Automatically detects Copy Number Variations (CNV) from Next Generation Sequencing data using a machine learning algorithm, Isolation forest. More details about the method can be found in the paper by Cabello-Aguilar (2022) <doi:10.1101/2022.01.03.474771>.

The proportion of cancer cells in solid tumor sample, known as the tumor purity, has adverse impact on a variety of data analyses if not properly accounted for. We develop InfiniumPurify', which is a comprehensive R package for estimating and accounting for tumor purity based on DNA methylation Infinium 450k array data. InfiniumPurify provides functionalities for tumor purity estimation. In addition, it can perform differential methylation detection and tumor sample clustering with the consideration of tumor purities.

Know which loop iteration the code execution is up to by including a single, convenient function call inside the loop.

This package implements a variety of nonparametric and parametric methods that are commonly used when the data set is a mixture of paired observations and independent samples. The package also calculates and returns values of different tests with their corresponding p-values. Bhoj, D. S. (1991) <doi:10.1002/bimj.4710330108> "Testing equality of means in the presence of correlation and missing data". Dubnicka, S. R., Blair, R. C., and Hettmansperger, T. P. (2002) <doi:10.22237/jmasm/1020254460> "Rank-based procedures for mixed paired and two-sample designs". Einsporn, R. L. and Habtzghi, D. (2013) <https://pdfs.semanticscholar.org/89a3/90bafeb2bc41ed4414533cfd5ab84a6b54b6.pdf> "Combining paired and two-sample data using a permutation test". Ekbohm, G. (1976) <doi:10.1093/biomet/63.2.299> "On comparing means in the paired case with incomplete data on both responses". Lin, P. E. and Stivers, L. E. (1974) <doi:10.1093/biomet/61.2.325> On difference of means with incomplete data". Maritz, J. S. (1995) <doi:10.1111/j.1467-842x.1995.tb00649.x> "A permutation paired test allowing for missing values".

This package provides functions and classes to compute, handle and visualise incidence from dated events for a defined time interval. Dates can be provided in various standard formats. The class incidence is used to store computed incidence and can be easily manipulated, subsetted, and plotted. In addition, log-linear models can be fitted to incidence objects using fit'. This package is part of the RECON (<https://www.repidemicsconsortium.org/>) toolkit for outbreak analysis.

Given a response y and a one- or two-dimensional predictor, the isotonic regression estimator is calculated with the usual orderings.

When added to an existing shiny app, users may subset any developer-chosen R data.frame on the fly. That is, users are empowered to slice & dice data by applying multiple (order specific) filters using the AND (&) operator between each, and getting real-time updates on the number of rows effected/available along the way. Thus, any downstream processes that leverage this data source (like tables, plots, or statistical procedures) will re-render after new filters are applied. The shiny moduleâ s user interface has a minimalist aesthetic so that the focus can be on the data & other visuals. In addition to returning a reactive (filtered) data.frame, IDEAFilter as also returns dplyr filter statements used to actually slice the data.

This package provides classes and functions for metrics calculation as part of the EarthScope MUSTANG project. The functionality in this package builds upon the base classes of the IRISSeismic package. Metrics include basic statistics as well as higher level health metrics that can help identify problematic seismometers.

Flexibly implements Integral Projection Models using a mathematical(ish) syntax. This package will not help with the vital rate modeling process, but will help convert those regression models into an IPM. ipmr handles density dependence and environmental stochasticity, with a couple of options for implementing the latter. In addition, provides functions to avoid unintentional eviction of individuals from models. Additionally, provides model diagnostic tools, plotting functionality, stochastic/deterministic simulations, and analysis tools. Integral projection models are described in depth by Easterling et al. (2000) <doi:10.1890/0012-9658(2000)081[0694:SSSAAN]2.0.CO;2>, Merow et al. (2013) <doi:10.1111/2041-210X.12146>, Rees et al. (2014) <doi:10.1111/1365-2656.12178>, and Metcalf et al. (2015) <doi:10.1111/2041-210X.12405>. Williams et al. (2012) <doi:10.1890/11-2147.1> discuss the problem of unintentional eviction.

This package provides a voxel is a representation of a value on a regular, three-dimensional grid; it is the 3D equivalent of a 2D pixel. Voxel data can be visualised with this package using fixed viewpoint isometric cubes for each data point. This package also provides sample voxel data and tools for transforming the data.

This package provides tools for mapping International Classification of Diseases codes to comorbidity, enabling the identification and analysis of various medical conditions within healthcare data.

Estimation and diagnostic tools for instrumental variables designs, which implements the guidelines proposed in Lal et al. (2023) <arXiv:2303.11399>, including bootstrapped confidence intervals, effective F-statistic, Anderson-Rubin test, valid-t ratio test, and local-to-zero tests.

Merges and downloads SPSS data from different International Large-Scale Assessments (ILSA), including: Trends in International Mathematics and Science Study (TIMSS), Progress in International Reading Literacy Study (PIRLS), and others.

Used in testing if the indirect effect from linear regression mediation analysis is equal to 0. Includes established methods such as the Sobel Test, Joint Significant test (maxP), and tests based off the distribution of the Product or Normal Random Variables. Additionally, this package adds more powerful tests based on Intersection-Union theory. These tests are the S-Test, the ps-test, and the ascending squares test. These new methods are uniformly more powerful than maxP, which is more powerful than Sobel and less anti-conservative than the Product of Normal Random Variables. These methods are explored by Kidd and Lin, (2024) <doi:10.1007/s12561-023-09386-6> and Kidd et al., (2025) <doi:10.1007/s10260-024-00777-7>.

This package provides a procedure for seeding R's built in random number generators using a variable-length sequence of values. Accumulates input entropy into a 256-bit hash digest or "ironseed" and is able to generate a variable-length sequence of output seeds from an ironseed.

Data sets and scripts for text examples and exercises in P. Dalgaard (2008), `Introductory Statistics with R', 2nd ed., Springer Verlag, ISBN 978-0387790534.

An R package for inferring cell-type specific gene regulatory network from single-cell RNA-seq data.

Implementation of a KL-based scoring rule to assess the quality of different missing value imputations in the broad sense as introduced in Michel et al. (2021) <arXiv:2106.03742>.

This package provides tools to assess model fit and identify misfitting items for Rasch models (RM) and partial credit models (PCM). Included are item fit statistics, item characteristic curves, item-restscore association, conditional likelihood ratio tests, assessment of measurement error, estimates of the reliability and test targeting as described in Christensen et al. (Eds.) (2013, ISBN:978-1-84821-222-0).

This package provides a collection of Irucka Embry's miscellaneous USGS functions (processing .exp and .psf files, statistical error functions, "+" dyadic operator for use with NA, creating ADAPS and QW spreadsheet files, calculating saturated enthalpy). Irucka created these functions while a Cherokee Nation Technology Solutions (CNTS) United States Geological Survey (USGS) Contractor and/or USGS employee.

Calculates various intraclass correlation coefficients used to quantify inter-rater and intra-rater reliability. The assumption here is that the raters produced quantitative ratings. Most of the statistical procedures implemented in this package are described in details in Gwet, K.L. (2014, ISBN:978-0970806284): "Handbook of Inter-Rater Reliability," 4th edition, Advanced Analytics, LLC.

Authentication can be the most difficult part about working with a new API. ibmAcousticR facilitates making a connection to the IBM Acoustic email campaign management API and executing various queries. The IBM Acoustic API documentation is available at <https://developer.ibm.com/customer-engagement/docs/>. This package is not supported by IBM'.

This package provides functions to clean and process international trade data into an international trade network (ITN) are provided. It then provides a set a functions to undertake analysis and plots of the ITN (extract the backbone, centrality, blockmodels, clustering). Examining the key players in the ITN and regional trade patterns.

This package provides functions to access real-time infectious disease data from the disease.sh API', including COVID-19 global, US states, continent, and country statistics, vaccination coverage, influenza-like illness data from Centers for Disease Control and Prevention (CDC), and more. Also includes curated datasets on a variety of infectious diseases such as influenza, measles, dengue, Ebola, tuberculosis, meningitis, AIDS, and others. The package supports epidemiological research and data analysis by combining API access with high-quality historical and survey datasets on infectious diseases. For more details on the disease.sh API', see <https://disease.sh/>.