Estimation and inference methods for causal relative and attributable risk in case-control and case-population studies under the monotone treatment response and monotone treatment selection assumptions. For more details, see the paper by Jun and Lee (2023), "Causal Inference under Outcome-Based Sampling with Monotonicity Assumptions," <arXiv:2004.08318 [econ.EM]>, accepted for publication in Journal of Business & Economic Statistics.

Different methods to conduct causal inference for multiple treatments with a binary outcome, including regression adjustment, vector matching, Bayesian additive regression trees, targeted maximum likelihood and inverse probability of treatment weighting using different generalized propensity score models such as multinomial logistic regression, generalized boosted models and super learner. For more details, see the paper by Hu et al. <doi:10.1177/0962280220921909>.

This package provides a collection of asymmetrical kernels belong to lifetime distributions for kernel density estimation is presented. Mean Squared Errors (MSE) are calculated for estimated curves. For this purpose, R functions allow the distribution to be Gamma, Exponential or Weibull. For details see Chen (2000a,b), Jin and Kawczak (2003) and Salha et al. (2014) <doi:10.12988/pms.2014.4616>.

Simple computation of spatial statistic functions of distance to characterize the spatial structures of mapped objects, following Marcon, Traissac, Puech, and Lang (2015) <doi:10.18637/jss.v067.c03>. Includes classical functions (Ripley's K and others) and more recent ones used by spatial economists (Duranton and Overman's Kd, Marcon and Puech's M). Relies on spatstat for some core calculation.

Estimates Two-way Fixed Effects difference-in-differences/event-study models using the approach proposed by Gardner (2021) <doi:10.48550/arXiv.2207.05943>. To avoid the problems caused by OLS estimation of the Two-way Fixed Effects model, this function first estimates the fixed effects and covariates using untreated observations and then in a second stage, estimates the treatment effects.

Tidy, analyze, and plot directed acyclic graphs (DAGs). ggdag is built on top of dagitty', an R package that uses the DAGitty web tool (<https://dagitty.net/>) for creating and analyzing DAGs. ggdag makes it easy to tidy and plot dagitty objects using ggplot2 and ggraph', as well as common analytic and graphical functions, such as determining adjustment sets and node relationships.

This package provides a simple mechanism to specify a symmetric block diagonal matrices (often used for covariance matrices). This is based on the domain specific language implemented in nlmixr2 but expanded to create matrices in R generally instead of specifying parts of matrices to estimate. It has expanded to include some matrix manipulation functions that are generally useful for rxode2 and nlmixr2'.

Access to the Greek New Testament (27 books) and the Old Testament (39 books) and allow users to do textual analysis on the data. The New and Old Testament have been provided in their original languages, Greek and Hebrew, respectively. Additionally, the Revised American Standard Bible is also provided for users who'd rather use a wordâ forâ word modern English translation.

Model stability and variable inclusion plots [Mueller and Welsh (2010, <doi:10.1111/j.1751-5823.2010.00108.x>); Murray, Heritier and Mueller (2013, <doi:10.1002/sim.5855>)] as well as the adaptive fence [Jiang et al. (2008, <doi:10.1214/07-AOS517>); Jiang et al. (2009, <doi:10.1016/j.spl.2008.10.014>)] for linear and generalised linear models.

The MCC-F1 analysis is a method to evaluate the performance of binary classifications. The MCC-F1 curve is more reliable than the Receiver Operating Characteristic (ROC) curve and the Precision-Recall (PR)curve under imbalanced ground truth. The MCC-F1 analysis also provides the MCC-F1 metric that integrates classifier performance over varying thresholds, and the best threshold of binary classification.

This package provides functions for manipulating nested data frames in a list-column using dplyr <https://dplyr.tidyverse.org/> syntax. Rather than unnesting, then manipulating a data frame, nplyr allows users to manipulate each nested data frame directly. nplyr is a wrapper for dplyr functions that provide tools for common data manipulation steps: filtering rows, selecting columns, summarising grouped data, among others.

Package for evaluating user-specified finite stage policies and learning optimal treatment policies via doubly robust loss functions. Policy learning methods include doubly robust learning of the blip/conditional average treatment effect and sequential policy tree learning. The package also include methods for optimal subgroup analysis. See Nordland and Holst (2022) <doi:10.48550/arXiv.2212.02335> for documentation and references.

This package implements the Phylogeny-Guided Microbiome OTU-Specific Association Test method, which boosts the testing power by adaptively borrowing information from phylogenetically close OTUs (operational taxonomic units) of the target OTU. This method is built on a kernel machine regression framework and allows for flexible modeling of complex microbiome effects, adjustments for covariates, and can accommodate both continuous and binary outcomes.

Efficient implementations for Sorted L-One Penalized Estimation (SLOPE): generalized linear models regularized with the sorted L1-norm (Bogdan et al. 2015). Supported models include ordinary least-squares regression, binomial regression, multinomial regression, and Poisson regression. Both dense and sparse predictor matrices are supported. In addition, the package features predictor screening rules that enable fast and efficient solutions to high-dimensional problems.

This package provides a pipeline for short tandem repeat instability analysis from fragment analysis data. Inputs of fsa files or peak tables, and a user supplied metadata data-frame. The package identifies ladders, calls peaks, identifies the modal peaks, calls repeats, then calculates repeat instability metrics (e.g. expansion index from Lee et al. (2010) <doi:10.1186/1752-0509-4-29>).

Robust normalization and difference calling procedures for ChIP-seq and alike data. Read counts are modeled jointly as a binomial mixture model with a user-specified number of components. A fitted background estimate accounts for the effect of enrichment in certain regions and, therefore, represents an appropriate null hypothesis. This robust background is used to identify significantly enriched or depleted regions.

Use multiple factor analysis to calculate individualized pathway-centric scores of deviation with respect to the sampled population based on multi-omic assays (e.g., RNA-seq, copy number alterations, methylation, etc). Graphical and numerical outputs are provided to identify highly aberrant individuals for a particular pathway of interest, as well as the gene and omics drivers of aberrant multi-omic profiles.

This package provides colour choice in information visualisation. It important in order to avoid being mislead by inherent bias in the used colour palette. This package provides access to the perceptually uniform and colour-blindness friendly palettes developed by Fabio Crameri and released under the "Scientific Colour-Maps" moniker. The package contains 24 different palettes and includes both diverging and sequential types.

This package contains various tools for working with and evaluating cross-validated area under the ROC curve (AUC) estimators. The primary functions of the package are ci.cvAUC and ci.pooled.cvAUC, which report cross-validated AUC and compute confidence intervals for cross-validated AUC estimates based on influence curves for i.i.d. and pooled repeated measures data, respectively.

This package provides resampling procedures to assess the stability of selected variables with additional finite sample error control for high-dimensional variable selection procedures such as Lasso or boosting. Both, standard stability selection (Meinshausen & Buhlmann, 2010) and complementary pairs stability selection with improved error bounds (Shah & Samworth, 2013) are implemented. The package can be combined with arbitrary user specified variable selection approaches.

T (extent of the primary tumor), N (absence or presence and extent of regional lymph node metastasis) and M (absence or presence of distant metastasis) are three components to describe the anatomical tumor extent. TNM stage is important in treatment decision-making and outcome predicting. The existing oropharyngeal Cancer (OPC) TNM stages have not made distinction of the two sub sites of Human papillomavirus positive (HPV+) and Human papillomavirus negative (HPV-) diseases. We developed novel criteria to assess performance of the TNM stage grouping schemes based on parametric modeling adjusting on important clinical factors. These criteria evaluate the TNM stage grouping scheme in five different measures: hazard consistency, hazard discrimination, explained variation, likelihood difference, and balance. The methods are described in Xu, W., et al. (2015) <https://www.austinpublishinggroup.com/biometrics/fulltext/biometrics-v2-id1014.php>.

An implementation of Bayesian model-averaged t-tests that allows users to draw inferences about the presence versus absence of an effect, variance heterogeneity, and potential outliers. The RoBTT package estimates ensembles of models created by combining competing hypotheses and applies Bayesian model averaging using posterior model probabilities. Users can obtain model-averaged posterior distributions and inclusion Bayes factors, accounting for uncertainty in the data-generating process (Maier et al., 2024, <doi:10.3758/s13423-024-02590-5>). The package also provides a truncated likelihood version of the model-averaged t-test, enabling users to exclude potential outliers without introducing bias (Godmann et al., 2024, <doi:10.31234/osf.io/j9f3s>). Users can specify a wide range of informative priors for all parameters of interest. The package offers convenient functions for summary, visualization, and fit diagnostics.

Ranking of Alternatives through Functional mapping of criterion sub-intervals into a Single Interval Method is designed to perform multi-criteria decision-making (MCDM), developed by Mališa Žižovic in 2020 (<doi:10.3390/math8061015>). It calculates the final sorted rankings based on a decision matrix where rows represent alternatives and columns represent criteria. The method uses: - A numeric vector of weights for each criterion (the sum of weights must be 1). - A numeric vector of ideal values for each criterion. - A numeric vector of anti-ideal values for each criterion. - Numeric values representing the extent to which the ideal value is preferred over the anti-ideal value, and the extent to which the anti-ideal value is considered worse. The function standardizes the decision matrix, normalizes the data, applies weights, and returns the final sorted rankings.

Estimation and interpretation of Bayesian distributed lag interaction models (BDLIMs). A BDLIM regresses a scalar outcome on repeated measures of exposure and allows for modification by a categorical variable under four specific patterns of modification. The main function is bdlim(). There are also summary and plotting files. Details on methodology are described in Wilson et al. (2017) <doi:10.1093/biostatistics/kxx002>.