The BACON algorithms are methods for multivariate outlier nomination (detection) and robust linear regression by Billor, Hadi, and Velleman (2000) <doi:10.1016/S0167-9473(99)00101-2>. The extension to weighted problems is due to Beguin and Hulliger (2008) <https://www150.statcan.gc.ca/n1/en/catalogue/12-001-X200800110616>; see also <doi:10.21105/joss.03238>.

MEIGOR provides a comprehensive environment for performing global optimization tasks in bioinformatics and systems biology. It leverages advanced metaheuristic algorithms to efficiently search the solution space and is specifically tailored to handle the complexity and high-dimensionality of biological datasets. This package supports various optimization routines and is integrated with Bioconductor's infrastructure for a seamless analysis workflow.

An R package for multiple-group comparison to detect tissue/cell-specific marker genes among subtypes. It provides functions to compute OVESEG-test statistics, derive component weights in the mixture null distribution model and estimate p-values from weightedly aggregated permutations. Obtained posterior probabilities of component null hypotheses can also portrait all kinds of upregulation patterns among subtypes.

r128gain is a multi platform command line tool to scan your audio files and tag them with loudness metadata (ReplayGain v2 or Opus R128 gain format), to allow playback of several tracks or albums at a similar loudness level. r128gain can also be used as a Python module from other Python projects to scan and/or tag audio files.

This R package lets you estimate signatures of mutational processes and their activities on mutation count data. Starting from a set of single-nucleotide variants (SNVs), it allows both estimation of the exposure of samples to predefined mutational signatures (including whether the signatures are present at all), and identification of signatures de novo from the mutation counts.

This package provides tools for data importation, recoding, and inspection. There are functions to create new project folders, R code templates, create uniquely named output directories, and to quickly obtain a visual summary for each variable in a data frame. The main feature here is the systematic implementation of the "variable key" framework for data importation and recoding.

Nucleotide conversion sequencing experiments have been developed to add a temporal dimension to RNA-seq and single-cell RNA-seq. Such experiments require specialized tools for primary processing such as GRAND-SLAM, and specialized tools for downstream analyses. grandR provides a comprehensive toolbox for quality control, kinetic modeling, differential gene expression analysis and visualization of such data.

Redshift adjusts the color temperature according to the position of the sun. A different color temperature is set during night and daytime. During twilight and early morning, the color temperature transitions smoothly from night to daytime temperature to allow your eyes to slowly adapt. At night the color temperature should be set to match the lamps in your room.

Analysis of DNA mixtures involving relatives by computation of likelihood ratios that account for dropout and drop-in, mutations, silent alleles and population substructure. This is useful in kinship cases, like non-invasive prenatal paternity testing, where deductions about individuals relationships rely on DNA mixtures, and in criminal cases where the contributors to a mixed DNA stain may be related. Relationships are represented by pedigrees and can include kinship between more than two individuals. The main function is relMix() and its graphical user interface relMixGUI(). The implementation and method is described in Dorum et al. (2017) <doi:10.1007/s00414-016-1526-x>, Hernandis et al. (2019) <doi:10.1016/j.fsigss.2019.09.085> and Kaur et al. (2016) <doi:10.1007/s00414-015-1276-1>.

Helps users in quickly visualizing risk-of-bias assessments performed as part of a systematic review. It allows users to create weighted bar-plots of the distribution of risk-of-bias judgments within each bias domain, in addition to traffic-light plots of the specific domain-level judgments for each study. The resulting figures are of publication quality and are formatted according the risk-of-bias assessment tool use to perform the assessments. Currently, the supported tools are ROB2.0 (for randomized controlled trials; Sterne et al (2019) <doi:10.1136/bmj.l4898>), ROBINS-I (for non-randomised studies of interventions; Sterne et al (2016) <doi:10.1136/bmj.i4919>), and QUADAS-2 (for diagnostic accuracy studies; Whiting et al (2011) <doi:10.7326/0003-4819-155-8-201110180-00009>).

This package provides a set of functions for receiver operating characteristic (ROC) curve estimation and area under the curve (AUC) calculation. All functions are designed to work with aggregated data; nevertheless, they can also handle raw samples. In ROCket', we distinguish two types of ROC curve representations: 1) parametric curves - the true positive rate (TPR) and the false positive rate (FPR) are functions of a parameter (the score), 2) functions - TPR is a function of FPR. There are several ROC curve estimation methods available. An introduction to the mathematical background of the implemented methods (and much more) can be found in de Zea Bermudez, Gonçalves, Oliveira & Subtil (2014) <https://www.ine.pt/revstat/pdf/rs140101.pdf> and Cai & Pepe (2004) <doi:10.1111/j.0006-341X.2004.00200.x>.

This package contains tools for working with data during statistical analysis, promoting flexible, intuitive, and reproducible workflows. There are functions designated for specific statistical tasks such building a custom univariate descriptive table, computing pairwise association statistics, etc. These are built on a collection of data manipulation tools designed for general use that are motivated by the functional programming concept.

This package implements a kernel-based association test for copy number variation (CNV) aggregate analysis in a certain genomic region (e.g., gene set, chromosome, or genome) that is robust to the within-locus and across-locus etiological heterogeneity, and bypass the need to define a "locus" unit for CNVs. Brucker, A., et al. (2020) <doi:10.1101/666875>.

Interact with Condor from R via SSH connection. Files are first uploaded from user machine to submitter machine, and the job is then submitted from the submitter machine to Condor'. Functions are provided to submit, list, and download Condor jobs from R. Condor is an open source high-throughput computing software framework for distributed parallelization of computationally intensive tasks.

This package produces diversity estimates and species lists with associated global distribution for any vascular plant family and genus from Plants of the World Online database <https://powo.science.kew.org/>, by interacting with the source code of each plant taxon page. It also creates global maps of species richness, graphics of species discoveries and nomenclatural changes over time.

This Rcpp'-based package implements highly efficient functions for the calculation of the Jonckheere-Terpstra statistic. It can be used for a variety of applications, including feature selection in machine learning problems, or to conduct genome-wide association studies (GWAS) with multiple quantitative phenotypes. The code leverages OpenMP directives for multi-core computing to reduce overall processing time.

This package contains functions for operations with fuzzy cognitive maps using t-norm and s-norm operators. T-norms and S-norms are described by Dov M. Gabbay and George Metcalfe (2007) <doi:10.1007/s00153-007-0047-1>. System indicators are described by Cox, Earl D. (1995) <isbn:1886801010>. Executable examples are provided in the "inst/examples" folder.

This package contains Rcpp and RcppEigen implementations of matrix operations useful for Gaussian process models, such as the inversion of a symmetric Toeplitz matrix, sampling from multivariate normal distributions, evaluation of the log-density of a multivariate normal vector, and Bayesian inference for latent variable Gaussian process models with elliptical slice sampling (Murray, Adams, and MacKay 2010).

Approximate frequentist inference for generalized linear mixed model analysis with expectation propagation used to circumvent the need for multivariate integration. In this version, the random effects can be any reasonable dimension. However, only probit mixed models with one level of nesting are supported. The methodology is described in Hall, Johnstone, Ormerod, Wand and Yu (2018) <arXiv:1805.08423v1>.

H-index and h-alpha are a bibliometric indicators. This package provides functions to simulate how these indicators may develop over time for a given set of researchers and to visualize the simulation data. The implementation is based on the STATA ado h-index and is described in more detail in Bornmann et al. (2019) <arXiv:1905.11052>.

An RStudio Addin for Hippie Expand (AKA Hippie Code Completion or Cyclic Expand Word). This type of completion searches for matching tokens within the user's current source editor file, regardless of file type. By searching only within the current source file, hippie offers a fast way to identify and insert completions that appear around the user's cursor.

This package provides a set of streamlined functions that allow easy generation of linear regression diagnostic plots necessarily for checking linear model assumptions. This package is meant for easy scheming of linear regression diagnostics, while preserving merits of "The Grammar of Graphics" as implemented in ggplot2'. See the ggplot2 website for more information regarding the specific capability of graphics.

Analyses species distribution models and evaluates their performance. It includes functions for variation partitioning, extracting variable importance, computing several metrics of model discrimination and calibration performance, optimizing prediction thresholds based on a number of criteria, performing multivariate environmental similarity surface (MESS) analysis, and displaying various analytical plots. Initially described in Barbosa et al. (2013) <doi:10.1111/ddi.12100>.

This package provides a way to estimate and test marginal mediation effects for zero-inflated compositional mediators. Estimates of Natural Indirect Effect (NIE), Natural Direct Effect (NDE) of each taxon, as well as their standard errors and confident intervals, were provided as outputs. Zeros will not be imputed during analysis. See Wu et al. (2022) <doi:10.3390/genes13061049>.