This package implements a parsimonious evolutionary model to analyze and predict gene-functional annotations in phylogenetic trees as described in Vega Yon et al. (2021) <doi:10.1371/journal.pcbi.1007948>. Focusing on computational efficiency, aphylo makes it possible to estimate pooled phylogenetic models, including thousands (hundreds) of annotations (trees) in the same run. The package also provides the tools for visualization of annotated phylogenies, calculation of posterior probabilities (prediction) and goodness-of-fit assessment featured in Vega Yon et al. (2021).

Fitting Bayesian multiple and mixed-effect regression models for circular data based on the projected normal distribution. Both continuous and categorical predictors can be included. Sampling from the posterior is performed via an MCMC algorithm. Posterior descriptives of all parameters, model fit statistics and Bayes factors for hypothesis tests for inequality constrained hypotheses are provided. See Cremers, Mulder & Klugkist (2018) <doi:10.1111/bmsp.12108> and Nuñez-Antonio & Guttiérez-Peña (2014) <doi:10.1016/j.csda.2012.07.025>.

Demonstrate the results of a statistical model object as a dynamic nomogram in an RStudio panel or web browser. The package provides two generics functions: DynNom, which display statistical model objects as a dynamic nomogram; DNbuilder, which builds required scripts to publish a dynamic nomogram on a web server such as the <https://www.shinyapps.io/>. Current version of DynNom supports stats::lm, stats::glm, survival::coxph, rms::ols, rms::Glm, rms::lrm, rms::cph, and mgcv::gam model objects.

This package provides functions for range estimation in birds based on Pennycuick (2008) and Pennycuick (1975), Flight program which compliments Pennycuick (2008) requires manual entry of birds which can be tedious when there are thousands of birds to estimate. Implemented are two ODE methods discussed in Pennycuick (1975) and time-marching computation method "constant muscle mass" as in Pennycuick (1998). See Pennycuick (1975, ISBN:978-0-12-249405-5), Pennycuick (1998) <doi:10.1006/jtbi.1997.0572>, and Pennycuick (2008, ISBN:9780080557816).

Implementation of Forecastable Component Analysis ('ForeCA'), including main algorithms and auxiliary function (summary, plotting, etc.) to apply ForeCA to multivariate time series data. ForeCA is a novel dimension reduction (DR) technique for temporally dependent signals. Contrary to other popular DR methods, such as PCA or ICA', ForeCA takes time dependency explicitly into account and searches for the most forecastable signal. The measure of forecastability is based on the Shannon entropy of the spectral density of the transformed signal.

This function is an extension of the Small Area Estimation (SAE) model. Geoadditive Small Area Model is a combination of the geoadditive model with the Small Area Estimation (SAE) model, by adding geospatial information to the SAE model. This package refers to J.N.K Rao and Isabel Molina (2015, ISBN: 978-1-118-73578-7), Bocci, C., & Petrucci, A. (2016)<doi:10.1002/9781118814963.ch13>, and Ardiansyah, M., Djuraidah, A., & Kurnia, A. (2018)<doi:10.21082/jpptp.v2n2.2018.p101-110>.

Allows to evaluate Higher Order Assortativity of complex networks defined through objects of class igraph from the package of the same name. The package returns a result also for directed and weighted graphs. References, Arcagni, A., Grassi, R., Stefani, S., & Torriero, A. (2017) <doi:10.1016/j.ejor.2017.04.028> Arcagni, A., Grassi, R., Stefani, S., & Torriero, A. (2021) <doi:10.1016/j.jbusres.2019.10.008> Arcagni, A., Cerqueti, R., & Grassi, R. (2023) <doi:10.48550/arXiv.2304.01737>.

This package provides a shiny app that supports both dual and bulk RNA-seq, with the dual RNA-seq functionality offering the flexibility to perform either a sequential approach (where reads are mapped separately to each genome) or a combined approach (where reads are aligned to a single merged genome). The user-friendly interface automates the analysis process, providing step-by-step guidance, making it easy for users to navigate between different analysis steps, and download intermediate results and publication-ready plots.

This package provides a comprehensive computational framework for joint mapping, developed by Li (2016) <doi:10.11841/j.issn.1007-4333.2016.06.002>, supports quantitative trait locus detection in structured genetic populations. It integrates robust phenotype summarization, computes genotype probabilities, and imputes missing markers for association and linkage mapping. Empirical significance thresholds are estimated via permutation testing coupled with stepwise regression. The framework enables genome-wide scans under both univariate and multivariate trait models, streamlining the discovery of complex genetic architectures.

It uses phenological and productivity-related variables derived from time series of vegetation indexes, such as the Normalized Difference Vegetation Index, to assess ecosystem dynamics and change, which eventually might drive to land degradation. The final result of the Land Productivity Dynamics indicator is a categorical map with 5 classes of land productivity dynamics, ranging from declining to increasing productivity. See www.sciencedirect.com/science/article/pii/S1470160X21010517/ for a description of the methods used in the package to calculate the indicator.

Implementation of marginalized models for zero-inflated count data. The package provides tools to estimate marginalized count regression models for direct inference on the effect of covariates on the marginal mean of the outcome. The methods include the marginalized zero-inflated Poisson (MZIP) model described in Long et al. (2014) <doi:10.1002/sim.6293> and the marginalized zero- and N-inflated binomial (MZNIB) model, which extends marginalized modeling to fractional count outcomes with boundary inflation at zero and the upper limit.

Fits regularization paths for linear regression, GLM, and Cox regression models using lasso or nonconvex penalties, in particular the minimax concave penalty (MCP) and smoothly clipped absolute deviation (SCAD) penalty, with options for additional L2 penalties (the "elastic net" idea). Utilities for carrying out cross-validation as well as post-fitting visualization, summarization, inference, and prediction are also provided. For more information, see Breheny and Huang (2011) <doi:10.1214/10-AOAS388> or visit the ncvreg homepage <https://pbreheny.github.io/ncvreg/>.

The author has retired from academic research. Accordingly, this package should not be considered a validated tool for use in peer-reviewed publications or as the basis for grant applications. Backward compatibility with user-code published in <doi:10.1186/s12859-023-05408-8>, <doi:10.1016/j.labinv.2023.100158> and <doi:10.1093/bioinformatics/btaf182> is not maintained in versions >= 0.4.0 (June 2026) of this package. The authors of those publications are the appropriate contacts for reproducibility inquiries.

Estimate the receiver operating characteristic (ROC) curve, area under the curve (AUC) and optimal cut-off points for individual classification taking into account complex sampling designs when working with complex survey data. Methods implemented in this package are described in: A. Iparragirre, I. Barrio, I. Arostegui (2024) <doi:10.1002/sta4.635>; A. Iparragirre, I. Barrio, J. Aramendi, I. Arostegui (2022) <doi:10.2436/20.8080.02.121>; A. Iparragirre, I. Barrio (2024) <doi:10.1007/978-3-031-65723-8_7>.

Soft-margin support vector machines (SVMs) are a common class of classification models. The training of SVMs usually requires that the data be available all at once in a single batch, however the Stochastic majorization-minimization (SMM) algorithm framework allows for the training of SVMs on streamed data instead Nguyen, Jones & McLachlan(2018)<doi:10.1007/s42081-018-0001-y>. This package utilizes the SMM framework to provide functions for training SVMs with hinge loss, squared-hinge loss, and logistic loss.

Calculates total survey error (TSE) for one or more surveys, using both scale-dependent and scale-independent metrics. Package works directly from the data set, with no hand calculations required: just upload a properly structured data set (see TESTIND and its documentation), properly input column names (see functions documentation), and run your functions. For more on TSE, see: Weisberg, Herbert (2005, ISBN:0-226-89128-3); Biemer, Paul (2010) <doi:10.1093/poq/nfq058>; Biemer, Paul et.al. (2017, ISBN:9781119041672); etc.

In diagnostic contexts, individuals are often assessed using multiple tests that measure the same latent variable (e.g., intelligence). These test scores are typically not exactly identical. Simple averaging neglects the correlation between tests and the reduced variance of their combination. The unifyR package provides functions to compute statistically accurate unified scores, reliabilities and validities of multiple tests. The underlying algorithms build on and extend the method proposed by Evans (1996, <DOI:10.3758/BF03204767>) and have been validated through simulations.

This package implements functions for varying coefficient meta-analysis methods. These methods do not assume effect size homogeneity. Subgroup effect size comparisons, general linear effect size contrasts, and linear models of effect sizes based on varying coefficient methods can be used to describe effect size heterogeneity. Varying coefficient meta-analysis methods do not require the unrealistic assumptions of the traditional fixed-effect and random-effects meta-analysis methods. For details see: Statistical Methods for Psychologists, Volume 5, <https://dgbonett.sites.ucsc.edu/>.

Enables interaction with the National Weather Service application programming web-interface for fetching of real-time and forecast meteorological data. Users can provide latitude and longitude, Automated Surface Observing System identifier, or Automated Weather Observing System identifier to fetch recent weather observations and recent forecasts for the given location or station. Additionally, auxiliary functions exist to identify stations nearest to a point, convert wind direction from character to degrees, and fetch active warnings. Results are returned as simple feature objects whenever possible.

This package provides a one-to-one mapping from gene to "best" probe set for four Affymetrix human gene expression microarrays: hgu95av2, hgu133a, hgu133plus2, and u133x3p. On Affymetrix gene expression microarrays, a single gene may be measured by multiple probe sets. This can present a mild conundrum when attempting to evaluate a gene "signature" that is defined by gene names rather than by specific probe sets. This package also includes the pre-calculated probe set quality scores that were used to define the mapping.

This package implements an approach for scanning the genome to detect and perform accurate inference on differentially methylated regions from Whole Genome Bisulfite Sequencing data. The method is based on comparing detected regions to a pooled null distribution, that can be implemented even when as few as two samples per population are available. Region-level statistics are obtained by fitting a generalized least squares (GLS) regression model with a nested autoregressive correlated error structure for the effect of interest on transformed methylation proportions.

This is a package for fast and user-friendly estimation of econometric models with multiple fixed-effects. It includes ordinary least squares (OLS), generalized linear models (GLM) and the negative binomial. The core of the package is based on optimized parallel C++ code, scaling especially well for large data sets. The method to obtain the fixed-effects coefficients is based on Berge (2018). It further provides tools to export and view the results of several estimations with intuitive design to cluster the standard-errors.

Select hits from synthetic lethal RNAi screen data. For example, there are two identical celllines except one gene is knocked-down in one cellline. The interest is to find genes that lead to stronger lethal effect when they are knocked-down further by siRNA. Quality control and various visualisation tools are implemented. Four different algorithms could be used to pick up the interesting hits. This package is designed based on 384 wells plates, but may apply to other platforms with proper configuration.

Uniparental disomy (UPD) is a genetic condition where an individual inherits both copies of a chromosome or part of it from one parent, rather than one copy from each parent. This package contains a HMM for detecting UPDs through HTS (High Throughput Sequencing) data from trio assays. By analyzing the genotypes in the trio, the model infers a hidden state (normal, father isodisomy, mother isodisomy, father heterodisomy and mother heterodisomy). For details see Sevilla-Porras et al. (2026) <doi:10.1093/bioinformatics/btag062>.