The tictoc package provides the timing functions tic and toc that can be nested. It provides an alternative to system.time() with a different syntax similar to that in another well-known software package. tic and toc are easy to use, and are especially useful when timing several sections in more than a few lines of code.

This package provides an implementation of an algorithm for general-purpose unconstrained non-linear optimization. The algorithm is of quasi-Newton type with BFGS updating of the inverse Hessian and soft line search with a trust region type monitoring of the input to the line search algorithm. The interface of ucminf is designed for easy interchange with the package optim.

This package contains two main functions. The first is fdr.ma which takes normalized expression data array, experimental design and computes adjusted p-values It returns the fdr adjusted p-values and plots, according to the methods described in (Reiner, Yekutieli and Benjamini 2002). The second, is fdr.gui() which creates a simple graphic user interface to access fdr.ma.

HubPub provides users with functionality to help with the Bioconductor Hub structures. The package provides the ability to create a skeleton of a Hub style package that the user can then populate with the necessary information. There are also functions to help add resources to the Hub package metadata files as well as publish data to the Bioconductor S3 bucket.

icetea (Integrating Cap Enrichment with Transcript Expression Analysis) provides functions for end-to-end analysis of multiple 5'-profiling methods such as CAGE, RAMPAGE and MAPCap, beginning from raw reads to detection of transcription start sites using replicates. It also allows performing differential TSS detection between group of samples, therefore, integrating the mRNA cap enrichment information with transcript expression analysis.

This package fits a model to the pattern of dropouts in single-cell RNASeq data. This model is used as a null to identify significantly variable (i.e. differentially expressed) genes for use in downstream analysis, such as clustering cells. Also includes an method for calculating exact Pearson residuals in UMI-tagged data using a library-size aware negative binomial model.

standR is an user-friendly R package providing functions to assist conducting good-practice analysis of Nanostring's GeoMX DSP data. All functions in the package are built based on the SpatialExperiment object, allowing integration into various spatial transcriptomics-related packages from Bioconductor. standR allows data inspection, quality control, normalization, batch correction and evaluation with informative visualizations.

The pattern of digestion and protection from DNA nucleases such as DNAse I, micrococcal nuclease, and Tn5 transposase can be used to infer the location of associated proteins. This package contains useful functions to analyze patterns of paired-end sequencing fragment density. VplotR facilitates the generation of V-plots and footprint profiles over single or aggregated genomic loci of interest.

Create, upload and run Acumos R models. Acumos (<https://www.acumos.org>) is a platform and open source framework intended to make it easy to build, share, and deploy AI apps. Acumos is part of the LF AI Foundation', an umbrella organization within The Linux Foundation'. With this package, user can create a component, and push it to an Acumos platform.

Fit various smoothing spline models. Includes an ssr() function for smoothing spline regression, an nnr() function for nonparametric nonlinear regression, an snr() function for semiparametric nonlinear regression, an slm() function for semiparametric linear mixed-effects models, and an snm() function for semiparametric nonlinear mixed-effects models. See Wang (2011) <doi:10.1201/b10954> for an overview.

This package implements Bayesian inference to detect signal from blinded clinical trial when total number of adverse events of special concerns and total risk exposures from all patients are available in the study. For more details see the article by Mukhopadhyay et. al. (2018) titled Bayesian Detection of Potential Risk Using Inference on Blinded Safety Data', in Pharmaceutical Statistics (to appear).

This package provides functions to compute the joint probability mass function (pmf), cumulative distribution function (cdf), and survival function (sf) of the Basu-Dhar bivariate geometric distribution. Additional functionalities include the calculation of the correlation coefficient, covariance, and cross-factorial moments, as well as the generation of random variates. The package also implements parameter estimation based on the method of moments.

This package provides classes (S4) of circular-linear, symmetric copulas with corresponding methods, extending the copula package. These copulas are especially useful for modeling correlation in discrete-time movement data. Methods for density, (conditional) distribution, random number generation, bivariate dependence measures and fitting parameters using maximum likelihood and other approaches. The package also contains methods for visualizing movement data and copulas.

This package provides the analysis of variance table including the expected mean squares (EMS) for various types of experimental design. When some variables are random effects or we use special experimental design such as nested design, repeated-measures design, or split-plot design, it is not easy to find the appropriate test, especially denominator for F-statistic which depends on EMS.

Classical (bottom-up and top-down), optimal combination and heuristic point (Di Fonzo and Girolimetto, 2023 <doi:10.1016/j.ijforecast.2021.08.004>) and probabilistic (Girolimetto et al. 2024 <doi:10.1016/j.ijforecast.2023.10.003>) forecast reconciliation procedures for linearly constrained time series (e.g., hierarchical or grouped time series) in cross-sectional, temporal, or cross-temporal frameworks.

Triangular and trapezoidal fuzzy numbers are used to study fuzzy logic, fuzzy reasoning and approximating, fuzzy regression models, etc. This package builds the generating function for triangular and trapezoidal fuzzy numbers based on Souliotis et al. (2022)<doi:10.3390/math10183350>. They proposed a method for the construction of fuzzy numbers via a cumulative distribution function based on the possibility theory.

Miscellaneous convenience functions and wrapper functions to convert frequencies between Hz, semitones, mel and Bark, to create a matrix of dummy columns from a factor, to determine whether x lies in range [a,b], and to add a bracketed line to an existing plot. This package also contains an example data set of a stratified sample of 80 talkers of Dutch.

This package performs a homogeneity analysis (multiple correspondence analysis) and various extensions. Rank restrictions on the category quantifications can be imposed (nonlinear PCA). The categories are transformed by means of optimal scaling with options for nominal, ordinal, and numerical scale levels (for rank-1 restrictions). Variables can be grouped into sets, in order to emulate regression analysis and canonical correlation analysis.

Item response theory (IRT) parameter estimation using marginal maximum likelihood and expectation-maximization algorithm (Bock \& Aitkin, 1981 <doi:10.1007/BF02293801>). Within parameter estimation algorithm, several methods for latent distribution estimation are available. Reflecting some features of the true latent distribution, these latent distribution estimation methods can possibly enhance the estimation accuracy and free the normality assumption on the latent distribution.

Select set of parametric and non-parametric statistical tests. inferr builds upon the solid set of statistical tests provided in stats package by including additional data types as inputs, expanding and restructuring the test results. The tests included are t tests, variance tests, proportion tests, chi square tests, Levene's test, McNemar Test, Cochran's Q test and Runs test.

Modular implementation of Multiobjective Evolutionary Algorithms based on Decomposition (MOEA/D) [Zhang and Li (2007), <DOI:10.1109/TEVC.2007.892759>] for quick assembling and testing of new algorithmic components, as well as easy replication of published MOEA/D proposals. The full framework is documented in a paper published in the Journal of Statistical Software [<doi:10.18637/jss.v092.i06>].

Implementation of marginalized models for zero-inflated count data. This package provides a tool to implement an estimation algorithm for the marginalized count models, which directly makes inference on the effect of each covariate on the marginal mean of the outcome. The method involves the marginalized zero-inflated Poisson model described in Long et al. (2014) <doi:10.1002/sim.6293>.

This package provides tools from the domain of graph theory can be used to quantify the complexity and vulnerability to failure of a software package. That is the guiding philosophy of this package. pkgnet provides tools to analyze the dependencies between functions in an R package and between its imported packages. See the pkgnet website for vignettes and other supplementary information.

Bayesian variable selection for linear regression models using hierarchical priors. There is a prior that combines information across responses and one that combines information across covariates, as well as a standard spike and slab prior for comparison. An MCMC samples from the marginal posterior distribution for the 0-1 variables indicating if each covariate belongs to the model for each response.