This package performs Monte Carlo hypothesis tests, allowing a couple of different sequential stopping boundaries. For example, a truncated sequential probability ratio test boundary (Fay, Kim and Hachey, 2007 <DOI:10.1198/106186007X257025>) and a boundary proposed by Besag and Clifford, 1991 <DOI:10.1093/biomet/78.2.301>. Gives valid p-values and confidence intervals on p-values.

This package provides methods to analyze cluster alternatives based on multi-objective optimization of cluster validation indices. For details see Kraus et al. (2011) <doi:10.1007/s00180-011-0244-6>.

Nonparametric unfolding item response theory (IRT) model for dichotomous data (see W.H. Van Schuur (1984). Structure in Political Beliefs: A New Model for Stochastic Unfolding with Application to European Party Activists, and W.J.Post (1992). Nonparametric Unfolding Models: A Latent Structure Approach). The package implements MUDFOLD (Multiple UniDimensional unFOLDing), an iterative item selection algorithm that constructs unfolding scales from dichotomous preferential-choice data without explicitly assuming a parametric form of the item response functions. Scale diagnostics from Post(1992) and estimates for the person locations proposed by Johnson(2006) and Van Schuur(1984) are also available. This model can be seen as the unfolding variant of Mokken(1971) scaling method.

Framework to facilitate patient subtyping with similarity network fusion and meta clustering. The similarity network fusion (SNF) algorithm was introduced by Wang et al. (2014) in <doi:10.1038/nmeth.2810>. SNF is a data integration approach that can transform high-dimensional and diverse data types into a single similarity network suitable for clustering with minimal loss of information from each initial data source. The meta clustering approach was introduced by Caruana et al. (2006) in <doi:10.1109/ICDM.2006.103>. Meta clustering involves generating a wide range of cluster solutions by adjusting clustering hyperparameters, then clustering the solutions themselves into a manageable number of qualitatively similar solutions, and finally characterizing representative solutions to find ones that are best for the user's specific context. This package provides a framework to easily transform multi-modal data into a wide range of similarity network fusion-derived cluster solutions as well as to visualize, characterize, and validate those solutions. Core package functionality includes easy customization of distance metrics, clustering algorithms, and SNF hyperparameters to generate diverse clustering solutions; calculation and plotting of associations between features, between patients, and between cluster solutions; and standard cluster validation approaches including resampled measures of cluster stability, standard metrics of cluster quality, and label propagation to evaluate generalizability in unseen data. Associated vignettes guide the user through using the package to identify patient subtypes while adhering to best practices for unsupervised learning.

This package provides a simple tool allowing users to easily and dynamically explore or document a data set using a tree structure.

Use multi-state splitting to apply Adaptive-Dynamic PCA (ADPCA) to data generated from a continuous-time multivariate industrial or natural process. Employ PCA-based dimension reduction to extract linear combinations of relevant features, reducing computational burdens. For a description of ADPCA, see <doi:10.1007/s00477-016-1246-2>, the 2016 paper from Kazor et al. The multi-state application of ADPCA is from a manuscript under current revision entitled "Multi-State Multivariate Statistical Process Control" by Odom, Newhart, Cath, and Hering, and is expected to appear in Q1 of 2018.

This package provides density, cumulative distribution function, quantile function, random number generation, survival function, hazard rate function, statistical properties, classical point and interval estimation (maximum likelihood, ordinary least squares, weighted least squares, Cramer-von Mises, and maximum product of spacings), Bayesian estimation under symmetric and asymmetric loss functions (squared error, entropy, precautionary, and generalized entropy loss functions) with highest posterior density intervals, censoring schemes (random, Type-I, Type-II, and progressive Type-II censoring), and real data applications for the Modified Topp-Leone distribution. Methods are based on Singh et al. (2025) <https://statassoc.or.th>, Cheng and Amin (1983) <doi:10.1111/j.2517-6161.1983.tb01267.x>, Swain et al. (1988) <doi:10.1080/00949658808811094>, Chen and Shao (1999) <doi:10.1080/10618600.1999.10474802>, and Balakrishnan and Aggarwala (2000) <doi:10.1007/978-1-4612-1178-5>.

With foundations on the work by Goutali and Chebana (2024) <doi:10.1016/j.envsoft.2024.106090>, this package contains various univariate and multivariate trend tests. The main functions regard the Multivariate Dependence Trend and Multivariate Overall Trend tests as proposed by Goutali and Chebana (2024), as well as a plotting function that proves useful as a summary and complement of the tests. Although many packages and methods carry univariate tests, the Mann-Kendall and Spearman's rho test implementations are included in the package with an adapted version to hydrological formulation (e.g. as in Rao and Hamed 1998 <doi:10.1016/S0022-1694(97)00125-X> or Chebana 2022 <doi:10.1016/C2021-0-01317-1>). For better understanding of the example use of the functions, three datasets are included. These are synthetic data and shouldn't be used beyond that purpose.

Projects mean squared out-of-sample error for a linear regression based upon the methodology developed in Rohlfs (2022) <doi:10.48550/arXiv.2209.01493>. It consumes as inputs the lm object from an estimated OLS regression (based on the "training sample") and a data.frame of out-of-sample cases (the "test sample") that have non-missing values for the same predictors. The test sample may or may not include data on the outcome variable; if it does, that variable is not used. The aim of the exercise is to project what what mean squared out-of-sample error can be expected given the predictor values supplied in the test sample. Output consists of a list of three elements: the projected mean squared out-of-sample error, the projected out-of-sample R-squared, and a vector of out-of-sample "hat" or "leverage" values, as defined in the paper.

This package provides new functions info(), warn() and error(), similar to message(), warning() and stop() respectively. However, the new functions can have a level associated with them, so that when executed the global level option determines whether they are shown or not. This allows debug modes, outputting more information. The can also output all messages to a log file.

Acoustic template detection and monitoring database interface. Create, modify, save, and use templates for detection of animal vocalizations. View, verify, and extract results. Upload a MySQL schema to a existing instance, manage survey metadata, write and read templates and detections locally or to the database.

Mobile-monitoring or "sensors on a mobile platform", is an increasingly popular approach to measure high-resolution pollution data at the street level. Coupled with location data, spatial visualisation of air-quality parameters helps detect localized areas of high air-pollution, also called hotspots. In this approach, portable sensors are mounted on a vehicle and driven on predetermined routes to collect high frequency data (1 Hz). mmaqshiny is for analysing, visualising and spatial mapping of high-resolution air-quality data collected by specific devices installed on a moving platform. 1 Hz data of PM2.5 (mass concentrations of particulate matter with size less than 2.5 microns), Black carbon mass concentrations (BC), ultra-fine particle number concentrations, carbon dioxide along with GPS coordinates and relative humidity (RH) data collected by popular portable instruments (TSI DustTrak-8530, Aethlabs microAeth-AE51, TSI CPC3007, LICOR Li-830, Garmin GPSMAP 64s, Omega USB RH probe respectively). It incorporates device specific cleaning and correction algorithms. RH correction is applied to DustTrak PM2.5 following the Chakrabarti et al., (2004) <doi:10.1016/j.atmosenv.2004.03.007>. Provision is given to add linear regression coefficients for correcting the PM2.5 data (if required). BC data will be cleaned for the vibration generated noise, by adopting the statistical procedure as explained in Apte et al., (2011) <doi:10.1016/j.atmosenv.2011.05.028>, followed by a loading correction as suggested by Ban-Weiss et al., (2009) <doi:10.1021/es8021039>. For the number concentration data, provision is given for dilution correction factor (if a diluter is used with CPC3007; default value is 1). The package joins the raw, cleaned and corrected data from the above said instruments and outputs as a downloadable csv file.

This package provides a flexible framework for fitting multivariate ordinal regression models with composite likelihood methods. Methodological details are given in Hirk, Hornik, Vana (2020) <doi:10.18637/jss.v093.i04>.

Fits multiple variable mixtures of various parametric proportional hazard models using the EM-Algorithm. Proportionality restrictions can be imposed on the latent groups and/or on the variables. Several survival distributions can be specified. Missing values and censored values are allowed. Independence is assumed over the single variables.

Modelling Multivariate Binary Data with Blocks of Specific One-Factor Distribution. Variables are grouped into independent blocks. Each variable is described by two continuous parameters (its marginal probability and its dependency strength with the other block variables), and one binary parameter (positive or negative dependency). Model selection consists in the estimation of the repartition of the variables into blocks. It is carried out by the maximization of the BIC criterion by a deterministic (faster) algorithm or by a stochastic (more time consuming but optimal) algorithm. Tool functions facilitate the model interpretation.

Mahalanobis-Taguchi (MT) system is a collection of multivariate analysis methods developed for the field of quality engineering. MT system consists of two families depending on their purpose. One is a family of Mahalanobis-Taguchi (MT) methods (in the broad sense) for diagnosis (see Woodall, W. H., Koudelik, R., Tsui, K. L., Kim, S. B., Stoumbos, Z. G., and Carvounis, C. P. (2003) <doi:10.1198/004017002188618626>) and the other is a family of Taguchi (T) methods for forecasting (see Kawada, H., and Nagata, Y. (2015) <doi:10.17929/tqs.1.12>). The MT package contains three basic methods for the family of MT methods and one basic method for the family of T methods. The MT method (in the narrow sense), the Mahalanobis-Taguchi Adjoint (MTA) methods, and the Recognition-Taguchi (RT) method are for the MT method and the two-sided Taguchi (T1) method is for the family of T methods. In addition, the Ta and Tb methods, which are the improved versions of the T1 method, are included.

An increasingly important source of health-related bibliographic content are preprints - preliminary versions of research articles that have yet to undergo peer review. The two preprint repositories most relevant to health-related sciences are medRxiv <https://www.medrxiv.org/> and bioRxiv, both of which are operated by the Cold Spring Harbor Laboratory. medrxivr provides programmatic access to the Cold Spring Harbour Laboratory (CSHL) API <https://api.biorxiv.org/>, allowing users to easily download medRxiv and bioRxiv preprint metadata (e.g. title, abstract, publication date, author list, etc) into R. medrxivr also provides functions to search the downloaded preprint records using regular expressions and Boolean logic, as well as helper functions that allow users to export their search results to a .BIB file for easy import to a reference manager and to download the full-text PDFs of preprints matching their search criteria.

Fit Bayesian Dynamic Generalized Additive Models to multivariate observations. Users can build nonlinear State-Space models that can incorporate semiparametric effects in observation and process components, using a wide range of observation families. Estimation is performed using Markov Chain Monte Carlo with Hamiltonian Monte Carlo in the software Stan'. References: Clark & Wells (2023) <doi:10.1111/2041-210X.13974>.

Estimates key quantities in causal mediation analysis - including average causal mediation effects (indirect effects), average direct effects, total effects, and proportions mediated - in the presence of multiple uncausally related mediators. Methods are described by Jerolon et al., (2021) <doi:10.1515/ijb-2019-0088> and extended to accommodate survival outcomes as described by Domingo-Relloso et al., (2024) <doi:10.1101/2024.02.16.24302923>.

This package implements three families of parsimonious hidden Markov models (HMMs) for matrix-variate longitudinal data using the Expectation-Conditional Maximization (ECM) algorithm. The package supports matrix-variate normal, t, and contaminated normal distributions as emission distributions. For each hidden state, parsimony is achieved through the eigen-decomposition of the covariance matrices associated with the emission distribution. This approach results in a comprehensive set of 98 parsimonious HMMs for each type of emission distribution. Atypical matrix detection is also supported, utilizing the fitted (heavy-tailed) models.

This package implements a general interface for model-based estimations for a wide variety of models, used in the computation of marginal means, contrast analysis and predictions. For a list of supported models, see insight::supported_models()'.

Supplementary materials and datasets for the book "Modern Psychometrics With R" (Mair, 2018, Springer useR! series).

Implemented are various tests for semi-parametric repeated measures and general MANOVA designs that do neither assume multivariate normality nor covariance homogeneity, i.e., the procedures are applicable for a wide range of general multivariate factorial designs. In addition to asymptotic inference methods, novel bootstrap and permutation approaches are implemented as well. These provide more accurate results in case of small to moderate sample sizes. Furthermore, post-hoc comparisons are provided for the multivariate analyses. Friedrich, S., Konietschke, F. and Pauly, M. (2019) <doi:10.32614/RJ-2019-051>.

MHCnuggets (<https://github.com/KarchinLab/mhcnuggets>) is a Python tool to predict MHC class I and MHC class II epitopes. This package allows one to call MHCnuggets from R.