Utilities for single nucleotide polymorphism (SNP) based kinship analysis testing and evaluation. The skater package contains functions for importing, parsing, and analyzing pedigree data, performing relationship degree inference, benchmarking relationship degree classification, and summarizing identity by descent (IBD) segment data. Package functions and methods are described in Turner et al. (2021) "skater: An R package for SNP-based Kinship Analysis, Testing, and Evaluation" <doi:10.1101/2021.07.21.453083>.

Similarity regression, evaluating the probability of association between sets of ontological terms and binary response vector. A no-association model is compared with one in which the log odds of a true response is linked to the semantic similarity between terms and a latent characteristic ontological profile - Phenotype Similarity Regression for Identifying the Genetic Determinants of Rare Diseases', Greene et al 2016 <doi:10.1016/j.ajhg.2016.01.008>.

Sample size calculation to detect dynamic treatment regime (DTR) effects based on change in clinical attachment level (CAL) outcomes from a non-surgical chronic periodontitis treatments study. The experiment is performed under a Sequential Multiple Assignment Randomized Trial (SMART) design. The clustered tooth (sub-unit) level CAL outcomes are skewed, spatially-referenced, and non-randomly missing. The implemented algorithm is available in Xu et al. (2019+) <arXiv:1902.09386>.

Stationary subspace analysis (SSA) is a blind source separation (BSS) variant where stationary components are separated from non-stationary components. Several SSA methods for multivariate time series are provided here (Flumian et al. (2021); Hara et al. (2010) <doi:10.1007/978-3-642-17537-4_52>) along with functions to simulate time series with time-varying variance and autocovariance (Patilea and Raissi(2014) <doi:10.1080/01621459.2014.884504>).

This package provides a simple approach for constructing dynamic materials modeling suggested by Prasad and Gegel (1984) <doi:10.1007/BF02664902>. It can easily generate various processing-maps based on this model as well. The calculation result in this package contains full materials constants, information about power dissipation efficiency factor, and rheological properties, can be exported completely also, through which further analysis and customized plots will be applicable as well.

Computes a point pattern in R^2 or on a graph that is representative of a collection of many data patterns. The result is an approximate barycenter (also known as Fréchet mean or prototype) based on a transport-transform metric. Possible choices include Optimal SubPattern Assignment (OSPA) and Spike Time metrics. Details can be found in Müller, Schuhmacher and Mateu (2020) <doi:10.1007/s11222-020-09932-y>.

Mixed type vectors are useful for combining semantically similar classes. Some examples of semantically related classes include time across different granularities (e.g. daily, monthly, annual) and probability distributions (e.g. Normal, Uniform, Poisson). These groups of vector types typically share common statistical operations which vary in results with the attributes of each vector. The vecvec data structure facilitates efficient storage and computation across multiple vectors within the same object.

Toolkit to support and perform discrete event simulations with and without resource constraints in the context of health technology assessments (HTA). The package focuses on cost-effectiveness modelling and aims to be submission-ready to relevant HTA bodies in alignment with NICE TSD 15 <https://sheffield.ac.uk/nice-dsu/tsds/patient-level-simulation>. More details an examples can be found in the package website <https://jsanchezalv.github.io/WARDEN/>.

Enables researchers to sample redistricting plans from a pre-specified target distribution using Sequential Monte Carlo and Markov Chain Monte Carlo algorithms. The package allows for the implementation of various constraints in the redistricting process such as geographic compactness and population parity requirements. Tools for analysis such as computation of various summary statistics and plotting functionality are also included. The package implements the SMC algorithm of McCartan and Imai (2023) <doi:10.1214/23-AOAS1763>, the enumeration algorithm of Fifield, Imai, Kawahara, and Kenny (2020) <doi:10.1080/2330443X.2020.1791773>, the Flip MCMC algorithm of Fifield, Higgins, Imai and Tarr (2020) <doi:10.1080/10618600.2020.1739532>, the Merge-split/Recombination algorithms of Carter et al. (2019) <doi:10.48550/arXiv.1911.01503> and DeFord et al. (2021) <doi:10.1162/99608f92.eb30390f>, and the Short-burst optimization algorithm of Cannon et al. (2020) <doi:10.48550/arXiv.2011.02288>.

This package implements core utilities for single-cell RNA-seq data analysis. Contained within are utility functions for working with DE matrices and count matrices, a collection of functions for manipulating and plotting data via ggplot2, and functions to work with cell graphs and cell embeddings. Graph-based methods include embedding kNN cell graphs into a UMAP, collapsing vertices of each cluster in the graph, and propagating graph labels.

This is an alternative mechanism for importing objects from packages. The syntax allows for importing multiple objects from a package with a single command in an expressive way. The import package bridges some of the gap between using library (or require) and direct (single-object) imports. Furthermore the imported objects are not placed in the current environment. It is also possible to import objects from stand-alone .R files.

Circle Manhattan Plot is an R package that can lay out genome-wide association study P-value results in both traditional rectangular patterns, QQ-plot and novel circular ones. United in only one bull's eye style plot, association results from multiple traits can be compared interactively, thereby to reveal both similarities and differences between signals. Additional functions include: highlight signals, a group of SNPs, chromosome visualization and candidate genes around SNPs.

Infer biological pathway activity of cells from single-cell RNA-sequencing data by calculating a pathway score for each cell (pathway genes are specified by the user). It is recommended to have the data in Transcripts-Per-Million (TPM) or Counts-Per-Million (CPM) units for best results. Scores may change when adding cells to or removing cells off the data. SiPSiC stands for Single Pathway analysis in Single Cells.

Self-organizing maps (also known as SOM, see Kohonen (2001) <doi:10.1007/978-3-642-56927-2>) are a method for dimensionality reduction and clustering of continuous data. This package introduces interactive (html) graphics for easier analysis of SOM results. It also features an interactive interface, for push-button training and visualization of SOM on numeric, categorical or mixed data, as well as tools to evaluate the quality of SOM.

This R package offers block Gibbs samplers for the Bayesian (adaptive) graphical lasso, ridge, and naive elastic net priors. These samplers facilitate the simulation of the posterior distribution of precision matrices for Gaussian distributed data and were originally proposed by: Wang (2012) <doi:10.1214/12-BA729>; Smith et al. (2022) <doi:10.48550/arXiv.2210.16290> and Smith et al. (2023) <doi:10.48550/arXiv.2306.14199>, respectively.

This package performs Correspondence Analysis on the given dataframe and plots the results in a scatterplot that emphasizes the geometric interpretation aspect of the analysis, following Borg-Groenen (2005) and Yelland (2010). It is particularly useful for highlighting the relationships between a selected row (or column) category and the column (or row) categories. See Borg-Groenen (2005, ISBN:978-0-387-28981-6); Yelland (2010) <doi:10.3888/tmj.12-4>.

Statistical tests for the comparison between two or more alpha coefficients based on either dependent or independent groups of individuals. A web interface is available at http://comparingcronbachalphas.org. A plugin for the R GUI and IDE RKWard is included. Please install RKWard from https:// rkward.kde.org to use this feature. The respective R package rkward cannot be installed directly from a repository, as it is a part of RKWard.

This package provides constrained triangulation of polygons. Ear cutting (or ear clipping) applies constrained triangulation by successively cutting triangles from a polygon defined by path/s. Holes are supported by introducing a bridge segment between polygon paths. This package wraps the header-only library earcut.hpp <https://github.com/mapbox/earcut.hpp> which includes a reference to the method used by Held, M. (2001) <doi:10.1007/s00453-001-0028-4>.

Programmatic interface to the European Centre for Medium-Range Weather Forecasts dataset web services (ECMWF; <https://www.ecmwf.int/>) and Copernicus's Data Stores. Allows for easy downloads of weather forecasts and climate reanalysis data in R. Data stores covered include the Climate Data Store (CDS; <https://cds.climate.copernicus.eu>), Atmosphere Data Store (ADS; <https://ads.atmosphere.copernicus.eu>) and Early Warning Data Store (CEMS; <https://ewds.climate.copernicus.eu>).

This package provides methods for closed testing using Simes local tests. In particular, calculates adjusted p-values for Hommel's multiple testing method, and provides lower confidence bounds for true discovery proportions. A robust but more conservative variant of the closed testing procedure that does not require the assumption of Simes inequality is also implemented. The methods have been described in detail in Goeman et al (Biometrika 106, 841-856, 2019).

Build powerful, linked-view dashboards in shiny applications. With a declarative, one-line setup, you can create bidirectional links between interactive components. When a user interacts with one element (e.g., clicking a map marker), all linked components (such as DT tables or other charts) instantly update. Supports leaflet maps, DT tables, plotly charts, and spatial data via sf objects out-of-the-box, with an extensible API for custom components.

Inspired by pattern matching and enum types in Rust and many functional programming languages, this package offers an updated version of the switch function called Match that accepts atomic values, functions, expressions, and enum variants. Conditions and return expressions are separated by -> and multiple conditions can be associated with the same return expression using |'. Match also includes support for fallthrough'. The package also replicates the Result and Option enums from Rust.

Straightforward and detailed evaluation of machine learning models. MLeval can produce receiver operating characteristic (ROC) curves, precision-recall (PR) curves, calibration curves, and PR gain curves. MLeval accepts a data frame of class probabilities and ground truth labels, or, it can automatically interpret the Caret train function results from repeated cross validation, then select the best model and analyse the results. MLeval produces a range of evaluation metrics with confidence intervals.

Developed for the following tasks. 1- simulating realizations from the canonical, restricted, and unrestricted finite mixture models. 2- Monte Carlo approximation for density function of the finite mixture models. 3- Monte Carlo approximation for the observed Fisher information matrix, asymptotic standard error, and the corresponding confidence intervals for parameters of the mixture models sing the method proposed by Basford et al. (1997) <https://espace.library.uq.edu.au/view/UQ:57525>.