This package provides a number of functions to create and analyze factorial plans according to the Design of Experiments (DoE) approach, with the addition of some utility function to perform some statistical analyses. DoE approach follows the approach in "Design and Analysis of Experiments" by Douglas C. Montgomery (2019, ISBN:978-1-119-49244-3). The package also provides utilities used in the course "Analysis of Data and Statistics" at the University of Trento, Italy.

Blocks units into experimental blocks, with one unit per treatment condition, by creating a measure of multivariate distance between all possible pairs of units. Maximum, minimum, or an allowable range of differences between units on one variable can be set. Randomly assign units to treatment conditions. Diagnose potential interference between units assigned to different treatment conditions. Write outputs to .tex and .csv files. For more information on the methods implemented, see Moore (2012) <doi:10.1093/pan/mps025>.

Processing and analyzing omics data from genomics, transcriptomics, proteomics, and metabolomics platforms. It provides functions for preprocessing, normalization, visualization, and statistical analysis, as well as machine learning algorithms for predictive modeling. omicsTools is an essential tool for researchers working with high-throughput omics data in fields such as biology, bioinformatics, and medicine.The QC-RLSC (quality controlâ based robust LOESS signal correction) algorithm is used for normalization. Dunn et al. (2011) <doi:10.1038/nprot.2011.335>.

ProTracker is a popular music tracker to sequence music on a Commodore Amiga machine. This package offers the opportunity to import, export, manipulate and play ProTracker module files. Even though the file format could be considered archaic, it still remains popular to this date. This package intends to contribute to this popularity and therewith keeping the legacy of ProTracker and the Commodore Amiga alive. This package is the successor of ProTrackR providing better performance.

Standardized accuracy (staccuracy) is a framework for expressing accuracy scores such that 50% represents a reference level of performance and 100% is a perfect prediction. The staccuracy package provides tools for creating staccuracy functions as well as some recommended staccuracy measures. It also provides functions for some classic performance metrics such as mean absolute error (MAE), root mean squared error (RMSE), and area under the receiver operating characteristic curve (AUCROC), as well as their winsorized versions when applicable.

Label propagation approaches are a widely used procedure in computational biology for giving context to molecular entities using network data. Node labels, which can derive from gene expression, genome-wide association studies, protein domains or metabolomics profiling, are propagated to their neighbours in the network, effectively smoothing the scores through prior annotated knowledge and prioritising novel candidates. The R package diffuStats contains a collection of diffusion kernels and scoring approaches that facilitates their computation, characterisation and benchmarking.

An implementation of methods for designing, evaluating, and comparing primer sets for multiplex PCR. Primers are designed by solving a set cover problem such that the number of covered template sequences is maximized with the smallest possible set of primers. To guarantee that high-quality primers are generated, only primers fulfilling constraints on their physicochemical properties are selected. A Shiny app providing a user interface for the functionalities of this package is provided by the openPrimeRui package.

ChemmineOB provides an R interface to a subset of cheminformatics functionalities implemented by the OpelBabel C++ project. OpenBabel is an open source cheminformatics toolbox that includes utilities for structure format interconversions, descriptor calculations, compound similarity searching and more. ChemineOB aims to make a subset of these utilities available from within R. For non-developers, ChemineOB is primarily intended to be used from ChemmineR as an add-on package rather than used directly.

EdDSA over Curve25519 is specified in RFC 8032. This package contains an ed25519::Signature type which other packages can use in conjunction with the signature::Signer and signature::Verifier traits. It doesn't contain an implementation of Ed25519.

These traits allow packages which produce and consume Ed25519 signatures to be written abstractly in such a way that different signer/verifier providers can be plugged in, enabling support for using different Ed25519 implementations, including HSMs or Cloud KMS services.

EdDSA over Curve25519 is specified in RFC 8032. This package contains an ed25519::Signature type which other packages can use in conjunction with the signature::Signer and signature::Verifier traits. It doesn't contain an implementation of Ed25519.

These traits allow packages which produce and consume Ed25519 signatures to be written abstractly in such a way that different signer/verifier providers can be plugged in, enabling support for using different Ed25519 implementations, including HSMs or Cloud KMS services.

This package implements the hybrid framework for event prediction described in Fang & Zheng (2011, <doi:10.1016/j.cct.2011.05.013>). To estimate the survival function the event prediction is based on, a piecewise exponential hazard function is fit to the time-to-event data to infer the potential change points. Prior to the last identified change point, the survival function is estimated using Kaplan-Meier, and the tail after the change point is fit using piecewise exponential.

Multimodal mediation analysis is an emerging problem in microbiome data analysis. Multimedia make advanced mediation analysis techniques easy to use, ensuring that all statistical components are transparent and adaptable to specific problem contexts. The package provides a uniform interface to direct and indirect effect estimation, synthetic null hypothesis testing, bootstrap confidence interval construction, and sensitivity analysis. More details are available in Jiang et al. (2024) "multimedia: Multimodal Mediation Analysis of Microbiome Data" <doi:10.1101/2024.03.27.587024>.

This package provides a basic interface for accessing annotation data from the Multi-CAST collection, a database of spoken natural language texts edited by Geoffrey Haig and Stefan Schnell. The collection draws from a diverse set of languages and has been annotated across multiple levels. Annotation data is downloaded on request from the servers of the University of Bamberg. See the Multi-CAST website <https://multicast.aspra.uni-bamberg.de/> for more information and a list of related publications.

Estimates micro effects on macro structures (MEMS) and average micro mediated effects (AMME). URL: <https://github.com/sduxbury/netmediate>. BugReports: <https://github.com/sduxbury/netmediate/issues>. Robins, Garry, Phillipa Pattison, and Jodie Woolcock (2005) <doi:10.1086/427322>. Snijders, Tom A. B., and Christian E. G. Steglich (2015) <doi:10.1177/0049124113494573>. Imai, Kosuke, Luke Keele, and Dustin Tingley (2010) <doi:10.1037/a0020761>. Duxbury, Scott (2023) <doi:10.1177/00811750231209040>. Duxbury, Scott (2024) <doi:10.1177/00811750231220950>.

The function generates and plots random snowflakes. Each snowflake is defined by a given diameter, width of the crystal, color, and random seed. Snowflakes are plotted in such way that they always remain round, no matter what the aspect ratio of the plot is. Snowflakes can be created using transparent colors, which creates a more interesting, somewhat realistic, image. Images of the snowflakes can be separately saved as svg files and used in websites as static or animated images.

With given inputs that include number of points, discrete design space, a measure of skewness, models and parameter value, this package calculates the objective value, optimal designs and plot the equivalence theory under A- and D-optimal criteria under the second-order Least squares estimator. This package is based on the paper "Properties of optimal regression designs under the second-order least squares estimator" by Chi-Kuang Yeh and Julie Zhou (2021) <doi:10.1007/s00362-018-01076-6>.

Fast, lightweight toolkit for data splitting. Data sets can be partitioned into disjoint groups (e.g. into training, validation, and test) or into (repeated) k-folds for subsequent cross-validation. Besides basic splits, the package supports stratified, grouped as well as blocked splitting. Furthermore, cross-validation folds for time series data can be created. See e.g. Hastie et al. (2001) <doi:10.1007/978-0-387-84858-7> for the basic background on data partitioning and cross-validation.

Privacy protected raster maps can be created from spatial point data. Protection methods include smoothing of dichotomous variables by de Jonge and de Wolf (2016) <doi:10.1007/978-3-319-45381-1_9>, continuous variables by de Wolf and de Jonge (2018) <doi:10.1007/978-3-319-99771-1_23>, suppressing revealing values and a generalization of the quad tree method by Suñé, Rovira, Ibáñez and Farré (2017) <doi:10.2901/EUROSTAT.C2017.001>.

Shows color patches for encoding fold changes (e.g. log ratios) together with confidence values within a single diagram. This is especially useful for rendering gene expression data as well as other types of differential experiments. In addition to different rendering methods (ggplot extensions) functionality for perceptually optimizing color palettes are provided. Furthermore the package provides extension methods of the colorspace color-class in order to simplify the work with palettes (a.o. length, as.list, and append are supported).

Useful tools for conveniently downloading FHIR resources in xml format and converting them to R data.frames. The package uses FHIR-search to download bundles from a FHIR server, provides functions to save and read xml-files containing such bundles and allows flattening the bundles to data.frames using XPath expressions. FHIR® is the registered trademark of HL7 and is used with the permission of HL7. Use of the FHIR trademark does not constitute endorsement of this product by HL7.

It provides an interesting solution for handling a high number of segmentation variables in partial least squares structural equation modeling. The package implements the "Pathmox" algorithm (Lamberti, Sanchez, and Aluja,(2016)<doi:10.1002/asmb.2168>) including the F-coefficient test (Lamberti, Sanchez, and Aluja,(2017)<doi:10.1002/asmb.2270>) to detect the path coefficients responsible for the identified differences). The package also allows running the hybrid multi-group approach (Lamberti (2021) <doi:10.1007/s11135-021-01096-9>).

Prototypes for construction of a Gaussian Stochastic Process emulator (GASP) of a computer model. This is done within the objective Bayesian implementation of the GASP. The package allows for construction of a linked GASP of the composite computer model. Computational implementation follows the mathematical exposition given in publication: Ksenia N. Kyzyurova, James O. Berger, Robert L. Wolpert. Coupling computer models through linking their statistical emulators. SIAM/ASA Journal on Uncertainty Quantification, 6(3): 1151-1171, (2018).<DOI:10.1137/17M1157702>.

Enable operationalized evaluation of disease outcomes in multiple sclerosis. â MSoutcomesâ requires longitudinally recorded clinical data structured in long format. The package is based on the research developed at Clinical Outcomes Research unit (CORe), University of Melbourne and Neuroimmunology Centre, Royal Melbourne Hospital. Kalincik et al. (2015) <doi:10.1093/brain/awv258>. Lorscheider et al. (2016) <doi:10.1093/brain/aww173>. Sharmin et al. (2022) <doi:10.1111/ene.15406>. Dzau et al. (2023) <doi:10.1136/jnnp-2023-331748>.

Software to support the introductory *MOSAIC Calculus* textbook <https://www.mosaic-web.org/MOSAIC-Calculus/>), one of many data- and modeling-oriented educational resources developed by Project MOSAIC (<https://www.mosaic-web.org/>). Provides symbolic and numerical differentiation and integration, as well as support for applied linear algebra (for data science), and differential equations/dynamics. Includes grammar-of-graphics-based functions for drawing vector fields, trajectories, etc. The software is suitable for general use, but intended mainly for teaching calculus.