This package provides a set of commands to manage an abstract optimization method. The goal is to provide a building block for a large class of specialized optimization methods. This package manages: the number of variables, the minimum and maximum bounds, the number of non linear inequality constraints, the cost function, the logging system, various termination criteria, etc...

This package implements novel tools for estimating sample sizes needed for phylogenetic studies, including studies focused on estimating the probability of true pathogen transmission between two cases given phylogenetic linkage and studies focused on tracking pathogen variants at a population level. Methods described in Wohl, Giles, and Lessler (2021) and in Wohl, Lee, DiPrete, and Lessler (2023).

Fits Emax models to pharmacokinetic/pharmacodynamic (PK/PD) data, estimate key parameters, and visualise model fits for multiple PK/PD indices. Methods are described in Macdougall J (2006) <doi:10.1007/0-387-33706-7_9>, Spiess AN, Neumeyer N (2010) <doi:10.1186/1471-2210-10-6>, and Burnham KP, Anderson DR (2004) <doi:10.1177/0049124104268644>.

Fast computation of the required sample size or the achieved power, for GWAS studies with different types of covariate effects and different types of covariate-gene dependency structure. For the detailed description of the methodology, see Zhang (2022) "Power and Sample Size Computation for Genetic Association Studies of Binary Traits: Accounting for Covariate Effects" <arXiv:2203.15641>.

This package provides a facility to generate sliced (orthogonal) Latin hypercube designs with four and five slices. For details about sliced and orthogonal Latin hypercube designs, see Yang, J. F., Lin, C. D., Qian, P. Z., and Lin, D. K. (2013). "Construction of sliced orthogonal Latin hypercube designs". Statistica Sinica, 1117-1130, <doi:10.5705/ss.2012.037>.

This package provides tools for reading and writing biological sequences in multiple formats, including FASTA', PHYLIP', CLUSTAL', STOCKHOLM', MEGA and GenBank'. Supports interleaved and sequential layouts where applicable, converts between formats, and manipulates sequence sets (e.g., filtering by patterns and computing consensus sequences from alignments). Also includes functions to download nucleotide records from NCBI by accession.

This package provides functions for converting among CIE XYZ, xyY, Lab, and Luv. Calculate Correlated Color Temperature (CCT) and the Planckian and daylight loci. The XYZs of some standard illuminants and some standard linear chromatic adaptation transforms (CATs) are included. Three standard color difference metrics are included, plus the forward direction of the CIECAM02 color appearance model.

Create highly customized tables with this simple and dependency-free package. Data frames can be converted to HTML', LaTeX', Markdown', Word', PNG', PDF', or Typst tables. The user interface is minimalist and easy to learn. The syntax is concise. HTML tables can be customized using the flexible Bootstrap framework, and LaTeX code with the tabularray package.

Bindings for the Tabula <https://tabula.technology/> Java library, which can extract tables from PDF files. This tool can reduce time and effort in data extraction processes in fields like investigative journalism. It allows for automatic and manual table extraction, the latter facilitated through a Shiny interface, enabling manual areas selection\ with a computer mouse for data retrieval.

Create, store, read and manage structured collections of datasets and other objects using a workspace', then bundle it into a compressed archive. Using open and interoperable formats makes it possible to exchange bundled data from R to other languages such as Python or Julia'. Multiple formats are supported Parquet', JSON', yaml', spatial data and raster data are supported.

This package provides a set of wrappers intended to check, read and download information from the Wikimedia sources. It is specifically created to work with names of celebrities, in which case their information and statistics can be downloaded. Additionally, it also builds links and snippets to use in combination with the function gallery() in netCoin package.

Application of reinsurance treaties to claims portfolios. The package creates a class Claims whose objective is to store claims and premiums, on which different treaties can be applied. A statistical analysis can then be applied to measure the impact of reinsurance, producing a table or graphical output. This package can be used for estimating the impact of reinsurance on several portfolios or for pricing treaties through statistical analysis. Documentation for the implemented methods can be found in "Reinsurance: Actuarial and Statistical Aspects" by Hansjöerg Albrecher, Jan Beirlant, Jozef L. Teugels (2017, ISBN: 978-0-470-77268-3) and "REINSURANCE: A Basic Guide to Facultative and Treaty Reinsurance" by Munich Re (2010) <https://www.munichre.com/site/mram/get/documents_E96160999/mram/assetpool.mr_america/PDFs/3_Publications/reinsurance_basic_guide.pdf>.

This package provides functions for annotation-agnostic differential expression analysis of RNA-seq data. Two implementations of the DER Finder approach are included in this package:

1. single base-level F-statistics and

2. DER identification at the expressed regions-level.

The DER Finder approach can also be used to identify differentially bounded ChIP-seq peaks.

This package provides .C64(), an enhanced version of .C() and .Fortran() from the R foreign function interface. .C64() supports long vectors, arguments of type 64-bit integer, and provides a mechanism to avoid unnecessary copies of read-only and write-only arguments. This makes it a convenient and fast interface to C/C++ and Fortran code.

git-repo provides Git extensions for interacting conveniently with AGit-Flow or Gerrit servers. It makes it possible to create, update or fetch PR, and more. It is based on the repo tool that was developed for the Gerrit project, but also supports AGit-Flow and lifts the requirement to use a manifest file.

This package provides functionalities to translate gene or protein identifiers between state-of-art biological databases: CARD (<https://card.mcmaster.ca/>), NCBI Protein, Nucleotide and Gene (<https://www.ncbi.nlm.nih.gov/>), UniProt (<https://www.uniprot.org/>) and KEGG (<https://www.kegg.jp>). Also offers complementary functionality like NCBI identical proteins or UniProt similar genes clusters retrieval.

This package contains the experimental data and a complete executable transcript (vignette) of the analysis of the HCT116 genetic interaction matrix presented in the paper "Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping" by C. Laufer, B. Fischer, M. Billmann, W. Huber, M. Boutros; Nature Methods (2013) 10:427-31. doi: 10.1038/nmeth.2436.

The main purpose of this package is to propose a transparent methodological framework to compare bioregionalization methods based on hierarchical and non-hierarchical clustering algorithms (Kreft & Jetz (2010) <doi:10.1111/j.1365-2699.2010.02375.x>) and network algorithms (Lenormand et al. (2019) <doi:10.1002/ece3.4718> and Leroy et al. (2019) <doi:10.1111/jbi.13674>).

This package performs simple correspondence analysis on a two-way contingency table, or multiple correspondence analysis (homogeneity analysis) on data with p categorical variables, and produces bootstrap-based elliptical confidence regions around the projected coordinates for the category points. Includes routines to plot the results in a variety of styles. Also reports the standard numerical output for correspondence analysis.

Given the non-negative data and its distribution, the package estimates the rank parameter for Non-negative Matrix Factorization. The method is based on hypothesis testing, using a deconvolved bootstrap distribution to assess the significance level accurately despite the large amount of optimization error. The distribution of the non-negative data can be either Normal distributed or Poisson distributed.

This package provides an interactive viewer for data.frame and tibble objects using shiny <https://shiny.posit.co/> and DT <https://rstudio.github.io/DT/>. It supports complex filtering, column selection, and automatic generation of reproducible dplyr <https://dplyr.tidyverse.org/> code for data manipulation. The package is designed for ease of use in data exploration and reporting workflows.

Links datasets through fuzzy string matching using pretrained text embeddings. Produces more accurate record linkage when lexical string distance metrics are a poor guide to match quality (e.g., "Patricia" is more lexically similar to "Patrick" than it is to "Trish"). Capable of performing multilingual record linkage. Methods are described in Ornstein (2025) <doi:10.1017/pan.2025.10016>.

Spatio-temporal causal inference based on point process data. You provide the raw data of locations and timings of treatment and outcome events, specify counterfactual scenarios, and the package estimates causal effects over specified spatial and temporal windows. See Papadogeorgou, et al. (2022) <doi:10.1111/rssb.12548> and Mukaigawara, et al. (2024) <doi:10.31219/osf.io/5kc6f>.

An implementation of the nonnegative garrote method that incorporates hierarchical relationships among variables. The core function, HiGarrote(), offers an automated approach for analyzing experiments while respecting hierarchical structures among effects. For methodological details, refer to Yu and Joseph (2025) <doi:10.1080/00224065.2025.2513508>. This work is supported by U.S. National Science Foundation grant DMS-2310637.