Epidemiological population dynamics models traditionally define a pathogen's virulence as the increase in the per capita rate of mortality of infected hosts due to infection. This package provides functions allowing virulence to be estimated by maximum likelihood techniques. The approach is based on the analysis of relative survival comparing survival in matching cohorts of infected vs. uninfected hosts (Agnew 2019) <doi:10.1101/530709>.

The functions in this package inspect, read, edit and run files for APSIM "Next Generation" ('JSON') and APSIM "Classic" ('XML'). The files with an apsim extension correspond to APSIM Classic (7.x) - Windows only - and the ones with an apsimx extension correspond to APSIM "Next Generation". For more information about APSIM see (<https://www.apsim.info/>) and for APSIM next generation (<https://apsimnextgeneration.netlify.app/>).

To address the violation of the assumption of normally distributed variables, researchers frequently employ bootstrapping. Building upon established packages for R (Sigmann et al. (2024) <doi:10.32614/CRAN.package.afex>, Lenth (2024) <doi:10.32614/CRAN.package.emmeans>), we provide bootstrapping functions to approximate a normal distribution of the parameter estimates for between-subject, within-subject, and mixed one-way and two-way ANOVA.

An implementation of intervention effect estimation for DAGs (directed acyclic graphs) learned from binary or continuous data. First, parameters are estimated or sampled for the DAG and then interventions on each node (variable) are propagated through the network (do-calculus). Both exact computation (for continuous data or for binary data up to around 20 variables) and Monte Carlo schemes (for larger binary networks) are implemented.

Fits unimodal and multimodal gambin distributions to species-abundance distributions from ecological data, as in in Matthews et al. (2014) <DOI:10.1111/ecog.00861>. gambin is short for gamma-binomial'. The main function is fit_abundances(), which estimates the alpha parameter(s) of the gambin distribution using maximum likelihood. Functions are also provided to generate the gambin distribution and for calculating likelihood statistics.

The method aims to identify important factors in screening experiments by aggregation over random models as studied in Singh and Stufken (2022) <doi:10.48550/arXiv.2205.13497>. This package provides functions to run the Gauss-Dantzig selector on screening experiments when interactions may be affecting the response. Currently, all functions require each factor to be at two levels coded as +1 and -1.

An implementation of the modelling and reporting features described in reference textbook and guidelines (Briggs, Andrew, et al. Decision Modelling for Health Economic Evaluation. Oxford Univ. Press, 2011; Siebert, U. et al. State-Transition Modeling. Medical Decision Making 32, 690-700 (2012).): deterministic and probabilistic sensitivity analysis, heterogeneity analysis, time dependency on state-time and model-time (semi-Markov and non-homogeneous Markov models), etc.

Vector operations between grapes: An infix-only package! The invctr functions perform common and less common operations on vectors, data frames matrices and list objects: - Extracting a value (range), or, finding the indices of a value (range). - Trimming, or padding a vector with a value of your choice. - Simple polynomial regression. - Set and membership operations. - General check & replace function for NAs, Inf and other values.

An easy way to work with census, survey, and geographic data provided by IPUMS in R. Generate and download data through the IPUMS API and load IPUMS files into R with their associated metadata to make analysis easier. IPUMS data describing 1.4 billion individuals drawn from over 750 censuses and surveys is available free of charge from the IPUMS website <https://www.ipums.org>.

This package implements penalised multivariate regression (i.e., for multiple outcomes and many features) by stacked generalisation (<doi:10.1093/bioinformatics/btab576>). For positively correlated outcomes, a single multivariate regression is typically more predictive than multiple univariate regressions. Includes functions for model fitting, extracting coefficients, outcome prediction, and performance measurement. For optional comparisons, install remMap from GitHub (<https://github.com/cran/remMap>).

An R code with a GUI for microclimate time series, with an emphasis on underground environments. KarsTS provides linear and nonlinear methods, including recurrence analysis (Marwan et al. (2007) <doi:10.1016/j.physrep.2006.11.001>) and filling methods (Moffat et al. (2007) <doi:10.1016/j.agrformet.2007.08.011>), as well as tools to manipulate easily time series and gap sets.

This package provides extensions for packages leaflet & mapdeck', many of which are used by package mapview'. Focus is on functionality readily available in Geographic Information Systems such as Quantum GIS'. Includes functions to display coordinates of mouse pointer position, query image values via mouse pointer and zoom-to-layer buttons. Additionally, provides a feature type agnostic function to add points, lines, polygons to a map.

Extends the mlr3 package with a backend to transparently work with databases such as SQLite', DuckDB', MySQL', MariaDB', or PostgreSQL'. The package provides three additional backends: DataBackendDplyr relies on the abstraction of package dbplyr to interact with most DBMS. DataBackendDuckDB operates on DuckDB data bases and also on Apache Parquet files. DataBackendPolars operates on Polars data frames.

Import bathymetric and hypsometric data from the NOAA (National Oceanic and Atmospheric Administration, <https://www.ncei.noaa.gov/products/etopo-global-relief-model>), GEBCO (General Bathymetric Chart of the Oceans, <https://www.gebco.net>) and other sources, plot xyz data to prepare publication-ready figures, analyze xyz data to extract transects, get depth / altitude based on geographical coordinates, or calculate z-constrained least-cost paths.

The QRI_func() function performs quantile regression analysis using age and sex as predictors to calculate the Quantile Regression Index (QRI) score for each individualâ s regional brain imaging metrics and then averages across the regional scores to generate an average tissue specific score for each subject. The QRI_plot() is used to plot QRI and generate the normative curves for individual measurements.

This package provides models to identify bimodally expressed genes from RNAseq data based on the Bimodality Index. SIBERG models the RNAseq data in the finite mixture modeling framework and incorporates mechanisms for dealing with RNAseq normalization. Three types of mixture models are implemented, namely, the mixture of log normal, negative binomial, or generalized Poisson distribution. See Tong et al. (2013) <doi:10.1093/bioinformatics/bts713>.

Predicts the occurrence times (in day-of-year) of spring phenological events. Three methods, including the accumulated degree days (ADD) method, the accumulated days transferred to a standardized temperature (ADTS) method, and the accumulated developmental progress (ADP) method, were used. See Shi et al. (2017a) <doi:10.1016/j.agrformet.2017.04.001> and Shi et al. (2017b) <doi:10.1093/aesa/sax063> for details.

Estimate vaccine efficacy (VE) using immunogenicity data. The inclusion of immunogenicity data in regression models can increase precision in VE. The methods are described in the publications "Elucidating vaccine efficacy using a correlate of protection, demographics, and logistic regression" and "Improving precision of vaccine efficacy evaluation using immune correlate data in time-to-event models" by Julie Dudasova, Zdenek Valenta, and Jeffrey R. Sachs (2024).

Hamiltonian Monte Carlo for both continuous and discontinuous posterior distributions with a customizable trajectory length termination criterion. See Nishimura et al. (2020) <doi:10.1093/biomet/asz083> for the original Discontinuous Hamiltonian Monte Carlo; Hoffman et al. (2014) <doi:10.48550/arXiv.1111.4246> and Betancourt (2016) <doi:10.48550/arXiv.1601.00225> for the definition of possible Hamiltonian Monte Carlo termination criteria.

This package provides a comprehensive suite of utilities for univariate continuous probability distributions and reliability models. Includes functions to compute the probability density, cumulative distribution, quantile, reliability, and hazard functions, along with random variate generation. Also offers diagnostic and model assessment tools such as Quantile-Quantile (Q-Q) and Probability-Probability (P-P) plots, the Kolmogorov-Smirnov goodness-of-fit test, and model selection criteria including the Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC). Currently implements the following distributions: Burr X, Chen, Exponential Extension, Exponentiated Logistic, Exponentiated Weibull, Exponential Power, Flexible Weibull, Generalized Exponential, Gompertz, Generalized Power Weibull, Gumbel, Inverse Generalized Exponential, Linear Failure Rate, Log-Gamma, Logistic-Exponential, Logistic-Rayleigh, Log-log, Marshall-Olkin Extended Exponential, Marshall-Olkin Extended Weibull, and Weibull Extension distributions. Serves as a valuable resource for teaching and research in probability theory, reliability analysis, and applied statistical modeling.

ASURAT is a software for single-cell data analysis. Using ASURAT, one can simultaneously perform unsupervised clustering and biological interpretation in terms of cell type, disease, biological process, and signaling pathway activity. Inputting a single-cell RNA-seq data and knowledge-based databases, such as Cell Ontology, Gene Ontology, KEGG, etc., ASURAT transforms gene expression tables into original multivariate tables, termed sign-by-sample matrices (SSMs).

scider is an user-friendly R package providing functions to model the global density of cells in a slide of spatial transcriptomics data. All functions in the package are built based on the SpatialExperiment object, allowing integration into various spatial transcriptomics-related packages from Bioconductor. After modelling density, the package allows for serveral downstream analysis, including colocalization analysis, boundary detection analysis and differential density analysis.

Signal-to-Noise applied to Gene Expression Experiments. Signal-to-noise ratios can be used as a proxy for quality of gene expression studies and samples. The SNRs can be calculated on any gene expression data set as long as gene IDs are available, no access to the raw data files is necessary. This allows to flag problematic studies and samples in any public data set.

Various mRNA sequencing library preparation methods generate sequencing reads specifically from the transcript ends. Analyses that focus on quantification of isoform usage from such data can be aided by using truncated versions of transcriptome annotations, both at the alignment or pseudo-alignment stage, as well as in downstream analysis. This package implements some convenience methods for readily generating such truncated annotations and their corresponding sequences.