For high-dimensional streaming heavy-tailed elliptical data, traditional sliced inverse regression methods require full offline data and cannot adapt to incremental data arrival. This package implements Online Sliced Inverse Regression for Elliptical Model with Streaming Data (OE-SIR) algorithm with two recursive updating strategies, including offline batch SIR as benchmark, elliptical heavy-tailed data simulator, subspace evaluation metric and batch simulation tools for numerical experiments. Cai, Z., Li, R., & Zhu, L. (2020) <doi:10.48550/arXiv.2002.02795>.

This package contains methods for the simulation of tempered stable subordinators and related distributions. Including classical tempered stable (both finite and infinite variation), rapidly deceasing tempered stable, truncated stable, truncated tempered stable, generalized Dickman, truncated gamma, generalized gamma, and p-gamma. For details, see Dassios et al (2019) <doi:10.1017/jpr.2019.6>, Dassios et al (2020) <doi:10.1145/3368088>, Grabchak (2021) <doi:10.1016/j.spl.2020.109015>, Grabchak (2026) <doi:10.48550/arXiv.2604.17732>.

This package implements spatial optimization algorithms across several problem families including contiguity-constrained regionalization, discrete facility location, market share analysis, and least-cost corridor and route optimization over raster cost surfaces. Facility location problems also accept user-supplied network travel-time matrices. Uses a Rust backend via extendr for graph and routing algorithms, and the HiGHS solver via the highs package for facility location mixed-integer programs. Method-level references are provided in the documentation of the individual functions.

Variational Autoencoded Multivariate Spatial Fay-Herriot models are designed to efficiently estimate population parameters in small area estimation. This package implements the variational generalized multivariate spatial Fay-Herriot model (VGMSFH) using NumPyro and PyTorch backends, as demonstrated by Wang, Parker, and Holan (2025) <doi:10.48550/arXiv.2503.14710>. The vmsae package provides utility functions to load weights of the pretrained variational autoencoders (VAEs) as well as tools to train custom VAEs tailored to users specific applications.

This package provides robust methods to detect change-points in uni- or multivariate time series. They can cope with corrupted data and heavy tails. Focus is on the detection of abrupt changes in location, but changes in the scale or dependence structure can be detected as well. This package provides tests for change detection in uni- and multivariate time series based on Huberized versions of CUSUM tests proposed in Duerre and Fried (2019) <DOI:10.48550/arXiv.1905.06201>, and tests for change detection in univariate time series based on 2-sample U-statistics or 2-sample U-quantiles as proposed by Dehling et al. (2015) <DOI:10.1007/978-1-4939-3076-0_12> and Dehling, Fried and Wendler (2020) <DOI:10.1093/biomet/asaa004>. Furthermore, the packages provides tests on changes in the scale or the correlation as proposed in Gerstenberger, Vogel and Wendler (2020) <DOI:10.1080/01621459.2019.1629938>, Dehling et al. (2017) <DOI:10.1017/S026646661600044X>, and Wied et al. (2014) <DOI:10.1016/j.csda.2013.03.005>.

This package aims to make NMR spectroscopy data analysis as easy as possible. It only requires a small set of functions to perform an entire analysis. Speaq offers the possibility of raw spectra alignment and quantitation but also an analysis based on features whereby the spectra are converted to peaks which are then grouped and turned into features. These features can be processed with any number of statistical tools either included in speaq or available elsewhere on CRAN.

MeLSI (Metric Learning for Statistical Inference) is a novel machine learning method for microbiome data analysis that learns optimal distance metrics to improve statistical power in detecting group differences. Unlike traditional distance metrics (Bray-Curtis, Euclidean, Jaccard), MeLSI adapts to the specific characteristics of your dataset to maximize separation between groups. The method uses an ensemble of weak learners to identify which microbial features drive group differences, providing both improved statistical power and biological interpretability through feature importance weights.

xcore is an R package for transcription factor activity modeling based on known molecular signatures and user's gene expression data. Accompanying xcoredata package provides a collection of molecular signatures, constructed from publicly available ChiP-seq experiments. xcore use ridge regression to model changes in expression as a linear combination of molecular signatures and find their unknown activities. Obtained, estimates can be further tested for significance to select molecular signatures with the highest predicted effect on the observed expression changes.

Shows a grey placeholder in the shape of the content while a shiny output loads, in place of a spinner. The user can thus see what is coming, and not only that something happens. The shape comes from the type of the output. The placeholder keeps the space of the content, so the page does not move when the content arrives. When an output calculates again, the old content stays on the screen, dimmed, and a placeholder does not replace it.

This package implements Dirichlet multinomial modeling of relative abundance data using functionality provided by the Stan software. The purpose of this package is to provide a user friendly way to interface with Stan that is suitable for those new to modeling. For more regarding the modeling mathematics and computational techniques we use see our publication in Molecular Ecology Resources titled Dirichlet multinomial modeling outperforms alternatives for analysis of ecological count data (Harrison et al. 2020 <doi:10.1111/1755-0998.13128>).

This package contains Coverage Adjusted Standardized Mutual Information ('CASMI')-based functions. CASMI is a fundamental concept of a series of methods. For more information about CASMI and CASMI'-related methods, please refer to the corresponding publications (e.g., a feature selection method, Shi, J., Zhang, J., & Ge, Y. (2019) <doi:10.3390/e21121179>, and a dataset quality measurement method, Shi, J., Zhang, J., & Ge, Y. (2019) <doi:10.1109/ICHI.2019.8904553>) or contact the package author for the latest updates.

We consider a set of sample counts obtained by sampling arbitrary fractions of a finite volume containing an homogeneously dispersed population of identical objects. This package implements a Bayesian derivation of the posterior probability distribution of the population size using a binomial likelihood and non-conjugate, discrete uniform priors under sampling with or without replacement. This can be used for a variety of statistical problems involving absolute quantification under uncertainty. See Comoglio et al. (2013) <doi:10.1371/journal.pone.0074388>.

This package provides functions for calculating various measures of foreign policy similarity or association commonly used in the study of international relations. These include Signorino and Ritter's S statistic (weighted and unweighted), Benati and Capurri's chance-corrected S statistic (A), Cohen's weighted kappa, Scott's pi, and Kendall's tau-b. The package facilitates the generation of dyadic similarity scores for empirical analyses and can also serve as an educational resource for understanding how such measures are calculated.

Accurate estimates of the diets of predators are required in many areas of ecology, but for many species current methods are imprecise, limited to the last meal, and often biased. The diversity of fatty acids and their patterns in organisms, coupled with the narrow limitations on their biosynthesis, properties of digestion in monogastric animals, and the prevalence of large storage reservoirs of lipid in many predators, led to the development of quantitative fatty acid signature analysis (QFASA) to study predator diets.

Identify statistically significant flow clusters using the local spatial network autocorrelation statistic G_ij* proposed by Berglund and Karlström (1999) <doi:10.1007/s101090050013>. The metric, an extended statistic of Getis/Ord G ('Getis and Ord 1992) <doi:10.1111/j.1538-4632.1992.tb00261.x>, detects a group of flows having similar traits in terms of directionality. You provide OD data and the associated polygon to get results with several parameters, some of which are defined by spdep package.

This package provides methods for sensory discrimination methods; duotrio, tetrad, triangle, 2-AFC, 3-AFC, A-not A, same-different, 2-AC and degree-of-difference. This enables the calculation of d-primes, standard errors of d-primes, sample size and power computations, and comparisons of different d-primes. Methods for profile likelihood confidence intervals and plotting are included. Most methods are described in Brockhoff, P.B. and Christensen, R.H.B. (2010) <doi:10.1016/j.foodqual.2009.04.003>.

Random generation, density function and parameter estimation for the Voigt distribution. The main objective of this package is to provide R users with efficient estimation of Voigt parameters using classic iid data in a Bayesian framework. The estimating function allows flexible prior specification, specification of fixed parameters and several options for Markov Chain Monte Carlo posterior simulation. A basic version of the algorithm is described in: Cannas M. and Piras, N. (2025) <doi:10.1007/978-3-031-96303-2_53>.

The ggbio package extends and specializes the grammar of graphics for biological data. The graphics are designed to answer common scientific questions, in particular those often asked of high throughput genomics data. All core Bioconductor data structures are supported, where appropriate. The package supports detailed views of particular genomic regions, as well as genome-wide overviews. Supported overviews include ideograms and grand linear views. High-level plots include sequence fragment length, edge-linked interval to data view, mismatch pileup, and several splicing summaries.

This package wires together large collections of single-cell RNA-seq datasets, which allows for both the identification of recurrent cell clusters and the propagation of information between datasets in multi-sample or atlas-scale collections. Conos focuses on the uniform mapping of homologous cell types across heterogeneous sample collections. For instance, users could investigate a collection of dozens of peripheral blood samples from cancer patients combined with dozens of controls, which perhaps includes samples of a related tissue such as lymph nodes.

SGSeq is a package for analyzing splice events from RNA-seq data. Input data are RNA-seq reads mapped to a reference genome in BAM format. Genes are represented as a splice graph, which can be obtained from existing annotation or predicted from the mapped sequence reads. Splice events are identified from the graph and are quantified locally using structurally compatible reads at the start or end of each splice variant. The software includes functions for splice event prediction, quantification, visualization and interpretation.

Computational evaluation of variability across DNA or RNA sequencing datasets is a crucial step in genomics, as it allows both to evaluate reproducibility of replicates, and to compare different datasets to identify potential correlations. fCCAC applies functional Canonical Correlation Analysis to allow the assessment of: (i) reproducibility of biological or technical replicates, analyzing their shared covariance in higher order components; and (ii) the associations between different datasets. fCCAC represents a more sophisticated approach that complements Pearson correlation of genomic coverage.

Assists the evaluation of whether and where to focus code optimization, using Amdahl's law and visual aids based on line profiling. Amdahl's profiler organizes profiling output files (including memory profiling) in a visually appealing way. It is meant to help to balance development vs. execution time by helping to identify the most promising sections of code to optimize and projecting potential gains. The package is an addition to R's standard profiling tools and is not a wrapper for them.

This package provides functions to fit, via Expectation-Maximization (EM) algorithm, the Bessel and Beta regressions to a data set with a bounded continuous response variable. The Bessel regression is a new and robust approach proposed in the literature. The EM version for the well known Beta regression is another major contribution of this package. See details in the references Barreto-Souza, Mayrink and Simas (2022) <doi:10.1111/anzs.12354> and Barreto-Souza, Mayrink and Simas (2020) <arXiv:2003.05157>.

This package provides a collection of Bayesian networks (discrete, Gaussian, and conditional linear Gaussian) collated from recent academic literature. The bnRep_summary object provides an overview of the Bayesian networks in the repository and the package documentation includes details about the variables in each network. A Shiny app to explore the repository can be launched with bnRep_app() and is available online at <https://manueleleonelli.shinyapps.io/bnRep>. Reference: M. Leonelli (2025) <doi:10.1016/j.neucom.2025.129502>.