This package corrects GC and mappability biases for readcounts (i.e. coverage) in non-overlapping windows of fixed length for single whole genome samples, yielding a rough estimate of copy number for further analysis. It was designed for rapid correction of high coverage whole genome tumor and normal samples.

MMUPHin is an R package for meta-analysis tasks of microbiome cohorts. It has function interfaces for:

• covariate-controlled batch- and cohort effect adjustment;

• meta-analysis differential abundance testing;

• meta-analysis unsupervised discrete structure (clustering) discovery;

• meta-analysis unsupervised continuous structure discovery.

This package provides functions for analysing, manipulating, displaying, editing and synthesizing time waves (particularly sound). This package processes time analysis (oscillograms and envelopes), spectral content, resonance quality factor, entropy, cross correlation and autocorrelation, zero-crossing, dominant frequency, analytic signal, frequency coherence, 2D and 3D spectrograms and many other analyses.

This package provides a tool for calculating z-scores and centiles for weight-for-age, length/height-for-age, weight-for-length/height, BMI-for-age, head circumference-for-age, age circumference-for-age, subscapular skinfold-for-age, triceps skinfold-for-age based on the WHO Child Growth Standards.

Ruby i18n is an internationalization and localization solution for Ruby programs. It features translation and localization, interpolation of values to translations, pluralization, customizable transliteration to ASCII, flexible defaults, bulk lookup, lambdas as translation data, custom key/scope separator, custom exception handlers, and an extensible architecture with a swappable backend.

This package provides a platform-independent API to access the operating system's credential store. It currently supports Keychain on macOS, Credential Store on Windows, the Secret Service API on GNU/Linux, and a simple, platform independent store implemented with environment variables. Additional storage back-ends can be added easily.

This package implements an efficient O(n) algorithm based on bucket-sorting for fast computation of standard clustering comparison measures. Available measures include adjusted Rand index (ARI), normalized information distance (NID), normalized mutual information (NMI), adjusted mutual information (AMI), normalized variation information (NVI) and entropy.

Libretro is a simple but powerful development interface that allows for the easy creation of emulators, games and multimedia applications that can plug straight into any libretro-compatible frontend. RetroArch is the official reference frontend for the libretro API, currently used by most as a modular multi-system game/emulator system.

This package provides functionality for processing and statistical analysis of multiplexed assays of variant effect (MAVE) and similar data. The package contains functions covering the full workflow from raw FASTQ files to publication-ready visualizations. A broad range of library designs can be processed with a single, unified interface.

Explore and download data from the recount project available at https://jhubiostatistics.shinyapps.io/recount/. Using the recount package you can download RangedSummarizedExperiment objects at the gene, exon or exon-exon junctions level, the raw counts, the phenotype metadata used, the urls to the sample coverage bigWig files or the mean coverage bigWig file for a particular study. The RangedSummarizedExperiment objects can be used by different packages for performing differential expression analysis. Using http://bioconductor.org/packages/derfinder you can perform annotation-agnostic differential expression analyses with the data from the recount project as described at https://www.nature.com/nbt/journal/v35/n4/full/nbt.3838.html.

Keep track of dates in terms of fractional calendar months per Damien Laker "Time Calculations for Annualizing Returns: the Need for Standardization", The Journal of Performance Measurement, 2008. Model dates as of close of business. Perform date arithmetic in units of "months" and "years". Allow "infinite" dates to model "ultimate" time.

Haml is a layer on top of HTML or XML that is designed to express the structure of documents using indentation rather than closing tags. It was originally envisioned as a plugin for Ruby on Rails, but it can function as a stand-alone templating engine.

The PSMatch package helps proteomics practitioners to load, handle and manage peptide spectrum matches. It provides functions to model peptide-protein relations as adjacency matrices and connected components, visualise these as graphs and make informed decision about shared peptide filtering. The package also provides functions to calculate and visualise MS2 fragment ions.

This package provides a function to format R source code. Spaces and indent will be added to the code automatically, and comments will be preserved under certain conditions, so that R code will be more human-readable and tidy. There is also a Shiny app as a user interface in this package.

This package provides tools to identify global ("unknown" or "free") objects in R expressions by code inspection using various strategies, e.g. conservative or liberal. The objective of this package is to make it as simple as possible to identify global objects for the purpose of exporting them in distributed compute environments.

This package offers features plots for mlr3 objects such as tasks, learners, predictions, benchmark results, tuning instances and filters via the autoplot() generic of ggplot2. The mlr3viz package draws plots with the viridis color palette and applies the minimal theme. Visualizations include barplots, boxplots, histograms, ROC curves, and precision-recall curves.

Puma is a simple, fast, threaded, and highly concurrent HTTP 1.1 server for Ruby/Rack applications. Puma is intended for use in both development and production environments. In order to get the best throughput, it is highly recommended that you use a Ruby implementation with real threads like Rubinius or JRuby.

Rosenpass is free and open-source software based on the latest research in the field of cryptography. It is intended to be used with WireGuard VPN, but can work with all software that uses pre-shared keys. It uses two cryptographic methods (Classic McEliece and Kyber) to secure systems against attacks with quantum computers.

This package analyzes and creates plots of array CGH data. Also, it allows usage of CBS, wavelet-based smoothing, HMM, BioHMM, GLAD, CGHseg. Most computations are parallelized (either via forking or with clusters, including MPI and sockets clusters) and use ff for storing data.

This package contains the functions to find the gene expression modules that represent the drivers of Kauffman's attractor landscape. The modules are the core attractor pathways that discriminate between different cell types of groups of interest. Each pathway has a set of synexpression groups, which show transcriptionally-coordinated changes in gene expression.

This package provides a collection of functions to explore and to investigate basic properties of financial returns and related quantities. The covered fields include techniques of explorative data analysis and the investigation of distributional properties, including parameter estimation and hypothesis testing. Even more, there are several utility functions for data handling and management.

This package provides large-scale single-cell omics data manipulation using Genomic Data Structure (GDS) files. It combines dense and sparse matrices stored in GDS files and the Bioconductor infrastructure framework (SingleCellExperiment and DelayedArray) to provide out-of-memory data storage and large-scale manipulation using the R programming language.

The package provides two frameworks. One for the differential transcript usage analysis between different conditions and one for the tuQTL analysis. Both are based on modeling the counts of genomic features (i.e., transcripts) with the Dirichlet-multinomial distribution. The package also makes available functions for visualization and exploration of the data and results.

The main function in the h5mread package is h5mread(), which allows reading arbitrary data from an HDF5 dataset into R, similarly to what the h5read() function from the rhdf5 package does. In the case of h5mread(), the implementation has been optimized to make it as fast and memory-efficient as possible.