Computationally efficient procedures for regularized estimation with the semiparametric additive hazards regression model.

This package provides functions and examples for the weak and strong density asymmetry measures in the articles: "A measure of asymmetry", Patil, Patil and Bagkavos (2012) <doi:10.1007/s00362-011-0401-6> and "A measure of asymmetry based on a new necessary and sufficient condition for symmetry", Patil, Bagkavos and Wood (2014) <doi:10.1007/s13171-013-0034-z>. The measures provided here are useful for quantifying the asymmetry of the shape of a density of a random variable. The package facilitates implementation of the measures which are applicable in a variety of fields including e.g. probability theory, statistics and economics.

This package provides functions to perform statistical inference in the balanced one-way ANOVA model with a random factor: confidence intervals, prediction interval, and Weerahandi generalized pivotal quantities. References: Burdick & Graybill (1992, ISBN-13: 978-0824786441); Weerahandi (1995) <doi:10.1007/978-1-4612-0825-9>; Lin & Liao (2008) <doi:10.1016/j.jspi.2008.01.001>.

With the functions in this package you can check the validity of the Greek Tax Identification Number (AFM) and the Greek Personal Number (PA) <https://pa.gov.gr>. The PA is a new universal ID for Greek citizens across all public services and it is to replace older numbers issued by various Greek state agencies. Its format is a 12-character ID consisting of three alphanumeric characters followed by the nine numerical digits of the AFM.

Visual exploration and presentation of networks should not be difficult. This package includes functions for plotting networks and network-related metrics with sensible and pretty defaults. It includes ggplot2'-based plot methods for many popular network package classes. It also includes some novel layout algorithms, and options for straightforward, consistent themes.

For researchers to quickly and comprehensively acquire disease genes, so as to understand the mechanism of disease, we developed this program to acquire disease-related genes. The data is integrated from three public databases. The three databases are eDGAR', DrugBank and MalaCards'. The eDGAR is a comprehensive database, containing data on the relationship between disease and genes. DrugBank contains information on 13443 drugs and 5157 targets. MalaCards integrates human disease information, including disease-related genes.

Compute an anomaly score for multivariate time series based on the k-nearest neighbors algorithm. Different computations of distances between time series are provided.

Estimation of regression models for sparse asynchronous longitudinal observations, where time-dependent response and covariates are mismatched and observed intermittently within subjects. Kernel weighted estimating equations are used for generalized linear models with either time-invariant or time-dependent coefficients. Cao, H., Li, J., and Fine, J. P. (2016) <doi:10.1214/16-EJS1141>. Cao, H., Zeng, D., and Fine, J. P. (2015) <doi:10.1111/rssb.12086>.

This package provides tools to read/write/publish metadata based on the Atom XML syndication format. This includes support of Dublin Core XML implementation, and a client to API(s) implementing the AtomPub - SWORD API specification.

This package provides a Tcl/Tk GUI for some basic functions in the ade4 package.

Package ACV (short for Affine Cross-Validation) offers an improved time-series cross-validation loss estimator which utilizes both in-sample and out-of-sample forecasting performance via a carefully constructed affine weighting scheme. Under the assumption of stationarity, the estimator is the best linear unbiased estimator of the out-of-sample loss. Besides that, the package also offers improved versions of Diebold-Mariano and Ibragimov-Muller tests of equal predictive ability which deliver more power relative to their conventional counterparts. For more information, see the accompanying article Stanek (2021) <doi:10.2139/ssrn.3996166>.

An isotope natural abundance correction algorithm that is needed especially for high resolution mass spectrometers. Supports correction for 13C, 2H and 15N. Su X, Lu W and Rabinowitz J (2017) <doi:10.1021/acs.analchem.7b00396>.

Visualization of antibody titer scores is valuable for examination of vaccination effects. AntibodyTiters visualizes antibody titers of all or selected patients. This package also produces empty excel files in a specified format, in which users can fill in experimental data for visualization. Excel files with toy data can also be produced, so that users can see how it is visualized before obtaining real data. The data should contain titer scores at pre-vaccination, after-1st shot, after-2nd shot, and at least one additional sampling points. Patients with missing values can be included. The first two sampling points (pre-vaccination and after-1st shot) will be plotted discretely, whereas those following will be plotted on a continuous time scale that starts from the day of second shot. Half-life of titer can also be calculated for each pair of sampling points.

Fits a linear-binomial model using a modified Newton-type algorithm for solving the maximum likelihood estimation problem under linear box constraints. Similar methods are described in Wagenpfeil, Schöpe and Bekhit (2025, ISBN:9783111341972) "Estimation of adjusted relative risks in log-binomial regression using the BSW algorithm". In: Mau, Mukhin, Wang and Xu (Eds.), Biokybernetika. De Gruyter, Berlin, pp. 665â 676.

The Genetic Algorithm (GA) is a type of optimization method of Evolutionary Algorithms. It uses the biologically inspired operators such as mutation, crossover, selection and replacement.Because of their global search and robustness abilities, GAs have been widely utilized in machine learning, expert systems, data science, engineering, life sciences and many other areas of research and business. However, the regular GAs need the techniques to improve their efficiency in computing time and performance in finding global optimum using some adaptation and hybridization strategies. The adaptive GAs (AGA) increase the convergence speed and success of regular GAs by setting the parameters crossover and mutation probabilities dynamically. The hybrid GAs combine the exploration strength of a stochastic GAs with the exact convergence ability of any type of deterministic local search algorithms such as simulated-annealing, in addition to other nature-inspired algorithms such as ant colony optimization, particle swarm optimization etc. The package adana includes a rich working environment with its many functions that make possible to build and work regular GA, adaptive GA, hybrid GA and hybrid adaptive GA for any kind of optimization problems. Cebeci, Z. (2021, ISBN: 9786254397448).

Machine learning based package to predict anti-angiogenic peptides using heterogeneous sequence descriptors. AntAngioCOOL exploits five descriptor types of a peptide of interest to do prediction including: pseudo amino acid composition, k-mer composition, k-mer composition (reduced alphabet), physico-chemical profile and atomic profile. According to the obtained results, AntAngioCOOL reached to a satisfactory performance in anti-angiogenic peptide prediction on a benchmark non-redundant independent test dataset.

Optimize one or two-arm, two-stage designs for clinical trials with respect to several implemented objective criteria or custom objectives. Optimization under uncertainty and conditional (given stage-one outcome) constraints are supported. See Pilz et al. (2019) <doi:10.1002/sim.8291> and Kunzmann et al. (2021) <doi:10.18637/jss.v098.i09> for details.

This package implements a Bayesian adaptive graphical lasso data-augmented block Gibbs sampler. The sampler simulates the posterior distribution of precision matrices of a Gaussian Graphical Model. This sampler was adapted from the original MATLAB routine proposed in Wang (2012) <doi:10.1214/12-BA729>.

This wrapper package for mgcv makes it easier to create high-performing Generalized Additive Models (GAMs). With its central function autogam(), by entering just a dataset and the name of the outcome column as inputs, AutoGAM tries to automate the procedure of configuring a highly accurate GAM which performs at reasonably high speed, even for large datasets.

Build and control interactive 2D and 3D maps with R/Shiny'. Lean set of powerful commands wrapping native calls to AMap <https://lbs.amap.com/api/jsapi-v2/summary/>. Deliver rich mapping functionality with minimal overhead.

This package performs statistical testing to compare predictive models based on multiple observations of the A statistic (also known as Area Under the Receiver Operating Characteristic Curve, or AUC). Specifically, it implements a testing method based on the equivalence between the A statistic and the Wilcoxon statistic. For more information, see Hanley and McNeil (1982) <doi:10.1148/radiology.143.1.7063747>.

This package provides tools for classical parameter estimation of adsorption isotherm models, including both linear and nonlinear forms of the Freundlich, Langmuir, and Temkin isotherms. This package allows users to fit these models to experimental data, providing parameter estimates along with fit statistics such as Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC). Error metrics are computed to evaluate model performance, and the package produces model fit plots with bootstrapped 95% confidence intervals. Additionally, it generates residual plots for diagnostic assessment of the models. Researchers and engineers in material science, environmental engineering, and chemical engineering can rigorously analyze adsorption behavior in their systems using this straightforward, non-Bayesian approach. For more details, see Harding (1907) <doi:10.2307/2987516>.

Data sets used in Cayuela and De la Cruz (2022, ISBN:978-84-8476-833-3).

Age-Period-Cohort (APC) analyses are used to differentiate relevant drivers for long-term developments. The APCtools package offers visualization techniques and general routines to simplify the workflow of an APC analysis. Sophisticated functions are available both for descriptive and regression model-based analyses. For the former, we use density (or ridgeline) matrices and (hexagonally binned) heatmaps as innovative visualization techniques building on the concept of Lexis diagrams. Model-based analyses build on the separation of the temporal dimensions based on generalized additive models, where a tensor product interaction surface (usually between age and period) is utilized to represent the third dimension (usually cohort) on its diagonal. Such tensor product surfaces can also be estimated while accounting for further covariates in the regression model. See Weigert et al. (2021) <doi:10.1177/1354816620987198> for methodological details.