This package provides the dose transition pathways (DTP) to project in advance the doses recommended by a model-based design for subsequent patients (stay, escalate, deescalate or stop early) using all the accumulated toxicity information; See Yap et al (2017) <doi: 10.1158/1078-0432.CCR-17-0582>. DTP can be used as a design and an operational tool and can be displayed as a table or flow diagram. The dtpcrm package also provides the modified continual reassessment method (CRM) and time-to-event CRM (TITE-CRM) with added practical considerations to allow stopping early when there is sufficient evidence that the lowest dose is too toxic and/or there is a sufficient number of patients dosed at the maximum tolerated dose.

This package provides a weekly, monthly, yearly summary of dengue cases by state/ province/ country.

Comparison of the accuracy of two binary diagnostic tests in a "paired" study design, i.e. when each test is applied to each subject in the study.

This package provides a software package for using DEXi models. DEXi models are hierarchical qualitative multi-criteria decision models developed according to the method DEX (Decision EXpert, <https://dex.ijs.si/documentation/DEX_Method/DEX_Method.html>), using the program DEXi (<https://kt.ijs.si/MarkoBohanec/dexi.html>) or DEXiWin (<https://dex.ijs.si/dexisuite/dexiwin.html>). A typical workflow with DEXiR consists of: (1) reading a .dxi file, previously made using the DEXi software (function read_dexi()), (2) making a data frame containing input values of one or more decision alternatives, (3) evaluating those alternatives (function evaluate()), (4) analyzing alternatives (selective_explanation(), plus_minus(), compare_alternatives()), (5) drawing charts. DEXiR is restricted to using models produced externally by the DEXi software and does not provide functionality for creating and/or editing DEXi models directly in R'.

This package contains functions that check for formatting of the Subject Phenotype data set and data dictionary as specified by the National Center for Biotechnology Information (NCBI) Database of Genotypes and Phenotypes (dbGaP) <https://www.ncbi.nlm.nih.gov/gap/docs/submissionguide/>.

This package provides a d-statistic tests the null hypothesis of no treatment effect in a matched, nonrandomized study of the effects caused by treatments. A d-statistic focuses on subsets of matched pairs that demonstrate insensitivity to unmeasured bias in such an observational study, correcting for double-use of the data by conditional inference. This conditional inference can, in favorable circumstances, substantially increase the power of a sensitivity analysis (Rosenbaum (2010) <doi:10.1007/978-1-4419-1213-8_14>). There are two examples, one concerning unemployment from Lalive et al. (2006) <doi:10.1111/j.1467-937X.2006.00406.x>, the other concerning smoking and periodontal disease from Rosenbaum (2017) <doi:10.1214/17-STS621>.

This package performs drug demand forecasting by modeling drug dispensing data while taking into account predicted enrollment and treatment discontinuation dates. The gap time between randomization and the first drug dispensing visit is modeled using interval-censored exponential, Weibull, log-logistic, or log-normal distributions (Anderson-Bergman (2017) <doi:10.18637/jss.v081.i12>). The number of skipped visits is modeled using Poisson, zero-inflated Poisson, or negative binomial distributions (Zeileis, Kleiber & Jackman (2008) <doi:10.18637/jss.v027.i08>). The gap time between two consecutive drug dispensing visits given the number of skipped visits is modeled using linear regression based on least squares or least absolute deviations (Birkes & Dodge (1993, ISBN:0-471-56881-3)). The number of dispensed doses is modeled using linear or linear mixed-effects models (McCulloch & Searle (2001, ISBN:0-471-19364-X)).

Leverages dplyr to process the calculations of a plot inside a database. This package provides helper functions that abstract the work at three levels: outputs a ggplot', outputs the calculations, outputs the formula needed to calculate bins.

This package provides functions to run the CRM and TITE-CRM in phase I trials and calibration tools for trial planning purposes.

Several tools for handling block-matrix diagonals and similar constructs are implemented. Block-diagonal matrices can be extracted or removed using two small functions implemented here. In addition, non-square matrices are supported. Block diagonal matrices occur when two dimensions of a data set are combined along one edge of a matrix. For example, trade-flow data in the decompr and gvc packages have each country-industry combination occur along both edges of the matrix.

Gives access to data visualisation methods that are relevant from the statistician's point of view. Using D3''s existing data visualisation tools to empower R language and environment. The throw chart method is a line chart used to illustrate paired data sets (such as before-after, male-female).

Create donut charts positioned on maps from tidy data. The package provides helpers to compute donut polygon geometries, optional origin-destination flow lines, ready-to-use ggplot2 map layers, and interactive leaflet widgets.

Estimates the local average treatment effect (LATE) and the local average treatment effect on the treated (LATT) using observational data with a binary instrument, implementing the complete estimator suite of Sloczynski, Uysal, and Wooldridge: the doubly robust estimators of Sloczynski, Uysal, and Wooldridge (2022) <doi:10.48550/arXiv.2208.01300> -- inverse probability weighted regression adjustment (IPWRA), inverse probability weighting (IPW), augmented inverse probability weighting (AIPW), and regression adjustment (RA) -- and the Abadie-kappa weighting estimators of Sloczynski, Uysal, and Wooldridge (2025) <doi:10.1080/07350015.2024.2332763>. Supports linear, logistic, probit, Poisson, and fractional (fractional-logit and fractional-probit) outcome and treatment models, and instrument propensity scores estimated by maximum likelihood, covariate balancing (CBPS), or inverse probability tilting (IPT). Standard errors are computed jointly for all estimation stages by stacking the moment conditions of every model into a single M-estimation system; weak-instrument-robust Fieller confidence sets, cluster-aware bootstrap inference, design diagnostics, and a doubly robust Hausman-type test of unconfoundedness are included. Estimates and standard errors are validated against the authors Stata commands drlate (Statistical Software Components S459708) and kappalate (S459257).

Data screening is an important first step of any statistical analysis. dataMaid auto generates a customizable data report with a thorough summary of the checks and the results that a human can use to identify possible errors. It provides an extendable suite of test for common potential errors in a dataset.

This package provides methods for evaluating the probability mass function, cumulative distribution function, and generating random samples from discrete tempered stable distributions. For more details see Grabchak (2021) <doi:10.1007/s11009-021-09904-3>.

Access diverse ggplot2'-compatible color palettes for simplified data visualization.

This package provides a `.` object which can be used for unpacking assignments. For example, `.[rows, columns] <- dim(cars)` could be used to pull the number of rows and number of columns from `dim(cars)` into individual variables `rows` and `columns` in a single step.

Clustered or multilevel data structures are common in the assessment of differential item functioning (DIF), particularly in the context of large-scale assessment programs. This package allows users to implement extensions of the Mantel-Haenszel DIF detection procedures in the presence of multilevel data based on the work of Begg (1999) <doi:10.1111/j.0006-341X.1999.00302.x>, Begg & Paykin (2001) <doi:10.1080/00949650108812115>, and French & Finch (2013) <doi:10.1177/0013164412472341>.

Simulation models (apps) of various within-host immune response scenarios. The purpose of the package is to help individuals learn about within-host infection and immune response modeling from a dynamical systems perspective. All apps include explanations of the underlying models and instructions on what to do with the models.

Functionalities for analyzing high-dimensional and longitudinal biomarker data to facilitate precision medicine, using a joint model of Bayesian sparse factor analysis and dependent Gaussian processes. This paper illustrates the method in detail: J Cai, RJB Goudie, C Starr, BDM Tom (2023) <doi:10.48550/arXiv.2307.02781>.

Implementation of DetMCD, a new algorithm for robust and deterministic estimation of location and scatter. The benefits of robust and deterministic estimation are explained in Hubert, Rousseeuw and Verdonck (2012) <doi:10.1080/10618600.2012.672100>.

Extends daltoolbox with Python-backed components for deep learning, scikit-learn classification, and time-series forecasting through reticulate'. The package provides objects that follow the daltoolbox architecture while delegating model creation, fitting, encoding, and prediction to Python libraries such as torch and scikit-learn'. In the package name, dp stands for Deep Python'. The overall workflow is inspired by the Experiment Lines approach described in Ogasawara et al. (2009) <doi:10.1007/978-3-642-02279-1_20>.

Four global value chain (GVC) decompositions are implemented. The Leontief decomposition derives the value added origin of exports by country and industry as in Hummels, Ishii and Yi (2001). The Koopman, Wang and Wei (2014) decomposition splits country-level exports into 9 value added components, and the Wang, Wei and Zhu (2013) decomposition splits bilateral exports into 16 value added components. The Borin and Mancini (2019) decomposition splits country-, sector- or bilateral-level exports into up to 13 value added and GVC components. Various GVC indicators based on these decompositions are computed in the complimentary gvc package. --- References: --- Hummels, D., Ishii, J., & Yi, K. M. (2001). The nature and growth of vertical specialization in world trade. Journal of international Economics, 54(1), 75-96. Koopman, R., Wang, Z., & Wei, S. J. (2014). Tracing value-added and double counting in gross exports. American Economic Review, 104(2), 459-94. Wang, Z., Wei, S. J., & Zhu, K. (2013). Quantifying international production sharing at the bilateral and sector levels (No. w19677). National Bureau of Economic Research. Borin, A., & Mancini, M. (2019). Measuring What Matters in Global Value Chains and Value-Added Trade. World Bank Policy Research Working Paper 8804.

Make inference in a mixture of discrete Laplace distributions using the EM algorithm. This can e.g. be used for modelling the distribution of Y chromosomal haplotypes as described in [1, 2] (refer to the URL section).