Data sets and sample analyses from Pinheiro and Bates, "Mixed-effects Models in S and S-PLUS" (Springer, 2000).

Extract, transform and load MITRE standards. This package gives you an approach to cybersecurity data sets. All data sets are build on runtime downloading raw data from MITRE public services. MITRE <https://www.mitre.org/> is a government-funded research organization based in Bedford and McLean. Current version includes most used standards as data frames. It also provide a list of nodes and edges with all relationships.

Allows practitioners and researchers a wholesale approach for deriving magnitude-based inferences from raw data. A major goal of mbir is to programmatically detect appropriate statistical tests to run in lieu of relying on practitioners to determine correct stepwise procedures independently.

Multi-penalty linear, logistic and cox ridge regression, including estimation of the penalty parameters by efficient (repeated) cross-validation and marginal likelihood maximization. Multiple high-dimensional data types that require penalization are allowed, as well as unpenalized variables. Paired and preferential data types can be specified. See Van de Wiel et al. (2021), <arXiv:2005.09301>.

Analyzes subject-level data in clinical trials using the metalite data structure. The package simplifies the workflow to create production-ready tables, listings, and figures discussed in the subject-level analysis chapters of "R for Clinical Study Reports and Submission" by Zhang et al. (2022) <https://r4csr.org/>.

This package provides fast and accurate inference for the parameter estimation problem in Ordinary Differential Equations, including the case when there are unobserved system components. Implements the MAGI method (MAnifold-constrained Gaussian process Inference) of Yang, Wong, and Kou (2021) <doi:10.1073/pnas.2020397118>. A user guide is provided by the accompanying software paper Wong, Yang, and Kou (2024) <doi:10.18637/jss.v109.i04>.

This package provides an implementation of methods for multivariate multiple regression with adaptive shrinkage priors as described in F. Morgante et al (2023) <doi:10.1371/journal.pgen.1010539>.

An easy-to-use IMAP client that provides tools for message searching, selective fetching of message attributes, mailbox management, attachment extraction, and several other IMAP features, paving the way for e-mail data analysis in R.

This package provides a glycolipid mass spectrometry technology has the potential to accurately identify individual bacterial species from polymicrobial samples. To develop bacterial identification algorithms (e.g. machine learning) using this glycolipid technology, it is necessary to generate a large number of various in-silico polymicrobial mass spectra that are similar to real mass spectra. MGMS2 (Membrane Glycolipid Mass Spectrum Simulator) generates such in-silico mass spectra, considering errors in m/z (mass-to-charge ratio) and variances of intensity values, occasions of missing signature ions, and noise peaks. It estimates summary statistics of monomicrobial mass spectra for each strain or species and simulates polymicrobial glycolipid mass spectra using the summary statistics of monomicrobial mass spectra. References: Ryu, S.Y., Wendt, G.A., Chandler, C.E., Ernst, R.K. and Goodlett, D.R. (2019) <doi:10.1021/acs.analchem.9b03340> "Model-based Spectral Library Approach for Bacterial Identification via Membrane Glycolipids." Gibb, S. and Strimmer, K. (2012) <doi:10.1093/bioinformatics/bts447> "MALDIquant: a versatile R package for the analysis of mass spectrometry data.".

Framework to facilitate patient subtyping with similarity network fusion and meta clustering. The similarity network fusion (SNF) algorithm was introduced by Wang et al. (2014) in <doi:10.1038/nmeth.2810>. SNF is a data integration approach that can transform high-dimensional and diverse data types into a single similarity network suitable for clustering with minimal loss of information from each initial data source. The meta clustering approach was introduced by Caruana et al. (2006) in <doi:10.1109/ICDM.2006.103>. Meta clustering involves generating a wide range of cluster solutions by adjusting clustering hyperparameters, then clustering the solutions themselves into a manageable number of qualitatively similar solutions, and finally characterizing representative solutions to find ones that are best for the user's specific context. This package provides a framework to easily transform multi-modal data into a wide range of similarity network fusion-derived cluster solutions as well as to visualize, characterize, and validate those solutions. Core package functionality includes easy customization of distance metrics, clustering algorithms, and SNF hyperparameters to generate diverse clustering solutions; calculation and plotting of associations between features, between patients, and between cluster solutions; and standard cluster validation approaches including resampled measures of cluster stability, standard metrics of cluster quality, and label propagation to evaluate generalizability in unseen data. Associated vignettes guide the user through using the package to identify patient subtypes while adhering to best practices for unsupervised learning.

This package performs mean shift classification using linear and k-d tree based nearest neighbor implementations for the Gaussian, Epanechnikov, and biweight product kernels.

Read, process, and analyse data from muscle near-infrared spectroscopy (mNIRS) devices. Import raw data from .csv or .xls(x) files and return time-series data and metadata. Includes standardised methods for cleaning, filtering, and pre-processing mNIRS data for subsequent analysis. Also includes a custom plot theme and colour palette. Intended for mNIRS researchers and practitioners in exercise physiology, sports science, and clinical rehabilitation with minimal coding experience required.

Information of the centroids and geographical limits of the regions, departments, provinces and districts of Peru.

Similarity plots based on correlation and median absolute deviation (MAD); adjusting colors for heatmaps; aggregate technical replicates; calculate pairwise fold-changes and log fold-changes; compute one- and two-way ANOVA; simplified interface to package limma (Ritchie et al. (2015), <doi:10.1093/nar/gkv007> ) for moderated t-test and one-way ANOVA; Hamming and Levenshtein (edit) distance of strings as well as optimal alignment scores for global (Needleman-Wunsch) and local (Smith-Waterman) alignments with constant gap penalties (Merkl and Waack (2009), ISBN:978-3-527-32594-8).

Researchers often have expectations about the relations between means of different groups or standardized regression coefficients; using informative hypothesis testing to incorporate these expectations into the analysis through order constraints increases statistical power Vanbrabant and Rosseel (2020) <doi:10.4324/9780429273872-14>. Another valuable tool, the Bayes factor, can evaluate evidence for multiple hypotheses without concerns about multiple testing, and can be used in Bayesian updating Hoijtink, Mulder, van Lissa & Gu (2019) <doi:10.1037/met0000201>. The bain R package enables informative hypothesis testing using the Bayes factor. The mmibain package provides shiny web applications based on bain'. The RepliCrisis() function launches a shiny card game to simulate the evaluation of replication studies while the mmibain() function launches a shiny application to fit Bayesian informative hypotheses evaluation models from bain'.

Response Surface Designs (RSDs) involving factors not all at same levels are called Mixed Level RSDs (or Asymmetric RSDs). In many practical situations, RSDs with asymmetric levels will be more suitable as it explores more regions in the design space. (J.S. Mehta and M.N. Das (1968) <doi:10.2307/1267046>. "Asymmetric rotatable designs and orthogonal transformations").This package contains function named ATORDs_I() for generating asymmetric third order rotatable designs (ATORDs) based on third order designs given by Das and Narasimham (1962). Function ATORDs_II() generates asymmetric third order rotatable designs developed using t-design of unequal set sizes, which are smaller in size as compared to design generated by function ATORDs_I(). In general, third order rotatable designs can be classified into two classes viz., designs that are suitable for sequential experimentation and designs for non-sequential experimentation. The sequential experimentation approach involves conducting the trials step by step whereas, in the non-sequential experimentation approach, the entire runs are executed in one go (M. N. Das and V. Narasimham (1962) <doi:10.1214/AOMS/1177704374>. "Construction of Rotatable Designs through Balanced Incomplete Block Designs"). ATORDs_I() and ATORDs_II() functions generate non-sequential asymmetric third order designs. Function named SeqTORD() generates symmetric sequential third order design in blocks and also gives G-efficiency of the given design. Function named Asymseq() generates asymmetric sequential third order designs in blocks (M. Hemavathi, Eldho Varghese, Shashi Shekhar and Seema Jaggi (2020) <doi:10.1080/02664763.2020.1864817>. "Sequential asymmetric third order rotatable designs (SATORDs)"). In response surface design, situations may arise in which some of the factors are qualitative in nature (Jyoti Divecha and Bharat Tarapara (2017) <doi:10.1080/08982112.2016.1217338>. "Small, balanced, efficient, optimal, and near rotatable response surface designs for factorial experiments asymmetrical in some quantitative, qualitative factors"). The Function named QualRSD() generates second order design with qualitative factors along with their D-efficiency and G-efficiency. The function named RotatabilityQ() calculates a measure of rotatability (measure Q, 0 <= Q <= 1) given by Draper and Pukelshiem(1990) for given a design based on a second order model, (Norman R. Draper and Friedrich Pukelsheim(1990) <doi:10.1080/00401706.1990.10484635>. "Another look at rotatability").

This package provides a low-dependency implementation of GSIF::mpspline() <https://r-forge.r-project.org/scm/viewvc.php/pkg/R/mpspline.R?view=markup&revision=240&root=gsif>, which applies a mass-preserving spline to soil attributes. Splining soil data is a safe way to make continuous down-profile estimates of attributes measured over discrete, often discontinuous depth intervals.

This package provides functions to calculate hazard and survival function of Multi-Stage Clonal Expansion Models used in cancer epidemiology. For the Two-Stage Clonal Expansion Model an exact solution is implemented assuming piecewise constant parameters, see Heidenreich, Luebeck, Moolgavkar (1997) <doi:10.1111/j.1539-6924.1997.tb00878.x>. Numerical solutions are provided for its extensions, see also Little, Vineis, Li (2008) <doi:10.1016/j.jtbi.2008.05.027>.

Routines for assessing multivariate normality. Implements three Wald's type chi-squared tests; non-parametric Anderson-Darling and Cramer-von Mises tests; Doornik-Hansen test, Royston test and Henze-Zirkler test.

Test for overall association between microbiome composition data and phenotypes via phylogenetic kernels. The phenotype can be univariate continuous or binary (Zhao et al. (2015) <doi:10.1016/j.ajhg.2015.04.003>), survival outcomes (Plantinga et al. (2017) <doi:10.1186/s40168-017-0239-9>), multivariate (Zhan et al. (2017) <doi:10.1002/gepi.22030>) and structured phenotypes (Zhan et al. (2017) <doi:10.1111/biom.12684>). The package can also use robust regression (unpublished work) and integrated quantile regression (Wang et al. (2021) <doi:10.1093/bioinformatics/btab668>). In each case, the microbiome community effect is modeled nonparametrically through a kernel function, which can incorporate phylogenetic tree information.

This package provides functions for diagnostic meta-analysis. Next to basic analysis and visualization the bivariate Model of Reitsma et al. (2005) that is equivalent to the HSROC of Rutter & Gatsonis (2001) can be fitted. A new approach based to diagnostic meta-analysis of Holling et al. (2012) is also available. Standard methods like summary, plot and so on are provided.

Generate central composite designs (CCD)with full as well as fractional factorial points (half replicate) and Box Behnken designs (BBD) with minimally changed run sequence.

This package provides a set of tools for likelihood-based estimation, model selection and testing of two- and three-range shift and migration models for animal movement data as described in Gurarie et al. (2017) <doi: 10.1111/1365-2656.12674>. Provided movement data (X, Y and Time), including irregularly sampled data, functions estimate the time, duration and location of one or two range shifts, as well as the ranging area and auto-correlation structure of the movment. Tests assess, for example, whether the shift was "significant", and whether a two-shift migration was a true return migration.

Used for general multiple mediation analysis. The analysis method is described in Yu and Li (2022) (ISBN: 9780367365479) "Statistical Methods for Mediation, Confounding and Moderation Analysis Using R and SAS", published by Chapman and Hall/CRC; and Yu et al.(2017) <DOI:10.1016/j.sste.2017.02.001> "Exploring racial disparity in obesity: a mediation analysis considering geo-coded environmental factors", published on Spatial and Spatio-temporal Epidemiology, 21, 13-23.