Open Cancer TherApeutic Discovery (OCTAD) package implies sRGES approach for the drug discovery. The essential idea is to identify drugs that reverse the gene expression signature of a disease by tamping down over-expressed genes and stimulating weakly expressed ones. The following package contains all required precomputed data for whole OCTAD pipeline computation.

Tool to help debug / hack at the BCM283x GPIO. You can dump the state of a GPIO or (all GPIOs). You can change a GPIO mode and pulls (and level if set as an output). Beware this tool writes directly to the BCM283x GPIO reisters, ignoring anything else that may be using them (like Linux drivers).

The function estimates the hazard function non parametrically from a survival object (possibly adjusted for covariates). The smoothed estimate is based on B-splines from the perspective of generalized linear mixed models. Left truncated and right censoring data are allowed. The package is based on the work in Rebora P (2014) <doi:10.32614/RJ-2014-028>.

This package provides functions to compute the asymptotic covariance matrices of mixing and unmixing matrix estimates of the following blind source separation (BSS) methods: symmetric and squared symmetric FastICA, regular and adaptive deflation-based FastICA, FOBI, JADE, AMUSE and deflation-based and symmetric SOBI. Also functions to estimate these covariances based on data are available.

Software to facilitates taking movement data in xyt format and pairing it with raster covariates within a continuous time Markov chain (CTMC) framework. As described in Hanks et al. (2015) <DOI:10.1214/14-AOAS803> , this allows flexible modeling of movement in response to covariates (or covariate gradients) with model fitting possible within a Poisson GLM framework.

This package contains the Correlates of State Policy Project dataset (+ codebook) assembled by Marty P. Jordan and Matt Grossmann (2020) <http://ippsr.msu.edu/public-policy/correlates-state-policy> used by the cspp package. The Correlates data contains over 3000 variables across more than 100 years that pertain to state politics and policy in the United States.

In discrimination experiments candidates are sent on the same test (e.g. job, house rental) and one examines whether they receive the same outcome. The number of non negative answers are first examined in details looking for outcome differences. Then various statistics are computed. This package can also be used for analyzing the results from random experiments.

Uses optimal transport distances to find probabilistic matching estimators for causal inference. These methods are described in Dunipace, Eric (2021) <arXiv:2109.01991>. The package will build the weights, estimate treatment effects, and calculate confidence intervals via the methods described in the paper. The package also supports several other methods as described in the help files.

Easy and rapid quantitative estimation of small terrestrial ectotherm temperature regulation effectiveness in R. ectotemp is built on classical formulas that evaluate temperature regulation by means of various indices, inaugurated by Hertz et al. (1993) <doi: 10.1086/285573>. Options for bootstrapping and permutation testing are included to test hypotheses about divergence between organisms, species or populations.

This package provides tools to run genome-wide association study (GWAS) and genome-wide by environment interaction study (GWEIS) scans using the genetic data stored in a binary dosage file. The user provides a data frame with the subject's covariate data and the information about the binary dosage file returned by the BinaryDosage::getbdinfo() routine.

LimeSurvey is Free/Libre Open Source Software for the development and administrations of online studies, using sophisticated tailoring capabilities to support multiple study designs (see <https://www.limesurvey.org>). This package supports programmatic creation of surveys that can then be imported into LimeSurvey', as well as user friendly import of responses from LimeSurvey studies.

Multi-criteria design of experiments algorithm that simultaneously optimizes up to six different criteria ('I', Id', D', Ds', A and As'). The algorithm finds the optimal Pareto front and, if requested, selects a possible symmetrical design on it. The symmetrical design is selected based on two techniques: minimum distance with the Utopia point or the TOPSIS approach.

This package implements statistical tools for analyzing, simulating, and computing properties of the New Topp-Leone Kumaraswamy Inverse Exponential (NTLKwIEx) distribution. See Atchadé M, Otodji T, and Djibril A (2024) <doi:10.1063/5.0179458> and Atchadé M, Otodji T, Djibril A, and N'bouké M (2023) <doi:10.1515/phys-2023-0151> for details.

This package provides a sigmoidal quantile function estimator based on a newly defined generalized expectile function. The generalized sigmoidal quantile function can estimate quantiles beyond the range of the data, which is important for certain applications given smaller sample sizes. The package is based on the method introduced in Hutson (2024) <doi:10.1080/03610918.2022.2032161>.

Introduces a fast and efficient Surrogate Variable Analysis algorithm that captures variation of unknown sources (batch effects) for high-dimensional data sets. The algorithm is built on the irwsva.build function of the sva package and proposes a revision on it that achieves an order of magnitude faster running time while trading no accuracy loss in return.

This is a collection of functions to calculate stop-signal reaction time (SSRT). Includes functions for both "integration" and "mean" methods; both fixed and adaptive stop-signal delays are supported (see appropriate functions). Calculation is based on Verbruggen et al. (2019) <doi:10.7554/eLife.46323.001> and Verbruggen et al. (2013) <doi:10.1177/0956797612457390>.

This package implements the TWO-Component Single Cell Model-Based Association Method (TWO-SIGMA) for gene-level differential expression (DE) analysis and DE-based gene set testing of single-cell RNA-sequencing datasets. See Van Buren et al. (2020) <doi:10.1002/gepi.22361> and Van Buren et al. (2021) <doi:10.1101/2021.01.24.427979>.

Calculate the win ratio for prioritized outcomes and the 95% confidence interval based on Bebu and Lachin (2016) <doi:10.1093/biostatistics/kxv032>. Three type of outcomes can be analyzed: survival "failure-time" events, repeated survival "failure-time" events and continuous or ordinal "non-failure time" events that are captured at specific time-points in the study.

This package provides a package to merge, filter sort, organise and otherwise mash together metabolite annotation tables. Metabolite annotations can be imported from multiple sources (software) and combined using workflow steps based on S4 class templates derived from the `struct` package. Other modular workflow steps such as filtering, merging, splitting, normalisation and rest-api queries are included.

This package provides tools to import transcript-level abundance, estimated counts and transcript lengths, and to summarize them into matrices for use with downstream gene-level analysis packages. Average transcript length, weighted by sample-specific transcript abundance estimates, is provided as a matrix which can be used as an offset for different expression of gene-level counts.

This package contains methods for converting standard objects constructed by bioinformatics packages, especially those in Bioconductor, and converting them to tidy data. It thus serves as a complement to the broom package, and follows the same tidy, augment, glance division of tidying methods. Tidying data makes it easy to recombine, reshape and visualize bioinformatics analyses.

This package aims to bring the power and flexibility of AnnData to the R ecosystem, allowing you to effortlessly manipulate and analyze your single-cell data. This package lets you work with backed h5ad and zarr files, directly access various slots (e.g. X, obs, var), or convert the data into SingleCellExperiment and Seurat objects.

This package provides flexible parametric models for time-to-event data, including the Royston-Parmar spline model, generalized gamma and generalized F distributions. Any user-defined parametric distribution can be fitted, given at least an R function defining the probability density or hazard. There are also tools for fitting and predicting from fully parametric multi-state models.

Computes a variety of statistics for relational event models. Relational event models enable researchers to investigate both exogenous and endogenous factors influencing the evolution of a time-ordered sequence of events. These models are categorized into tie-oriented models (Butts, C., 2008, <doi:10.1111/j.1467-9531.2008.00203.x>), where the probability of a dyad interacting next is modeled in a single step, and actor-oriented models (Stadtfeld, C., & Block, P., 2017, <doi:10.15195/v4.a14>), which first model the probability of a sender initiating an interaction and subsequently the probability of the sender's choice of receiver. The package is designed to compute a variety of statistics that summarize exogenous and endogenous influences on the event stream for both types of models.