An S4 class and several functions which utilize internally stored datasets and gauging data enable 1d water level interpolation. The S4 class (WaterLevelDataFrame) structures the computation and visualisation of 1d water level information along the German federal waterways Elbe and Rhine. hyd1d delivers 1d water level data - extracted from the FLYS database - and validated gauging data - extracted from the hydrological database WISKI7 - package-internally. For computations near real time gauging data are queried externally from the PEGELONLINE REST API <https://pegelonline.wsv.de/webservice/dokuRestapi>.

This package provides tools to generate synthetic electronic health records including patients, encounters, vitals, labs, medications, procedures, and allergies, with optional COVID-19-focused and computed tomography (CT)-research views, and export them to comma separated values ('CSV'), SQLite', and Excel formats for researchers and developers.

Automatic construction of regular and irregular histograms as described in Rozenholc/Mildenberger/Gather (2010).

This model divides coefficients into three types, i.e., local fixed effects, global fixed effects, and random effects (Hu et al., 2022)<doi:10.1177/23998083211063885>. If data have spatial hierarchical structures (especially are overlapping on some locations), it is worth trying this model to reach better fitness.

Builds on the EMD package to provide additional tools for empirical mode decomposition (EMD) and Hilbert spectral analysis. It also implements the ensemble empirical decomposition (EEMD) and the complete ensemble empirical mode decomposition (CEEMD) methods to avoid mode mixing and intermittency problems found in EMD analysis. The package comes with several plotting methods that can be used to view intrinsic mode functions, the HHT spectrum, and the Fourier spectrum.

Holistic generalized linear models (HGLMs) extend generalized linear models (GLMs) by enabling the possibility to add further constraints to the model. The holiglm package simplifies estimating HGLMs using convex optimization. Additional information about the package can be found in the reference manual, the README and the accompanying paper <doi:10.18637/jss.v108.i07>.

This package provides functions for the fitting and summarizing of heteroscedastic t-regression.

This package provides uniform testing procedures for existence and heterogeneity of threshold effects in high-dimensional nonparametric panel regression models. The package accompanies the paper Chen, Keilbar, Su and Wang (2023) "Inference on many jumps in nonparametric panel regression models". arXiv preprint <doi:10.48550/arXiv.2312.01162>.

Implementation of MCMC algorithms to estimate the Hierarchical Dirichlet Process Generalized Linear Model (hdpGLM) presented in the paper Ferrari (2020) Modeling Context-Dependent Latent Heterogeneity, Political Analysis <DOI:10.1017/pan.2019.13> and <doi:10.18637/jss.v107.i10>.

By analyzing time series, it is possible to observe significant changes in the behavior of observations that frequently characterize events. Events present themselves as anomalies, change points, or motifs. In the literature, there are several methods for detecting events. However, searching for a suitable time series method is a complex task, especially considering that the nature of events is often unknown. This work presents Harbinger, a framework for integrating and analyzing event detection methods. Harbinger contains several state-of-the-art methods described in Salles et al. (2020) <doi:10.5753/sbbd.2020.13626>.

When considering count data, it is often the case that many more zero counts than would be expected of some given distribution are observed. It is well established that data such as this can be reliably modelled using zero-inflated or hurdle distributions, both of which may be applied using the functions in this package. Bayesian analysis methods are used to best model problematic count data that cannot be fit to any typical distribution. The package functions are flexible and versatile, and can be applied to varying count distributions, parameter estimation with or without explanatory variable information, and are able to allow for multiple hurdles as it is also not uncommon that count data have an abundance of large-number observations which would be considered outliers of the typical distribution. In lieu of throwing out data or misspecifying the typical distribution, these extreme observations can be applied to a second, extreme distribution. With the given functions of this package, such a two-hurdle model may be easily specified in order to best manage data that is both zero-inflated and over-dispersed.

This package provides a user-friendly tool to fit Bayesian regression models. It can fit 3 types of Bayesian models using individual-level, summary-level, and individual plus pedigree-level (single-step) data for both Genomic prediction/selection (GS) and Genome-Wide Association Study (GWAS), it was designed to estimate joint effects and genetic parameters for a complex trait, including: (1) fixed effects and coefficients of covariates, (2) environmental random effects, and its corresponding variance, (3) genetic variance, (4) residual variance, (5) heritability, (6) genomic estimated breeding values (GEBV) for both genotyped and non-genotyped individuals, (7) SNP effect size, (8) phenotype/genetic variance explained (PVE) for single or multiple SNPs, (9) posterior probability of association of the genomic window (WPPA), (10) posterior inclusive probability (PIP). The functions are not limited, we will keep on going in enriching it with more features. References: Lilin Yin et al. (2025) <doi:10.18637/jss.v114.i06>; Meuwissen et al. (2001) <doi:10.1093/genetics/157.4.1819>; Gustavo et al. (2013) <doi:10.1534/genetics.112.143313>; Habier et al. (2011) <doi:10.1186/1471-2105-12-186>; Yi et al. (2008) <doi:10.1534/genetics.107.085589>; Zhou et al. (2013) <doi:10.1371/journal.pgen.1003264>; Moser et al. (2015) <doi:10.1371/journal.pgen.1004969>; Lloyd-Jones et al. (2019) <doi:10.1038/s41467-019-12653-0>; Henderson (1976) <doi:10.2307/2529339>; Fernando et al. (2014) <doi:10.1186/1297-9686-46-50>.

This R package has been developed with a focus on air pollution and noise but can be applied to other exposures. The initial development has been funded by the European Union project BEST-COST. Disclaimer: It is work in progress and the developers are not liable for any calculation errors or inaccuracies resulting from the use of this package. Selection of relevant references (in chronological order): WHO (2003) <https://www.who.int/publications/i/item/9241546204>, Murray et al. (2003) <doi:10.1186/1478-7954-1-1>, Miller & Hurley (2003) <doi:10.1136/jech.57.3.200>, Steenland & Armstrong (2006) <doi:10.1097/01.ede.0000229155.05644.43>, WHO (2011) <https://iris.who.int/items/723ab97c-5c33-4e3b-8df1-744aa5bc1c27>, GBD 2019 Risk Factors Collaborators (2020) <doi:10.1016/S0140-6736(20)30752-2>.

Perform high dimensional Feature Selection in the presence of survival outcome. Based on Feature Selection method and different survival analysis, it will obtain the best markers with optimal threshold levels according to their effect on disease progression and produce the most consistent level according to those threshold values. The functions methodology is based on by Sonabend et al (2021) <doi:10.1093/bioinformatics/btab039> and Bhattacharjee et al (2021) <arXiv:2012.02102>.

Bipartite graph-based hierarchical clustering, developed for pharmacogenomic datasets and datasets sharing the same data structure. The goal is to construct a hierarchical clustering of groups of samples based on association patterns between two sets of variables. In the context of pharmacogenomic datasets, the samples are cell lines, and the two sets of variables are typically expression levels and drug sensitivity values. For this method, sparse canonical correlation analysis from Lee, W., Lee, D., Lee, Y. and Pawitan, Y. (2011) <doi:10.2202/1544-6115.1638> is first applied to extract association patterns for each group of samples. Then, a nuclear norm-based dissimilarity measure is used to construct a dissimilarity matrix between groups based on the extracted associations. Finally, hierarchical clustering is applied.

Machine learning hierarchical risk clustering portfolio allocation strategies. The implemented methods are: Hierarchical risk parity (De Prado, 2016) <DOI: 10.3905/jpm.2016.42.4.059>. Hierarchical clustering-based asset allocation (Raffinot, 2017) <DOI: 10.3905/jpm.2018.44.2.089>. Hierarchical equal risk contribution portfolio (Raffinot, 2018) <DOI: 10.2139/ssrn.3237540>. A Constrained Hierarchical Risk Parity Algorithm with Cluster-based Capital Allocation (Pfitzingera and Katzke, 2019) <https://www.ekon.sun.ac.za/wpapers/2019/wp142019/wp142019.pdf>.

Translation between experimental null hypotheses, hypothesis matrices, and contrast matrices as used in linear regression models. The package is based on the method described in Schad et al. (2019) <doi:10.1016/j.jml.2019.104038> and Rabe et al. (2020) <doi:10.21105/joss.02134>.

Antitrust analysis of healthcare markets. Contains functions to implement the semiparametric estimation technique described in Raval, Rosenbaum, and Tenn (2017) "A Semiparametric Discrete Choice Model: An Application to Hospital Mergers" <doi:10.1111/ecin.12454>.

Probability functions and other utilities for the generalized Hermite distribution.

Inference of chromosome-length haplotypes using a few haploid gametes of an individual. The gamete genotype data may be generated from various platforms including genotyping arrays and sequencing even with low-coverage. Hapi simply takes genotype data of known hetSNPs in single gamete cells as input and report the high-resolution haplotypes as well as confidence of each phased hetSNPs. The package also includes a module allowing downstream analyses and visualization of identified crossovers in the gametes.

Most common exact, asymptotic and resample based tests are provided for testing the homogeneity of variances of k normal distributions under normality. These tests are Barlett, Bhandary & Dai, Brown & Forsythe, Chang et al., Gokpinar & Gokpinar, Levene, Liu and Xu, Gokpinar. Also, a data generation function from multiple normal distribution is provided using any multiple normal parameters. Bartlett, M. S. (1937) <doi:10.1098/rspa.1937.0109> Bhandary, M., & Dai, H. (2008) <doi:10.1080/03610910802431011> Brown, M. B., & Forsythe, A. B. (1974).<doi:10.1080/01621459.1974.10482955> Chang, C. H., Pal, N., & Lin, J. J. (2017) <doi:10.1080/03610918.2016.1202277> Gokpinar E. & Gokpinar F. (2017) <doi:10.1080/03610918.2014.955110> Liu, X., & Xu, X. (2010) <doi:10.1016/j.spl.2010.05.017> Levene, H. (1960) <https://cir.nii.ac.jp/crid/1573950400526848896> Gökpınar, E. (2020) <doi:10.1080/03610918.2020.1800037>.

Uses support vector machines to identify a perfectly separating hyperplane (linear or curvilinear) between two entities in high-dimensional space. If this plane exists, the entities do not overlap. Applications include overlap detection in morphological, resource or environmental dimensions. More details can be found in: Brown et al. (2020) <doi:10.1111/2041-210X.13363> .

This package implements Data Envelopment Analysis (DEA) with a hyperbolic orientation using a non-linear programming solver. It enables flexible estimations with weight restrictions, non-discretionary variables, and a generalized distance function. Additionally, it allows for the calculation of slacks and super-efficiency scores. The methods are detailed in à ttl et al. (2023), <doi:10.1016/j.dajour.2023.100343>. Furthermore, the package provides a non-linear profitability estimation built upon the DEA framework.

This package provides a comprehensive suite of spatial functions created to analyze and assess data heterogeneity and climate variability in spatial datasets. This package is specifically designed to address the challenges associated with characterizing and understanding complex spatial patterns in environmental and climate-related data.