Grammatical evolution (see O'Neil, M. and Ryan, C. (2003,ISBN:1-4020-7444-1)) uses decoders to convert linear (binary or integer genes) into programs. In addition, automatic determination of codon precision with a limited rule choice bias is provided. For a recent survey of grammatical evolution, see Ryan, C., O'Neill, M., and Collins, J. J. (2018) <doi:10.1007/978-3-319-78717-6>.

This package facilitates phyloseq exploration and analysis of taxonomic profiling data. This package provides tools for the manipulation, statistical analysis, and visualization of taxonomic profiling data. In addition to targeted case-control studies, microbiome facilitates scalable exploration of population cohorts. This package supports the independent phyloseq data format and expands the available toolkit in order to facilitate the standardization of the analyses and the development of best practices.

Estimation of regression models for sparse asynchronous longitudinal observations, where time-dependent response and covariates are mismatched and observed intermittently within subjects. Kernel weighted estimating equations are used for generalized linear models with either time-invariant or time-dependent coefficients. Cao, H., Li, J., and Fine, J. P. (2016) <doi:10.1214/16-EJS1141>. Cao, H., Zeng, D., and Fine, J. P. (2015) <doi:10.1111/rssb.12086>.

This package performs Bayesian non-parametric calibration of multiple related radiocarbon determinations, and summarises the calendar age information to plot their joint calendar age density (see Heaton (2022) <doi:10.1111/rssc.12599>). Also models the occurrence of radiocarbon samples as a variable-rate (inhomogeneous) Poisson process, plotting the posterior estimate for the occurrence rate of the samples over calendar time, and providing information about potential change points.

Calculate p-values and confidence intervals using cluster-adjusted t-statistics (based on Ibragimov and Muller (2010) <DOI:10.1198/jbes.2009.08046>, pairs cluster bootstrapped t-statistics, and wild cluster bootstrapped t-statistics (the latter two techniques based on Cameron, Gelbach, and Miller (2008) <DOI:10.1162/rest.90.3.414>. Procedures are included for use with GLM, ivreg, plm (pooling or fixed effects), and mlogit models.

Fits engression models for nonlinear distributional regression. Predictors and targets can be univariate or multivariate. Functionality includes estimation of conditional mean, estimation of conditional quantiles, or sampling from the fitted distribution. Training is done full-batch on CPU (the python version offers GPU-accelerated stochastic gradient descent). Based on "Engression: Extrapolation for nonlinear regression?" by Xinwei Shen and Nicolai Meinshausen (2023). Also supports classification (experimental). <arxiv:2307.00835>.

Simulate general insurance policies, losses and loss emergence. The functions contemplate deterministic and stochastic policy retention and growth scenarios. Retention and growth rates are percentages relative to the expiring portfolio. Claims are simulated for each policy. This is accomplished either be assuming a frequency distribution per development lag or by generating random wait times until claim emergence and settlement. Loss simulation uses standard loss distributions for claim amounts.

Phenotypic analysis of field trials using mixed models with and without spatial components. One of a series of statistical genetic packages for streamlining the analysis of typical plant breeding experiments developed by Biometris. Some functions have been created to be used in conjunction with the R package asreml for the ASReml software, which can be obtained upon purchase from VSN international (<https://vsni.co.uk/software/asreml-r/>).

C++ classes for sparse matrix methods including implementation of sparse LDL decomposition of symmetric matrices and solvers described by Timothy A. Davis (2016) <https://fossies.org/linux/SuiteSparse/LDL/Doc/ldl_userguide.pdf>. Provides a set of C++ classes for basic sparse matrix specification and linear algebra, and a class to implement sparse LDL decomposition and solvers. See <https://github.com/samuel-watson/SparseChol> for details.

This package provides functions for fitting multi-state semi-Markov models to longitudinal data. A parametric maximum likelihood estimation method adapted to deal with Exponential, Weibull and Exponentiated Weibull distributions is considered. Right-censoring can be taken into account and both constant and time-varying covariates can be included using a Cox proportional model. Reference: A. Krol and P. Saint-Pierre (2015) <doi:10.18637/jss.v066.i06>.

The fit.models function and its associated methods (coefficients, print, summary, plot, etc.) were originally provided in the robust package to compare robustly and classically fitted model objects. The aim of the fit.models package is to separate this fitted model object comparison functionality from the robust package and to extend it to support fitting methods (e.g., classical, robust, Bayesian, regularized, etc.) more generally.

Implementations of several robust nonparametric two-sample tests for location or scale differences. The test statistics are based on robust location and scale estimators, e.g. the sample median or the Hodges-Lehmann estimators as described in Fried & Dehling (2011) <doi:10.1007/s10260-011-0164-1>. The p-values can be computed via the permutation principle, the randomization principle, or by using the asymptotic distributions of the test statistics under the null hypothesis, which ensures (approximate) distribution independence of the test decision. To test for a difference in scale, we apply the tests for location difference to transformed observations; see Fried (2012) <doi:10.1016/j.csda.2011.02.012>. Random noise on a small range can be added to the original observations in order to hold the significance level on data from discrete distributions. The location tests assume homoscedasticity and the scale tests require the location parameters to be zero.

Imputation of missing numerical outcomes for a longitudinal trial with protocol deviations. The package uses distinct treatment arm-based assumptions for the unobserved data, following the general algorithm of Carpenter, Roger, and Kenward (2013) <doi:10.1080/10543406.2013.834911>, and the causal model of White, Royes and Best (2020) <doi:10.1080/10543406.2019.1684308>. Sensitivity analyses to departures from these assumptions can be done by the Delta method of Roger. The program uses the same algorithm as the mimix Stata package written by Suzie Cro, with additional coding for the causal model and delta method. The reference-based methods are jump to reference (J2R), copy increments in reference (CIR), copy reference (CR), and the causal model, all of which must specify the reference treatment arm. Other methods are missing at random (MAR) and the last mean carried forward (LMCF). Individual-specific imputation methods (and their reference groups) can be specified.

This package provides a random-effects stochastic model that allows quick detection of clonal dominance events from clonal tracking data collected in gene therapy studies. Starting from the Ito-type equation describing the dynamics of cells duplication, death and differentiation at clonal level, we first considered its local linear approximation as the base model. The parameters of the base model, which are inferred using a maximum likelihood approach, are assumed to be shared across the clones. Although this assumption makes inference easier, in some cases it can be too restrictive and does not take into account possible scenarios of clonal dominance. Therefore we extended the base model by introducing random effects for the clones. In this extended formulation the dynamic parameters are estimated using a tailor-made expectation maximization algorithm. Further details on the methods can be found in L. Del Core et al., (2022) <doi:10.1101/2022.05.31.494100>.

Set of functions for analyzing Atomic Force Microscope (AFM) force-distance curves. It allows to obtain the contact and unbinding points, perform the baseline correction, estimate the Young's modulus, fit up to two exponential decay function to a stress-relaxation / creep experiment, obtain adhesion energies. These operations can be done either over a single F-d curve or over a set of F-d curves in batch mode.

This package provides an accessible and robust implementation of core BME methodologies for spatial prediction. It enables the systematic integration of heterogeneous data sources including both hard data (precise measurements) and soft interval data (bounded or uncertain observations) while incorporating prior knowledge and supporting variogram-based spatial modeling. The BME methodology is described in Christakos (1990) <doi:10.1007/BF00890661> and Serre and Christakos (1999) <doi:10.1007/s004770050029>.

This package provides functions for the clustering of variables around Latent Variables, for 2-way or 3-way data. Each cluster of variables, which may be defined as a local or directional cluster, is associated with a latent variable. External variables measured on the same observations or/and additional information on the variables can be taken into account. A "noise" cluster or sparse latent variables can also be defined.

Synthesizing joint distributions from marginal densities, focusing on controlling key statistical properties such as correlation for continuous data, mutual information for categorical data, and inducing Simpson's Paradox. Generate datasets with specified correlation structures for continuous variables, adjust mutual information between categorical variables, and manipulate subgroup correlations to intentionally create Simpson's Paradox. Joe (1997) <doi:10.1201/b13150> Sklar (1959) <https://en.wikipedia.org/wiki/Sklar%27s_theorem>.

Circumplex models, which organize constructs in a circle around two underlying dimensions, are popular for studying interpersonal functioning, mood/affect, and vocational preferences/environments. This package provides tools for analyzing and visualizing circular data, including scoring functions for relevant instruments and a generalization of the bootstrapped structural summary method from Zimmermann & Wright (2017) <doi:10.1177/1073191115621795> and functions for creating publication-ready tables and figures from the results.

Providing a set of functions to easily generate and iterate complex networks. The functions can be used to generate realistic networks with a wide range of different clustering, density, and average path length. For more information consult research articles by Amiyaal Ilany and Erol Akcay (2016) <doi:10.1093/icb/icw068> and Ilany and Erol Akcay (2016) <doi:10.1101/026120>, which have inspired many methods in this package.

This package provides a general toolkit for drug target identification. We include functionality to reduce large graphs to subgraphs and prioritize nodes. In addition to being optimized for use with generic graphs, we also provides support to analyze protein-protein interactions networks from online repositories. For more details on core method, refer to Weaver et al. (2021) <https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008755>.

This package provides the necessary functions to identify and extract a selection of already available barcode constructs (Cornils, K. et al. (2014) <doi:10.1093/nar/gku081>) and freely choosable barcode designs from next generation sequence (NGS) data. Furthermore, it offers the possibility to account for sequence errors, the calculation of barcode similarities and provides a variety of visualisation tools (Thielecke, L. et al. (2017) <doi:10.1038/srep43249>).

We provide extensions to the classical dataset "Example 4: Death by the kick of a horse in the Prussian Army" first used by Ladislaus von Bortkeiwicz in his treatise on the Poisson distribution "Das Gesetz der kleinen Zahlen", <DOI:10.1017/S0370164600019453>. As well as an extended time series for the horse-kick death data, we also provide, in parallel, deaths by falling from a horse and by drowning.

This package provides a generalization of the Synth package that is designed for data at a more granular level (e.g., micro-level). Provides functions to construct weights (including propensity score-type weights) and run analyses for synthetic control methods with micro- and meso-level data; see Robbins, Saunders, and Kilmer (2017) <doi:10.1080/01621459.2016.1213634> and Robbins and Davenport (2021) <doi:10.18637/jss.v097.i02>.