Functionalities for facilitating systematic reviews, data extractions, and meta-analyses. It includes a GUI (graphical user interface) to help screen the abstracts and titles of bibliographic data; tools to assign screening effort across multiple collaborators/reviewers and to assess inter- reviewer reliability; tools to help automate the download and retrieval of journal PDF articles from online databases; figure and image extractions from PDFs; web scraping of citations; automated and manual data extraction from scatter-plot and bar-plot images; PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagrams; simple imputation tools to fill gaps in incomplete or missing study parameters; generation of random effects sizes for Hedges d, log response ratio, odds ratio, and correlation coefficients for Monte Carlo experiments; covariance equations for modelling dependencies among multiple effect sizes (e.g., effect sizes with a common control); and finally summaries that replicate analyses and outputs from widely used but no longer updated meta-analysis software (i.e., metawin). Funding for this package was supported by National Science Foundation (NSF) grants DBI-1262545 and DEB-1451031. CITE: Lajeunesse, M.J. (2016) Facilitating systematic reviews, data extraction and meta-analysis with the metagear package for R. Methods in Ecology and Evolution 7, 323-330 <doi:10.1111/2041-210X.12472>.

Normally building a GODB is fairly complicated, involving downloading multiple database files and using these to build e.g. a mySQL database. Accessing this database is also complicated, involving an intimate knowledge of the database in order to construct reliable queries. Here we have a more modest goal, generating GOGOA3, which is a stripped down version of the GODB that was originally restricted to human genes as designated by the HUGO Gene Nomenclature Committee (HGNC) (see <https://geneontology.org/>). I have now added about two dozen additional species, namely all species represented on the Gene Ontology download page <https://current.geneontology.org/products/pages/downloads.html>. This covers most of the model organisms that are commonly used in bio-medical and basic research (assuming that anyone still has a grant to do such research). This can be built in a matter of seconds from 2 easily downloaded files (see <https://current.geneontology.org/products/pages/downloads.html> and <https://geneontology.org/docs/download-ontology/>), and it can be queried by e.g. w<-which(GOGOA3[,"HGNC"] %in% hgncList) where GOGOA3 is a matrix representing the minimalist GODB and hgncList is a list of gene identifiers. This database will be used in my upcoming package GoMiner which is based on my previous publication (see Zeeberg, B.R., Feng, W., Wang, G. et al. (2003)<doi:10.1186/gb-2003-4-4-r28>). Relevant .RData files are available from GitHub (<https://github.com/barryzee/GO/tree/main/databases>).

Fits latent Dirichlet allocation (LDA), supervised topic models, and multilevel supervised topic models for text data with multiple outcome variables. Core estimation routines are implemented in C++ using the Rcpp ecosystem. For topic models, see Blei et al. (2003) <https://www.jmlr.org/papers/volume3/blei03a/blei03a.pdf>. For supervised topic models, see Blei and McAuliffe (2007) <https://papers.nips.cc/paper_files/paper/2007/hash/d56b9fc4b0f1be8871f5e1c40c0067e7-Abstract.html>.

Researchers often have expectations about the relations between means of different groups or standardized regression coefficients; using informative hypothesis testing to incorporate these expectations into the analysis through order constraints increases statistical power Vanbrabant and Rosseel (2020) <doi:10.4324/9780429273872-14>. Another valuable tool, the Bayes factor, can evaluate evidence for multiple hypotheses without concerns about multiple testing, and can be used in Bayesian updating Hoijtink, Mulder, van Lissa & Gu (2019) <doi:10.1037/met0000201>. The bain R package enables informative hypothesis testing using the Bayes factor. The mmibain package provides shiny web applications based on bain'. The RepliCrisis() function launches a shiny card game to simulate the evaluation of replication studies while the mmibain() function launches a shiny application to fit Bayesian informative hypotheses evaluation models from bain'.

This package provides a function for measuring the difference between two independent or non-independent empirical distributions and returning a significance level of the difference.

Easily create functions to map between different sets of values, such as for re-labeling categorical variables.

Calculate predicted levels and marginal effects, using the delta method to calculate standard errors. This is an R-based version of the margins command from Stata.

The rapid screening of effective and optimal therapies from large numbers of candidate combinations, as well as exploring subgroup efficacy, remains challenging, which necessitates innovative, integrated, and efficient trial designs(Yuan, Y., et al. (2016) <doi:10.1002/sim.6971>). MIDAS-2 package enables quick and continuous screening of promising combination strategies and exploration of their subgroup effects within a unified platform design framework. We used a regression model to characterize the efficacy pattern in subgroups. Information borrowing was applied through Bayesian hierarchical model to improve trial efficiency considering the limited sample size in subgroups(Cunanan, K. M., et al. (2019) <doi:10.1177/1740774518812779>). MIDAS-2 provides an adaptive drug screening and subgroup exploring framework to accelerate immunotherapy development in an efficient, accurate, and integrated fashion(Wathen, J. K., & Thall, P. F. (2017) <doi: 10.1177/1740774517692302>).

Train and make predictions from a multi-layer perceptron neural network with optional partial monotonicity constraints.

Subset a control group to match an intervention group on a set of features using multivariate matching and propensity score calipers. Based on methods in Rosenbaum and Rubin (1985).

This package provides functions for MultiDimensional Feature Selection (MDFS): calculating multidimensional information gains, scoring variables, finding important variables, plotting selection results. This package includes an optional CUDA implementation that speeds up information gain calculation using NVIDIA GPGPUs. R. Piliszek et al. (2019) <doi:10.32614/RJ-2019-019>.

Solve scalar-on-function linear models, including generalized linear mixed effect model and quantile linear regression model, and bias correction estimation methods due to measurement error. Details about the measurement error bias correction methods, see Luan et al. (2023) <doi:10.48550/arXiv.2305.12624>, Tekwe et al. (2022) <doi:10.1093/biostatistics/kxac017>, Zhang et al. (2023) <doi:10.5705/ss.202021.0246>, Tekwe et al. (2019) <doi:10.1002/sim.8179>.

Functionality to estimate relative risks, risk differences, and partial effects from mixed model. Marginalisation over random effect terms is accomplished using Markov Chain Monte Carlo.

Shiny for Open Science to visualize, share, and inventory the main existing human datasets for researchers.

Calculates and differentiates probabilities and density of (conditional) multivariate normal distribution and Gaussian copula (with various marginal distributions) using methods described in A. Genz (2004) <doi:10.1023/B:STCO.0000035304.20635.31>, A. Genz, F. Bretz (2009) <doi:10.1007/978-3-642-01689-9>, H. I. Gassmann (2003) <doi:10.1198/1061860032283> and E. Kossova, B. Potanin (2018) <https://ideas.repec.org/a/ris/apltrx/0346.html>.

Mixtures of skewed and elliptical distributions are implemented using mixtures of multivariate skew power exponential and power exponential distributions, respectively. A generalized expectation-maximization framework is used for parameter estimation. See citation() for how to cite.

This package provides an interface to the Mapbox GL JS (<https://docs.mapbox.com/mapbox-gl-js/guides>) and the MapLibre GL JS (<https://maplibre.org/maplibre-gl-js/docs/>) interactive mapping libraries to help users create custom interactive maps in R. Users can create interactive globe visualizations; layer sf objects to create filled maps, circle maps, heatmaps', and three-dimensional graphics; and customize map styles and views. The package also includes utilities to use Mapbox and MapLibre maps in Shiny web applications.

Algorithms compute robust estimators for loss functions in the concave convex (CC) family by the iteratively reweighted convex optimization (IRCO), an extension of the iteratively reweighted least squares (IRLS). The IRCO reduces the weight of the observation that leads to a large loss; it also provides weights to help identify outliers. Applications include robust (penalized) generalized linear models and robust support vector machines. The package also contains penalized Poisson, negative binomial, zero-inflated Poisson, zero-inflated negative binomial regression models and robust models with non-convex loss functions. Wang et al. (2014) <doi:10.1002/sim.6314>, Wang et al. (2015) <doi:10.1002/bimj.201400143>, Wang et al. (2016) <doi:10.1177/0962280214530608>, Wang (2021) <doi:10.1007/s11749-021-00770-2>, Wang (2024) <doi:10.1111/anzs.12409>.

Focus-glue-context (FGC) fisheye transformations to two-dimensional coordinates and spatial vector geometries. Implements a smooth radial distortion that enlarges a focal region, transitions through a glue ring, and preserves outside context. Methods build on generalized fisheye views and focus+context mapping. For more details see Furnas (1986) <doi:10.1145/22339.22342>, Furnas (2006) <doi:10.1145/1124772.1124921> and Yamamoto et al. (2009) <doi:10.1145/1653771.1653788>.

This package provides common components (classes, methods, documentation) for packages that conduct meta-analytic corrections and sensitivity analyses for within-study and/or across-study biases in meta-analysis. See the packages PublicationBias', phacking', and multibiasmeta'. These package implement methods described in, respectively: Mathur & VanderWeele (2020) <doi:10.31219/osf.io/s9dp6>; Mathur (2022) <doi:10.31219/osf.io/ezjsx>; Mathur (2022) <doi:10.31219/osf.io/u7vcb>.

This package provides weighted versions of several metrics and performance measures used in machine learning, including average unit deviances of the Bernoulli, Tweedie, Poisson, and Gamma distributions, see Jorgensen B. (1997, ISBN: 978-0412997112). The package also contains a weighted version of generalized R-squared, see e.g. Cohen, J. et al. (2002, ISBN: 978-0805822236). Furthermore, dplyr chains are supported.

Calculate Krippendorff's alpha for multi-valued data using the methods introduced by Krippendorff and Craggs (2016) <doi:10.1080/19312458.2016.1228863>. Nominal, ordinal, interval, and ratio data types are supported, with options to create bootstrapped estimates of alpha and/or parallelize calculations.

The inference in multi-state models is traditionally performed under a Markov assumption that claims that past and future of the process are independent given the present state. In this package, we consider tests of the Markov assumption that are applicable to general multi-state models. Three approaches using existing methodology are considered: a simple method based on including covariates depending on the history in Cox models for the transition intensities; methods based on measuring the discrepancy of the non-Markov estimators of the transition probabilities to the Markov Aalen-Johansen estimators; and, finally, methods that were developed by considering summaries from families of log-rank statistics where patients are grouped by the state occupied of the process at a particular time point (see Soutinho G, Meira-Machado L (2021) <doi:10.1007/s00180-021-01139-7> and Titman AC, Putter H (2020) <doi:10.1093/biostatistics/kxaa030>).

This package contains functions for performing Mokken scale analysis on test and questionnaire data. It includes an automated item selection algorithm, and various checks of model assumptions.