Radare2 is a complete framework for reverse-engineering, debugging, and analyzing binaries. It is composed of a set of small utilities that can be used together or independently from the command line.
Radare2 is built around a scriptable disassembler and hexadecimal editor that support a variety of executable formats for different processors and operating systems, through multiple back ends for local and remote files and disk images.
It can also compare (diff) binaries with graphs and extract information like relocation symbols. It is able to deal with malformed binaries, making it suitable for security research and analysis.
Radare2 is a complete framework for reverse-engineering, debugging, and analyzing binaries. It is composed of a set of small utilities that can be used together or independently from the command line.
Radare2 is built around a scriptable disassembler and hexadecimal editor that support a variety of executable formats for different processors and operating systems, through multiple back ends for local and remote files and disk images.
It can also compare (diff) binaries with graphs and extract information like relocation symbols. It is able to deal with malformed binaries, making it suitable for security research and analysis.
GLDEX offers fitting algorithms corresponding to two major objectives. One is to provide a smoothing device to fit distributions to data using the weighted and unweighted discretised approach based on the bin width of the histogram. The other is to provide a definitive fit to the data set using the maximum likelihood and quantile matching estimation. Other methods such as moment matching, starship method, and L moment matching are also provided. Diagnostics on goodness of fit can be done via qqplots, KS-resample tests and comparing mean, variance, skewness and kurtosis of the data with the fitted distribution.
This package provides simulation methods for the evolution of antibody repertoires. The heavy and light chain variable region of both human and C57BL/6 mice can be simulated in a time-dependent fashion. Both single lineages using one set of V-, D-, and J-genes or full repertoires can be simulated. The algorithm begins with an initial V-D-J recombination event, starting the first phylogenetic tree. Upon completion, the main loop of the algorithm begins, with each iteration representing one simulated time step. Various mutation events are possible at each time step, contributing to a diverse final repertoire.
Designed for studies where animals tagged with acoustic tags are expected to move through receiver arrays. This package combines the advantages of automatic sorting and checking of animal movements with the possibility for user intervention on tags that deviate from expected behaviour. The three analysis functions (explore(), migration() and residency()) allow the users to analyse their data in a systematic way, making it easy to compare results from different studies. CJS calculations are based on Perry et al. (2012) <https://www.researchgate.net/publication/256443823_Using_mark-recapture_models_to_estimate_survival_from_telemetry_data>.
The Pritchard-Stephens-Donnelly (PSD) admixture model has k intermediate subpopulations from which n individuals draw their alleles dictated by their individual-specific admixture proportions. The BN-PSD model additionally imposes the Balding-Nichols (BN) allele frequency model to the intermediate populations, which therefore evolved independently from a common ancestral population T with subpopulation-specific FST (Wright's fixation index) parameters. The BN-PSD model can be used to yield complex population structures. This simulation approach is now extended to subpopulations related by a tree. Method described in Ochoa and Storey (2021) <doi:10.1371/journal.pgen.1009241>.
Estimates the conditional association between an exposure and an outcome given covariates. Three methods are implemented: O-estimation, where a nuisance model for the association between the covariates and the outcome is used; E-estimation where a nuisance model for the association between the covariates and the exposure is used, and doubly robust (DR) estimation where both nuisance models are used. In DR-estimation, the estimates will be consistent when at least one of the nuisance models is correctly specified, not necessarily both. For more information, see Zetterqvist and Sjölander (2015) <doi:10.1515/em-2014-0021>.
High-throughput single-cell measurements of DNA methylomes can quantify methylation heterogeneity and uncover its role in gene regulation. However, technical limitations and sparse coverage can preclude this task. scMET is a hierarchical Bayesian model which overcomes sparsity, sharing information across cells and genomic features to robustly quantify genuine biological heterogeneity. scMET can identify highly variable features that drive epigenetic heterogeneity, and perform differential methylation and variability analyses. We illustrate how scMET facilitates the characterization of epigenetically distinct cell populations and how it enables the formulation of novel hypotheses on the epigenetic regulation of gene expression.
This package provides a comprehensive statistical analysis of the accuracy of blood pressure devices based on the method of AAMI/ANSI SP10 standards developed by the AAMI Sphygmomanometer Committee for indirect measurement of blood pressure, incorporated into IS0 81060-2. The bpAcc package gives the exact probability of accepting a device D derived from the join distribution of the sample standard deviation and a non-linear transformation of the sample mean for a specified sample size introduced by Chandel et al. (2023) and by the Association for the Advancement of Medical Instrumentation (2003, ISBN:1-57020-183-8).
This package provides a header only, C++ interface to R with enhancements over cpp11'. Enforces copy-on-write semantics consistent with R behavior. Offers native support for ALTREP objects, UTF-8 string handling, modern C++11 features and idioms, and reduced memory requirements. Allows for vendoring, making it useful for restricted environments. Compared to cpp11', it adds support for converting C++ maps to R lists, Roxygen documentation directly in C++ code, proper handling of matrix attributes, support for nullable external pointers, bidirectional copy of complex number types, flexibility in type conversions, use of nullable pointers, and various performance optimizations.
In the era of big data, data redundancy and distributed characteristics present novel challenges to data analysis. This package introduces a method for estimating optimal subsets of redundant distributed data, based on PPCDT (Conjunction of Power and P-value in Distributed Settings). Leveraging PPC technology, this approach can efficiently extract valuable information from redundant distributed data and determine the optimal subset. Experimental results demonstrate that this method not only enhances data quality and utilization efficiency but also assesses its performance effectively. The philosophy of the package is described in Guo G. (2020) <doi:10.1007/s00180-020-00974-4>.
High-throughput analysis of growth curves and fluorescence data using three methods: linear regression, growth model fitting, and smooth spline fit. Analysis of dose-response relationships via smoothing splines or dose-response models. Complete data analysis workflows can be executed in a single step via user-friendly wrapper functions. The results of these workflows are summarized in detailed reports as well as intuitively navigable R data containers. A shiny application provides access to all features without requiring any programming knowledge. The package is described in further detail in Wirth et al. (2023) <doi:10.1038/s41596-023-00850-7>.
Health research using data from electronic health records (EHR) has gained popularity, but misclassification of EHR-derived disease status and lack of representativeness of the study sample can result in substantial bias in effect estimates and can impact power and type I error for association tests. Here, the assumed target of inference is the relationship between binary disease status and predictors modeled using a logistic regression model. SAMBA implements several methods for obtaining bias-corrected point estimates along with valid standard errors as proposed in Beesley and Mukherjee (2020) <doi:10.1101/2019.12.26.19015859>, currently under review.
Pleiotropy-informed significance analysis of genome-wide association studies with surrogate functional false discovery rates (sfFDR). The sfFDR framework adapts the fFDR to leverage informative data from multiple sets of GWAS summary statistics to increase power in study while accommodating for linkage disequilibrium. sfFDR provides estimates of key FDR quantities in a significance analysis such as the functional local FDR and $q$-value, and uses these estimates to derive a functional $p$-value for type I error rate control and a functional local Bayes factor for post-GWAS analyses (e.g., fine mapping and colocalization).
Rapidly build accurate genetic prediction models for genome-wide association or whole-genome sequencing study data by smooth-threshold multivariate genetic prediction (STMGP) method. Variable selection is performed using marginal association test p-values with an optimal p-value cutoff selected by Cp-type criterion. Quantitative and binary traits are modeled respectively via linear and logistic regression models. A function that works through PLINK software (Purcell et al. 2007 <DOI:10.1086/519795>, Chang et al. 2015 <DOI:10.1186/s13742-015-0047-8>) <https://www.cog-genomics.org/plink2> is provided. Covariates can be included in regression model.
This package implements the SISAL algorithm by Tikka and Hollmén. It is a sequential backward selection algorithm which uses a linear model in a cross-validation setting. Starting from the full model, one variable at a time is removed based on the regression coefficients. From this set of models, a parsimonious (sparse) model is found by choosing the model with the smallest number of variables among those models where the validation error is smaller than a threshold. Also implements extensions which explore larger parts of the search space and/or use ridge regression instead of ordinary least squares.
ISLET is a method to conduct signal deconvolution for general -omics data. It can estimate the individual-specific and cell-type-specific reference panels, when there are multiple samples observed from each subject. It takes the input of the observed mixture data (feature by sample matrix), and the cell type mixture proportions (sample by cell type matrix), and the sample-to-subject information. It can solve for the reference panel on the individual-basis and conduct test to identify cell-type-specific differential expression (csDE) genes. It also improves estimated cell type mixture proportions by integrating personalized reference panels.
Our recently developed fully robust Bayesian semiparametric mixed-effect model for high-dimensional longitudinal studies with heterogeneous observations can be implemented through this package. This model can distinguish between time-varying interactions and constant-effect-only cases to avoid model misspecifications. Facilitated by spike-and-slab priors, this model leads to superior performance in estimation, identification and statistical inference. In particular, robust Bayesian inferences in terms of valid Bayesian credible intervals on both parametric and nonparametric effects can be validated on finite samples. The Markov chain Monte Carlo algorithms of the proposed and alternative models are efficiently implemented in C++'.
This package provides a suite of loon related packages providing data analytic tools for Direct Interactive Visual Exploration in R ('diveR'). These tools work with and complement those of the tidyverse suite, extending the grammar of ggplot2 to become a grammar of interactive graphics. The suite provides many visual tools designed for moderately (100s of variables) high dimensional data analysis, through zenplots and novel tools in loon', and extends the ggplot2 grammar to provide parallel coordinates, Andrews plots, and arbitrary glyphs through ggmulti'. The diveR package gathers together and installs all these related packages in a single step.
An interface for fitting generalized additive models (GAMs) and generalized additive mixed models (GAMMs) using the lme4 package as the computational engine, as described in Helwig (2024) <doi:10.3390/stats7010003>. Supports default and formula methods for model specification, additive and tensor product splines for capturing nonlinear effects, and automatic determination of spline type based on the class of each predictor. Includes an S3 plot method for visualizing the (nonlinear) model terms, an S3 predict method for forming predictions from a fit model, and an S3 summary method for conducting significance testing using the Bayesian interpretation of a smoothing spline.
Meta-analysis traditionally assigns more weight to studies with lower standard errors, assuming higher precision. However, in observational research, precision must be estimated and is vulnerable to manipulation, such as p-hacking, to achieve statistical significance. This can lead to spurious precision, invalidating inverse-variance weighting and bias-correction methods like funnel plots. Common methods for addressing publication bias, including selection models, often fail or exacerbate the problem. This package introduces an instrumental variable approach to limit bias caused by spurious precision in meta-analysis. Methods are described in Irsova et al. (2025) <doi:10.1038/s41467-025-63261-0>.
Implementations of MOSUM-based statistical procedures and algorithms for detecting multiple changes in the mean. This comprises the MOSUM procedure for estimating multiple mean changes from Eichinger and Kirch (2018) <doi:10.3150/16-BEJ887> and the multiscale algorithmic extension from Cho and Kirch (2022) <doi:10.1007/s10463-021-00811-5>, as well as the bootstrap procedure for generating confidence intervals about the locations of change points as proposed in Cho and Kirch (2022) <doi:10.1016/j.csda.2022.107552>. See also Meier, Kirch and Cho (2021) <doi:10.18637/jss.v097.i08> which accompanies the R package.
This package provides a collection of statistical tools for objective (non-supervised) applications of the Regional Frequency Analysis methods in hydrology. The package refers to the index-value method and, more precisely, helps the hydrologist to: (1) regionalize the index-value; (2) form homogeneous regions with similar growth curves; (3) fit distribution functions to the empirical regional growth curves. Most of the methods are those described in the Flood Estimation Handbook (Centre for Ecology & Hydrology, 1999, ISBN:9781906698003). Homogeneity tests from Hosking and Wallis (1993) <doi:10.1029/92WR01980> and Viglione et al. (2007) <doi:10.1029/2006WR005095> are available.
This package provides a tool for survival analysis using a discrete time approach with ensemble binary classification. spect provides a simple interface consistent with commonly used R data analysis packages, such as caret', a variety of parameter options to help facilitate search automation, a high degree of transparency to the end-user - all intermediate data sets and parameters are made available for further analysis and useful, out-of-the-box visualizations of model performance. Methods for transforming survival data into discrete-time are adapted from the autosurv package by Suresh et al., (2022) <doi:10.1186/s12874-022-01679-6>.