Fast approximate methods for mixed logistic regression in genome-wide analysis studies (GWAS). Two computationnally efficient methods are proposed for obtaining effect size estimates (beta) in Mixed Logistic Regression in GWAS: the Approximate Maximum Likelihood Estimate (AMLE), and the Offset method. The wald test obtained with AMLE is identical to the score test. Data can be genotype matrices in plink format, or dosage (VCF files). The methods are described in details in Milet et al (2020) <doi:10.1101/2020.01.17.910109>.

Vitamin and mineral deficiencies continue to be a significant public health problem. This is particularly critical in developing countries where deficiencies to vitamin A, iron, iodine, and other micronutrients lead to adverse health consequences. Cross-sectional surveys are helpful in answering questions related to the magnitude and distribution of deficiencies of selected vitamins and minerals. This package provides tools for calculating and determining select vitamin and mineral deficiencies based on World Health Organization (WHO) guidelines found at <https://www.who.int/teams/nutrition-and-food-safety/databases/vitamin-and-mineral-nutrition-information-system>.

This package provides tools and demonstrates methods for working with individual undergraduate student-level records (registrar's data) in R'. Tools include filters for program codes, data sufficiency, and timely completion. Methods include gathering blocs of records, computing quantitative metrics such as graduation rate, and creating charts to visualize comparisons. midfieldr interacts with practice data provided in midfielddata', an R data package available at <https://midfieldr.github.io/midfielddata/>. midfieldr also interacts with the full MIDFIELD database for users who have access. This work is supported by the US National Science Foundation through grant numbers 1545667 and 2142087.

Kernel-based methods are powerful methods for integrating heterogeneous types of data. mixKernel aims at providing methods to combine kernel for unsupervised exploratory analysis. Different solutions are provided to compute a meta-kernel, in a consensus way or in a way that best preserves the original topology of the data. mixKernel also integrates kernel PCA to visualize similarities between samples in a non linear space and from the multiple source point of view <doi:10.1093/bioinformatics/btx682>. A method to select (as well as funtions to display) important variables is also provided <doi:10.1093/nargab/lqac014>.

Statistical Analyses and Pooling after Multiple Imputation. A large variety of repeated statistical analysis can be performed and finally pooled. Statistical analysis that are available are, among others, Levene's test, Odds and Risk Ratios, One sample proportions, difference between proportions and linear and logistic regression models. Functions can also be used in combination with the Pipe operator. More and more statistical analyses and pooling functions will be added over time. Heymans (2007) <doi:10.1186/1471-2288-7-33>. Eekhout (2017) <doi:10.1186/s12874-017-0404-7>. Wiel (2009) <doi:10.1093/biostatistics/kxp011>. Marshall (2009) <doi:10.1186/1471-2288-9-57>. Sidi (2021) <doi:10.1080/00031305.2021.1898468>. Lott (2018) <doi:10.1080/00031305.2018.1473796>. Grund (2021) <doi:10.31234/osf.io/d459g>.

This package contains a suite of functions for health economic evaluations with missing outcome data. The package can fit different types of statistical models under a fully Bayesian approach using the software JAGS (which should be installed locally and which is loaded in missingHE via the R package R2jags'). Three classes of models can be fitted under a variety of missing data assumptions: selection models, pattern mixture models and hurdle models. In addition to model fitting, missingHE provides a set of specialised functions to assess model convergence and fit, and to summarise the statistical and economic results using different types of measures and graphs. The methods implemented are described in Mason (2018) <doi:10.1002/hec.3793>, Molenberghs (2000) <doi:10.1007/978-1-4419-0300-6_18> and Gabrio (2019) <doi:10.1002/sim.8045>.

This package provides functions to calculate the minimum and maximum possible values of Cronbach's alpha when item-level missing data are present. Cronbach's alpha (Cronbach, 1951 <doi:10.1007/BF02310555>) is one of the most widely used measures of internal consistency in the social, behavioral, and medical sciences (Bland & Altman, 1997 <doi:10.1136/bmj.314.7080.572>; Tavakol & Dennick, 2011 <doi:10.5116/ijme.4dfb.8dfd>). However, conventional implementations assume complete data, and listwise deletion is often applied when missingness occurs, which can lead to biased or overly optimistic reliability estimates (Enders, 2003 <doi:10.1037/1082-989X.8.3.322>). This package implements computational strategies including enumeration, Monte Carlo sampling, and optimization algorithms (e.g., Genetic Algorithm, Differential Evolution, Sequential Least Squares Programming) to obtain sharp lower and upper bounds of Cronbach's alpha under arbitrary missing data patterns. The approach is motivated by Manski's partial identification framework and pessimistic bounding ideas from optimization literature.

The microplot function writes a set of R graphics files to be used as microplots (sparklines) in tables in either LaTeX', HTML', Word', or Excel files. For LaTeX', we provide methods for the Hmisc::latex() generic function to construct latex tabular environments which include the graphs. These can be used directly with the operating system pdflatex or latex command, or by using one of Sweave', knitr', rmarkdown', or Emacs org-mode as an intermediary. For MS Word', the msWord() function uses the flextable package to construct Word tables which include the graphs. There are several distinct approaches for constructing HTML files. The simplest is to use the msWord() function with argument filetype="html". Alternatively, use either Emacs org-mode or the htmlTable::htmlTable() function to construct an HTML file containing tables which include the graphs. See the documentation for our as.htmlimg() function. For Excel use on Windows', the file examples/irisExcel.xls includes VBA code which brings the individual panels into individual cells in the spreadsheet. Examples in the examples and demo subdirectories are shown with lattice graphics, ggplot2 graphics, and base graphics. Examples for LaTeX include Sweave (both LaTeX'-style and Noweb'-style), knitr', emacs org-mode', and rmarkdown input files and their pdf output files. Examples for HTML include org-mode and Rmd input files and their webarchive HTML output files. In addition, the as.orgtable() function can display a data.frame in an org-mode document. The examples for MS Word (with either filetype="docx" or filetype="html") work with all operating systems. The package does not require the installation of LaTeX or MS Word to be able to write .tex or .docx files.

Enables you to create accessible modal dialogs, with confidence and with minimal configuration.

Codelink Mouse Inflammation 16 Bioarray annotation data (chip mi16cod) assembled using data from public repositories.

This package provides a package containing an environment representing the miRNA-2_0.cdf file.

This package provides a package containing an environment representing the miRNA-1_0.CDF file.

miRBase: the microRNA database assembled using data from miRBase (http://www.mirbase.org/).

Generate central composite designs (CCD)with full as well as fractional factorial points (half replicate) and Box Behnken designs (BBD) with minimally changed run sequence.

This package provides a simple and trustworthy methodology for the analysis of misreported continuous time series. See Moriña, D, Fernández-Fontelo, A, Cabaña, A, Puig P. (2021) <arXiv:2003.09202v2>.

This package implements two methods: a nonparametric risk adjustment and a data imputation method that use general population mortality tables to allow a correct analysis of time to disease recurrence. Also includes a powerful set of object oriented survival data simulation functions.

This package provides an extension to the lolog package by introducing the minTriadicClosure() statistic to capture higher-order interactions among triplets of nodes. This function facilitates improved modelling of group formations and triadic closure in networks. A smoothing parameter has been incorporated to avoid numerical errors.

This package primarily identifies variants in mitochondrial genomes from BAM alignment files. It filters these variants to remove RNA editing events then estimates their evolutionary relationship (i.e. their phylogenetic tree) and groups single cells into clones. It also visualizes the mutations and providing additional genomic context.

The nls.lm function provides an R interface to lmder and lmdif from the MINPACK library, for solving nonlinear least-squares problems by a modification of the Levenberg-Marquardt algorithm, with support for lower and upper parameter bounds. The implementation can be used via nls-like calls using the nlsLM function.

Mixedpower uses pilotdata and a linear mixed model fitted with lme4 to simulate new data sets. Power is computed separate for every effect in the model output as the relation of significant simulations to all simulations. More conservative simulations as a protection against a bias in the pilotdata are available as well as methods for plotting the results.

This package contains the function mice.impute.midastouch(). Technically this function is to be run from within the mice package (van Buuren et al. 2011), type ??mice. It substitutes the method pmm within mice by midastouch'. The authors have shown that midastouch is superior to default pmm'. Many ideas are based on Siddique / Belin 2008's MIDAS.

Using this package, one can determine the minimum sample size required so that the absolute deviation of the sample mean and the population mean of a distribution becomes less than some pre-determined epsilon, i.e. it helps the user to determine the minimum sample size required to attain the pre-fixed precision level by minimizing the difference between the sample mean and population mean.

Providing C implementation for the computing of monotonic spline bases, including M-splines, I-splines, and C-splines, denoted by MIC splines. The definitions of the spline bases are described in Meyer (2008) <doi: 10.1214/08-AOAS167>. The package also provides the computing of constrained least-squares estimates when a subset of or all of the regression coefficients are constrained to be non-negative.

Using this package, one can determine the minimum sample size required so that the mean square error of the sample mean and the population mean of a distribution becomes less than some pre-determined epsilon, i.e. it helps the user to determine the minimum sample size required to attain the pre-fixed precision level by minimizing the difference between the sample mean and population mean.