Offers tools to estimate the climate representativeness of reference polygons and quantifies its transformation under future climate change scenarios. Approaches described in Mingarro and Lobo (2018) <doi:10.32800/abc.2018.41.0333> and Mingarro and Lobo (2022) <doi:10.1017/S037689292100014X>.

Cellular cooperation compromises the plating efficiency-based analysis of clonogenic survival data. This tool provides functions that enable a robust analysis of colony formation assay (CFA) data in presence or absence of cellular cooperation. The implemented method has been described in Brix et al. (2020). (Brix, N., Samaga, D., Hennel, R. et al. "The clonogenic assay: robustness of plating efficiency-based analysis is strongly compromised by cellular cooperation." Radiat Oncol 15, 248 (2020). <doi:10.1186/s13014-020-01697-y>) Power regression for parameter estimation, calculation of survival fractions, uncertainty analysis and plotting functions are provided.

This package implements the model-free multiscale idealisation approaches: Jump-Segmentation by MUltiResolution Filter (JSMURF), Hotz et al. (2013) <doi:10.1109/TNB.2013.2284063>, JUmp Local dEconvolution Segmentation filter (JULES), Pein et al. (2018) <doi:10.1109/TNB.2018.2845126>, and Heterogeneous Idealization by Local testing and DEconvolution (HILDE), Pein et al. (2021) <doi:10.1109/TNB.2020.3031202>. Further details on how to use them are given in the accompanying vignette.

Generates the calibration simplex (a generalization of the reliability diagram) for three-category probability forecasts, as proposed by Wilks (2013) <doi:10.1175/WAF-D-13-00027.1>.

This package provides a suite of routines for Clifford algebras, using the Map class of the Standard Template Library. Canonical reference: Hestenes (1987, ISBN 90-277-1673-0, "Clifford algebra to geometric calculus"). Special cases including Lorentz transforms, quaternion multiplication, and Grassmann algebra, are discussed. Vignettes presenting conformal geometric algebra, quaternions and split quaternions, dual numbers, and Lorentz transforms are included. The package follows disordR discipline.

Various estimators of causal effects based on inverse probability weighting, doubly robust estimation, and double machine learning. Specifically, the package includes methods for estimating average treatment effects, direct and indirect effects in causal mediation analysis, and dynamic treatment effects. The models refer to studies of Froelich (2007) <doi:10.1016/j.jeconom.2006.06.004>, Huber (2012) <doi:10.3102/1076998611411917>, Huber (2014) <doi:10.1080/07474938.2013.806197>, Huber (2014) <doi:10.1002/jae.2341>, Froelich and Huber (2017) <doi:10.1111/rssb.12232>, Hsu, Huber, Lee, and Lettry (2020) <doi:10.1002/jae.2765>, and others.

Implementation of two-dimensional (2D) correlation analysis based on the Fourier-transformation approach described by Isao Noda (I. Noda (1993) <DOI:10.1366/0003702934067694>). Additionally there are two plot functions for the resulting correlation matrix: The first one creates colored 2D plots, while the second one generates 3D plots.

This package provides an expectation maximization (EM) algorithm to fit a mixture of continuous time Markov models for use with clickstream or other sequence type data. Gallaugher, M.P.B and McNicholas, P.D. (2018) <arXiv:1802.04849>.

This package provides a set of common functions to be used for displaying messages, checking variables, finding absolute paths, starting applications, etc. More functions will be added later.

This package performs the Cram method, a general and efficient approach to simultaneous learning and evaluation using a generic machine learning algorithm. In a single pass of batched data, the proposed method repeatedly trains a machine learning algorithm and tests its empirical performance. Because it utilizes the entire sample for both learning and evaluation, cramming is significantly more data-efficient than sample-splitting. Unlike cross-validation, Cram evaluates the final learned model directly, providing sharper inference aligned with real-world deployment. The method naturally applies to both policy learning and contextual bandits, where decisions are based on individual features to maximize outcomes. The package includes cram_policy() for learning and evaluating individualized binary treatment rules, cram_ml() to train and assess the population-level performance of machine learning models, and cram_bandit() for on-policy evaluation of contextual bandit algorithms. For all three functions, the package provides estimates of the average outcome that would result if the model were deployed, along with standard errors and confidence intervals for these estimates. Details of the method are described in Jia, Imai, and Li (2024) <https://www.hbs.edu/ris/Publication%20Files/2403.07031v1_a83462e0-145b-4675-99d5-9754aa65d786.pdf> and Jia et al. (2025) <doi:10.48550/arXiv.2403.07031>.

The vctrs package provides a concept of vector prototype that can be especially useful when deploying models and code. Serialize these object prototypes to JSON so they can be used to check and coerce data in production systems, and deserialize JSON back to the correct object prototypes.

Conditional moments test, as proposed by Newey (1985) <doi:10.2307/1911011 > and Tauchen (1985) <doi:10.1016/0304-4076(85)90149-6>, useful to detect specification violations for models estimated by maximum likelihood. Methods for probit and tobit models are provided.

There are 6 novel robust tests for equal correlation. They are all based on logistic regressions. The score statistic U is proportion to difference of two correlations based on different types of correlation in 6 methods. The ST1() is based on Pearson correlation. ST2() improved ST1() by using median absolute deviation. ST3() utilized type M correlation and ST4() used Spearman correlation. ST5() and ST6() used two different ways to combine ST3() and ST4(). We highly recommend ST5() according to the article titled New Statistical Methods for Constructing Robust Differential Correlation Networks to characterize the interactions among microRNAs published in Scientific Reports. Please see the reference: Yu et al. (2019) <doi:10.1038/s41598-019-40167-8>.

Computes 138 standard climate indices at monthly, seasonal and annual resolution. These indices were selected, based on their direct and significant impacts on target sectors, after a thorough review of the literature in the field of extreme weather events and natural hazards. Overall, the selected indices characterize different aspects of the frequency, intensity and duration of extreme events, and are derived from a broad set of climatic variables, including surface air temperature, precipitation, relative humidity, wind speed, cloudiness, solar radiation, and snow cover. The 138 indices have been classified as follow: Temperature based indices (42), Precipitation based indices (22), Bioclimatic indices (21), Wind-based indices (5), Aridity/ continentality indices (10), Snow-based indices (13), Cloud/radiation based indices (6), Drought indices (8), Fire indices (5), Tourism indices (5).

This package provides tools for penalized estimation of flexible hidden Markov models for time series of counts w/o the need to specify a (parametric) family of distributions. These include functions for model fitting, model checking, and state decoding. For details, see Adam, T., Langrock, R., and Weià , C.H. (2019): Penalized Estimation of Flexible Hidden Markov Models for Time Series of Counts. <arXiv:1901.03275>.

This package provides a standardized and reproducible framework for characterizing and classifying discrete color classes from digital images of biological organisms. The package automatically determines the presence or absence of 10 human-visible color categories (black, blue, brown, green, grey, orange, purple, red, white, yellow) using a biologically-inspired Color Look-Up Table (CLUT) that partitions HSV color space. Supports both fully automated and semi-automated (interactive) workflows with complete provenance tracking for reproducibility. Pre-processes images using the recolorize package (Weller et al. 2024 <doi:10.1111/ele.14378>) for spatial-color binning, and integrates with pavo (Maia et al. 2019 <doi:10.1111/2041-210X.13174>) for color pattern geometry statistics. Designed for high-throughput analysis and seamless integration with downstream evolutionary analyses.

In phase I clinical trials, the primary objective is to ascertain the maximum tolerated dose (MTD) corresponding to a specified target toxicity rate. The subsequent phase II trials are designed to examine the potential efficacy of the drug based on the MTD obtained from the phase I trials, with the aim of identifying the optimal biological dose (OBD). The CFO package facilitates the implementation of dose-finding trials by utilizing calibration-free odds type (CFO-type) designs. Specifically, it encompasses the calibration-free odds (CFO) (Jin and Yin (2022) <doi:10.1177/09622802221079353>), randomized CFO (rCFO), precision CFO (pCFO), two-dimensional CFO (2dCFO) (Wang et al. (2023) <doi:10.3389/fonc.2023.1294258>), time-to-event CFO (TITE-CFO) (Jin and Yin (2023) <doi:10.1002/pst.2304>), fractional CFO (fCFO), accumulative CFO (aCFO), TITE-aCFO, and f-aCFO (Fang and Yin (2024) <doi: 10.1002/sim.10127>). It supports phase I/II trials for the CFO design and only phase I trials for the other CFO-type designs. The â CFO package accommodates diverse CFO-type designs, allowing users to tailor the approach based on factors such as dose information inclusion, handling of late-onset toxicity, and the nature of the target drug (single-drug or drug-combination). The functionalities embedded in CFO package include the determination of the dose level for the next cohort, the selection of the MTD for a real trial, and the execution of single or multiple simulations to obtain operating characteristics. Moreover, these functions are equipped with early stopping and dose elimination rules to address safety considerations. Users have the flexibility to choose different distributions, thresholds, and cohort sizes among others for their specific needs. The output of the CFO package can be summary statistics as well as various plots for better visualization. An interactive web application for CFO is available at the provided URL.

Publicly available COVID-19 data for Norway cleaned and merged into one dataset, including PCR confirmed cases, tests, hospitalisation and vaccination.

Multiple comparison techniques are typically applied following an F test from an ANOVA to decide which means are significantly different from one another. As an alternative to traditional methods, cluster analysis can be performed to group the means of different treatments into non-overlapping clusters. Treatments in different groups are considered statistically different. Several approaches have been proposed, with varying clustering methods and cut-off criteria. This package implements cluster-based multiple comparisons tests and also provides a visual representation in the form of a dendrogram. Di Rienzo, J. A., Guzman, A. W., & Casanoves, F. (2002) <jstor.org/stable/1400690>. Bautista, M. G., Smith, D. W., & Steiner, R. L. (1997) <doi:10.2307/1400402>.

This package provides a tool for transforming coordinates in a color space to common color names using data from the Royal Horticultural Society and the International Union for the Protection of New Varieties of Plants.

This package provides tools that allow developers to write functions for cross-validation with minimal programming effort and assist users with model selection.

Advertisers use a variety of online marketing channels to reach consumers and they want to know the degree each channel contributes to their marketing success. This is called online multi-channel attribution problem. This package contains a probabilistic algorithm for the attribution problem. The model uses a k-order Markov representation to identify structural correlations in the customer journey data. The package also contains three heuristic algorithms (first-touch, last-touch and linear-touch approach) for the same problem. The algorithms are implemented in C++.

This package provides tools for sampling from a conditional copula density decomposed via Pair-Copula Constructions as C- or D- vine. Here, the vines which can be used for such a sampling are those which sample as first the conditioning variables (when following the sampling algorithms shown in Aas et al. (2009) <DOI:10.1016/j.insmatheco.2007.02.001>). The used sampling algorithm is presented and discussed in Bevacqua et al. (2017) <DOI:10.5194/hess-2016-652>, and it is a modified version of that from Aas et al. (2009) <DOI:10.1016/j.insmatheco.2007.02.001>. A function is available to select the best vine (based on information criteria) among those which allow for such a conditional sampling. The package includes a function to compare scatterplot matrices and pair-dependencies of two multivariate datasets.

This package provides several functions to identify and analyse miRNA sponge, including popular methods for identifying miRNA sponge interactions, two types of global ceRNA regulation prediction methods and four types of context-specific prediction methods( Li Y et al.(2017) <doi:10.1093/bib/bbx137>), which are based on miRNA-messenger RNA regulation alone, or by integrating heterogeneous data, respectively. In addition, For predictive ceRNA relationship pairs, this package provides several downstream analysis algorithms, including regulatory network analysis and functional annotation analysis, as well as survival prognosis analysis based on expression of ceRNA ternary pair.