ModelingWithR/index.html>.

This package provides a shiny application that enables the user to create a prototype UI, being able to drag and drop UI components before being able to save or download the equivalent R code.

Analyzes group patterns using discourse analysis data with graph theory mathematics. Takes the order of which individuals talk and converts it to a network edge and weight list. Returns the density, centrality, centralization, and subgroup information for each group. Based on the analytical framework laid out in Chai et al. (2019) <doi:10.1187/cbe.18-11-0222>.

Preferred methods for common analytical tasks that are undertaken across the Department, including number formatting, project templates and curated reference data.

This package provides a set of tools to generate dynamic spectrogram visualizations in video format.

Fast & memory-efficient functions to analyze and manipulate large data sets. It leverages the fast analytical capabilities of DuckDB and its spatial extension (see <https://duckdb.org/community_extensions/extensions/h3>) while maintaining compatibility with Râ s spatial data ecosystem to work with spatial vector data.

Various diffusion models to forecast new product growth. Currently the package contains Bass, Gompertz, Gamma/Shifted Gompertz and Weibull curves. See Meade and Islam (2006) <doi:10.1016/j.ijforecast.2006.01.005>.

Rare variant association test integrating variant position information. It aims to identify the presence of clusters of disease-risk variants in specific gene regions. For more details, please read the publication from Persyn et al. (2017) <doi:10.1371/journal.pone.0179364>.

This package provides helper functions to scrape the online archive of the Deutsche Turnliga <https://www.deutsche-turnliga.de/archiv.html>. Also included is data of one competition and one matchday as test data.

Extends daltoolbox with Python-backed components for deep learning, scikit-learn classification, and time-series forecasting through reticulate'. The package provides objects that follow the daltoolbox architecture while delegating model creation, fitting, encoding, and prediction to Python libraries such as torch and scikit-learn'. In the package name, dp stands for Deep Python'. The overall workflow is inspired by the Experiment Lines approach described in Ogasawara et al. (2009) <doi:10.1007/978-3-642-02279-1_20>.

Statistical modelling and forecasting in claims reserving in non-life insurance under the Double Chain Ladder framework by Martinez-Miranda, Nielsen and Verrall (2012).

Intensive longitudinal data have become increasingly prevalent in various scientific disciplines. Many such data sets are noisy, multivariate, and multi-subject in nature. The change functions may also be continuous, or continuous but interspersed with periods of discontinuities (i.e., showing regime switches). The package dynr (Dynamic Modeling in R) is an R package that implements a set of computationally efficient algorithms for handling a broad class of linear and nonlinear discrete- and continuous-time models with regime-switching properties under the constraint of linear Gaussian measurement functions. The discrete-time models can generally take on the form of a state-space or difference equation model. The continuous-time models are generally expressed as a set of ordinary or stochastic differential equations. All estimation and computations are performed in C, but users are provided with the option to specify the model of interest via a set of simple and easy-to-learn model specification functions in R. Model fitting can be performed using single-subject time series data or multiple-subject longitudinal data. Ou, Hunter, & Chow (2019) <doi:10.32614%2FRJ-2019-012> provided a detailed introduction to the interface and more information on the algorithms.

This package provides a method for identifying pattern changes between 2 experimental conditions in correlation networks (e.g., gene co-expression networks), which builds on a commonly used association measure, such as Pearson's correlation coefficient. This package includes functions to calculate correlation matrices for high-dimensional dataset and to test differential correlation, which means the changes in the correlation relationship among variables (e.g., genes and metabolites) between 2 experimental conditions.

Detection of runs of homozygosity and of heterozygosity in diploid genomes using two methods: sliding windows (Purcell et al (2007) <doi:10.1086/519795>) and consecutive runs (Marras et al (2015) <doi:10.1111/age.12259>).

Automated data exploration process for analytic tasks and predictive modeling, so that users could focus on understanding data and extracting insights. The package scans and analyzes each variable, and visualizes them with typical graphical techniques. Common data processing methods are also available to treat and format data.

Implementation of the Dual Feature Reduction (DFR) approach for the Sparse Group Lasso (SGL) and the Adaptive Sparse Group Lasso (aSGL) (Feser and Evangelou (2024) <doi:10.48550/arXiv.2405.17094>). The DFR approach is a feature reduction approach that applies strong screening to reduce the feature space before optimisation, leading to speed-up improvements for fitting SGL (Simon et al. (2013) <doi:10.1080/10618600.2012.681250>) and aSGL (Mendez-Civieta et al. (2020) <doi:10.1007/s11634-020-00413-8> and Poignard (2020) <doi:10.1007/s10463-018-0692-7>) models. DFR is implemented using the Adaptive Three Operator Splitting (ATOS) (Pedregosa and Gidel (2018) <doi:10.48550/arXiv.1804.02339>) algorithm, with linear and logistic SGL models supported, both of which can be fit using k-fold cross-validation. Dense and sparse input matrices are supported.