This package performs causal mediation analysis for count and zero-inflated count data without or with a post-treatment confounder; calculates power to detect prespecified causal mediation effects, direct effects, and total effects; performs sensitivity analysis when there is a treatment- induced mediator-outcome confounder as described by Cheng, J., Cheng, N.F., Guo, Z., Gregorich, S., Ismail, A.I., Gansky, S.A. (2018) <doi:10.1177/0962280216686131>. Implements Instrumental Variable (IV) method to estimate the controlled (natural) direct and mediation effects, and compute the bootstrap Confidence Intervals as described by Guo, Z., Small, D.S., Gansky, S.A., Cheng, J. (2018) <doi:10.1111/rssc.12233>. This software was made possible by Grant R03DE028410 from the National Institute of Dental and Craniofacial Research, a component of the National Institutes of Health.

This package provides tools and functions to fit a multilevel index of dissimilarity.

Color palettes inspired by the works of Mexican painters and muralists. The package includes functions that return vectors of colors and also functions to use color and fill scales in ggplot2 visualizations.

Inference of Multiscale graphical models with neighborhood selection approach. The method is based on solving a convex optimization problem combining a Lasso and fused-group Lasso penalties. This allows to infer simultaneously a conditional independence graph and a clustering partition. The optimization is based on the Continuation with Nesterov smoothing in a Shrinkage-Thresholding Algorithm solver (Hadj-Selem et al. 2018) <doi:10.1109/TMI.2018.2829802> implemented in python.

Diagnostic tools as residual analysis, global, local and total-local influence for the multivariate model from the random intercept Poisson generalized log gamma model are available in this package. Including also, the estimation process by maximum likelihood method, for details see Fabio, L. C; Villegas, C. L.; Carrasco, J.M.F and de Castro, M. (2023) <doi:10.1080/03610926.2021.1939380> and Fábio, L. C.; Villegas, C.; Mamun, A. S. M. A. and Carrasco, J. M. F. (2025) <doi:10.28951/bjb.v43i1.728>.

Mixed effects cumulative and baseline logit link models for the analysis of ordinal or nominal responses, with non-parametric distribution for the random effects.

Download data from the Ada and Archibald MacLeish Field Station in Whately, MA. The Ada and Archibald MacLeish Field Station is a 260-acre patchwork of forest and farmland located in West Whately, MA that provides opportunities for faculty and students to pursue environmental research, outdoor education, and low-impact recreation (see <https://www.smith.edu/discover-smith/smith-action/sustainable-smith/macleish-field-station> for more information). This package contains weather data over several years, and spatial data on various man-made and natural structures.

This package provides a set of basic and extensible data structures and functions for multivariate analysis, including dimensionality reduction techniques, projection methods, and preprocessing functions. The aim of this package is to offer a flexible and user-friendly framework for multivariate analysis that can be easily extended for custom requirements and specific data analysis tasks.

Wrapper around the Unix join facility which is more efficient than the built-in R routine merge(). The package enables the joining of multiple files on disk at once. The files can be compressed and various filters can be deployed before joining. Compiles only under Unix.

This package contains functions for multiple imputation which complements existing functionality in R. In particular, several imputation methods for the mice package (van Buuren & Groothuis-Oudshoorn, 2011, <doi:10.18637/jss.v045.i03>) are implemented. Main features of the miceadds package include plausible value imputation (Mislevy, 1991, <doi:10.1007/BF02294457>), multilevel imputation for variables at any level or with any number of hierarchical and non-hierarchical levels (Grund, Luedtke & Robitzsch, 2018, <doi:10.1177/1094428117703686>; van Buuren, 2018, Ch.7, <doi:10.1201/9780429492259>), imputation using partial least squares (PLS) for high dimensional predictors (Robitzsch, Pham & Yanagida, 2016), nested multiple imputation (Rubin, 2003, <doi:10.1111/1467-9574.00217>), substantive model compatible imputation (Bartlett et al., 2015, <doi:10.1177/0962280214521348>), and features for the generation of synthetic datasets (Reiter, 2005, <doi:10.1111/j.1467-985X.2004.00343.x>; Nowok, Raab, & Dibben, 2016, <doi:10.18637/jss.v074.i11>).

This package provides tools for cleaning, processing, and preparing microbiome sequencing data (e.g., 16S rRNA) for downstream analysis. Supports CSV, TXT, and Excel file formats. The main function, ezclean(), automates microbiome data transformation, including format validation, transposition, numeric conversion, and metadata integration. It also handles taxonomic levels efficiently, resolves duplicated taxa entries, and outputs a well-structured, analysis-ready dataset. The companion functions ezstat() run statistical tests and summarize results, while ezviz() produces publication-ready visualizations.

Generates multivariate subgaussian stable probabilities using the QRSVN algorithm as detailed in Genz and Bretz (2002) <DOI:10.1198/106186002394> but by sampling positive stable variates not chi/sqrt(nu).

This package implements Gibbs sampling and Bayes factors for multinomial models with linear inequality constraints on the vector of probability parameters. As special cases, the model class includes models that predict a linear order of binomial probabilities (e.g., p[1] < p[2] < p[3] < .50) and mixture models assuming that the parameter vector p must be inside the convex hull of a finite number of predicted patterns (i.e., vertices). A formal definition of inequality-constrained multinomial models and the implemented computational methods is provided in: Heck, D.W., & Davis-Stober, C.P. (2019). Multinomial models with linear inequality constraints: Overview and improvements of computational methods for Bayesian inference. Journal of Mathematical Psychology, 91, 70-87. <doi:10.1016/j.jmp.2019.03.004>. Inequality-constrained multinomial models have applications in the area of judgment and decision making to fit and test random utility models (Regenwetter, M., Dana, J., & Davis-Stober, C.P. (2011). Transitivity of preferences. Psychological Review, 118, 42â 56, <doi:10.1037/a0021150>) or to perform outcome-based strategy classification to select the decision strategy that provides the best account for a vector of observed choice frequencies (Heck, D.W., Hilbig, B.E., & Moshagen, M. (2017). From information processing to decisions: Formalizing and comparing probabilistic choice models. Cognitive Psychology, 96, 26â 40. <doi:10.1016/j.cogpsych.2017.05.003>).

This package provides a way to estimate and test marginal mediation effects for zero-inflated compositional mediators. Estimates of Natural Indirect Effect (NIE), Natural Direct Effect (NDE) of each taxon, as well as their standard errors and confident intervals, were provided as outputs. Zeros will not be imputed during analysis. See Wu et al. (2022) <doi:10.3390/genes13061049>.

Covariate measurement error correction is implemented by means of regression calibration by Carroll RJ, Ruppert D, Stefanski LA & Crainiceanu CM (2006, ISBN:1584886331), efficient regression calibration by Spiegelman D, Carroll RJ & Kipnis V (2001) <doi:10.1002/1097-0258(20010115)20:1%3C139::AID-SIM644%3E3.0.CO;2-K> and maximum likelihood estimation by Bartlett JW, Stavola DBL & Frost C (2009) <doi:10.1002/sim.3713>. Outcome measurement error correction is implemented by means of the method of moments by Buonaccorsi JP (2010, ISBN:1420066560) and efficient method of moments by Keogh RH, Carroll RJ, Tooze JA, Kirkpatrick SI & Freedman LS (2014) <doi:10.1002/sim.7011>. Standard error estimation of the corrected estimators is implemented by means of the Delta method by Rosner B, Spiegelman D & Willett WC (1990) <doi:10.1093/oxfordjournals.aje.a115715> and Rosner B, Spiegelman D & Willett WC (1992) <doi:10.1093/oxfordjournals.aje.a116453>, the Fieller method described by Buonaccorsi JP (2010, ISBN:1420066560), and the Bootstrap by Carroll RJ, Ruppert D, Stefanski LA & Crainiceanu CM (2006, ISBN:1584886331).

This package provides a collection of multivariate nonparametric methods, selected in part to support an MS level course in nonparametric statistical methods. Methods include adjustments for multiple comparisons, implementation of multivariate Mann-Whitney-Wilcoxon testing, inversion of these tests to produce a confidence region, some permutation tests for linear models, and some algorithms for calculating exact probabilities associated with one- and two- stage testing involving Mann-Whitney-Wilcoxon statistics. Supported by grant NSF DMS 1712839. See Kolassa and Seifu (2013) <doi:10.1016/j.acra.2013.03.006>.

Distance between multivariate generalised Gaussian distributions, as presented by N. Bouhlel and A. Dziri (2019) <doi:10.1109/LSP.2019.2915000>. Manipulation of multivariate generalised Gaussian distributions (methods presented by Gomez, Gomez-Villegas and Marin (1998) <doi:10.1080/03610929808832115> and Pascal, Bombrun, Tourneret and Berthoumieu (2013) <doi:10.1109/TSP.2013.2282909>).

This package provides new functions info(), warn() and error(), similar to message(), warning() and stop() respectively. However, the new functions can have a level associated with them, so that when executed the global level option determines whether they are shown or not. This allows debug modes, outputting more information. The can also output all messages to a log file.

Implementation of the Monothetic Clustering algorithm (Chavent, 1998 <doi:10.1016/S0167-8655(98)00087-7>) on continuous data sets. A lot of extensions are included in the package, including applying Monothetic clustering on data sets with circular variables, visualizations with the results, and permutation and cross-validation based tests to support the decision on the number of clusters.

Evaluate whether a microbiome sample is a mixture of two samples, by fitting a model for the number of read counts as a function of single nucleotide polymorphism (SNP) allele and the genotypes of two potential source samples. Lobo et al. (2021) <doi:10.1093/g3journal/jkab308>.

R interface to POSIX mmap and Window's MapViewOfFile.

Use a glmmkin class object (GMMAT package) from the null model to perform generalized linear mixed model-based single-variant and variant set main effect tests, gene-environment interaction tests, and joint tests for association, as proposed in Wang et al. (2020) <DOI:10.1002/gepi.22351>.

API wrapper to gather news stories, media information and tags from the mediacloud.org API, based on a multilevel query <https://mediacloud.org/>. A personal API key is required.

This package provides a GUI with which users can construct and interact with Multibiplot Analysis.