This package implements model-robust standardization for cluster-randomized trials (CRTs). Provides functions that standardize user-specified regression models to estimate marginal treatment effects. The targets include the cluster-average and individual-average treatment effects, with utilities for variance estimation and example simulation datasets. Methods are described in Li, Tong, Fang, Cheng, Kahan, and Wang (2025) <doi:10.1002/sim.70270>.

This package provides a metadata structure for clinical data analysis and reporting based on Analysis Data Model (ADaM) datasets. The package simplifies clinical analysis and reporting tool development by defining standardized inputs, outputs, and workflow. The package can be used to create analysis and reporting planning grid, mock table, and validated analysis and reporting results based on consistent inputs.

For single tensor data, any matrix factorization method can be specified the matricised tensor in each dimension by Multi-way Component Analysis (MWCA). An originally extended MWCA is also implemented to specify and decompose multiple matrices and tensors simultaneously (CoupledMWCA). See the reference section of GitHub README.md <https://github.com/rikenbit/mwTensor>, for details of the methods.

Implementation of Sequential BATTing (bootstrapping and aggregating of thresholds from trees) for developing threshold-based multivariate (prognostic/predictive) biomarker signatures. Variable selection is automatically built-in. Final signatures are returned with interaction plots for predictive signatures. Cross-validation performance evaluation and testing dataset results are also output. Detail algorithms are described in Huang et al (2017) <doi:10.1002/sim.7236>.

This package provides functions for the analysis of time series using copula models. The package is based on methodology described in the following references. McNeil, A.J. (2021) <doi:10.3390/risks9010014>, Bladt, M., & McNeil, A.J. (2021) <doi:10.1016/j.ecosta.2021.07.004>, Bladt, M., & McNeil, A.J. (2022) <doi:10.1515/demo-2022-0105>.

Calculates one-sample unbiased central moment estimates and two-sample pooled estimates up to 6th order, including estimates of powers and products of central moments. Provides the machinery for obtaining unbiased central moment estimators beyond 6th order by generating expressions for expectations of raw sample moments and their powers and products. Gerlovina and Hubbard (2019) <doi:10.1080/25742558.2019.1701917>.

This package provides a consistent interface for common feature importance methods as described in Ewald et al. (2024) <doi:10.1007/978-3-031-63797-1_22>, including permutation feature importance (PFI), conditional and relative feature importance (CFI, RFI), leave one covariate out (LOCO), and Shapley additive global importance (SAGE), as well as feature sampling mechanisms to support conditional importance methods.

The implemented R6 class SCM aims to simplify working with structural causal models. The missing data mechanism can be defined as a part of the structural model. The class contains methods for 1) defining a structural causal model via functions, text or conditional probability tables, 2) printing basic information on the model, 3) plotting the graph for the model using packages igraph or qgraph', 4) simulating data from the model, 5) applying an intervention, 6) checking the identifiability of a query using the R packages causaleffect and dosearch', 7) defining the missing data mechanism, 8) simulating incomplete data from the model according to the specified missing data mechanism and 9) checking the identifiability in a missing data problem using the R package dosearch'. In addition, there are functions for running experiments and doing counterfactual inference using simulation.

Computes a variety of statistics for relational event models (Meijerink et al., 2022, <doi:10.3758/s13428-022-01821-8>). Relational event models enable researchers to investigate exogenous and endogenous factors, and interactions, influencing the evolution of a time-ordered sequence of events. These models are categorized into tie-oriented models (Butts, C., 2008, <doi:10.1111/j.1467-9531.2008.00203.x>), where the probability of a dyad interacting next is modeled in a single step, and actor-oriented models (Stadtfeld, C., & Block, P., 2017, <doi:10.15195/v4.a14>), which first model the probability of a sender initiating an interaction and subsequently the probability of the sender's choice of receiver. The package is designed to compute a variety of statistics that summarize exogenous and endogenous influences on the event stream for both types of models.

This package provides basic functions for analyzing shallow whole-genome sequencing (~0.3X or more) of cell-free DNA (cfDNA). The package basically extracts the length of cfDNA fragments and aids the vistualization of fragment-length information. The package also extract fragment-length information per non-overlapping fixed-sized bins and used it for calculating ctDNA estimation score (CES).

The package implements GUIDE-seq and PEtag-seq analysis workflow including functions for filtering UMI and reads with low coverage, obtaining unique insertion sites (proxy of cleavage sites), estimating the locations of the insertion sites, aka, peaks, merging estimated insertion sites from plus and minus strand, and performing off target search of the extended regions around insertion sites with mismatches and indels.

The package conducts pathway testing from untargetted metabolomics data. It requires the user to supply feature-level test results, from case-control testing, regression, or other suitable feature-level tests for the study design. Weights are given to metabolic features based on how many metabolites they could potentially match to. The package can combine positive and negative mode results in pathway tests.

This package provides methods for high-throughput adaptive immune receptor repertoire sequencing (AIRR-Seq; Rep-Seq) analysis. In particular, immunoglobulin (Ig) sequence lineage reconstruction, lineage topology analysis, diversity profiling, amino acid property analysis and gene usage. Citations: Gupta and Vander Heiden, et al (2017) <doi:10.1093/bioinformatics/btv359>, Stern, Yaari and Vander Heiden, et al (2014) <doi:10.1126/scitranslmed.3008879>.

Full implementation of the 28 distributions introduced as benchmarks for nonparametric density estimation by Berlinet and Devroye (1994) <https://hal.science/hal-03659919>. Includes densities, cdfs, quantile functions and generators for samples as well as additional information on features of the densities. Also contains the 4 histogram densities used in Rozenholc/Mildenberger/Gather (2010) <doi:10.1016/j.csda.2010.04.021>.

An implementation of methods for extracting a sparse unweighted network (i.e. a backbone) from an unweighted network (e.g., Hamann et al., 2016 <doi:10.1007/s13278-016-0332-2>), a weighted network (e.g., Serrano et al., 2009 <doi:10.1073/pnas.0808904106>), or a weighted projection (e.g., Neal et al., 2021 <doi:10.1038/s41598-021-03238-3>).

Compose and send out responsive HTML email messages that render perfectly across a range of email clients and device sizes. Helper functions let the user insert embedded images, web link buttons, and ggplot2 plot objects into the message body. Messages can be sent through an SMTP server, through the Posit Connect service, or through the Mailgun API service <https://www.mailgun.com/>.

Inference by sequential Monte Carlo for dynamic tree regression and classification models with hooks provided for sequential design and optimization, fully online learning with drift, variable selection, and sensitivity analysis of inputs. Illustrative examples from the original dynamic trees paper (Gramacy, Taddy & Polson (2011); <doi:10.1198/jasa.2011.ap09769>) are facilitated by demos in the package; see demo(package="dynaTree").

Work with the Ecological Community Data Design Pattern. ecocomDP is a flexible data model for harmonizing ecological community surveys, in a research question agnostic format, from source data published across repositories, and with methods that keep the derived data up-to-date as the underlying sources change. Described in O'Brien et al. (2021), <doi:10.1016/j.ecoinf.2021.101374>.

This package provides a collection of four datasets based around the population dynamics of migratory fish. Datasets contain both basic size information on a per fish basis, as well as otolith data that contains a per day record of fish growth history. All data in this package was collected by the author, from 2015-2016, in the Wellington region of New Zealand.

To provide a comprehensive analysis of high dimensional longitudinal data,this package provides analysis for any combination of 1) simultaneous variable selection and estimation, 2) mean regression or quantile regression for heterogeneous data, 3) cross-sectional or longitudinal data, 4) balanced or imbalanced data, 5) moderate, high or even ultra-high dimensional data, via computationally efficient implementations of penalized generalized estimating equations.

This package provides a collection of Geoms for R's ggplot2 library. geom_shadowpath(), geom_shadowline(), geom_shadowstep() and geom_shadowpoint() functions draw a shadow below lines to make busy plots more aesthetically pleasing. geom_glowpath(), geom_glowline(), geom_glowstep() and geom_glowpoint() add a neon glow around lines to get a steampunk style.

Calculate and visualize Healthy Eating Index (HEI) scores from National Health and Nutrition Examination Survey 24-hour dietary recall data utilizing three methods recommended by the National Cancer Institute (2024) <https://epi.grants.cancer.gov/hei/hei-methods-and-calculations.html#:~:text=To%20use%20the%20simple%20HEI,the%20total%20scores%20across%20individuals.>. Effortlessly analyze HEI scores across different demographic groups and years.

This package provides methods for fast segmentation of multivariate signals into piecewise constant profiles and for generating realistic copy-number profiles. A typical application is the joint segmentation of total DNA copy numbers and allelic ratios obtained from Single Nucleotide Polymorphism (SNP) microarrays in cancer studies. The methods are described in Pierre-Jean, Rigaill and Neuvial (2015) <doi:10.1093/bib/bbu026>.

This package provides functions to implement K Nearest Neighbor forecasting using a weighted similarity metric tailored to the problem of forecasting univariate time series where recent observations, seasonal patterns, and exogenous predictors are all relevant in predicting future observations of the series in question. For more information on the formulation of this similarity metric please see Trupiano (2021) <arXiv:2112.06266>.