This package provides a preprocessing pipeline for single cell RNA-seq/ATAC-seq data that starts from the fastq files and produces a feature count matrix with associated quality control information. It can process fastq data generated by CEL-seq, MARS-seq, Drop-seq, Chromium 10x and SMART-seq protocols.

The signeR package provides an empirical Bayesian approach to mutational signature discovery. It is designed to analyze single nucleotide variation (SNV) counts in cancer genomes, but can also be applied to other features as well. Functionalities to characterize signatures or genome samples according to exposure patterns are also provided.

This package provides a tidy text corpus of Aesop's Fables sourced from the Library of Congress, along with analysis-ready datasets for sentiment, emotion, and linguistic analysis of moral storytelling. The package includes both full narrative texts and word-level representations to support exploratory text analysis and teaching workflows.

Bayesian dynamic borrowing with covariate adjustment via inverse probability weighting for simulations and data analyses in clinical trials. This makes it easy to use propensity score methods to balance covariate distributions between external and internal data. This methodology based on Psioda et al (2025) <doi:10.1080/10543406.2025.2489285>.

Constrained quantile regression is performed. One constraint is that all beta coefficients (including the constant) cannot be negative, they can be either 0 or strictly positive. Another constraint is that the beta coefficients lie within an interval. References: Koenker R. (2005) Quantile Regression, Cambridge University Press. <doi:10.1017/CBO9780511754098>.

Correlates of protection (CoP) and correlates of risk (CoR) study the immune biomarkers associated with an infectious disease outcome, e.g. COVID or HIV-1 infection. This package contains shared functions for analyzing CoP and CoR, including bootstrapping procedures, competing risk estimation, and bootstrapping marginalized risks.

Enables user interactivity with large-language models ('LLM') inside the RStudio integrated development environment (IDE). The user can interact with the model using the shiny app included in this package, or directly in the R console. It comes with back-ends for OpenAI', GitHub Copilot', and LlamaGPT'.

Exploration of simulation models (apps) of various infectious disease transmission dynamics scenarios. The purpose of the package is to help individuals learn about infectious disease epidemiology (ecology/evolution) from a dynamical systems perspective. All apps include explanations of the underlying models and instructions on what to do with the models.

This package provides tools to estimate and manage empirical distributions, which should work with survey data. One of the main features is the possibility to create data cubes of estimated statistics, that include all the combinations of the variables of interest (see for example functions dcc5() and dcc6()).

This package provides a collection of functions to estimate parameters of a diffusion model via a D*M analysis. Build in models are: the Ratcliff diffusion model, the RWiener diffusion model, and Linear Ballistic Accumulator models. Custom models functions can be specified as long as they have a density function.

This package provides functions and example datasets to run a decision-analytic model for prevention and treatment strategies across depression severity states (sub-clinical, mild, moderate, severe, and recurrent). The package supports scenario analyses (base and alternative inputs) and summarises outcomes such as coverage, adherence, effect sizes, and healthcare costs.

Simulation models (apps) of various within-host immune response scenarios. The purpose of the package is to help individuals learn about within-host infection and immune response modeling from a dynamical systems perspective. All apps include explanations of the underlying models and instructions on what to do with the models.

DataSHIELD is an infrastructure and series of R packages that enables the remote and non-disclosive analysis of sensitive research data. This DataSHIELD Interface implementation is for analyzing datasets living in the current R session. The purpose of this is primarily for lightweight DataSHIELD analysis package development.

The core of this package is a function eDT() which enhances DT::datatable() such that it can be used to interactively modify data in shiny'. By the use of generic dplyr methods it supports many types of data storage, with relational databases ('dbplyr') being the main use case.

Given a continuous-time dynamic network, this package allows one to fit a stochastic blockmodel where nodes belonging to the same group create interactions and non-interactions of similar lengths. This package implements the methodology described by R. Rastelli and M. Fop (2020) <doi:10.1007/s11634-020-00403-w>.

Simulates from discrete and continuous target distributions using geometric Metropolis-Hastings (MH) algorithms. Users specify the target distribution by an R function that evaluates the log un-normalized pdf or pmf. The package also contains a function implementing a specific geometric MH algorithm for performing high dimensional Bayesian variable selection.

Maps of France in 1830, multivariate datasets from A.-M. Guerry and others, and statistical and graphic methods related to Guerry's "Moral Statistics of France". The goal is to facilitate the exploration and development of statistical and graphic methods for multivariate data in a geospatial context of historical interest.

Constructs tables of counts and proportions out of data sets with possibility to insert tables to Excel, Word, HTML, and PDF documents. Transforms tables to data suitable for modelling. Features Gibbs sampling based log-linear (NB2) and power analyses (original by Oleksandr Ocheredko <doi:10.35566/isdsa2019c5>) for tabulated data.

Maximum entropy density based dependent data bootstrap. An algorithm is provided to create a population of time series (ensemble) without assuming stationarity. The reference paper (Vinod, H.D., 2004 <DOI:10.1016/j.jempfin.2003.06.002>) explains how the algorithm satisfies the ergodic theorem and the central limit theorem.

Quantifies and removes technical noise from high-throughput sequencing data. Two approaches are used, one based on the count matrix, and one using the alignment BAM files directly. Contains several options for every step of the process, as well as tools to quality check and assess the stability of output.

Statistical tools for analyzing time-to-event data using machine learning. Implements survival stacking for conditional survival estimation, standardized survival function estimation for current status data, and methods for algorithm-agnostic variable importance. See Wolock CJ, Gilbert PB, Simon N, and Carone M (2024) <doi:10.1080/10618600.2024.2304070>.

Create carousels using the JavaScript library Swiper and the package htmlwidgets'. The carousels can be displayed in the RStudio viewer pane, in Shiny applications and in R markdown documents. The package also provides a RStudio addin allowing to choose image files and to display them in the viewer pane.

Two one-sided tests (TOST) procedure to test equivalence for t-tests, correlations, differences between proportions, and meta-analyses, including power analysis for t-tests and correlations. Allows you to specify equivalence bounds in raw scale units or in terms of effect sizes. See: Lakens (2017) <doi:10.1177/1948550617697177>.

Craft polished tables and plots in Markdown reports. Simply choose whether to treat your data as counts or metrics, and the package will automatically generate well-designed default tables and plots for you. Boiled down to the basics, with labeling features and simple interactive reports. All functions are tidyverse compatible.