ATAC-seq, an assay for Transposase-Accessible Chromatin using sequencing, is a rapid and sensitive method for chromatin accessibility analysis. It was developed as an alternative method to MNase-seq, FAIRE-seq and DNAse-seq. The ATACseqQC package was developed to help users to quickly assess whether their ATAC-seq experiment is successful. It includes diagnostic plots of fragment size distribution, proportion of mitochondria reads, nucleosome positioning pattern, and CTCF or other Transcript Factor footprints.

An easy to use tool that can compare splicing events in tumor and normal tissue samples using either a user generated matrix, or data from The Cancer Genome Atlas (TCGA). This package generates a matrix of splicing outliers that are significantly over or underexpressed in tumors samples compared to normal denoted by chromosome location. The package also will calculate the splicing burden in each tumor and characterize the types of splicing events that occur.

This package contains a function to plot publication-ready survival curves using the Kaplan-Meier method (1958) <doi:10.2307/2281868>, a function to format p-values, and a function to automatically select statistical tests for comparing continuous variables between groups, which are useful for repetitive analyses. BiMaU stands for the Biostatistics and Mathematics Research Unit at the Sant Joan de Déu - Pediatric Cancer Center Barcelona <https://github.com/BiMaU-PCCB>.

Includes modern base-R functions. Functions beginning with p_ are wrapper functions for existing base-R functions, supporting native piping. Other functions are wrapper functions for core base-R features, including bracket notation and dollar-sign notation. base_match() and base_when() mimic case_match() and case_when() from dplyr but return a factor by default with levels ordered according to user input. et() mimics count() from dplyr'.

Indicators and measures by country and time describe what happens at economic and social levels. This package provides functions to calculate several measures of convergence after imputing missing values. The automated downloading of Eurostat data, followed by the production of country fiches and indicator fiches, makes possible to produce automated reports. The Eurofound report (<doi:10.2806/68012>) "Upward convergence in the EU: Concepts, measurements and indicators", 2018, is a detailed presentation of convergence.

Generates utility-oriented synthetic data for supported flat, nested, longitudinal and tree-linked multi-table designs, including patients, admissions, procedures and laboratory results linked by identifiers. The default engine uses sequential conditional synthesis; an opt-in differentially private engine implements person-level (epsilon, delta) mechanisms and records their budget accounting. Synthetic output is not anonymisation. Empirical utility and disclosure-risk diagnostics are descriptive and do not by themselves establish that a release is safe.

Rcpp implementation of the multivariate Kim filter, which combines the Kalman and Hamilton filters for state probability inference. The filter is designed for state space models and can handle missing values and exogenous data in the observation and state equations. Kim, Chang-Jin and Charles R. Nelson (1999) "State-Space Models with Regime Switching: Classical and Gibbs-Sampling Approaches with Applications" <doi:10.7551/mitpress/6444.001.0001><http://econ.korea.ac.kr/~cjkim/>.

Compute power and sample size for linear models of longitudinal data. Supported models include mixed-effects models and models fit by generalized least squares and generalized estimating equations. The package is described in Iddi and Donohue (2022) <DOI:10.32614/RJ-2022-022>. Relevant formulas are derived by Liu and Liang (1997) <DOI:10.2307/2533554>, Diggle et al (2002) <ISBN:9780199676750>, and Lu, Luo, and Chen (2008) <DOI:10.2202/1557-4679.1098>.

This package implements parametric modal regression for continuous positive distributions of the exponential family and beyond (e.g., Log-Logistic, Birnbaum-Saunders) under right censoring. Provides functions to link the conditional mode to a linear predictor using alternative parameterizations. Includes maximum likelihood estimation via numerical optimization, asymptotic inference based on the observed Fisher information matrix, and model diagnostics using randomized quantile residuals. See Galarza and Lachos (2026) <doi:10.48550/arXiv.2603.07099>.

Clean the MS/MS spectrum, calculate spectral entropy, unweighted entropy similarity, and entropy similarity for mass spectrometry data. The entropy similarity is a novel similarity measure for MS/MS spectra which outperform the widely used dot product similarity in compound identification. For more details, please refer to the paper: Yuanyue Li et al. (2021) "Spectral entropy outperforms MS/MS dot product similarity for small-molecule compound identification" <doi:10.1038/s41592-021-01331-z>.

This package implements two differentially private algorithms for estimating L2-regularized logistic regression coefficients. A randomized algorithm F is epsilon-differentially private (C. Dwork, Differential Privacy, ICALP 2006 <DOI:10.1007/11681878_14>), if |log(P(F(D) in S)) - log(P(F(D') in S))| <= epsilon for any pair D, D of datasets that differ in exactly one record, any measurable set S, and the randomness is taken over the choices F makes.

Data analysis based on panel partially-observed Markov process (PanelPOMP) models. To implement such models, simulate them and fit them to panel data, panelPomp extends some of the facilities provided for time series data by the pomp package. Implemented methods include filtering (panel particle filtering) and maximum likelihood estimation (Panel Iterated Filtering) as proposed in Breto, Ionides and King (2020) "Panel Data Analysis via Mechanistic Models" <doi:10.1080/01621459.2019.1604367>.

This package provides a lightweight vector database for text retrieval in R with embedded machine learning models and no external API (Application Programming Interface) keys. Supports dense and hybrid search, optional HNSW (Hierarchical Navigable Small World) approximate nearest-neighbor indexing, faceted filters with ACL (Access Control List) metadata, command-line tools, and a local dashboard built with shiny'. The HNSW method is described by Malkov and Yashunin (2018) <doi:10.1109/TPAMI.2018.2889473>.

Implementations for several robust procedures that allow for (online) extraction of the signal of univariate or multivariate time series by applying robust regression techniques to a moving time window are provided. Included are univariate filtering procedures based on repeated-median regression as well as hybrid and trimmed filters derived from it; see Schettlinger et al. (2006) <doi:10.1515/BMT.2006.010>. The adaptive online repeated median by Schettlinger et al. (2010) <doi:10.1002/acs.1105> and the slope comparing adaptive repeated median by Borowski and Fried (2013) <doi:10.1007/s11222-013-9391-7> choose the width of the moving time window adaptively. Multivariate versions are also provided; see Borowski et al. (2009) <doi:10.1080/03610910802514972> for a multivariate online adaptive repeated median and Borowski (2012) <doi:10.17877/DE290R-14393> for a multivariate slope comparing adaptive repeated median. Furthermore, a repeated-median based filter with automatic outlier replacement and shift detection is provided; see Fried (2004) <doi:10.1080/10485250410001656444>.

The S4Vectors package defines the Vector and List virtual classes and a set of generic functions that extend the semantic of ordinary vectors and lists in R. Package developers can easily implement vector-like or list-like objects as concrete subclasses of Vector or List. In addition, a few low-level concrete subclasses of general interest (e.g. DataFrame, Rle, and Hits) are implemented in the S4Vectors package itself.

repo2docker fetches a repository (from GitHub, GitLab, Zenodo, Figshare, Dataverse installations, a Git repository or a local directory) and builds a container image in which the code can be executed. The image build process is based on the configuration files found in the repository. repo2docker can be used to explore a repository locally by building and executing the constructed image of the repository, or as a means of building images that are pushed to a Docker registry.

We present a statistical simulator, scDesign3, to generate realistic single-cell and spatial omics data, including various cell states, experimental designs, and feature modalities, by learning interpretable parameters from real data. Using a unified probabilistic model for single-cell and spatial omics data, scDesign3 infers biologically meaningful parameters; assesses the goodness-of-fit of inferred cell clusters, trajectories, and spatial locations; and generates in silico negative and positive controls for benchmarking computational tools.

Self-Attention algorithm helper functions and demonstration vignettes of increasing depth on how to construct the Self-Attention algorithm, this is based on Vaswani et al. (2017) <doi:10.48550/arXiv.1706.03762>, Dan Jurafsky and James H. Martin (2022, ISBN:978-0131873216) <https://web.stanford.edu/~jurafsky/slp3/> "Speech and Language Processing (3rd ed.)" and Alex Graves (2020) <https://www.youtube.com/watch?v=AIiwuClvH6k> "Attention and Memory in Deep Learning".

This package provides methods for assessing animal movement from telemetry and biologging data using non-parametric Bayesian methods. This includes features for pre- processing and analysis of data, as well as the visualization of results from the models. This framework does not rely on standard parametric density functions, which provides flexibility during model fitting. Further details regarding part of this framework can be found in Cullen et al. (2022) <doi:10.1111/2041-210X.13745>.

Several tools for handling block-matrix diagonals and similar constructs are implemented. Block-diagonal matrices can be extracted or removed using two small functions implemented here. In addition, non-square matrices are supported. Block diagonal matrices occur when two dimensions of a data set are combined along one edge of a matrix. For example, trade-flow data in the decompr and gvc packages have each country-industry combination occur along both edges of the matrix.

This package provides methods for distance covariance and distance correlation (Szekely, et al. (2007) <doi:10.1214/009053607000000505>), generalized version thereof (Sejdinovic, et al. (2013) <doi:10.1214/13-AOS1140>) and corresponding tests (Berschneider, Bottcher (2018) <doi:10.48550/arXiv.1808.07280>. Distance standard deviation methods (Edelmann, et al. (2020) <doi:10.1214/19-AOS1935>) and distance correlation methods for survival endpoints (Edelmann, et al. (2021) <doi:10.1111/biom.13470>) are also included.

An implementation of a clustering algorithm for functional data based on adaptive density peak detection technique, in which the density is estimated by functional k-nearest neighbor density estimation based on a proposed semi-metric between functions. The proposed functional data clustering algorithm is computationally fast since it does not need iterative process. (Alex Rodriguez and Alessandro Laio (2014) <doi:10.1126/science.1242072>; Xiao-Feng Wang and Yifan Xu (2016) <doi:10.1177/0962280215609948>).

The different methods for defining, detecting, and categorising the extreme events known as heatwaves or cold-spells, as first proposed in Hobday et al. (2016) <doi: 10.1016/j.pocean.2015.12.014> and Hobday et al. (2018) <https://www.jstor.org/stable/26542662>. The functions in this package work on both air and water temperature data of hourly and daily temporal resolution. These detection algorithms may be used on non-temperature data as well.

This package provides tidy, harmonized access to demographic data from the Spanish National Statistics Institute (INE) fenomenos demograficos domain, including population, births, and deaths, retrieved live via the official ineapir API wrapper, with optional spatial integration at municipality and province level via mapSpain'. Mortality indicators follow the Human Mortality Database Methods Protocol, including the average age at death in infancy method of Andreev and Kingkade (2015) <doi:10.4054/DemRes.2015.33.13>.