An easy-to-use workflow that provides tools to create, update and fill literature matrices commonly used in research, specifically epidemiology and health sciences research. The project is born out of need as an easyâ toâ use tool for my research methods classes.

Uses dplyr and tidyeval to fit statistical models inside the database. It currently supports KMeans and linear regression models.

Package to carry out merged block randomization (Van der Pas (2019), <doi:10.1177/1740774519827957>), a restricted randomization method designed for small clinical trials (at most 100 subjects) or trials with small strata, for example in multicentre trials. It can be used for more than two groups or unequal randomization ratios.

It is designed to work with text written in Bahasa Malaysia. We provide functions and data sets that will make working with Bahasa Malaysia text much easier. For word stemming in particular, we will look up the Malay words in a dictionary and then proceed to remove "extra suffix" as explained in Khan, Rehman Ullah, Fitri Suraya Mohamad, Muh Inam UlHaq, Shahren Ahmad Zadi Adruce, Philip Nuli Anding, Sajjad Nawaz Khan, and Abdulrazak Yahya Saleh Al-Hababi (2017) <https://ijrest.net/vol-4-issue-12.html> . This package includes a dictionary of Malay words that may be used to perform word stemming, a dataset of Malay stop words, a dataset of sentiment words and a dataset of normalized words.

Meta-analysis of generalized additive models and generalized additive mixed models. A typical use case is when data cannot be shared across locations, and an overall meta-analytic fit is sought. metagam provides functionality for removing individual participant data from models computed using the mgcv and gamm4 packages such that the model objects can be shared without exposing individual data. Furthermore, methods for meta-analysing these fits are provided. The implemented methods are described in Sorensen et al. (2020), <doi:10.1016/j.neuroimage.2020.117416>, extending previous works by Schwartz and Zanobetti (2000) and Crippa et al. (2018) <doi:10.6000/1929-6029.2018.07.02.1>.

This package provides methods for analyzing DNA methylation data via Most Recurrent Methylation Patterns (MRMPs). Supports cell-type annotation, spatial deconvolution, unsupervised clustering, and cancer cell-of-origin inference. Includes C-backed summaries for YAME â .cg/.cmâ files (overlap counts, log2 odds ratios, beta/depth aggregation), an XGBoost classifier, NNLS deconvolution, and plotting utilities. Scales to large spatial and single-cell methylomes and is robust to extreme sparsity.

Run the same analysis over a range of arbitrary data processing decisions. multitool provides an interface for creating alternative analysis pipelines and turning them into a grid of all possible pipelines. Using this grid as a blueprint, you can model your data across all possible pipelines and summarize the results.

This is the core functions needed by the tsmp package. The low level and carefully checked mathematical functions are here. These are implementations of the Matrix Profile concept that was created by CS-UCR <http://www.cs.ucr.edu/~eamonn/MatrixProfile.html>.

This package provides multigroup Kitagawa-Blinder-Oaxaca ('mKBO') decompositions, that allow for more than two groups. Each group is compared to the sample average. For more details see Thaning and Nieuwenhuis (2025) <doi:10.31235/osf.io/6twvj_v1>.

Enables you to create accessible modal dialogs, with confidence and with minimal configuration.

Mixed model-based genome-wide association analysis that accommodate population membership information, variance adjustment, and correlated responses.

This package provides a collection of tools for analyzing significance of Markowitz portfolios, using the delta method on the second moment matrix, <arxiv:1312.0557>.

Simulates respiratory virus epidemics using meta-population compartmental models following Fadikar et. al. (2025) <doi:10.1109/WSC68292.2025.11338996>. MetaRVM implements a stochastic SEIRD (Susceptible-Exposed-Infected-Recovered-Dead) framework with demographic stratification by user provided attributes. It supports complex epidemiological scenarios including asymptomatic and presymptomatic transmission, hospitalization dynamics, vaccination schedules, and time-varying contact patterns via mixing matrices.

Mixed, low-rank, and sparse multivariate regression ('mixedLSR') provides tools for performing mixture regression when the coefficient matrix is low-rank and sparse. mixedLSR allows subgroup identification by alternating optimization with simulated annealing to encourage global optimum convergence. This method is data-adaptive, automatically performing parameter selection to identify low-rank substructures in the coefficient matrix.

This package provides a Shiny application to estimate the sample size required for a metabolomic experiment to achieve a desired statistical power. Estimation is possible with or without available data from a pilot study.

This package provides a suite of functions for performing analyses, based on a multiverse approach, for conditioning data. Specifically, given the appropriate data, the functions are able to perform t-tests, analyses of variance, and mixed models for the provided data and return summary statistics and plots. The function is also able to return for all those tests p-values, confidence intervals, and Bayes factors. The methods are described in Lonsdorf, Gerlicher, Klingelhofer-Jens, & Krypotos (2022) <doi:10.1016/j.brat.2022.104072>. Since November 2025, this package contains code from the ez R package (Copyright (c) 2016-11-01, Michael A. Lawrence <mike.lwrnc@gmail.com>), originally distributed under the GPL (equal and above 2) license.

Computes martingale difference correlation (MDC), martingale difference divergence, and their partial extensions to assess conditional mean dependence. The methods are based on Shao and Zhang (2014) <doi:10.1080/01621459.2014.887012>. Additionally, introduces a novel hypothesis test for evaluating covariate effects on the cure rate in mixture cure models, using MDC-based statistics. The methodology is described in Monroy-Castillo et al. (2025, manuscript submitted).

This package provides tools for the calculation of effect sizes (standardised mean difference) and mean difference in pre-post controlled studies, including robust imputation of missing variances (standard deviation of changes) and correlations (Pearson correlation coefficient). The main function metacor_dual() implements several methods for imputing missing standard deviation of changes or Pearson correlation coefficient, and generates transparent imputation reports. Designed for meta-analyses with incomplete summary statistics. For details on the methods, see Higgins et al. (2023) and Fu et al. (2013).

Maximum likelihood estimation for generalized linear mixed models via Monte Carlo EM. For a description of the algorithm see Brian S. Caffo, Wolfgang Jank and Galin L. Jones (2005) <DOI:10.1111/j.1467-9868.2005.00499.x>.

Uses memory-mapping to enable the random access of elements of a text file of characters separated by characters as if it were a simple R(cpp) matrix.

This package provides a data package containing public domain information on requests made by the MuckRock (https://www.muckrock.com/) project under the United States Freedom of Information Act.

This package provides functions provide comprehensive treatments for estimating, inferring, testing and model selecting in linear regression models with structural breaks. The tests, estimation methods, inference and information criteria implemented are discussed in Bai and Perron (1998) "Estimating and Testing Linear Models with Multiple Structural Changes" <doi:10.2307/2998540>.

This package provides functions for fitting models of trait evolution on phylogenies for continuous traits. The majority of functions are described in Thomas and Freckleton (2012) <doi:10.1111/j.2041-210X.2011.00132.x> and allow tests of variation in the rates of trait evolution.

The meta-analysis is performed to increase the statistical power by integrating the results from several experiments. The p-values are often combined in meta-analysis when the effect sizes are not available. The metapro R package provides not only traditional methods (Becker BJ (1994, ISBN:0-87154-226-9), Mosteller, F. & Bush, R.R. (1954, ISBN:0201048523) and Lancaster HO (1949, ISSN:00063444)), but also new method named weighted Fisherâ s method we developed. While the (weighted) Z-method is suitable for finding features effective in most experiments, (weighted) Fisherâ s method is useful for detecting partially associated features. Thus, the users can choose the function based on their purpose. Yoon et al. (2021) "Powerful p-value combination methods to detect incomplete association" <doi:10.1038/s41598-021-86465-y>.