Collection of indices and tools relating to clinical research that aid epidemiological cohort or retrospective chart review with big data. All indices and tools take commonly used lab values, patient demographics, and clinical measurements to compute various risk and predictive values for survival or further classification/stratification. References to original literature and validation contained in each function documentation. Includes all commonly available calculators available online.

Detect and quantify community assembly processes using trait values of individuals or populations, the T-statistics and other metrics, and dedicated null models.

This package provides a basic implementation of the change in mean detection method outlined in: Taylor, Wayne A. (2000) <https://variation.com/wp-content/uploads/change-point-analyzer/change-point-analysis-a-powerful-new-tool-for-detecting-changes.pdf>. The package recursively uses the mean-squared error change point calculation to identify candidate change points. The candidate change points are then re-estimated and Taylor's backwards elimination process is then employed to come up with a final set of change points. Many of the underlying functions are written in C++ for improved performance.

Creation and selection of (Advanced) Coupled Matrix and Tensor Factorization (ACMTF) and ACMTF-Regression (ACMTF-R) models. Selection of the optimal number of components can be done using ACMTF_modelSelection() and ACMTFR_modelSelection()'. The CMTF and ACMTF methods were originally described by Acar et al., 2011 <doi:10.48550/arXiv.1105.3422> and Acar et al., 2014 <doi:10.1186/1471-2105-15-239>, respectively.

Statistical analysis of axial using distributions Nonnegative Trigonometric Sums (NNTS). The package includes functions for calculation of densities and distributions, for the estimation of parameters, and more. Fernandez-Duran, J.J. and Gregorio-Dominguez, M.M. (2025), Multimodal distributions for circular axial data", <doi:10.48550/arXiv.2504.04681>.

This package provides a simple interface for multivariate correlation analysis that unifies various classical statistical procedures including t-tests, tests in univariate and multivariate linear models, parametric and nonparametric tests for correlation, Kruskal-Wallis tests, common approximate versions of Wilcoxon rank-sum and signed rank tests, chi-squared tests of independence, score tests of particular hypotheses in generalized linear models, canonical correlation analysis and linear discriminant analysis.

Process command line arguments, as part of a data analysis workflow. command makes it easier to construct a workflow consisting of lots of small, self-contained scripts, all run from a Makefile or shell script. The aim is a workflow that is modular, transparent, and reliable.

Statistical summary of STRUCTURE output. STRUCTURE is a K-means clustering method for inferring population structure and assigning individuals to populations using genetic data. Pritchard JK, Stephens M, Donnelly PJ (2000) <DOI:10.1093/genetics/155.2.945>. <https://web.stanford.edu/group/pritchardlab/structure.html>.

Analyze and compare conversations using various similarity measures including topic, lexical, semantic, structural, stylistic, sentiment, participant, and timing similarities. Supports both pairwise conversation comparisons and analysis of multiple dyads. Methods are based on established research: Topic modeling: Blei et al. (2003) <doi:10.1162/jmlr.2003.3.4-5.993>; Landauer et al. (1998) <doi:10.1080/01638539809545028>; Lexical similarity: Jaccard (1912) <doi:10.1111/j.1469-8137.1912.tb05611.x>; Semantic similarity: Salton & Buckley (1988) <doi:10.1016/0306-4573(88)90021-0>; Mikolov et al. (2013) <doi:10.48550/arXiv.1301.3781>; Pennington et al. (2014) <doi:10.3115/v1/D14-1162>; Structural and stylistic analysis: Graesser et al. (2004) <doi:10.1075/target.21131.ryu>; Sentiment analysis: Rinker (2019) <https://github.com/trinker/sentimentr>.

Providing more beautiful and more meaningful return messages for checkmate assertions and checks helping users to better understand errors.

CEU (CEU San Pablo University) Mass Mediator is an on-line tool for aiding researchers in performing metabolite annotation. cmmr (CEU Mass Mediator RESTful API) allows for programmatic access in R: batch search, batch advanced search, MS/MS (tandem mass spectrometry) search, etc. For more information about the API Endpoint please go to <https://github.com/YaoxiangLi/cmmr>.

This package provides a publication-ready toolkit for modern survival and competing risks analysis with a minimal, formula-based interface. Both nonparametric estimation and direct polytomous regression of cumulative incidence functions (CIFs) are supported. The main functions cifcurve()', cifplot()', and cifpanel() estimate survival and CIF curves and produce high-quality graphics with risk tables, censoring and competing-risk marks, and multi-panel or inset layouts built on ggplot2 and ggsurvfit'. The modeling function polyreg() performs direct polytomous regression for coherent joint modeling of all cause-specific CIFs to estimate risk ratios, odds ratios, or subdistribution hazard ratios at user-specified time points. All core functions adopt a formula-and-data syntax and return tidy and extensible outputs that integrate smoothly with modelsummary', broom', and the broader tidyverse ecosystem. Key numerical routines are implemented in C++ via Rcpp'.

This package provides robust and efficient methods for estimating causal effects in a target population using a multi-source dataset, including those of Dahabreh et al. (2019) <doi:10.1111/biom.13716>, Robertson et al. (2021) <doi:10.48550/arXiv.2104.05905>, and Wang et al. (2024) <doi:10.48550/arXiv.2402.02684>. The multi-source data can be a collection of trials, observational studies, or a combination of both, which have the same data structure (outcome, treatment, and covariates). The target population can be based on an internal dataset or an external dataset where only covariate information is available. The causal estimands available are average treatment effects and subgroup treatment effects. See Wang et al. (2025) <doi:10.1017/rsm.2025.5> for a detailed guide on using the package.

An R interface to Cheetah Grid', a high-performance JavaScript table widget. cheetahR allows users to render millions of rows in just a few milliseconds, making it an excellent alternative to other R table widgets. The package wraps the Cheetah Grid JavaScript functions and makes them readily available for R users. The underlying grid implementation is based on Cheetah Grid <https://github.com/future-architect/cheetah-grid>.

Cronbach's alpha and various formulas for confidence intervals. The relevant paper is Tsagris M., Frangos C.C. and Frangos C.C. (2013). "Confidence intervals for Cronbach's reliability coefficient". Recent Techniques in Educational Science, 14-16 May, Athens, Greece.

Assignment of cell type labels to single-cell RNA sequencing (scRNA-seq) clusters is often a time-consuming process that involves manual inspection of the cluster marker genes complemented with a detailed literature search. This is especially challenging when unexpected or poorly described populations are present. The clustermole R package provides methods to query thousands of human and mouse cell identity markers sourced from a variety of databases.

This package provides adaptive trend estimation, cycle detection, Fourier harmonic selection, bootstrap confidence intervals, change-point detection, and rolling-origin forecasting. Supports LOESS (Locally Estimated Scatterplot Smoothing), GAM (Generalized Additive Model), and GAMM (Generalized Additive Mixed Model), and automatically handles irregular sampling using the Lomb-Scargle periodogram. Methods implemented in this package are described in Cleveland et al. (1990) <doi:10.2307/2289548>, Wood (2017) <doi:10.1201/9781315370279>, and Scargle (1982) <doi:10.1086/160554>.

This package provides interactive command-line menu functionality with single and multiple selection menus, keyboard navigation (arrow keys or vi-style j/k), preselection, and graceful fallback for non-interactive environments. Inspired by tools such as inquirer.js <https://github.com/SBoudrias/Inquirer.js>, pick <https://github.com/aisk/pick>, and survey <https://github.com/AlecAivazis/survey>. Designed to be lightweight and easy to integrate into R packages and scripts.

Automated and robust framework for analyzing R-R interval (RRi) signals using advanced nonlinear modeling and preprocessing techniques. The package implements a dual-logistic model to capture the rapid drop and subsequent recovery of RRi during exercise, as described by Castillo-Aguilar et al. (2025) <doi:10.1038/s41598-025-93654-6>. In addition, CardioCurveR includes tools for filtering RRi signals using zero-phase Butterworth low-pass filtering and for cleaning ectopic beats via adaptive outlier replacement using local regression and robust statistics. These integrated methods preserve the dynamic features of RRi signals and facilitate accurate cardiovascular monitoring and clinical research.

This package implements lasso and ridge regression for dichotomised outcomes (<doi:10.1080/02664763.2023.2233057>), i.e., numerical outcomes that were transformed to binary outcomes. Such artificial binary outcomes indicate whether an underlying measurement is greater than a threshold.

Simulates clinical trials and summarizes causal effects and treatment policy estimands in the presence of intercurrent events in a transparent and intuitive manner.

CLUster Evaluation (CLUE) is a computational method for identifying optimal number of clusters in a given time-course dataset clustered by cmeans or kmeans algorithms and subsequently identify key kinases or pathways from each cluster. Its implementation in R is called ClueR. See README on <https://github.com/PYangLab/ClueR> for more details. P Yang et al. (2015) <doi:10.1371/journal.pcbi.1004403>.

Design and use of control charts for detecting mean changes based on a delayed updating of the in-control parameter estimates. See Capizzi and Masarotto (2019) <doi:10.1080/00224065.2019.1640096> for the description of the method.

Utilize the shiny interface to generate Goodness of Fit (GOF) plots and tables for Non-Linear Mixed Effects (NLME / NONMEM) pharmacometric models. From the interface, users can customize model diagnostics and generate the underlying R code to reproduce the diagnostic plots and tables outside of the shiny session. Model diagnostics can be included in a rmarkdown document and rendered to desired output format.