Efficiently implements the Graphical Lasso algorithm, utilizing the Armadillo C++ library for rapid computation. This algorithm introduces an L1 penalty to derive sparse inverse covariance matrices from observations of multivariate normal distributions. Features include the generation of random and structured sparse covariance matrices, beneficial for simulations, statistical method testing, and educational purposes in graphical modeling. A unique function for regularization parameter selection based on predefined sparsity levels is also offered, catering to users with specific sparsity requirements in their models. The methodology for sparse inverse covariance estimation implemented in this package is based on the work of Friedman, Hastie, and Tibshirani (2008) <doi:10.1093/biostatistics/kxm045>.

Defines classes and methods that can be used to implement genetic algorithms for feature selection. The idea is that we want to select a fixed number of features to combine into a linear classifier that can predict a binary outcome, and can use a genetic algorithm heuristically to select an optimal set of features.

This package provides the following types of models: Models for contingency tables (i.e. log-linear models) Graphical Gaussian models for multivariate normal data (i.e. covariance selection models) Mixed interaction models. Documentation about gRim is provided by vignettes included in this package and the book by Højsgaard, Edwards and Lauritzen (2012, <doi:10.1007/978-1-4614-2299-0>); see citation("gRim") for details.

Functional denoising and functional ANOVA through wavelet-domain Markov groves. Fore more details see: Ma L. and Soriano J. (2018) Efficient functional ANOVA through wavelet-domain Markov groves. <arXiv:1602.03990v2 [stat.ME]>.

This package provides a set of geometries to make line plots a little bit nicer. Use along with ggplot2 to: - Improve the clarity of line plots with many overlapping lines - Draw more realistic worms.

This package provides tools for specifying and evaluating standard and truncated probability distributions, with support for log-space computation and joint distribution specification. It enables Bayesian computation for cognition models and includes utilities for density calculation, sampling, and visualisation, facilitating prior distribution specification and model assessment in hierarchical Bayesian frameworks.

This package provides methods to Get Water Attributes Visually in R ('gwavr'). This allows the user to point and click on areas within the United States and get back hydrological data, e.g. flowlines, catchments, basin boundaries, comids, etc.

Implementation of the GTE (Group Technical Effects) model for single-cell data. GTE is a quantitative metric to assess batch effects for individual genes in single-cell data. For a single-cell dataset, the user can calculate the GTE value for individual features (such as genes), and then identify the highly batch-sensitive features. Removing these highly batch-sensitive features results in datasets with low batch effects.

The web service at <https://www.geonames.org/> provides a number of spatial data queries, including administrative area hierarchies, city locations and some country postal code queries. A (free) username is required and rate limits exist.

Guild AI is an open-source tool for managing machine learning experiments. It's for scientists, engineers, and researchers who want to run scripts, compare results, measure progress, and automate machine learning workflow. Guild AI is a light weight, external tool that runs locally. It works with any framework, doesn't require any changes to your code, or access to any web services. Users can easily record experiment metadata, track model changes, manage experiment artifacts, tune hyperparameters, and share results. Guild AI combines features from Git', SQLite', and Make to provide a lab notebook for machine learning.

Generalizes application of gray-level co-occurrence matrix (GLCM) metrics to objects outside of images. The current focus is to apply GLCM metrics to the study of biological networks and fitness landscapes that are used in studying evolutionary medicine and biology, particularly the evolution of cancer resistance. The package was developed as part of the author's publication in Physics in Medicine and Biology Barker-Clarke et al. (2023) <doi:10.1088/1361-6560/ace305>. A general reference to learn more about mathematical oncology can be found at Rockne et al. (2019) <doi:10.1088/1478-3975/ab1a09>.

Generation of survival data with one (binary) time-dependent covariate. Generation of survival data arising from a progressive illness-death model.

Allows plotting data on bathymetric maps using ggplot2'. Plotting oceanographic spatial data is made as simple as feasible, but also flexible for custom modifications. Data that contain geographic information from anywhere around the globe can be plotted on maps generated by the basemap() or qmap() functions using ggplot2 layers separated by the + operator. The package uses spatial shape- ('sf') and raster ('stars') files, geospatial packages for R to manipulate, and the ggplot2 package to plot these files. The package ships with low-resolution spatial data files and higher resolution files for detailed maps are stored in the ggOceanMapsLargeData repository on GitHub and downloaded automatically when needed.

Routines that allow the user to run goodness of fit tests based on empirical distribution functions for formal model evaluation in a general likelihood model. In addition, functions are provided to test if a sample follows Normal or Gamma distributions, validate the normality assumptions in a linear model, and examine the appropriateness of a Gamma distribution in generalized linear models with various link functions. Michael Arthur Stephens (1976) <http://www.jstor.org/stable/2958206>.

This package provides a collection of utilities that support creation of network attributes for hydrologic networks. Methods and algorithms implemented are documented in Moore et al. (2019) <doi:10.3133/ofr20191096>), Cormen and Leiserson (2022) <ISBN:9780262046305> and Verdin and Verdin (1999) <doi:10.1016/S0022-1694(99)00011-6>.

Paternal recombination rate and maternal linkage disequilibrium (LD) are estimated for pairs of biallelic markers such as single nucleotide polymorphisms (SNPs) from progeny genotypes and sire haplotypes. The implementation relies on paternal half-sib families. If maternal half-sib families are used, the roles of sire/dam are swapped. Multiple families can be considered. For parameter estimation, at least one sire has to be double heterozygous at the investigated pairs of SNPs. Based on recombination rates, genetic distances between markers can be estimated. Markers with unusually large recombination rate to markers in close proximity (i.e. putatively misplaced markers) shall be discarded in this derivation. A workflow description is attached as vignette. *A pipeline is available at GitHub* <https://github.com/wittenburg/hsrecombi> Hampel, Teuscher, Gomez-Raya, Doschoris, Wittenburg (2018) "Estimation of recombination rate and maternal linkage disequilibrium in half-sibs" <doi:10.3389/fgene.2018.00186>. Gomez-Raya (2012) "Maximum likelihood estimation of linkage disequilibrium in half-sib families" <doi:10.1534/genetics.111.137521>.

When considering count data, it is often the case that many more zero counts than would be expected of some given distribution are observed. It is well established that data such as this can be reliably modelled using zero-inflated or hurdle distributions, both of which may be applied using the functions in this package. Bayesian analysis methods are used to best model problematic count data that cannot be fit to any typical distribution. The package functions are flexible and versatile, and can be applied to varying count distributions, parameter estimation with or without explanatory variable information, and are able to allow for multiple hurdles as it is also not uncommon that count data have an abundance of large-number observations which would be considered outliers of the typical distribution. In lieu of throwing out data or misspecifying the typical distribution, these extreme observations can be applied to a second, extreme distribution. With the given functions of this package, such a two-hurdle model may be easily specified in order to best manage data that is both zero-inflated and over-dispersed.

Facilitates automated HTML report creation, in particular framed HTML pages and dynamically sortable tables.

We use the Alternating Direction Method of Multipliers (ADMM) for parameter estimation in high-dimensional, single-modality mediation models. To improve the sensitivity and specificity of estimated mediation effects, we offer the sure independence screening (SIS) function for dimension reduction. The available penalty options include Lasso, Elastic Net, Pathway Lasso, and Network-constrained Penalty. The methods employed in the package are based on Boyd, S., Parikh, N., Chu, E., Peleato, B., & Eckstein, J. (2011). <doi:10.1561/2200000016>, Fan, J., & Lv, J. (2008) <doi:10.1111/j.1467-9868.2008.00674.x>, Li, C., & Li, H. (2008) <doi:10.1093/bioinformatics/btn081>, Tibshirani, R. (1996) <doi:10.1111/j.2517-6161.1996.tb02080.x>, Zhao, Y., & Luo, X. (2022) <doi:10.4310/21-sii673>, and Zou, H., & Hastie, T. (2005) <doi:10.1111/j.1467-9868.2005.00503.x>.

Computes diagnostics for linear regression when treatment effects are heterogeneous. The output of hettreatreg represents ordinary least squares (OLS) estimates of the effect of a binary treatment as a weighted average of the average treatment effect on the treated (ATT) and the average treatment effect on the untreated (ATU). The program estimates the OLS weights on these parameters, computes the associated model diagnostics, and reports the implicit OLS estimate of the average treatment effect (ATE). See Sloczynski (2019), <http://people.brandeis.edu/~tslocz/Sloczynski_paper_regression.pdf>.

Hedgehog will eat all your bugs. Hedgehog is a property-based testing package in the spirit of QuickCheck'. With Hedgehog', one can test properties of their programs against randomly generated input, providing far superior test coverage compared to unit testing. One of the key benefits of Hedgehog is integrated shrinking of counterexamples, which allows one to quickly find the cause of bugs, given salient examples when incorrect behaviour occurs.

Processing, analysis and visualization of Hydrogen Deuterium eXchange monitored by Mass Spectrometry experiments (HDX-MS). HaDeX2 introduces a new standardized and reproducible workflow for the analysis of the HDX-MS data, including uncertainty propagation, data aggregation and visualization on 3D structure. Additionally, it covers data exploration, quality control and generation of publication-quality figures. All functionalities are also available in the accompanying shiny app.

Enables chat completion and text annotation with local and OpenAI <https://openai.com/> language models, supporting batch processing, multiple annotators, and consistent output formats.

Allows to estimate and test high-dimensional mediation effects based on advanced mediator screening and penalized regression techniques. Methods used in the package refer to Zhang H, Zheng Y, Hou L, Liu L, HIMA: An R Package for High-Dimensional Mediation Analysis. Journal of Data Science. (2025). <doi:10.6339/25-JDS1192>.