The robustness of many of the statistical techniques, such as factor analysis, applied in the social sciences rests upon the assumption of item-level normality. However, when dealing with real data, these assumptions are often not met. The Box-Cox transformation (Box & Cox, 1964) <http://www.jstor.org/stable/2984418> provides an optimal transformation for non-normal variables. Yet, for large datasets of continuous variables, its application in current software programs is cumbersome with analysts having to take several steps to normalise each variable. We present an R package normalr that enables researchers to make convenient optimal transformations of multiple variables in datasets. This R package enables users to quickly and accurately: (1) anchor all of their variables at 1.00, (2) select the desired precision with which the optimal lambda is estimated, (3) apply each unique exponent to its variable, (4) rescale resultant values to within their original X1 and X(n) ranges, and (5) provide original and transformed estimates of skewness, kurtosis, and other inferential assessments of normality.

This package provides tools for visual inference. Generate null data sets and null plots using permutation and simulation. Calculate distance metrics for a lineup, and examine the distributions of metrics.

Designed to replace the tables which were in the back of the first two editions of Hollander and Wolfe - Nonparametric Statistical Methods. Exact procedures are performed when computationally possible. Monte Carlo and Asymptotic procedures are performed otherwise. For those procedures included in the base packages, our code simply provides a wrapper to standardize the output with the other procedures in the package.

Estimate the NNT using the proposed method in Yang and Yin's paper (2019) <doi:10.1371/journal.pone.0223301>, in which the NNT-RMST (number needed to treat based on the restricted mean survival time) is defined as the RMST (restricted mean survival time) in the control group divided by the difference in RMSTs between the treatment and control groups up to a chosen time t.

We solve non linear least squares problems with optional equality and/or inequality constraints. Non linear iterations are globalized with back-tracking method. Linear problems are solved by dense QR decomposition from LAPACK which can limit the size of treated problems. On the other side, we avoid condition number degradation which happens in classical quadratic programming approach. Inequality constraints treatment on each non linear iteration is based on NNLS method (by Lawson and Hanson). We provide an original function lsi_ln for solving linear least squares problem with inequality constraints in least norm sens. Thus if Jacobian of the problem is rank deficient a solution still can be provided. However, truncation errors are probable in this case. Equality constraints are treated by using a basis of Null-space. User defined function calculating residuals must return a list having residual vector (not their squared sum) and Jacobian. If Jacobian is not in the returned list, package numDeriv is used to calculated finite difference version of Jacobian. The NLSIC method was fist published in Sokol et al. (2012) <doi:10.1093/bioinformatics/btr716>.

Estimates and plots (as a single plot and as a heat map) the rolling window correlation coefficients between two time series and computes their statistical significance, which is carried out through a non-parametric computing-intensive method. This method addresses the effects due to the multiple testing (inflation of the Type I error) when the statistical significance is estimated for the rolling window correlation coefficients. The method is based on Monte Carlo simulations by permuting one of the variables (e.g., the dependent) under analysis and keeping fixed the other variable (e.g., the independent). We improve the computational efficiency of this method to reduce the computation time through parallel computing. The NonParRolCor package also provides examples with synthetic and real-life environmental time series to exemplify its use. Methods derived from R. Telford (2013) <https://quantpalaeo.wordpress.com/2013/01/04/> and J.M. Polanco-Martinez and J.L. Lopez-Martinez (2021) <doi:10.1016/j.ecoinf.2021.101379>.

This package provides a suite of functions to work with data from the National Institutes of Health Brain Development Cohorts Data Hub. The package provides tools to create, clean, process, and filter datasets and associated metadata. These utilities are intended to simplify reproducible data-preparation for future research.

Researchers often want to evaluate whether there is a negligible relationship among variables. The negligible package provides functions that are useful for conducting negligible effect testing (also called equivalence testing). For example, there are functions for evaluating the equivalence of means or the presence of a negligible association (correlation or regression). Beribisky, N., Mara, C., & Cribbie, R. A. (2020) <doi:10.20982/tqmp.16.4.p424>. Beribisky, N., Davidson, H., Cribbie, R. A. (2019) <doi:10.7717/peerj.6853>. Shiskina, T., Farmus, L., & Cribbie, R. A. (2018) <doi:10.20982/tqmp.14.3.p167>. Mara, C. & Cribbie, R. A. (2017) <doi:10.1080/00220973.2017.1301356>. Counsell, A. & Cribbie, R. A. (2015) <doi:10.1111/bmsp.12045>. van Wieringen, K. & Cribbie, R. A. (2014) <doi:10.1111/bmsp.12015>. Goertzen, J. R. & Cribbie, R. A. (2010) <doi:10.1348/000711009x475853>. Cribbie, R. A., Gruman, J. & Arpin-Cribbie, C. (2004) <doi:10.1002/jclp.10217>.

Facilitates building a nesting or hierarchical structure as a list or data frame by using a human friendly syntax.

Non-linear shrinkage estimation of population eigenvalues and covariance matrices, based on publications by Ledoit and Wolf (2004, 2015, 2016).

This package provides a comprehensive set of functions providing frequentist methods for network meta-analysis (Balduzzi et al., 2023) <doi:10.18637/jss.v106.i02> and supporting Schwarzer et al. (2015) <doi:10.1007/978-3-319-21416-0>, Chapter 8 "Network Meta-Analysis": - frequentist network meta-analysis following Rücker (2012) <doi:10.1002/jrsm.1058>; - additive network meta-analysis for combinations of treatments (Rücker et al., 2020) <doi:10.1002/bimj.201800167>; - network meta-analysis of binary data using the Mantel-Haenszel or non-central hypergeometric distribution method (Efthimiou et al., 2019) <doi:10.1002/sim.8158>, or penalised logistic regression (Evrenoglou et al., 2022) <doi:10.1002/sim.9562>; - rankograms and ranking of treatments by the Surface under the cumulative ranking curve (SUCRA) (Salanti et al., 2013) <doi:10.1016/j.jclinepi.2010.03.016>; - ranking of treatments using P-scores (frequentist analogue of SUCRAs without resampling) according to Rücker & Schwarzer (2015) <doi:10.1186/s12874-015-0060-8>; - split direct and indirect evidence to check consistency (Dias et al., 2010) <doi:10.1002/sim.3767>, (Efthimiou et al., 2019) <doi:10.1002/sim.8158>; - league table with network meta-analysis results; - comparison-adjusted funnel plot (Chaimani & Salanti, 2012) <doi:10.1002/jrsm.57>; - net heat plot and design-based decomposition of Cochran's Q according to Krahn et al. (2013) <doi:10.1186/1471-2288-13-35>; - measures characterizing the flow of evidence between two treatments by König et al. (2013) <doi:10.1002/sim.6001>; - automated drawing of network graphs described in Rücker & Schwarzer (2016) <doi:10.1002/jrsm.1143>; - partial order of treatment rankings ('poset') and Hasse diagram for poset (Carlsen & Bruggemann, 2014) <doi:10.1002/cem.2569>; (Rücker & Schwarzer, 2017) <doi:10.1002/jrsm.1270>; - contribution matrix as described in Papakonstantinou et al. (2018) <doi:10.12688/f1000research.14770.3> and Davies et al. (2022) <doi:10.1002/sim.9346>; - network meta-regression with a single continuous or binary covariate; - subgroup network meta-analysis.

Set of functions to estimate kidney function and other traits of interest in nephrology.

Essentials for PK/PD (pharmacokinetics/pharmacodynamics) such as area under the curve, (geometric) coefficient of variation, and other calculations that are not part of base R. This is not a noncompartmental analysis (NCA) package.

The noweb system for source code, implemented in R.

This package provides a computational toolkit for analyzing nematode communities in ecological studies. Includes methods to quantify nematode-based ecological indicators such as metabolic footprints, energy flow metrics, and community structure. These tools support assessments of soil health, ecosystem functioning, and trophic interactions, standardizing the use of nematodes as bioindicators.

Generates functional Magnetic Resonance Imaging (fMRI) time series or 4D data. Some high-level functions are created for fast data generation with only a few arguments and a diversity of functions to define activation and noise. For more advanced users it is possible to use the low-level functions and manipulate the arguments. See Welvaert et al. (2011) <doi:10.18637/jss.v044.i10>.

This package provides a compact variation of the usual syntax of function declaration, in order to support tidyverse-style quasiquotation of a function's arguments and body.

This package provides tools for traversing and working with National Hydrography Dataset Plus (NHDPlus) data. All methods implemented in nhdplusTools are available in the NHDPlus documentation available from the US Environmental Protection Agency <https://www.epa.gov/waterdata/basic-information>.

This package performs network-based source estimation. Different approaches are available: effective distance median, recursive backtracking, and centrality-based source estimation. Additionally, we provide public transportation network data as well as methods for data preparation, source estimation performance analysis and visualization.

This package provides simple methods for centering and scaling of numeric data. Columns or rows can be ignored when normalizing or be normalized jointly.

Functions, examples and data from the first and the second edition of "Numerical Methods and Optimization in Finance" by M. Gilli, D. Maringer and E. Schumann (2019, ISBN:978-0128150658). The package provides implementations of optimisation heuristics (Differential Evolution, Genetic Algorithms, Particle Swarm Optimisation, Simulated Annealing and Threshold Accepting), and other optimisation tools, such as grid search and greedy search. There are also functions for the valuation of financial instruments such as bonds and options, for portfolio selection and functions that help with stochastic simulations.

There are three distinct approaches for phase error correction, they are: a single linear model with a choice of optimization functions, multiple linear models with optimization function choices and a shrinkage-based method. The methodology is based on our new algorithms and various references (Binczyk et al. (2015) <doi:10.1186/1475-925X-14-S2-S5>,Chen et al. (2002) <doi:10.1016/S1090-7807(02)00069-1>, de Brouwer (2009) <doi:10.1016/j.jmr.2009.09.017>, Džakula (2000) <doi:10.1006/jmre.2000.2123>, Ernst (1969) <doi:10.1016/0022-2364(69)90003-1>, Liland et al. (2010) <doi:10.1366/000370210792434350>).

Conduct a noncompartmental analysis with industrial strength. Some features are 1) Use of CDISC SDTM terms 2) Automatic or manual slope selection 3) Supporting both linear-up linear-down and linear-up log-down method 4) Interval(partial) AUCs with linear or log interpolation method * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

This package provides methods and tools for forecasting univariate time series using the NARFIMA (Neural AutoRegressive Fractionally Integrated Moving Average) model. It combines neural networks with fractional differencing to capture both nonlinear patterns and long-term dependencies. The NARFIMA model supports seasonal adjustment, Box-Cox transformations, optional exogenous variables, and the computation of prediction intervals. In addition to the NARFIMA model, this package provides alternative forecasting models including NARIMA (Neural ARIMA), NBSTS (Neural Bayesian Structural Time Series), and NNaive (Neural Naive) for performance comparison across different modeling approaches. The methods are based on algorithms introduced by Chakraborty et al. (2025) <doi:10.48550/arXiv.2509.06697>.