Synapsis is a Bioconductor software package for automated (unbiased and reproducible) analysis of meiotic immunofluorescence datasets. The primary functions of the software can i) identify cells in meiotic prophase that are labelled by a synaptonemal complex axis or central element protein, ii) isolate individual synaptonemal complexes and measure their physical length, iii) quantify foci and co-localise them with synaptonemal complexes, iv) measure interference between synaptonemal complex-associated foci. The software has applications that extend to multiple species and to the analysis of other proteins that label meiotic prophase chromosomes. The software converts meiotic immunofluorescence images into R data frames that are compatible with machine learning methods. Given a set of microscopy images of meiotic spread slides, synapsis crops images around individual single cells, counts colocalising foci on strands on a per cell basis, and measures the distance between foci on any given strand.

The four functions svdcp() ('cp for column partitioned), svdbip() or svdbip2() ('bip for bipartitioned), and svdbips() ('s for a simultaneous optimization of a set of r solutions), correspond to a singular value decomposition (SVD) by blocks notion, by supposing each block depending on relative subspaces, rather than on two whole spaces as usual SVD does. The other functions, based on this notion, are relative to two column partitioned data matrices x and y defining two sets of subsets x_i and y_j of variables and amount to estimate a link between x_i and y_j for the pair (x_i, y_j) relatively to the links associated to all the other pairs. These methods were first presented in: Lafosse R. & Hanafi M.,(1997) <https://eudml.org/doc/106424> and Hanafi M. & Lafosse, R. (2001) <https://eudml.org/doc/106494>.

Algorithms for computing and generating plots with and without error bars for Bayesian cluster validity index (BCVI) (O. Preedasawakul, and N. Wiroonsri, A Bayesian Cluster Validity Index, Computational Statistics & Data Analysis, 202, 108053, 2025. <doi:10.1016/j.csda.2024.108053>) based on several underlying cluster validity indexes (CVIs) including Calinski-Harabasz, Chou-Su-Lai, Davies-Bouldin, Dunn, Pakhira-Bandyopadhyay-Maulik, Point biserial correlation, the score function, Starczewski, and Wiroonsri indices for hard clustering, and Correlation Cluster Validity, the generalized C, HF, KWON, KWON2, Modified Pakhira-Bandyopadhyay-Maulik, Pakhira-Bandyopadhyay-Maulik, Tang, Wiroonsri-Preedasawakul, Wu-Li, and Xie-Beni indices for soft clustering. The package is compatible with K-means, fuzzy C means, EM clustering, and hierarchical clustering (single, average, and complete linkage). Though BCVI is compatible with any underlying existing CVIs, we recommend users to use either WI or WP as the underlying CVI.

Fit data to an ellipse, hyperbola, or parabola. Bootstrapping is available when needed. The conic curve can be rotated through an arbitrary angle and the fit will still succeed. Helper functions are provided to convert generator coefficients from one style to another, generate test data sets, rotate conic section parameters, and so on. References include Nikolai Chernov (2014) "Fitting ellipses, circles, and lines by least squares" <https://people.cas.uab.edu/~mosya/cl/>; A. W. Fitzgibbon, M. Pilu, R. B. Fisher (1999) "Direct Least Squares Fitting of Ellipses" IEEE Trans. PAMI, Vol. 21, pages 476-48; N. Chernov, Q. Huang, and H. Ma (2014) "Fitting quadratic curves to data points", British Journal of Mathematics & Computer Science, 4, 33-60; N. Chernov and H. Ma (2011) "Least squares fitting of quadratic curves and surfaces", Computer Vision, Editor S. R. Yoshida, Nova Science Publishers, pp. 285-302.

This package performs survival analysis using general non-linear models. Risk models can be the sum or product of terms. Each term is the product of exponential/linear functions of covariates. Additionally sub-terms can be defined as a sum of exponential, linear threshold, and step functions. Cox Proportional hazards <https://en.wikipedia.org/wiki/Proportional_hazards_model>, Poisson <https://en.wikipedia.org/wiki/Poisson_regression>, and Fine-Gray competing risks <https://www.publichealth.columbia.edu/research/population-health-methods/competing-risk-analysis> regression are supported. This work was sponsored by NASA Grants 80NSSC19M0161 and 80NSSC23M0129 through a subcontract from the National Council on Radiation Protection and Measurements (NCRP). The computing for this project was performed on the Beocat Research Cluster at Kansas State University, which is funded in part by NSF grants CNS-1006860, EPS-1006860, EPS-0919443, ACI-1440548, CHE-1726332, and NIH P20GM113109.

This package implements code to identify lexical competitors in a given list of words. We include many of the standard competitor types used in spoken word recognition research, such as functions to find cohorts, neighbors, and rhymes, amongst many others. The package includes documentation for using a variety of lexicon files, including those with form codes made up of multiple letters (i.e., phoneme codes) and also basic orthographies. Importantly, the code makes use of multiple CPU cores and vectorization when possible, making it extremely fast and able to handle large lexicons. Additionally, the package contains documentation for users to easily write new functions, allowing researchers to examine other relationships within a lexicon. Preprint: <https://osf.io/preprints/psyarxiv/8dyru/>. Open access: <doi:10.3758/s13428-021-01667-6>. Citation: Li, Z., Crinnion, A.M. & Magnuson, J.S. (2021). <doi:10.3758/s13428-021-01667-6>.

An implementation of DuMouchel's (1999) <doi:10.1080/00031305.1999.10474456> Bayesian data mining method for the market basket problem. Calculates Empirical Bayes Geometric Mean (EBGM) and posterior quantile scores using the Gamma-Poisson Shrinker (GPS) model to find unusually large cell counts in large, sparse contingency tables. Can be used to find unusually high reporting rates of adverse events associated with products. In general, can be used to mine any database where the co-occurrence of two variables or items is of interest. Also calculates relative and proportional reporting ratios. Builds on the work of the PhViD package, from which much of the code is derived. Some of the added features include stratification to adjust for confounding variables and data squashing to improve computational efficiency. Includes an implementation of the EM algorithm for hyperparameter estimation loosely derived from the mederrRank package.

Optimal hard thresholding of singular values. The procedure adaptively estimates the best singular value threshold under unknown noise characteristics. The threshold chosen by ScreeNOT is optimal (asymptotically, in the sense of minimum Frobenius error) under the the so-called "Spiked model" of a low-rank matrix observed in additive noise. In contrast to previous works, the noise is not assumed to be i.i.d. or white; it can have an essentially arbitrary and unknown correlation structure, across either rows, columns or both. ScreeNOT is proposed to practitioners as a mathematically solid alternative to Cattell's ever-popular but vague Scree Plot heuristic from 1966. If you use this package, please cite our paper: David L. Donoho, Matan Gavish and Elad Romanov (2023). "ScreeNOT: Exact MSE-optimal singular value thresholding in correlated noise." Annals of Statistics, 2023 (To appear). <arXiv:2009.12297>.

Urban water and sanitation survey dataset collected by Water and Sanitation for the Urban Poor (WSUP) with technical support from Valid International. These citywide surveys have been collecting data allowing water and sanitation service levels across the entire city to be characterised, while also allowing more detailed data to be collected in areas of the city of particular interest. These surveys are intended to generate useful information for others working in the water and sanitation sector. Current release version includes datasets collected from a survey conducted in Dhaka, Bangladesh in March 2017. This survey in Dhaka is one of a series of surveys to be conducted by WSUP in various cities in which they operate including Accra, Ghana; Nakuru, Kenya; Antananarivo, Madagascar; Maputo, Mozambique; and, Lusaka, Zambia. This package will be updated once the surveys in other cities are completed and datasets have been made available.

The DaMiRseq package offers a tidy pipeline of data mining procedures to identify transcriptional biomarkers and exploit them for both binary and multi-class classification purposes. The package accepts any kind of data presented as a table of raw counts and allows including both continous and factorial variables that occur with the experimental setting. A series of functions enable the user to clean up the data by filtering genomic features and samples, to adjust data by identifying and removing the unwanted source of variation (i.e. batches and confounding factors) and to select the best predictors for modeling. Finally, a "stacking" ensemble learning technique is applied to build a robust classification model. Every step includes a checkpoint that the user may exploit to assess the effects of data management by looking at diagnostic plots, such as clustering and heatmaps, RLE boxplots, MDS or correlation plot.

The experiment selector cross-validated targeted maximum likelihood estimator (ES-CVTMLE) aims to select the experiment that optimizes the bias-variance tradeoff for estimating a causal average treatment effect (ATE) where different experiments may include a randomized controlled trial (RCT) alone or an RCT combined with real-world data. Using cross-validation, the ES-CVTMLE separates the selection of the optimal experiment from the estimation of the ATE for the chosen experiment. The estimated bias term in the selector is a function of the difference in conditional mean outcome under control for the RCT compared to the combined experiment. In order to help include truly unbiased external data in the analysis, the estimated average treatment effect on a negative control outcome may be added to the bias term in the selector. For more details about this method, please see Dang et al. (2022) <arXiv:2210.05802>.

Toolbox to process raw data from closed loop flux chamber (or tent) setups into ecosystem gas fluxes usable for analysis. It goes from a data frame of gas concentration over time (which can contain several measurements) and a meta data file indicating which measurement was done when, to a data frame of ecosystem gas fluxes including quality diagnostics. Organized with one function per step, maximizing user flexibility and backwards compatibility. Different models to estimate the fluxes from the raw data are available: exponential as described in Zhao et al (2018) <doi:10.1016/j.agrformet.2018.08.022>, exponential as described in Hutchinson and Mosier (1981) <doi:10.2136/sssaj1981.03615995004500020017x>, quadratic, and linear. Other functions include quality assessment, plotting for visual check, calculation of fluxes based on the setup specific parameters (chamber size, plot area, ...), gross primary production and transpiration rate calculation, and light response curves.

This package provides basic functionalities to calculate the position of satellites given a known state vector. The package includes implementations of the SGP4 and SDP4 simplified perturbation models to propagate orbital state vectors, as well as utilities to read TLE files and convert coordinates between different frames of reference. Several of the functionalities of the package (including the high-precision numerical orbit propagator) require the coefficients and data included in the asteRiskData package, available in a drat repository. To install this data package, run install.packages("asteRiskData", repos="https://rafael-ayala.github.io/drat/")'. Felix R. Hoots, Ronald L. Roehrich and T.S. Kelso (1988) <https://celestrak.org/NORAD/documentation/spacetrk.pdf>. David Vallado, Paul Crawford, Richard Hujsak and T.S. Kelso (2012) <doi:10.2514/6.2006-6753>. Felix R. Hoots, Paul W. Schumacher Jr. and Robert A. Glover (2014) <doi:10.2514/1.9161>.

An implementation of ADPclust clustering procedures (Fast Clustering Using Adaptive Density Peak Detection). The work is built and improved upon the idea of Rodriguez and Laio (2014)<DOI:10.1126/science.1242072>. ADPclust clusters data by finding density peaks in a density-distance plot generated from local multivariate Gaussian density estimation. It includes an automatic centroids selection and parameter optimization algorithm, which finds the number of clusters and cluster centroids by comparing average silhouettes on a grid of testing clustering results; It also includes a user interactive algorithm that allows the user to manually selects cluster centroids from a two dimensional "density-distance plot". Here is the research article associated with this package: "Wang, Xiao-Feng, and Yifan Xu (2015)<DOI:10.1177/0962280215609948> Fast clustering using adaptive density peak detection." Statistical methods in medical research". url: http://smm.sagepub.com/content/early/2015/10/15/0962280215609948.abstract.

This package provides functions to compute fuzzy versions of species occurrence patterns based on presence-absence data (including inverse distance interpolation, trend surface analysis, and prevalence-independent favourability obtained from probability of presence), as well as pair-wise fuzzy similarity (based on fuzzy logic versions of commonly used similarity indices) among those occurrence patterns. Includes also functions for model consensus and comparison (overlap and fuzzy similarity, fuzzy loss, fuzzy gain), and for data preparation, such as obtaining unique abbreviations of species names, defining the background region, cleaning and gridding (thinning) point occurrence data onto raster maps, selecting among (pseudo)absences to address survey bias, converting species lists (long format) to presence-absence tables (wide format), transposing part of a data frame, selecting relevant variables for models, assessing the false discovery rate, or analysing and dealing with multicollinearity. Initially described in Barbosa (2015) <doi:10.1111/2041-210X.12372>.

General linear modeling with multiple responses (MANCOVA). An overall p-value for each model term is calculated by the 50-50 MANOVA method by Langsrud (2002) <doi:10.1111/1467-9884.00320>, which handles collinear responses. Rotation testing, described by Langsrud (2005) <doi:10.1007/s11222-005-4789-5>, is used to compute adjusted single response p-values according to familywise error rates and false discovery rates (FDR). The approach to FDR is described in the appendix of Moen et al. (2005) <doi:10.1128/AEM.71.4.2086-2094.2005>. Unbalanced designs are handled by Type II sums of squares as argued in Langsrud (2003) <doi:10.1023/A:1023260610025>. Furthermore, the Type II philosophy is extended to continuous design variables as described in Langsrud et al. (2007) <doi:10.1080/02664760701594246>. This means that the method is invariant to scale changes and that common pitfalls are avoided.

Datasets and functions for the book "Modélisation statistique par la pratique avec R", F. Bertrand, E. Claeys and M. Maumy-Bertrand (2019, ISBN:9782100793525, Dunod, Paris). The first chapter of the book is dedicated to an introduction to the R statistical software. The second chapter deals with correlation analysis: Pearson, Spearman and Kendall simple, multiple and partial correlation coefficients. New wrapper functions for permutation tests or bootstrap of matrices of correlation are provided with the package. The third chapter is dedicated to data exploration with factorial analyses (PCA, CA, MCA, MDA) and clustering. The fourth chapter is dedicated to regression analysis: fitting and model diagnostics are detailed. The exercises focus on covariance analysis, logistic regression, Poisson regression, two-way analysis of variance for fixed or random factors. Various example datasets are shipped with the package: for instance on pokemon, world of warcraft, house tasks or food nutrition analyses.

Multilevel models (mixed effects models) are the statistical tool of choice for analyzing multilevel data (Searle et al, 2009). These models account for the correlated nature of observations within higher level units by adding group-level error terms that augment the singular residual error of a standard OLS regression. Multilevel and mixed effects models often require specialized data pre-processing and further post-estimation derivations and graphics to gain insight into model results. The package presented here, mlmtools', is a suite of pre- and post-estimation tools for multilevel models in R'. Package implements post-estimation tools designed to work with models estimated using lme4''s (Bates et al., 2014) lmer() function, which fits linear mixed effects regression models. Searle, S. R., Casella, G., & McCulloch, C. E. (2009, ISBN:978-0470009598). Bates, D., Mächler, M., Bolker, B., & Walker, S. (2014) <doi:10.18637/jss.v067.i01>.

The methods discussed in this package are new non-parametric methods based on sequential normal scores SNS (Conover et al (2017) <doi:10.1080/07474946.2017.1360091>), designed for sequences of observations, usually time series data, which may occur singly or in batches, and may be univariate or multivariate. These methods are designed to detect changes in the process, which may occur as changes in location (mean or median), changes in scale (standard deviation, or variance), or other changes of interest in the distribution of the observations, over the time observed. They usually apply to large data sets, so computations need to be simple enough to be done in a reasonable time on a computer, and easily updated as each new observation (or batch of observations) becomes available. Some examples and more detail in SNS is presented in the work by Conover et al (2019) <arXiv:1901.04443>.

Screen for and analyze non-linear sparse direct effects in the presence of unobserved confounding using the spectral deconfounding techniques (Ä evid, Bühlmann, and Meinshausen (2020)<jmlr.org/papers/v21/19-545.html>, Guo, Ä evid, and Bühlmann (2022) <doi:10.1214/21-AOS2152>). These methods have been shown to be a good estimate for the true direct effect if we observe many covariates, e.g., high-dimensional settings, and we have fairly dense confounding. Even if the assumptions are violated, it seems like there is not much to lose, and the deconfounded models will, in general, estimate a function closer to the true one than classical least squares optimization. SDModels provides functions SDAM() for Spectrally Deconfounded Additive Models (Scheidegger, Guo, and Bühlmann (2025) <doi:10.1145/3711116>) and SDForest() for Spectrally Deconfounded Random Forests (Ulmer, Scheidegger, and Bühlmann (2025) <doi:10.48550/arXiv.2502.03969>).

User-friendly analysis of hierarchical multinomial processing tree (MPT) models that are often used in cognitive psychology. Implements the latent-trait MPT approach (Klauer, 2010) <DOI:10.1007/s11336-009-9141-0> and the beta-MPT approach (Smith & Batchelder, 2010) <DOI:10.1016/j.jmp.2009.06.007> to model heterogeneity of participants. MPT models are conveniently specified by an .eqn-file as used by other MPT software and data are provided by a .csv-file or directly in R. Models are either fitted by calling JAGS or by an MPT-tailored Gibbs sampler in C++ (only for nonhierarchical and beta MPT models). Provides tests of heterogeneity and MPT-tailored summaries and plotting functions. A detailed documentation is available in Heck, Arnold, & Arnold (2018) <DOI:10.3758/s13428-017-0869-7> and a tutorial on MPT modeling can be found in Schmidt, Erdfelder, & Heck (2023) <DOI:10.1037/met0000561>.

We developed a lightweight machine learning tool for RNA profiling of acute lymphoblastic leukemia (ALL), however, it can be used for any problem where multiple classes need to be identified from multi-dimensional data. The methodology is described in Makinen V-P, Rehn J, Breen J, Yeung D, White DL (2022) Multi-cohort transcriptomic subtyping of B-cell acute lymphoblastic leukemia, International Journal of Molecular Sciences 23:4574, <doi:10.3390/ijms23094574>. The classifier contains optimized mean profiles of the classes (centroids) as observed in the training data, and new samples are matched to these centroids using the shortest Euclidean distance. Centroids derived from a dataset of 1,598 ALL patients are included, but users can train the models with their own data as well. The output includes both numerical and visual presentations of the classification results. Samples with mixed features from multiple classes or atypical values are also identified.

Offers a set of tools for visualizing and analyzing size and power properties of the test for equal predictive accuracy, the Diebold-Mariano test that is based on heteroskedasticity and autocorrelation-robust (HAR) inference. A typical HAR inference is involved with non-parametric estimation of the long-run variance, and one of its tuning parameters, the truncation parameter, trades off a size and power. Lazarus, Lewis, and Stock (2021)<doi:10.3982/ECTA15404> theoretically characterize the size-power frontier for the Gaussian multivariate location model. ForeComp computes and visualizes the finite-sample size-power frontier of the Diebold-Mariano test based on fixed-b asymptotics together with the Bartlett kernel. To compute the finite-sample size and power, it works with the best approximating ARMA process to the given dataset. It informs the user how their choice of the truncation parameter performs and how robust the testing outcomes are.

This package provides functions for computing test subscores using different methods in both classical test theory (CTT) and item response theory (IRT). This package enables three types of subscoring methods within the framework of CTT and IRT, including (1) Wainer's augmentation method (Wainer et. al., 2001) <doi:10.4324/9781410604729>, (2) Haberman's subscoring methods (Haberman, 2008) <doi:10.3102/1076998607302636>, and (3) Yen's objective performance index (OPI; Yen, 1987) <https://www.ets.org/research/policy_research_reports/publications/paper/1987/hrap>. It also includes functions to compute Proportional Reduction of Mean Squared Errors (PRMSEs) in Haberman's methods which are used to examine whether test subscores are of added value. In addition, the package includes a function to assess the local independence assumption of IRT with Yen's Q3 statistic (Yen, 1984 <doi:10.1177/014662168400800201>; Yen, 1993 <doi:10.1111/j.1745-3984.1993.tb00423.x>).