Multivariate tool for analyzing genome-wide association study results in the form of univariate summary statistics. The goal of bmass is to comprehensively test all possible multivariate models given the phenotypes and datasets provided. Multivariate models are determined by assigning each phenotype to being either Unassociated (U), Directly associated (D) or Indirectly associated (I) with the genetic variant of interest. Test results for each model are presented in the form of Bayes factors, thereby allowing direct comparisons between models. The underlying framework implemented here is based on the modeling developed in "A Unified Framework for Association Analysis with Multiple Related Phenotypes", M. Stephens (2013) <doi:10.1371/journal.pone.0065245>.

This software downloads and manages air quality data from the European Environmental Agency (EEA) dataflow (<https://www.eea.europa.eu/data-and-maps/data/aqereporting-9>). See the web page <https://eeadmz1-downloads-webapp.azurewebsites.net/> for details on the EEA's Air Quality Download Service. The package allows dynamically mapping the stations, summarising and time aggregating the measurements and building spatial interpolation maps. See the web page <https://www.eea.europa.eu/en> for further information on EEA activities and history. Further details, as well as, an extended vignette of the main functions included in the package, are available at the GitHub web page dedicated to the project.

This package provides tools to fit Mixture Cure Rate models via the Expectation-Maximization (EM) algorithm, allowing for flexible link functions in the cure component and various survival distributions in the latency part. The package supports user-specified link functions, includes methods for parameter estimation and model diagnostics, and provides residual analysis tailored for cure models. The classical theory methods used are described in Berkson, J. and Gage, R. P. (1952) <doi:10.2307/2281318>, Dempster, A. P., Laird, N. M. and Rubin, D. B. (1977) <https://www.jstor.org/stable/2984875>, Bazán, J., Torres-Avilés, F., Suzuki, A. and Louzada, F. (2017)<doi:10.1002/asmb.2215>.

Reads EXIF data using ExifTool <https://exiftool.org> and returns results as a data frame. ExifTool is a platform-independent Perl library plus a command-line application for reading, writing and editing meta information in a wide variety of files. ExifTool supports many different metadata formats including EXIF, GPS, IPTC, XMP, JFIF, GeoTIFF, ICC Profile, Photoshop IRB, FlashPix, AFCP and ID3, as well as the maker notes of many digital cameras by Canon, Casio, FLIR, FujiFilm, GE, HP, JVC/Victor, Kodak, Leaf, Minolta/Konica-Minolta, Motorola, Nikon, Nintendo, Olympus/Epson, Panasonic/Leica, Pentax/Asahi, Phase One, Reconyx, Ricoh, Samsung, Sanyo, Sigma/Foveon and Sony.

Tabacchi et al. (2011) published a very detailed study producing a uniform system of functions to estimate tree volume and phytomass components (stem, branches, stool). The estimates of the 2005 Italian forest inventory (<https://www.inventarioforestale.org/it/>) are based on these functions. The study documents the domain of applicability of each function and the equations to quantify estimates accuracies for individual estimates as well as for aggregated estimates. This package makes the functions available in the R environment. Version 2 exposes two distinct functions for individual and summary estimates. To facilitate access to the functions, tree species identification is now based on EPPO species codes (<https://data.eppo.int/>).

This package provides a high-performance R interface to the kuzu graph database. It uses the reticulate package to wrap the official Python client ('kuzu', pandas', and networkx'), allowing users to interact with kuzu seamlessly from within R'. Key features include managing database connections, executing Cypher queries, and efficiently loading data from R data frames. It also provides seamless integration with the R ecosystem by converting query results directly into popular R data structures, including tibble', igraph', tidygraph', and g6R objects, making kuzu's powerful graph computation capabilities readily available for data analysis and visualization workflows in R'. The kuzu documentation can be found at <https://kuzudb.github.io/docs/>.

Generate the optimal maximin distance, minimax distance (only for low dimensions), and maximum projection designs within the class of Latin hypercube designs efficiently for computer experiments. Generate Pareto front optimal designs for each two of the three criteria and all the three criteria within the class of Latin hypercube designs efficiently. Provide criterion computing functions. References of this package can be found in Morris, M. D. and Mitchell, T. J. (1995) <doi:10.1016/0378-3758(94)00035-T>, Lu Lu and Christine M. Anderson-CookTimothy J. Robinson (2011) <doi:10.1198/Tech.2011.10087>, Joseph, V. R., Gul, E., and Ba, S. (2015) <doi:10.1093/biomet/asv002>.

Data integration Web application for biobanks by OBiBa'. Opal is the core database application for biobanks. Participant data, once collected from any data source, must be integrated and stored in a central data repository under a uniform model. Opal is such a central repository. It can import, process, validate, query, analyze, report, and export data. Opal is typically used in a research center to analyze the data acquired at assessment centres. Its ultimate purpose is to achieve seamless data-sharing among biobanks. This Opal client allows to interact with Opal web services and to perform operations on the R server side. DataSHIELD administration tools are also provided.

Fit finite mixtures of Plackett-Luce models for partial top rankings/orderings within the Bayesian framework. It provides MAP point estimates via EM algorithm and posterior MCMC simulations via Gibbs Sampling. It also fits MLE as a special case of the noninformative Bayesian analysis with vague priors. In addition to inferential techniques, the package assists other fundamental phases of a model-based analysis for partial rankings/orderings, by including functions for data manipulation, simulation, descriptive summary, model selection and goodness-of-fit evaluation. Main references on the methods are Mollica and Tardella (2017) <doi:10.1007/s11336-016-9530-0> and Mollica and Tardella (2014) <doi:10.1002/sim.6224>.

This package implements Time-Weighted Dynamic Time Warping (TWDTW), a measure for quantifying time series similarity. The TWDTW algorithm, described in Maus et al. (2016) <doi:10.1109/JSTARS.2016.2517118> and Maus et al. (2019) <doi:10.18637/jss.v088.i05>, is applicable to multi-dimensional time series of various resolutions. It is particularly suitable for comparing time series with seasonality for environmental and ecological data analysis, covering domains such as remote sensing imagery, climate data, hydrology, and animal movement. The twdtw package offers a user-friendly R interface, efficient Fortran routines for TWDTW calculations, flexible time weighting definitions, as well as utilities for time series preprocessing and visualization.

In the course of a genome-wide association study, the situation often arises that some phenotypes are known with greater precision than others. It could be that some individuals are known to harbor more micro-environmental variance than others. In the case of inbred strains of model organisms, it could be the case that more organisms were observed from some strains than others, so the strains with more organisms have better-estimated means. Package wISAM handles this situation by allowing for weighting of each observation according to residual variance. Specifically, the weight parameter to the function conduct_scan() takes the precision of each observation (one over the variance).

Biclustering by "Factor Analysis for Bicluster Acquisition" (FABIA). FABIA is a model-based technique for biclustering, that is clustering rows and columns simultaneously. Biclusters are found by factor analysis where both the factors and the loading matrix are sparse. FABIA is a multiplicative model that extracts linear dependencies between samples and feature patterns. It captures realistic non-Gaussian data distributions with heavy tails as observed in gene expression measurements. FABIA utilizes well understood model selection techniques like the EM algorithm and variational approaches and is embedded into a Bayesian framework. FABIA ranks biclusters according to their information content and separates spurious biclusters from true biclusters. The code is written in C.

An elaborate molecular evolutionary framework that facilitates straightforward simulation of codon genetic sequences subjected to different degrees and/or patterns of Darwinian selection. The model is built upon the fitness landscape paradigm of Sewall Wright, as popularised by the mutation-selection model of Halpern and Bruno. This enables realistic evolutionary process of living organisms to be reproducible seamlessly. For example, an Ornstein-Uhlenbeck fitness update algorithm is incorporated herein. Consequently, otherwise complex biological processes, such as the effect of the interplay between genetic drift and fitness landscape fluctuations on the inference of diversifying selection, may now be investigated with minimal effort. Frequency-dependent and stochastic fitness landscape update techniques are available.

Circadian rhythms are rhythms that oscillate about every 24 h, which has been observed in multiple physiological processes including core body temperature, hormone secretion, heart rate, blood pressure, and many others. Measuring circadian rhythm with wearables is based on a principle that there is increased movement during wake periods and reduced movement during sleep periods, and has been shown to be reliable and valid. This package can be used to extract nonparametric circadian metrics like intradaily variability (IV), interdaily stability (IS), and relative amplitude (RA); and parametric cosinor model and extended cosinor model coefficient. Details can be found in Junrui Di et al (2019) <doi:10.1007/s12561-019-09236-4>.

This package provides functions to calculate the relative crystallinity of starch by X-ray Diffraction (XRD) and Infrared Spectroscopy (FTIR). Starch is biosynthesized by plants in the form of granules semicrystalline. For XRD, the relative crystallinity is obtained by separating the crystalline peaks from the amorphous scattering region. For FTIR, the relative crystallinity is achieved by setting of a Gaussian holocrystalline-peak in the 800-1300 cm-1 region of FTIR spectrum of starch which is divided into amorphous region and crystalline region. The relative crystallinity of native starch granules varies from 14 of 45 percent. This package was supported by FONDECYT 3150630 and CIPA Conicyt-Regional R08C1002 is gratefully acknowledged.

Extends data.table join functionality, lets it work with any data frame class, and provides a familiar x'/'y'-style interface, enabling broad use across R. Offers NA-safe matching by default, on-the-fly column selection, multiple match-handling on both sides, x or y row order, and a row origin indicator. Performs inner, left, right, full, semi- and anti-joins with equality and inequality conditions, plus cross joins. Specific support for data.table', (grouped) tibble, and sf'/'sfc objects and their attributes; returns a plain data frame otherwise. Avoids data-copying of inputs and outputs. Allows displaying the data.table code instead of (or as well as) executing it.

To integrate multiple GSEA studies, we propose a hybrid strategy, iGSEA-AT, for choosing random effects (RE) versus fixed effect (FE) models, with an attempt to achieve the potential maximum statistical efficiency as well as stability in performance in various practical situations. In addition to iGSEA-AT, this package also provides options to perform integrative GSEA with testing based on a FE model (iGSEA-FE) and testing based on a RE model (iGSEA-RE). The approaches account for different set sizes when testing a database of gene sets. The function is easy to use, and the three approaches can be applied to both binary and continuous phenotypes.

This package provides a collection of functions for processing and analyzing metabolite data. The namesake function mrbin() converts 1D or 2D Nuclear Magnetic Resonance data into a matrix of values suitable for further data analysis and performs basic processing steps in a reproducible way. Negative values, a common issue in such data, can be replaced by positive values (<doi:10.1021/acs.jproteome.0c00684>). All used parameters are stored in a readable text file and can be restored from that file to enable exact reproduction of the data at a later time. The function fia() ranks features according to their impact on classifier models, especially artificial neural network models.

This package implements methods that are useful in designing research studies and analyzing data, with particular emphasis on methods that are developed for or used within the behavioral, educational, and social sciences (broadly defined). That being said, many of the methods implemented within MBESS are applicable to a wide variety of disciplines. MBESS has a suite of functions for a variety of related topics, such as effect sizes, confidence intervals for effect sizes (including standardized effect sizes and noncentral effect sizes), sample size planning (from the accuracy in parameter estimation (AIPE), power analytic, equivalence, and minimum-risk point estimation perspectives), mediation analysis, various properties of distributions, and a variety of utility functions.

Quantitative methods for benefit-risk analysis help to condense complex decisions into a univariate metric describing the overall benefit relative to risk. One approach is to use the multi-criteria decision analysis framework (MCDA), as in Mussen, Salek, and Walker (2007) <doi:10.1002/pds.1435>. Bayesian benefit-risk analysis incorporates uncertainty through posterior distributions which are inputs to the benefit-risk framework. The brisk package provides functions to assist with Bayesian benefit-risk analyses, such as MCDA. Users input posterior samples, utility functions, weights, and the package outputs quantitative benefit-risk scores. The posterior of the benefit-risk scores for each group can be compared. Some plotting capabilities are also included.

This package provides a suite of functions for rapid and flexible analysis of codon usage bias. It provides in-depth analysis at the codon level, including relative synonymous codon usage (RSCU), tRNA weight calculations, machine learning predictions for optimal or preferred codons, and visualization of codon-anticodon pairing. Additionally, it can calculate various gene- specific codon indices such as codon adaptation index (CAI), effective number of codons (ENC), fraction of optimal codons (Fop), tRNA adaptation index (tAI), mean codon stabilization coefficients (CSCg), and GC contents (GC/GC3s/GC4d). It also supports both standard and non-standard genetic code tables found in NCBI, as well as custom genetic code tables.

Coalescent simulators can rapidly simulate biological sequences evolving according to a given model of evolution. You can use this package to specify such models, to conduct the simulations and to calculate additional statistics from the results (Staab, Metzler, 2016 <doi:10.1093/bioinformatics/btw098>). It relies on existing simulators for doing the simulation, and currently supports the programs ms', msms and scrm'. It also supports finite-sites mutation models by combining the simulators with the program seq-gen'. Coala provides functions for calculating certain summary statistics, which can also be applied to actual biological data. One possibility to import data is through the PopGenome package (<https://github.com/pievos101/PopGenome>).

It is a novel tool used to identify the candidate drugs against a particular disease based on the drug target set enrichment analysis. It assumes the most effective drugs are those with a closer affinity in the protein-protein interaction network to the specified disease. (See Gómez-Carballa et al. (2022) <doi: 10.1016/j.envres.2022.112890> and Feng et al. (2022) <doi: 10.7150/ijms.67815> for disease expression profiles; see Wishart et al. (2018) <doi: 10.1093/nar/gkx1037> and Gaulton et al. (2017) <doi: 10.1093/nar/gkw1074> for drug target information; see Kanehisa et al. (2021) <doi: 10.1093/nar/gkaa970> for the details of KEGG database.).

An implementation of multiple-locus association mapping on a genome-wide scale. Eagle can handle inbred and outbred study populations, populations of arbitrary unknown complexity, and data larger than the memory capacity of the computer. Since Eagle is based on linear mixed models, it is best suited to the analysis of data on continuous traits. However, it can tolerate non-normal data. Eagle reports, as its findings, the best set of snp in strongest association with a trait. For users unfamiliar with R, to perform an analysis, run OpenGUI()'. This opens a web browser to the menu-driven user interface for the input of data, and for performing genome-wide analysis.