This is an add-on package to gamlss'. The purpose of this package is to allow users to fit GAMLSS (Generalised Additive Models for Location Scale and Shape) models when the response variable is defined either in the intervals [0,1), (0,1] and [0,1] (inflated at zero and/or one distributions), or in the positive real line including zero (zero-adjusted distributions). The mass points at zero and/or one are treated as extra parameters with the possibility to include a linear predictor for both. The package also allows transformed or truncated distributions from the GAMLSS family to be used for the continuous part of the distribution. Standard methods and GAMLSS diagnostics can be used with the resulting fitted object.

Providing tools for microRNA (miRNA) text mining. miRetrieve summarizes miRNA literature by extracting, counting, and analyzing miRNA names, thus aiming at gaining biological insights into a large amount of text within a short period of time. To do so, miRetrieve uses regular expressions to extract miRNAs and tokenization to identify meaningful miRNA associations. In addition, miRetrieve uses the latest miRTarBase version 8.0 (Hsi-Yuan Huang et al. (2020) "miRTarBase 2020: updates to the experimentally validated microRNAâ target interaction database" <doi:10.1093/nar/gkz896>) to display field-specific miRNA-mRNA interactions. The most important functions are available as a Shiny web application under <https://miretrieve.shinyapps.io/miRetrieve/>.

This package provides a suite of computer model test functions that can be used to test and evaluate algorithms for Bayesian (also known as sequential) optimization. Some of the functions have known functional forms, however, most are intended to serve as black-box functions where evaluation requires running computer code that reveals little about the functional forms of the objective and/or constraints. The primary goal of the package is to provide users (especially those who do not have access to real computer models) a source of reproducible and shareable examples that can be used for benchmarking algorithms. The package is a living repository, and so more functions will be added over time. For function suggestions, please do contact the author of the package.

This package provides a seamless interface to access diverse public data about Colombia through the API-Colombia', a RESTful API. The package enables users to explore various aspects of Colombia, including general information, geography, and cultural insights. It includes five API-related functions to retrieve data on topics such as Colombia's general information, airports, departments, regions, and presidents. Additionally, ColombiAPI offers a built-in function to view the datasets available within the package. The package also includes curated datasets covering Bogota air stations, business and holiday dates, public schools, Colombian coffee exports, cannabis licenses, Medellin rainfall, and malls in Bogota, making it a comprehensive tool for exploring Colombia's data. For more details on the API-Colombia', see <https://api-colombia.com/>.

Alternative implementation of the beautiful MissForest algorithm used to impute mixed-type data sets by chaining random forests, introduced by Stekhoven, D.J. and Buehlmann, P. (2012) <doi:10.1093/bioinformatics/btr597>. Under the hood, it uses the lightning fast random forest package ranger'. Between the iterative model fitting, we offer the option of using predictive mean matching. This firstly avoids imputation with values not already present in the original data (like a value 0.3334 in 0-1 coded variable). Secondly, predictive mean matching tries to raise the variance in the resulting conditional distributions to a realistic level. This would allow, e.g., to do multiple imputation when repeating the call to missRanger(). Out-of-sample application is supported as well.

This software has evolved from fisheries research conducted at the Pacific Biological Station (PBS) in Nanaimo', British Columbia, Canada. It extends the R language to include two-dimensional plotting features similar to those commonly available in a Geographic Information System (GIS). Embedded C code speeds algorithms from computational geometry, such as finding polygons that contain specified point events or converting between longitude-latitude and Universal Transverse Mercator (UTM) coordinates. Additionally, we include C++ code developed by Angus Johnson for the Clipper library, data for a global shoreline, and other data sets in the public domain. Under the user's R library directory .libPaths()', specifically in ./PBSmapping/doc', a complete user's guide is offered and should be consulted to use package functions effectively.

Providing equivalent functions for the dummy classifier and regressor used in Python scikit-learn library. Our goal is to allow R users to easily identify baseline performance for their classification and regression problems. Our baseline models use no predictors, and are useful in cases of class imbalance, multiclass classification, and when users want to quickly identify how much improvement their statistical and machine learning models are over several baseline models. We use a "better" default (proportional guessing) for the dummy classifier than the Python implementation ("prior", which is the most frequent class in the training set). The functions in the package can be used on their own, or introduce methods named dummy_regressor or dummy_classifier that can be used within the caret package pipeline.

It uses the first-order sensitivity index to measure whether the weights assigned by the creator of the composite indicator match the actual importance of the variables. Moreover, the variance inflation factor is used to reduce the set of correlated variables. In the case of a discrepancy between the importance and the assigned weight, the script determines weights that allow adjustment of the weights to the intended impact of variables. If the optimised weights are unable to reflect the desired importance, the highly correlated variables are reduced, taking into account variance inflation factor. The final outcome of the script is the calculated value of the composite indicator based on optimal weights and a reduced set of variables, and the linear ordering of the analysed objects.

This package provides a workflow for correction of Differential Interferometric Synthetic Aperture Radar (DInSAR) atmospheric delay base on Generic Atmospheric Correction Online Service for InSAR (GACOS) data and correction algorithms proposed by Chen Yu. This package calculate the Both Zenith and LOS direction (User Depend). You have to just download GACOS product on your area and preprocessed D-InSAR unwrapped images. Cite those references and this package in your work, when using this framework. References: Yu, C., N. T. Penna, and Z. Li (2017) <doi:10.1016/j.rse.2017.10.038>. Yu, C., Li, Z., & Penna, N. T. (2017) <doi:10.1016/j.rse.2017.10.038>. Yu, C., Penna, N. T., and Li, Z. (2017) <doi:10.1002/2016JD025753>.

Linear regression model and generalized linear models with nonparametric network effects on network-linked observations. The model is originally proposed by Le and Li (2022) <doi:10.48550/arXiv.2007.00803> and is assumed on observations that are connected by a network or similar relational data structure. A more recent work by Wang, Le and Li (2024) <doi:10.48550/arXiv.2410.01163> further extends the framework to generalized linear models. All these models are implemented in the current package. The model does not assume that the relational data or network structure to be precisely observed; thus, the method is provably robust to a certain level of perturbation of the network structure. The package contains the estimation and inference function for the model.

The core algorithm is described in "Ball mapper: a shape summary for topological data analysis" by Pawel Dlotko, (2019) <arXiv:1901.07410>. Please consult the following youtube video <https://www.youtube.com/watch?v=M9Dm1nl_zSQfor> the idea of functionality. Ball Mapper provide a topologically accurate summary of a data in a form of an abstract graph. To create it, please provide the coordinates of points (in the points array), values of a function of interest at those points (can be initialized randomly if you do not have it) and the value epsilon which is the radius of the ball in the Ball Mapper construction. It can be understood as the minimal resolution on which we use to create the model of the data.

This package provides a generic, easy-to-use and expandable implementation of a pharmacokinetic (PK) / pharmacodynamic (PD) model based on the S4 class system. This package allows the user to read/write a pharmacometric model from/to files and adapt it further on the fly in the R environment. For this purpose, this package provides an intuitive API to add, modify or delete equations, ordinary differential equations (ODE's), model parameters or compartment properties (like infusion duration or rate, bioavailability and initial values). Finally, this package also provides a useful export of the model for use with simulation packages rxode2 and mrgsolve'. This package is designed and intended to be used with package campsis', a PK/PD simulation platform built on top of rxode2 and mrgsolve'.

This toolkit is designed for manipulation and analysis of peptides. It provides functionalities to assist researchers in peptide engineering and proteomics. Users can manipulate peptides by adding amino acids at every position, count occurrences of each amino acid at each position, and transform amino acid counts based on probabilities. The package offers functionalities to select the best versus the worst peptides and analyze these peptides, which includes counting specific residues, reducing peptide sequences, extracting features through One Hot Encoding (OHE), and utilizing Quantitative Structure-Activity Relationship (QSAR) properties (based in the package Peptides by Osorio et al. (2015) <doi:10.32614/RJ-2015-001>). This package is intended for both researchers and bioinformatics enthusiasts working on peptide-based projects, especially for their use with machine learning.

PubTator <https://www.ncbi.nlm.nih.gov/CBBresearch/Lu/Demo/PubTator/> is a National Center for Biotechnology Information (NCBI) tool that enhances the annotation of articles on PubMed <https://www.ncbi.nlm.nih.gov/pubmed/>. It makes it possible to rapidly identify potential relationships between genes or proteins using text mining techniques. In contrast, manually searching for and reading the annotated articles would be very time consuming. PubTator offers both an online interface and a RESTful API, however, neither of these approaches are well suited for frequent, high-throughput analyses. The package pubtatordb provides a set of functions that make it easy for the average R user to download PubTator annotations, create, and then query a local version of the database.

The package xmapbridge can plot graphs in the X:Map genome browser. X:Map uses the Google Maps API to provide a scrollable view of the genome. It supports a number of species, and can be accessed at http://xmap.picr.man.ac.uk. This package exports plotting files in a suitable format. Graph plotting in R is done using calls to the functions xmap.plot and xmap.points, which have parameters that aim to be similar to those used by the standard plot methods in R. These result in data being written to a set of files (in a specific directory structure) that contain the data to be displayed, as well as some additional meta-data describing each of the graphs.

An updated implementation of R package ranger by Wright et al, (2017) <doi:10.18637/jss.v077.i01> for training and predicting from random forests, particularly suited to high-dimensional data, and for embedding in Multiple Imputation by Chained Equations (MICE) by van Buuren (2007) <doi:10.1177/0962280206074463>. Ensembles of classification and regression trees are currently supported. Sparse data of class dgCMatrix (R package Matrix') can be directly analyzed. Conventional bagged predictions are available alongside an efficient prediction for MICE via the algorithm proposed by Doove et al (2014) <doi:10.1016/j.csda.2013.10.025>. Survival and probability forests are not supported in the update, nor is data of class gwaa.data (R package GenABEL'); use the original ranger package for these analyses.

This package provides a graph community detection algorithm that aims to be performant on large graphs and robust, returning consistent results across runs. SpeakEasy 2 (SE2), the underlying algorithm, is described in Chris Gaiteri, David R. Connell & Faraz A. Sultan et al. (2023) <doi:10.1186/s13059-023-03062-0>. The core algorithm is written in C', providing speed and keeping the memory requirements low. This implementation can take advantage of multiple computing cores without increasing memory usage. SE2 can detect community structure across scales, making it a good choice for biological data, which often has hierarchical structure. Graphs can be passed to the algorithm as adjacency matrices using base R matrices, the Matrix library, igraph graphs, or any data that can be coerced into a matrix.

epidecodeR is a package capable of analysing impact of degree of DNA/RNA epigenetic chemical modifications on dysregulation of genes or proteins. This package integrates chemical modification data generated from a host of epigenomic or epitranscriptomic techniques such as ChIP-seq, ATAC-seq, m6A-seq, etc. and dysregulated gene lists in the form of differential gene expression, ribosome occupancy or differential protein translation and identify impact of dysregulation of genes caused due to varying degrees of chemical modifications associated with the genes. epidecodeR generates cumulative distribution function (CDF) plots showing shifts in trend of overall log2FC between genes divided into groups based on the degree of modification associated with the genes. The tool also tests for significance of difference in log2FC between groups of genes.

This package provides an integrated pipeline for the analysis of PAR-CLIP data. PAR-CLIP-induced transitions are first discriminated from sequencing errors, SNPs and additional non-experimental sources by a non- parametric mixture model. The protein binding sites (clusters) are then resolved at high resolution and cluster statistics are estimated using a rigorous Bayesian framework. Post-processing of the results, data export for UCSC genome browser visualization and motif search analysis are provided. In addition, the package integrates RNA-Seq data to estimate the False Discovery Rate of cluster detection. Key functions support parallel multicore computing. While wavClusteR was designed for PAR-CLIP data analysis, it can be applied to the analysis of other NGS data obtained from experimental procedures that induce nucleotide substitutions (e.g. BisSeq).

This package provides a powerful and flexible tool for visualizing proportional data across spatially resolved contexts. By combining the concepts of scatter plots and stacked bar charts, scatterbar allows users to create scattered bar chart plots, which effectively display the proportions of different categories at each (x, y) location. This visualization is particularly useful for applications where understanding the distribution of categories across spatial coordinates is essential. This package features automatic determination of optimal scaling factors based on data, customizable scaling and padding options for both x and y axes, flexibility to specify custom colors for each category, options to customize the legend title, and integration with ggplot2 for robust and high-quality visualizations. For more details, see Velazquez et al. (2024) <doi:10.1101/2024.08.14.606810>.

The Datasaurus Dozen is a set of datasets with the same summary statistics. They retain the same summary statistics despite having radically different distributions. The datasets represent a larger and quirkier object lesson that is typically taught via Anscombe's Quartet (available in the 'datasets' package). Anscombe's Quartet contains four very different distributions with the same summary statistics and as such highlights the value of visualisation in understanding data, over and above summary statistics. As well as being an engaging variant on the Quartet, the data is generated in a novel way. The simulated annealing process used to derive datasets from the original Datasaurus is detailed in "Same Stats, Different Graphs: Generating Datasets with Varied Appearance and Identical Statistics through Simulated Annealing" doi:10.1145/3025453.3025912.

In computer experiments space-filling designs are having great impact. Most popularly used space-filling designs are Uniform designs (UDs), Latin hypercube designs (LHDs) etc. For further references one can see Mckay (1979) <DOI:10.1080/00401706.1979.10489755> and Fang (1980) <https://cir.nii.ac.jp/crid/1570291225616774784>. In this package, we have provided algorithms for generate efficient LHDs and UDs. Here, generated LHDs are efficient as they possess lower value of Maxpro measure, Phi_p value and Maximum Absolute Correlation (MAC) value based on the weightage given to each criterion. On the other hand, the produced UDs are having good space-filling property as they always attain the lower bound of Discrete Discrepancy measure. Further, some useful functions added in this package for adding more value to this package.

In longitudinal studies, the same subjects are measured repeatedly over time, leading to correlations among the repeated measurements. Properly accounting for the intra-cluster correlations in the presence of data heterogeneity and long tailed distributions of the disease phenotype is challenging, especially in the context of high dimensional regressions. In this package, we developed a Bayesian quantile mixed effects model with spike- and -slab priors to dissect important gene - environment interactions under longitudinal genomics studies. An efficient Gibbs sampler has been developed to facilitate fast computation. The Markov chain Monte Carlo algorithms of the proposed and alternative methods are efficiently implemented in C++'. The development of this software package and the associated statistical methods have been partially supported by an Innovative Research Award from Johnson Cancer Research Center, Kansas State University.

This package provides a customisable R shiny app for immersively visualising, mapping and annotating panospheric (360 degree) imagery. The flexible interface allows annotation of any geocoded images using up to 4 user specified dropdown menus. The app uses leaflet to render maps that display the geo-locations of images and panellum <https://pannellum.org/>, a lightweight panorama viewer for the web, to render images in virtual 360 degree viewing mode. Key functions include the ability to draw on & export parts of 360 images for downstream applications. Users can also draw polygons and points on map imagery related to the panoramic images and export them for further analysis. Downstream applications include using annotations to train Artificial Intelligence/Machine Learning (AI/ML) models and geospatial modelling and analysis of camera based survey data.