This package provides access to teaching materials for various statistics courses, including R and Python programs, Shiny apps, data, and PDF/HTML documents. These materials are stored on the Internet as a ZIP file (e.g., in a GitHub repository) and can be downloaded and displayed or run locally. The content of the ZIP file is temporarily or permanently stored. By default, the package uses the GitHub repository sigbertklinke/mmstat4.data. Additionally, the package includes association_measures.R from the archived package ryouready by Mark Heckman and some auxiliary functions.

This package provides a comprehensive framework for calculating unbiased distances in datasets containing mixed-type variables (numerical and categorical). The package implements a general formulation that ensures multivariate additivity and commensurability, meaning that variables contribute equally to the overall distance regardless of their type, scale, or distribution. Supports multiple distance measures including Gower's distance, Euclidean distance, Manhattan distance, and various categorical variable distances such as simple matching, Eskin, occurrence frequency, and association-based distances. Provides tools for variable scaling (standard deviation, range, robust range, and principal component scaling), and handles both independent and association-based category dissimilarities. Implements methods to correct for biases that typically arise from different variable types, distributions, and number of categories. Particularly useful for cluster analysis, data visualization, and other distance-based methods when working with mixed data. Methods based on van de Velden et al. (2024) <doi:10.48550/arXiv.2411.00429> "Unbiased mixed variables distance".

Data sets and scripts for Modeling Psychophysical Data in R (Springer).

Summarize multiple biomarker responses of aquatic organisms to contaminants using Cliffâ s delta, as described in Pham & Sokolova (2023) <doi:10.1002/ieam.4676>.

Analyse, plot, and tabulate antimicrobial minimum inhibitory concentration (MIC) data. Validate the results of an MIC experiment by comparing observed MIC values to a gold standard assay, in line with standards from the International Organization for Standardization (2021) <https://www.iso.org/standard/79377.html>.

Extends the mlr3 machine learning framework with spatio-temporal resampling methods to account for the presence of spatiotemporal autocorrelation (STAC) in predictor variables. STAC may cause highly biased performance estimates in cross-validation if ignored. A JSS article is available at <doi:10.18637/jss.v111.i07>.

This package provides a collection of function to solve multiple criteria optimization problems using genetic algorithms (NSGA-II). Also included is a collection of test functions.

Function and support for medication and dosing information extraction from free-text clinical notes. Medication entities for the basic medExtractR implementation that can be extracted include drug name, strength, dose amount, dose, frequency, intake time, dose change, and time of last dose. The basic medExtractR is outlined in Weeks, Beck, McNeer, Williams, Bejan, Denny, Choi (2020) <doi: 10.1093/jamia/ocz207>. The extended medExtractR_tapering implementation is intended to extract dosing information for more tapering schedules, which are far more complex. The tapering extension allows for the extraction of additional entities including dispense amount, refills, dose schedule, time keyword, transition, and preposition.

Handy helper package for cross-referencing lake identifiers among different data sets in the Midwestern United States. There are multiple different state, regional, and federal agencies that have different identifiers on lakes. This package helps you to go between them.

This package provides a tool for implementing so called deft approach (see Fisher, David J., et al. (2017) <DOI:10.1136/bmj.j573>) and model visualization.

Calculate morphine milligram equivalents (MME) for opioid dose comparison using standardized methods. Can directly call the NIH HEAL MME Online Calculator <https://research-mme.wakehealth.edu/api> API or replicate API calculations on the user's local machine from the comfort of R'. Creation of the NIH HEAL MME Online Calculator and the MME calculations implemented in this package are described in Adams MCB, Sward KA, Perkins ML, Hurley RW (2025) <doi:10.1097/j.pain.0000000000003529>.

Enables the creation of Moodle quiz questions using literate programming with R Markdown. This makes it easy to quickly create a quiz that can be randomly replicated with new datasets, questions, and options for answers.

An easy-to-use workflow that provides tools to create, update and fill literature matrices commonly used in research, specifically epidemiology and health sciences research. The project is born out of need as an easyâ toâ use tool for my research methods classes.

This package implements likelihood-based estimation and diagnostics for multi-type recurrent event data with dynamic risk that depends on prior events and accommodates terminating events. Methods are described in Ghosh, Chan, Younes and Davis (2023) "A Dynamic Risk Model for Multitype Recurrent Events" <doi:10.1093/aje/kwac213>.

Matrix is an universal and sometimes primary object/unit in applied mathematics and statistics. We provide a number of algorithms for selected problems in optimization and statistical inference. For general exposition to the topic with focus on statistical context, see the book by Banerjee and Roy (2014, ISBN:9781420095388).

Random Forest Spatial Interpolation (RFSI, SekuliÄ et al. (2020) <doi:10.3390/rs12101687>) and spatio-temporal geostatistical (spatio-temporal regression Kriging (STRK)) interpolation for meteorological (Kilibarda et al. (2014) <doi:10.1002/2013JD020803>, SekuliÄ et al. (2020) <doi:10.1007/s00704-019-03077-3>) and other environmental variables. Contains global spatio-temporal models calculated using publicly available data.

Implementation of a framework for cluster analysis with selection of the final number of clusters and an optional variable selection procedure. The package is designed to integrate the results of multiple imputed datasets while accounting for the uncertainty that the imputations introduce in the final results. In addition, the package can also be used for a cluster analysis of the complete cases of a single dataset. The package also includes specific methods to summarize and plot the results. The methods are described in Basagana et al. (2013) <doi:10.1093/aje/kws289>.

Calculate Sample Size and Power for Association Studies Involving Mitochondrial DNA Haplogroups. Based on formulae by Samuels et al. AJHG, 2006. 78(4):713-720. <DOI:10.1086/502682>.

An interface to the Microsoft 365 (formerly known as Office 365') suite of cloud services, building on the framework supplied by the AzureGraph package. Enables access from R to data stored in Teams', SharePoint Online and OneDrive', including the ability to list drive folder contents, upload and download files, send messages, and retrieve data lists. Also provides a full-featured Outlook email client, with the ability to send emails and manage emails and mail folders.

Encodes several methods for performing Mendelian randomization analyses with summarized data. Similar to the MendelianRandomization package, but with fewer bells and whistles, and less frequent updates. As described in Yavorska (2017) <doi:10.1093/ije/dyx034> and Broadbent (2020) <doi:10.12688/wellcomeopenres.16374.2>.

This package provides functionality to generate compound optimal designs for targeting the multiple experimental objectives directly, ensuring that the full set of research questions is answered as economically as possible. Designs can be found using point or coordinate exchange algorithms combining estimation, inference and lack-of-fit criteria that account for model inadequacy. Details and examples are given by Koutra et al. (2024) <doi:10.48550/arXiv.2412.17158>.

Multivariate version of the two-sample Gehan and logrank tests, as described in L.J Wei & J.M Lachin (1984) and Persson et al. (2019).

Estimates key quantities in causal mediation analysis - including average causal mediation effects (indirect effects), average direct effects, total effects, and proportions mediated - in the presence of multiple uncausally related mediators. Methods are described by Jérolon et al., (2021) <doi:10.1515/ijb-2019-0088> and extended to accommodate survival outcomes as described by Domingo-Relloso et al., (2024) <doi:10.1101/2024.02.16.24302923>.

Calculates exact hypothesis tests to compare a treatment and a reference group with respect to multiple binary endpoints. The tested null hypothesis is an identical multidimensional distribution of successes and failures in both groups. The alternative hypothesis is a larger success proportion in the treatment group in at least one endpoint. The tests are based on the multivariate permutation distribution of subjects between the two groups. For this permutation distribution, rejection regions are calculated that satisfy one of different possible optimization criteria. In particular, regions with maximal exhaustion of the nominal significance level, maximal power under a specified alternative or maximal number of elements can be found. Optimization is achieved by a branch-and-bound algorithm. By application of the closed testing principle, the global hypothesis tests are extended to multiple testing procedures.