This package provides a systematic biology tool was developed to repurpose drugs via a drug-drug functional similarity network. DrugSim2DR first predict drug-drug functional similarity in the context of specific disease, and then using the similarity constructed a weighted drug similarity network. Finally, it used a network propagation algorithm on the network to identify drugs with significant target abnormalities as candidate drugs.

Computes unidimensional and multidimensional Reciprocity and Inaccuracy indices. These indices are applicable to common heterostylous populations and to any other type of stylar dimorphic and trimorphic populations, such as in enantiostylous and three-dimensional heterostylous plants. Simón-Porcar, V., A. J. Muñoz-Pajares, J. Arroyo, and S. D. Johnson. (in press) "FlowerMate: multidimensional reciprocity and inaccuracy indices for style-polymorphic plant populations.".

Genotyping of triploid individuals from luminescence data (marker probeset A and B). Works also for diploids and tetraploids. Three main functions: Create_Dataset_from_file() to build dataset ; Clustering_parallele_from_dir() that regroups individuals with a same genotype based on proximity and Genotyping_parallele_from_dir() that assigns a genotype to each cluster. For Shiny interface use: launch_GenoShiny().

This package performs a permutation test on the difference between two location parameters, a permutation correlation test, a permutation F-test, the Siegel-Tukey test, a ratio mean deviance test. Also performs some graphing techniques, such as for confidence intervals, vector addition, and Fourier analysis; and includes functions related to the Laplace (double exponential) and triangular distributions. Performs power calculations for the binomial test.

Constructs multi-resolution thin-plate spline basis functions on the sphere for use in spatial regression and large-scale spatial prediction problems. Implements the basis system described in Huang, Huang, and Ing (2025) "Multi-Resolution Spatial Methods on the Sphere: Efficient Prediction for Global Data", Environmetrics, <doi:10.1002/env.70092>. Heavy computations are written in C++ via Rcpp with optional OpenMP parallelism.

This package implements outranking-based trace clustering for process mining. Pairwise similarity between traces is assessed on multiple, problem-specific criteria using ELECTRE-III-style partial concordance and discordance indices with indifference, similarity and veto thresholds. The aggregated credibility matrix is then clustered using normalized spectral clustering or hierarchical clustering. Also includes outlier trimming, must-link/cannot-link adjustments, validation indices and diagnostic plots.

This package provides a complete data set of historic GB trig points in British National Grid (OSGB36) coordinate reference system. Trig points (aka triangulation stations) are fixed survey points used to improve the accuracy of map making in Great Britain during the 20th Century. Trig points are typically located on hilltops so still serve as a useful navigational aid for walkers and hikers today.

The package detects extended diffuse and compact blemishes on microarray chips. Harshlight marks the areas in a collection of chips (affybatch objects). A corrected AffyBatch object will result. The package replaces the defected areas with N/As or the median of the values of the same probe. The new version handles the substitute value as a whole matrix to solve the memory problem.

This package was derived from Rsymphony. The package provides an R interface to SYMPHONY, a linear programming solver written in C++. The main difference between this package and Rsymphony is that it includes the solver source code, while Rsymphony expects to find header and library files on the users' system. Thus the intention of lpsymphony is to provide an easy to install interface to SYMPHONY.

This package provides a forest plot that allows for multiple confidence intervals per row, custom fonts for each text element, custom confidence intervals, text mixed with expressions, and more. The aim is to extend the use of forest plots beyond meta-analyses. This is a more general version of the original rmeta package's forestplot() function and relies heavily on the grid package.

This package performs Bayesian calibration of computer models as per Kennedy and O'Hagan 2001. The package includes routines to find the hyperparameters and parameters; see the help page for stage1() for a worked example using the toy dataset. A tutorial is provided in the calex.Rnw vignette; and a suite of especially simple one dimensional examples appears in inst/doc/one.dim/.

This package provides a streamlined workflow for the quanTIseq method, developed to perform the quantification of the Tumor Immune contexture from RNA-seq data. The quantification is performed against the TIL10 signature (dissecting the contributions of ten immune cell types), carefully crafted from a collection of human RNA-seq samples. The TIL10 signature has been extensively validated using simulated, flow cytometry, and immunohistochemistry data.

Many complex plots are actually composite plots, such as oncoplot', funkyheatmap', upsetplot', etc. We can produce subplots using ggplot2 and combine them to create composite plots using aplot'. In this way, it is easy to customize these complex plots, by adding, deleting or modifying subplots in the final plot. This package provides a set of utilities to help users to create subplots and complex plots.

Generates different posterior distributions of adjusted odds ratio under different priors of sensitivity and specificity, and plots the models for comparison. It also provides estimations for the specifications of the models using diagnostics of exposure status with a non-linear mixed effects model. It implements the methods that are first proposed in <doi:10.1016/j.annepidem.2006.04.001> and <doi:10.1177/0272989X09353452>.

This package provides functions for predictor pruning using association-based and model-based approaches. Includes corrPrune() for fast correlation-based pruning, modelPrune() for regression pruning on the variance inflation factor (VIF) and the condition number, and exact graph-theoretic algorithms (Eppsteinâ Löfflerâ Strash, Bronâ Kerbosch) for exhaustive subset enumeration. Supports linear models, generalized linear models (GLMs), and mixed models ('lme4', glmmTMB').

Predicts anticancer peptides using random forests trained on the n-gram encoded peptides. The implemented algorithm can be accessed from both the command line and shiny-based GUI. The CancerGram model is too large for CRAN and it has to be downloaded separately from the repository: <https://github.com/BioGenies/CancerGramModel>. For more information see: Burdukiewicz et al. (2020) <doi:10.3390/pharmaceutics12111045>.

Set of shiny'-based RStudio add-ins for interactively creating datasets through graphical interfaces. Users can adjust graphical elements to define data generation parameters, and the resulting datasets can be saved to temporary RDS files for further analysis or visualization. Methods are described in: Chang et al. (2024) <https://CRAN.R-project.org/package=shiny>; Bostock et al. (2011) <doi:10.1109/TVCG.2011.185>.

Functionality for analyzing dose-volume histograms (DVH) in radiation oncology: Read DVH text files, calculate DVH metrics as well as generalized equivalent uniform dose (gEUD), biologically effective dose (BED), equivalent dose in 2 Gy fractions (EQD2), normal tissue complication probability (NTCP), and tumor control probability (TCP). Show DVH diagrams, check and visualize quality assurance constraints for the DVH. Includes web-based graphical user interface.

Method and tool for generating time series forecasts using an ensemble wavelet-based auto-regressive neural network architecture. This method provides additional support of exogenous variables and also generates confidence interval. This package provides EWNet model for time series forecasting based on the algorithm by Panja, et al. (2022) and Panja, et al. (2023) <arXiv:2206.10696> <doi:10.1016/j.chaos.2023.113124>.

Initially designed to distribute code for estimating the Gaussian graphical model with Lasso regularization, also known as the graphical lasso (glasso), using an Expectation-Maximization (EM) algorithm based on work by Städler and Bühlmann (2012) <doi:10.1007/s11222-010-9219-7>. As a byproduct, code for estimating means and covariances (or the precision matrix) under a multivariate normal (Gaussian) distribution is also available.

For functions that take and return vectors (or scalars), this package provides 8 algorithms for finding fixed point vectors (vectors for which the inputs and outputs to the function are the same vector). These algorithms include Anderson (1965) acceleration <doi:10.1145/321296.321305>, epsilon extrapolation methods (Wynn 1962 <doi:10.2307/2004051>) and minimal polynomial methods (Cabay and Jackson 1976 <doi:10.1137/0713060>).

This package provides ggplot2 extensions for creating dice-based visualizations where each dot position represents a specific categorical variable. The package includes geom_dice() for displaying presence/absence of categorical variables using traditional dice patterns. Each dice position (1-6) represents a different category, with dots shown only when that category is present. This allows intuitive visualization of up to 6 categorical variables simultaneously.

Providing C implementation for the computing of monotonic spline bases, including M-splines, I-splines, and C-splines, denoted by MIC splines. The definitions of the spline bases are described in Meyer (2008) <doi: 10.1214/08-AOAS167>. The package also provides the computing of constrained least-squares estimates when a subset of or all of the regression coefficients are constrained to be non-negative.

Using this package, one can determine the minimum sample size required so that the absolute deviation of the sample mean and the population mean of a distribution becomes less than some pre-determined epsilon, i.e. it helps the user to determine the minimum sample size required to attain the pre-fixed precision level by minimizing the difference between the sample mean and population mean.