Measures niche breadth and overlap of microbial taxa from large matrices. Niche breadth measurements include Levins niche breadth (Bn) index, Hurlbert's Bn and Feinsinger's proportional similarity (PS) index. (Feinsinger, P., Spears, E.E., Poole, R.W. (1981) <doi:10.2307/1936664>). Niche overlap measurements include Levin's Overlap (Ludwig, J.A. and Reynolds, J.F. (1988, ISBN:0471832359)) and a Jaccard similarity index of Feinsinger's PS values between taxa pairs, as Proportional Overlap.

Learning and using the Metropolis algorithm for Bayesian fitting of a generalized linear model. The package vignette includes examples of hand-coding a logistic model using several variants of the Metropolis algorithm. The package also contains R functions for simulating posterior distributions of Bayesian generalized linear model parameters using guided, adaptive, guided-adaptive and random walk Metropolis algorithms. The random walk Metropolis algorithm was originally described in Metropolis et al (1953); <doi:10.1063/1.1699114>.

Analyses and reports questionnaire and experiment data exported from PsyToolkit'. The package reads downloaded study folders, parses questionnaire structure, optionally merges demographic exports from CloudResearch or Prolific, and produces summary overviews of responses and completion times. It also provides helper functions to extract and aggregate experiment measures and survey variables, and to export results to spreadsheet files for further analysis and archiving. See Stoet (2017) <doi:10.1177/0098628316677643> for the PsyToolkit platform.

Find recursive dependencies of R packages from various sources. Solve the dependencies to obtain a consistent set of packages to install. Download packages, and install them. It supports packages on CRAN', Bioconductor and other CRAN-like repositories, GitHub', package URLs', and local package trees and files. It caches metadata and package files via the pkgcache package, and performs all HTTP requests, downloads, builds and installations in parallel. pkgdepends is the workhorse of the pak package.

Learn optimal policies via doubly robust empirical welfare maximization over trees. Given reward estimates, the algorithm finds a rule-based treatment allocation, where the policy takes the form of a shallow decision tree that is globally optimal (or nearly so). Methods are described in Sverdrup, Kanodia, Zhou, Athey, and Wager (2020) <doi:10.21105/joss.02232>, Athey and Wager (2021) <doi:10.3982/ECTA15732>, and Zhou, Athey, and Wager (2023) <doi:10.1287/opre.2022.2271>.

Summarizes participant flow and disposition in clinical trials, including CONSORT-style randomized controlled trials, parallel-group, crossover, cluster randomized, and multi-arm trials. Provides functions for screening failures, exclusions and reasons, allocation, follow-up, loss to follow-up, withdrawals, intention-to-treat and per-protocol populations, and participant-disposition summaries. The methods are based on established principles for reporting participant flow and disposition in randomized trials; see Schulz et al. (2010) <doi:10.1136/bmj.c332>.

ETS stands for Error, Trend, and Seasonality, and it is a popular time series forecasting method. Wavelet decomposition can be used for denoising, compression, and feature extraction of signals. By removing the high-frequency components, wavelet decomposition can remove noise from the data while preserving important features. A hybrid Wavelet ETS (Error Trend-Seasonality) model has been developed for time series forecasting using algorithm of Anjoy and Paul (2017) <DOI:10.1007/s00521-017-3289-9>.

This package provides a single function to fit data of an input data frame into one of the selected Weibull functions (w2, w3 and it's truncated versions), calculating the scale, location and shape parameters accordingly. The resulting plots and files are saved into the folder parameter provided by the user. References: a) John C. Nash, Ravi Varadhan (2011). "Unifying Optimization Algorithms to Aid Software System Users: optimx for R" <doi:10.18637/jss.v043.i09>.

ChromSCape - Chromatin landscape profiling for Single Cells - is a ready-to-launch user-friendly Shiny Application for the analysis of single-cell epigenomics datasets (scChIP-seq, scATAC-seq, scCUT&Tag, ...) from aligned data to differential analysis & gene set enrichment analysis. It is highly interactive, enables users to save their analysis and covers a wide range of analytical steps: QC, preprocessing, filtering, batch correction, dimensionality reduction, vizualisation, clustering, differential analysis and gene set analysis.

MPRAnalyze provides statistical framework for the analysis of data generated by Massively Parallel Reporter Assays (MPRAs), used to directly measure enhancer activity. MPRAnalyze can be used for quantification of enhancer activity, classification of active enhancers and comparative analyses of enhancer activity between conditions. MPRAnalyze construct a nested pair of generalized linear models (GLMs) to relate the DNA and RNA observations, easily adjustable to various experimental designs and conditions, and provides a set of rigorous statistical testig schemes.

Gene-regulatory network (GRN) modeling seeks to infer dependencies between genes and thereby provide insight into the regulatory relationships that exist within a cell. This package provides a computational Bayesian approach to GRN estimation from perturbation experiments using a ternary network model, in which gene expression is discretized into one of 3 states: up, unchanged, or down). The ternarynet package includes a parallel implementation of the replica exchange Monte Carlo algorithm for fitting network models, using MPI.

This package provides tools for simulating copy-number alteration (CNA) profiles, applying a non-decimated Haar wavelet transform to genomic signals, and extracting wavelet-derived features for use in supervised learning. Multiple machine learning methods including lasso and elastic-net regularisation, random forest, partial least squares, neural networks and k-nearest neighbours are implemented to train predictive models from genomic feature vectors. The workflow enables end-to-end analysis from CNA simulation to feature extraction and classification.

Provide a sparse matrix format with data stored on disk, to be used in both R and C++. This is intended for more efficient use of sparse data in C++ and also when parallelizing, since data on disk does not need copying. Only a limited number of features will be implemented. For now, conversion can be performed from a dgCMatrix or a dsCMatrix from R package Matrix'. A new compact format is also now available.

This package provides a management tool for specimen data ranging from public museum collections to private specimen repositories. The main types of data addressed are spatial (coordinates, longitude and latitude) and taxonomic data (ranking and nomenclature validity) with some additional options for user-determined dataset refinement. Combined or individual calls to the online repositories of the Global Biodiversity Information Facility (GBIF) via rgbif and the Integrated Taxonomic Information System (ITIS) via taxize enable built-in taxonomic checks.

This package provides a modified hierarchical test (Liu (2017) <doi:10.1214/17-AOS1539>) for detecting the structural difference between two Semiparametric Gaussian graphical models. The multiple testing procedure asymptotically controls the false discovery rate (FDR) at a user-specified level. To construct the test statistic, a truncated estimator is used to approximate the transformation functions and two R functions including lassoGGM() and lassoNPN() are provided to compute the lasso estimates of the regression coefficients.

Reconstruct birth-year specific probabilities of immune imprinting to influenza A, using the methods of Gostic et al. (2016) <doi:10.1126/science.aag1322>. Plot, save, or export the calculated probabilities for use in your own research. By default, the package calculates subtype-specific imprinting probabilities, but with user-provided frequency data, it is possible to calculate probabilities for arbitrary kinds of primary exposure to influenza A, including primary vaccination and exposure to specific clades, strains, etc.

Extract political party colors and logos from English Wikipedia party pages. Provides functions to scrape party infoboxes for color codes (HEX or HTML color names) and logo images. Includes integration with the Party Facts database for easy party lookups. Designed for political scientists and party researchers working with electoral and party data. For Party Facts, see Döring and Regel (2019) <doi:10.1177/1354068818820671> and Bederke, Döring, and Regel (2023) <doi:10.7910/DVN/TJINLQ>.

Enables small area estimation (SAE) of health and demographic indicators in low- and middle-income countries (LMICs). It powers an R shiny application for generating subnational estimates and prevalence maps of 150+ binary indicators from Demographic and Health Surveys (DHS). It builds on the SAE analysis workflow from the surveyPrev package. For documentation, visit <https://sae4health.stat.uw.edu/>. Methodological details can be found at Wu et al. (2025) <doi:10.48550/arXiv.2505.01467>.

Label propagation approaches are a widely used procedure in computational biology for giving context to molecular entities using network data. Node labels, which can derive from gene expression, genome-wide association studies, protein domains or metabolomics profiling, are propagated to their neighbours in the network, effectively smoothing the scores through prior annotated knowledge and prioritising novel candidates. The R package diffuStats contains a collection of diffusion kernels and scoring approaches that facilitates their computation, characterisation and benchmarking.

An implementation of methods for designing, evaluating, and comparing primer sets for multiplex PCR. Primers are designed by solving a set cover problem such that the number of covered template sequences is maximized with the smallest possible set of primers. To guarantee that high-quality primers are generated, only primers fulfilling constraints on their physicochemical properties are selected. A Shiny app providing a user interface for the functionalities of this package is provided by the openPrimeRui package.

This package provides a number of functions to create and analyze factorial plans according to the Design of Experiments (DoE) approach, with the addition of some utility function to perform some statistical analyses. DoE approach follows the approach in "Design and Analysis of Experiments" by Douglas C. Montgomery (2019, ISBN:978-1-119-49244-3). The package also provides utilities used in the course "Analysis of Data and Statistics" at the University of Trento, Italy.

Blocks units into experimental blocks, with one unit per treatment condition, by creating a measure of multivariate distance between all possible pairs of units. Maximum, minimum, or an allowable range of differences between units on one variable can be set. Randomly assign units to treatment conditions. Diagnose potential interference between units assigned to different treatment conditions. Write outputs to .tex and .csv files. For more information on the methods implemented, see Moore (2012) <doi:10.1093/pan/mps025>.

An implementation of the Fish Bioenergetics 4.0 framework described in Deslauriers et al. (2017) <doi:10.1080/03632415.2017.1377558>. Provides automated parameter optimization, multi-prey diet modeling, and comprehensive energy budget simulations for fisheries research and aquaculture applications. An optional TMB (Template Model Builder) backend delivers 10-50x speedup in maximum likelihood estimation while maintaining full backward compatibility. Includes species-specific parameter databases and tools for modeling fish growth, consumption, and metabolism under varying environmental conditions.

Useful tools for conveniently downloading FHIR resources in xml format and converting them to R data.frames. Uses FHIR-search to download bundles from a FHIR server, provides functions to save and read xml-files containing such bundles and allows flattening the bundles to data.frames using XPath expressions. FHIR® is the registered trademark of HL7 and is used with the permission of HL7. Use of the FHIR trademark does not constitute endorsement of this product by HL7.