This package provides access to a range of functions for analyzing, applying and visualizing Bayesian response-adaptive trial designs for a binary endpoint. Includes the predictive probability approach and the predictive evidence value designs for binary endpoints.

Use BirdNET', a state-of-the-art deep learning classifier, to automatically identify (bird) sounds. Analyze bioacoustic datasets without any computer science background using a pre-trained model or a custom trained classifier. Predict bird species occurrence based on location and week of the year. Kahl, S., Wood, C. M., Eibl, M., & Klinck, H. (2021) <doi:10.1016/j.ecoinf.2021.101236>.

The goal of this method is to identify associations between bacteria and an environmental variable in 16S or other compositional data. The environmental variable is any variable which is measure for each microbiome sample, for example, a butyrate measurement paired with every sample in the data. Microbiome data is compositional, meaning that the total abundance of each sample sums to 1, and this introduces severe statistical distortions. This method takes a Bayesian approach to correcting for these statistical distortions, in which the total abundance is treated as an unknown variable. This package runs the python implementation using reticulate.

Various layers of B.C., including administrative boundaries, natural resource management boundaries, census boundaries etc. All layers are available in BC Albers (<https://spatialreference.org/ref/epsg/3005/>) equal-area projection, which is the B.C. government standard. The layers are sourced from the British Columbia and Canadian government under open licenses, including B.C. Data Catalogue (<https://data.gov.bc.ca>), the Government of Canada Open Data Portal (<https://open.canada.ca/en/using-open-data>), and Statistics Canada (<https://www.statcan.gc.ca/en/reference/licence>).

This package provides a method for the Bayesian functional linear regression model (scalar-on-function), including two estimators of the coefficient function and an estimator of its support. A representation of the posterior distribution is also available. Grollemund P-M., Abraham C., Baragatti M., Pudlo P. (2019) <doi:10.1214/18-BA1095>.

Querying, extracting, and processing large-scale network data from Neo4j databases using the Neo4j Bolt <https://neo4j.com/docs/bolt/current/bolt/> protocol. This interface supports efficient data retrieval, batch processing for large datasets, and seamless conversion of query results into R data frames, making it ideal for bioinformatics, computational biology, and other graph-based applications.

This package provides functions to compute the asymptotic covariance matrices of mixing and unmixing matrix estimates of the following blind source separation (BSS) methods: symmetric and squared symmetric FastICA, regular and adaptive deflation-based FastICA, FOBI, JADE, AMUSE and deflation-based and symmetric SOBI. Also functions to estimate these covariances based on data are available.

This package implements the Bayesian Synthetic Control method for causal inference in comparative case studies. This package provides tools for estimating treatment effects in settings with a single treated unit and multiple control units, allowing for uncertainty quantification and flexible modeling of time-varying effects. The methodology is based on the paper by Vives and Martinez (2022) <doi:10.48550/arXiv.2206.01779>.

This package provides methods and tools for estimating, simulating and forecasting of so-called BEKK-models (named after Baba, Engle, Kraft and Kroner) based on the fast Berndtâ Hallâ Hallâ Hausman (BHHH) algorithm described in Hafner and Herwartz (2008) <doi:10.1007/s00184-007-0130-y>. For an overview, we refer the reader to Fülle et al. (2024) <doi:10.18637/jss.v111.i04>.

Subgroup analyses are routinely performed in clinical trial analyses. From a methodological perspective, two key issues of subgroup analyses are multiplicity (even if only predefined subgroups are investigated) and the low sample sizes of subgroups which lead to highly variable estimates, see e.g. Yusuf et al (1991) <doi:10.1001/jama.1991.03470010097038>. This package implements subgroup estimates based on Bayesian shrinkage priors, see Carvalho et al (2019) <https://proceedings.mlr.press/v5/carvalho09a.html>. In addition, estimates based on penalized likelihood inference are available, based on Simon et al (2011) <doi:10.18637/jss.v039.i05>. The corresponding shrinkage based forest plots address the aforementioned issues and can complement standard forest plots in practical clinical trial analyses.

This package provides a random forest variant block forest ('BlockForest') tailored to the prediction of binary, survival and continuous outcomes using block-structured covariate data, for example, clinical covariates plus measurements of a certain omics data type or multi-omics data, that is, data for which measurements of different types of omics data and/or clinical data for each patient exist. Examples of different omics data types include gene expression measurements, mutation data and copy number variation measurements. Block forest are presented in Hornung & Wright (2019). The package includes four other random forest variants for multi-omics data: RandomBlock', BlockVarSel', VarProb', and SplitWeights'. These were also considered in Hornung & Wright (2019), but performed worse than block forest in their comparison study based on 20 real multi-omics data sets. Therefore, we recommend to use block forest ('BlockForest') in applications. The other random forest variants can, however, be consulted for academic purposes, for example, in the context of further methodological developments. Reference: Hornung, R. & Wright, M. N. (2019) Block Forests: random forests for blocks of clinical and omics covariate data. BMC Bioinformatics 20:358. <doi:10.1186/s12859-019-2942-y>.

Some very simple infrastructure for basis functions.

Density, distribution, quantile function, random number generation for the BMT (Bezier-Montenegro-Torres) distribution. Torres-Jimenez C.J. and Montenegro-Diaz A.M. (2017) <doi:10.48550/arXiv.1709.05534>. Moments, descriptive measures and parameter conversion for different parameterizations of the BMT distribution. Fit of the BMT distribution to non-censored data by maximum likelihood, moment matching, quantile matching, maximum goodness-of-fit, also known as minimum distance, maximum product of spacing, also called maximum spacing, and minimum quantile distance, which can also be called maximum quantile goodness-of-fit. Fit of univariate distributions for non-censored data using maximum product of spacing estimation and minimum quantile distance estimation is also included.

Generate the James Blinding Index, as described in James et al (1996) <https://pubmed.ncbi.nlm.nih.gov/8841652/> and the Bang Blinding Index, as described in Bang et al (2004) <https://pubmed.ncbi.nlm.nih.gov/15020033/>. These are measures to assess whether or not satisfactory blinding has been maintained in a randomized, controlled, clinical trial. These can be generated for trial subjects, research coordinators and principal investigators, based upon standardized questionnaires that have been administered, to assess whether or not they can correctly guess to which treatment arm (e.g. placebo or treatment) subjects were assigned at randomization.

Simultaneous clustering of rows and columns, usually designated by biclustering, co-clustering or block clustering, is an important technique in two way data analysis. It consists of estimating a mixture model which takes into account the block clustering problem on both the individual and variables sets. The blockcluster package provides a bridge between the C++ core library build on top of the STK++ library, and the R statistical computing environment. This package allows to co-cluster binary <doi:10.1016/j.csda.2007.09.007>, contingency <doi:10.1080/03610920903140197>, continuous <doi:10.1007/s11634-013-0161-3> and categorical data-sets <doi:10.1007/s11222-014-9472-2>. It also provides utility functions to visualize the results. This package may be useful for various applications in fields of Data mining, Information retrieval, Biology, computer vision and many more. More information about the project and comprehensive tutorial can be found on the link mentioned in URL.

Barnard's unconditional test for 2x2 contingency tables.

Selecting linear and generalized linear models for large data sets using modified stepwise procedure and modern selection criteria (like modifications of Bayesian Information Criterion). Selection can be performed on data which exceed RAM capacity. Bogdan et al., (2004) <doi:10.1534/genetics.103.021683>.

Assists in the set-up of algorithms for Bayesian inference of vector autoregressive (VAR) and error correction (VEC) models. Functions for posterior simulation, forecasting, impulse response analysis and forecast error variance decomposition are largely based on the introductory texts of Chan, Koop, Poirier and Tobias (2019, ISBN: 9781108437493), Koop and Korobilis (2010) <doi:10.1561/0800000013> and Luetkepohl (2006, ISBN: 9783540262398).

Bootstrap resampling methods have been widely studied in the context of survey data. This package implements various bootstrap resampling techniques tailored for survey data, with a focus on stratified simple random sampling and stratified two-stage cluster sampling. It provides tools for precise and consistent bootstrap variance estimation for population totals, means, and quartiles. Additionally, it enables easy generation of bootstrap samples for in-depth analysis.

An implementation of methods for extracting a sparse unweighted network (i.e. a backbone) from an unweighted network (e.g., Hamann et al., 2016 <doi:10.1007/s13278-016-0332-2>), a weighted network (e.g., Serrano et al., 2009 <doi:10.1073/pnas.0808904106>), or a weighted projection (e.g., Neal et al., 2021 <doi:10.1038/s41598-021-03238-3>).

Analytically calculates the operating characteristics of single-stage and two-stage basket trials with equal sample sizes using the power prior design by Baumann et al. (2024) <doi:10.48550/arXiv.2309.06988> and the design by Fujikawa et al. (2020) <doi:10.1002/bimj.201800404>.

Interface to a high-performance implementation of k-medoids clustering described in Tiwari, Zhang, Mayclin, Thrun, Piech and Shomorony (2020) "BanditPAM: Almost Linear Time k-medoids Clustering via Multi-Armed Bandits" <https://proceedings.neurips.cc/paper/2020/file/73b817090081cef1bca77232f4532c5d-Paper.pdf>.

An all-encompassing R toolkit designed to streamline the process of calling various bioinformatics software and then performing data analysis and visualization in R. With blit', users can easily integrate a wide array of bioinformatics command line tools into their workflows, leveraging the power of R for sophisticated data manipulation and graphical representation.

Selection of informative features like genes, transcripts, RNA seq, etc. using Bootstrap Maximum Relevance and Minimum Redundancy technique from a given high dimensional genomic dataset. Informative gene selection involves identification of relevant genes and removal of redundant genes as much as possible from a large gene space. Main applications in high-dimensional expression data analysis (e.g. microarray data, NGS expression data and other genomics and proteomics applications).