Functionalities for calculating the local score and calculating statistical relevance (p-value) to find a local Score in a sequence of given distribution (S. Mercier and J.-J. Daudin (2001) <https://hal.science/hal-00714174/>) ; S. Karlin and S. Altschul (1990) <https://pmc.ncbi.nlm.nih.gov/articles/PMC53667/> ; S. Mercier, D. Cellier and F. Charlot (2003) <https://hal.science/hal-00937529v1/> ; A. Lagnoux, S. Mercier and P. Valois (2017) <doi:10.1093/bioinformatics/btw699> ).

Statistical methods for whole-trial and time-domain analysis of single cell neural response to multiple stimuli presented simultaneously. The package is based on the paper by C Glynn, ST Tokdar, A Zaman, VC Caruso, JT Mohl, SM Willett, and JM Groh (2021) "Analyzing second order stochasticity of neural spiking under stimuli-bundle exposure", is in press for publication by the Annals of Applied Statistics. A preprint may be found at <arXiv:1911.04387>.

Design and analyze two-stage randomized trials with a continuous outcome measure. The package contains functions to compute the required sample size needed to detect a given preference, treatment, and selection effect; alternatively, the package contains functions that can report the study power given a fixed sample size. Finally, analysis functions are provided to test each effect using either summary data (i.e. means, variances) or raw study data <doi:10.18637/jss.v094.c02>.

Calculation of the parametric, nonparametric confidence intervals for the difference or ratio of location parameters, nonparametric confidence interval for the Behrens-Fisher problem and for the difference, ratio and odds-ratio of binomial proportions for comparison of independent samples. Common wrapper functions to split data sets and apply confidence intervals or tests to these subsets. A by-statement allows calculation of CI separately for the levels of further factors. CI are not adjusted for multiplicity.

This package provides functions for performing set-theoretic multi-method research, QCA for clustered data, theory evaluation, Enhanced Standard Analysis, indirect calibration, radar visualisations. Additionally it includes data to replicate the examples in the books by Oana, I.E, C. Q. Schneider, and E. Thomann. Qualitative Comparative Analysis (QCA) using R: A Beginner's Guide. Cambridge University Press and C. Q. Schneider and C. Wagemann "Set Theoretic Methods for the Social Sciences", Cambridge University Press.

This package provides a simple, configurable, provider-agnostic OAuth 2.0 and OpenID Connect (OIDC) authentication framework for shiny applications using S7 classes. Defines providers, clients, and tokens, as well as various supporting functions and a shiny module. Features include cross-site request forgery (CSRF) protection, state encryption, Proof Key for Code Exchange (PKCE) handling, validation of OIDC identity tokens (nonces, signatures, claims), automatic user info retrieval, asynchronous flows, and hooks for audit logging.

Multiscale multifractal analysis (MMA) (GieraÅ towski et al., 2012)<DOI:10.1103/PhysRevE.85.021915> is a time series analysis method, designed to describe scaling properties of fluctuations within the signal analyzed. The main result of this procedure is the so called Hurst surface h(q,s) , which is a dependence of the local Hurst exponent h (fluctuation scaling exponent) on the multifractal parameter q and the scale of observation s (data window width).

ChemmineOB provides an R interface to a subset of cheminformatics functionalities implemented by the OpelBabel C++ project. OpenBabel is a free cheminformatics toolbox that includes utilities for structure format interconversions, descriptor calculations, compound similarity searching and more. ChemineOB aims to make a subset of these utilities available from within R. For non-developers, ChemineOB is primarily intended to be used from ChemmineR as an add-on package rather than used directly.

Implement various chromosomal instability metrics. CINmetrics (Chromosomal INstability metrics) provides functions to calculate various chromosomal instability metrics on masked Copy Number Variation(CNV) data at individual sample level. The chromosomal instability metrics have been implemented as described in the following studies: Baumbusch LO et al. 2013 <doi:10.1371/journal.pone.0054356>, Davidson JM et al. 2014 <doi:10.1371/journal.pone.0079079>, Chin SF et al. 2007 <doi:10.1186/gb-2007-8-10-r215>.

Decorate functions to make them return enhanced output. The enhanced output consists in an object of type chronicle containing the result of the function applied to its arguments, as well as a log detailing when the function was run, what were its inputs, what were the errors (if the function failed to run) and other useful information. Tools to handle decorated functions are included, such as a forward pipe operator that makes chaining decorated functions possible.

Optimal design analysis algorithms for any study design that can be represented or modelled as a generalised linear mixed model including cluster randomised trials, cohort studies, spatial and temporal epidemiological studies, and split-plot designs. See <https://github.com/samuel-watson/glmmrBase/blob/master/README.md> for a detailed manual on model specification. A detailed discussion of the methods in this package can be found in Watson, Hemming, and Girling (2023) <doi:10.1177/09622802231202379>.

Learning and using the Metropolis algorithm for Bayesian fitting of a generalized linear model. The package vignette includes examples of hand-coding a logistic model using several variants of the Metropolis algorithm. The package also contains R functions for simulating posterior distributions of Bayesian generalized linear model parameters using guided, adaptive, guided-adaptive and random walk Metropolis algorithms. The random walk Metropolis algorithm was originally described in Metropolis et al (1953); <doi:10.1063/1.1699114>.

Measures niche breadth and overlap of microbial taxa from large matrices. Niche breadth measurements include Levins niche breadth (Bn) index, Hurlbert's Bn and Feinsinger's proportional similarity (PS) index. (Feinsinger, P., Spears, E.E., Poole, R.W. (1981) <doi:10.2307/1936664>). Niche overlap measurements include Levin's Overlap (Ludwig, J.A. and Reynolds, J.F. (1988, ISBN:0471832359)) and a Jaccard similarity index of Feinsinger's PS values between taxa pairs, as Proportional Overlap.

This package provides tools for estimating model-agnostic prediction intervals using conformal prediction, bootstrapping, and parametric prediction intervals. The package is designed for ease of use, offering intuitive functions for both binned and full conformal prediction methods, as well as parametric interval estimation with diagnostic checks. Currently only working for continuous predictions. For details on the conformal and bin-conditional conformal prediction methods, see Randahl, Williams, and Hegre (2024) <DOI:10.48550/arXiv.2410.14507>.

Find recursive dependencies of R packages from various sources. Solve the dependencies to obtain a consistent set of packages to install. Download packages, and install them. It supports packages on CRAN', Bioconductor and other CRAN-like repositories, GitHub', package URLs', and local package trees and files. It caches metadata and package files via the pkgcache package, and performs all HTTP requests, downloads, builds and installations in parallel. pkgdepends is the workhorse of the pak package.

ETS stands for Error, Trend, and Seasonality, and it is a popular time series forecasting method. Wavelet decomposition can be used for denoising, compression, and feature extraction of signals. By removing the high-frequency components, wavelet decomposition can remove noise from the data while preserving important features. A hybrid Wavelet ETS (Error Trend-Seasonality) model has been developed for time series forecasting using algorithm of Anjoy and Paul (2017) <DOI:10.1007/s00521-017-3289-9>.

This package provides a single function to fit data of an input data frame into one of the selected Weibull functions (w2, w3 and it's truncated versions), calculating the scale, location and shape parameters accordingly. The resulting plots and files are saved into the folder parameter provided by the user. References: a) John C. Nash, Ravi Varadhan (2011). "Unifying Optimization Algorithms to Aid Software System Users: optimx for R" <doi:10.18637/jss.v043.i09>.

ChromSCape - Chromatin landscape profiling for Single Cells - is a ready-to-launch user-friendly Shiny Application for the analysis of single-cell epigenomics datasets (scChIP-seq, scATAC-seq, scCUT&Tag, ...) from aligned data to differential analysis & gene set enrichment analysis. It is highly interactive, enables users to save their analysis and covers a wide range of analytical steps: QC, preprocessing, filtering, batch correction, dimensionality reduction, vizualisation, clustering, differential analysis and gene set analysis.

MPRAnalyze provides statistical framework for the analysis of data generated by Massively Parallel Reporter Assays (MPRAs), used to directly measure enhancer activity. MPRAnalyze can be used for quantification of enhancer activity, classification of active enhancers and comparative analyses of enhancer activity between conditions. MPRAnalyze construct a nested pair of generalized linear models (GLMs) to relate the DNA and RNA observations, easily adjustable to various experimental designs and conditions, and provides a set of rigorous statistical testig schemes.

Gene-regulatory network (GRN) modeling seeks to infer dependencies between genes and thereby provide insight into the regulatory relationships that exist within a cell. This package provides a computational Bayesian approach to GRN estimation from perturbation experiments using a ternary network model, in which gene expression is discretized into one of 3 states: up, unchanged, or down). The ternarynet package includes a parallel implementation of the replica exchange Monte Carlo algorithm for fitting network models, using MPI.

Provide a sparse matrix format with data stored on disk, to be used in both R and C++. This is intended for more efficient use of sparse data in C++ and also when parallelizing, since data on disk does not need copying. Only a limited number of features will be implemented. For now, conversion can be performed from a dgCMatrix or a dsCMatrix from R package Matrix'. A new compact format is also now available.

One haplotype is a combination of SNP (Single Nucleotide Polymorphisms) within the QTL (Quantitative Trait Loci). clusterhap groups together all individuals of a population with the same haplotype. Each group contains individual with the same allele in each SNP, whether or not missing data. Thus, clusterhap groups individuals, that to be imputed, have a non-zero probability of having the same alleles in the entire sequence of SNP's. Moreover, clusterhap calculates such probability from relative frequencies.

This package provides a modified hierarchical test (Liu (2017) <doi:10.1214/17-AOS1539>) for detecting the structural difference between two Semiparametric Gaussian graphical models. The multiple testing procedure asymptotically controls the false discovery rate (FDR) at a user-specified level. To construct the test statistic, a truncated estimator is used to approximate the transformation functions and two R functions including lassoGGM() and lassoNPN() are provided to compute the lasso estimates of the regression coefficients.

This package provides a small set of tools for formatting numbers in R-markdown documents. Convert a numerical vector to character strings in power-of-ten form, decimal form, or measurement-units form; all are math-delimited for rendering as inline equations. Can also convert text into math-delimited text to match the font face and size of math-delimited numbers. Useful for rendering single numbers in inline R code chunks and for rendering columns in tables.