This package provides a new robust principal component analysis algorithm is implemented that relies upon the Cauchy Distribution. The algorithm is suitable for high dimensional data even if the sample size is less than the number of variables. The methodology is described in this paper: Fayomi A., Pantazis Y., Tsagris M. and Wood A.T.A. (2024). "Cauchy robust principal component analysis with applications to high-dimensional data sets". Statistics and Computing, 34: 26. <doi:10.1007/s11222-023-10328-x>.

Designs guide sequences for CRISPR/Cas9 genome editing and provides information on sequence features pertinent to guide efficiency. Sequence features include annotated off-target predictions in a user-selected genome and a predicted efficiency score based on the model described in Doench et al. (2016) <doi:10.1038/nbt.3437>. Users are able to import additional genomes and genome annotation files to use when searching and annotating off-target hits. All guide sequences and off-target data can be generated through the R console with sgRNA_Design() or through crispRdesignR's user interface with crispRdesignRUI(). CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and the associated protein Cas9 refer to a technique used in genome editing.

Generation of different Christmas cards, most of them being animated. Most of the cards can be generated in three languages (English, Catalan and Spanish). The collection started in 2009.

This package provides an array of statistical models common in causal inference such as standardization, IP weighting, propensity matching, outcome regression, and doubly-robust estimators. Estimates of the average treatment effects from each model are given with the standard error and a 95% Wald confidence interval (Hernan, Robins (2020) <https://miguelhernan.org/whatifbook/>).

This package provides a Bayesian meta-analysis method for studying cross-phenotype genetic associations. It uses summary-level data across multiple phenotypes to simultaneously measure the evidence of aggregate-level pleiotropic association and estimate an optimal subset of traits associated with the risk locus. CPBayes is based on a spike and slab prior. The methodology is available from: A Majumdar, T Haldar, S Bhattacharya, JS Witte (2018) <doi:10.1371/journal.pgen.1007139>.

This package implements the regression approach of Zuber and Strimmer (2011) "High-dimensional regression and variable selection using CAR scores" SAGMB 10: 34, <DOI:10.2202/1544-6115.1730>. CAR scores measure the correlation between the response and the Mahalanobis-decorrelated predictors. The squared CAR score is a natural measure of variable importance and provides a canonical ordering of variables. This package provides functions for estimating CAR scores, for variable selection using CAR scores, and for estimating corresponding regression coefficients. Both shrinkage as well as empirical estimators are available.

Compare double-precision floating point vectors using relative differences. All equality operations are calculated using cpp11'.

Light-weight functions for computing descriptive statistics in different circular spaces (e.g., 2pi, 180, or 360 degrees), to handle angle-dependent biases, pad circular data, and more. Specifically aimed for psychologists and neuroscientists analyzing circular data. Basic methods are based on Jammalamadaka and SenGupta (2001) <doi:10.1142/4031>, removal of cardinal biases is based on the approach introduced in van Bergen, Ma, Pratte, & Jehee (2015) <doi:10.1038/nn.4150> and Chetverikov and Jehee (2023) <doi:10.1038/s41467-023-43251-w>.

This package contains functions to help in selecting and exploring features ( or variables ) in binary classification problems. Provides functions to compute and display information value and weight of evidence (WoE) of the variables , and to convert numeric variables to categorical variables by binning. Functions are also provided to determine which levels ( or categories ) of a categorical variable can be collapsed (or combined ) based on their response rates. The functions provided only work for binary classification problems.

This package provides a local haplotyping visualization toolbox to capture major patterns of co-inheritance between clusters of linked variants, whilst connecting findings to phenotypic and demographic traits across individuals. crosshap enables users to explore and understand genomic variation across a trait-associated region. For an example of successful local haplotype analysis, see Marsh et al. (2022) <doi:10.1007/s00122-022-04045-8>.

Manipulate and analyze 3-D structural geometry of Protein Data Bank (PDB) files.

In computer experiments space-filling designs are having great impact. Most popularly used space-filling designs are Uniform designs (UDs), Latin hypercube designs (LHDs) etc. For further references one can see Mckay (1979) <DOI:10.1080/00401706.1979.10489755> and Fang (1980) <https://cir.nii.ac.jp/crid/1570291225616774784>. In this package, we have provided algorithms for generate efficient LHDs and UDs. Here, generated LHDs are efficient as they possess lower value of Maxpro measure, Phi_p value and Maximum Absolute Correlation (MAC) value based on the weightage given to each criterion. On the other hand, the produced UDs are having good space-filling property as they always attain the lower bound of Discrete Discrepancy measure. Further, some useful functions added in this package for adding more value to this package.

Allows clinicians to predict survival probabilities over the next two years for cystic fibrosis patients, based on the clinical prediction models published in Stanojevic et al. (2019) <doi:10.1183/13993003.00224-2019>.

Computes community climate statistics for volume and mismatch using species climate niches either unscaled or scaled relative to a regional species pool. These statistics can be used to describe biogeographic patterns and infer community assembly processes. Includes a vignette outlining usage.

Causal Inference Assistance (CIA) for performing causal inference within the structural causal modelling framework. Structure learning is performed using partition Markov chain Monte Carlo (Kuipers & Moffa, 2017) and several additional functions have been added to help with causal inference. Kuipers and Moffa (2017) <doi:10.1080/01621459.2015.1133426>.

Write executable specifications in a natural language that describes how your code should behave. Write specifications in feature files using Gherkin language and execute them using functions implemented in R. Use them as an extension to your testthat tests to provide a high level description of how your code works.

This package provides functions for the clustering of variables around Latent Variables, for 2-way or 3-way data. Each cluster of variables, which may be defined as a local or directional cluster, is associated with a latent variable. External variables measured on the same observations or/and additional information on the variables can be taken into account. A "noise" cluster or sparse latent variables can also be defined.

Set of forecasting tools to predict ICU beds using a Vector Error Correction model with a single cointegrating vector. Method described in Berta, P. Lovaglio, P.G. Paruolo, P. Verzillo, S., 2020. "Real Time Forecasting of Covid-19 Intensive Care Units demand" Health, Econometrics and Data Group (HEDG) Working Papers 20/16, HEDG, Department of Economics, University of York, <https://www.york.ac.uk/media/economics/documents/hedg/workingpapers/2020/2016.pdf>.

The analysis of conflicting claims arises when an amount has to be divided among a set of agents with claims that exceed what is available. A rule is a way of selecting a division among the claimants. This package computes the main rules introduced in the literature from ancient times to the present. The inventory of rules covers the proportional and the adjusted proportional rules, the constrained equal awards and the constrained equal losses rules, the constrained egalitarian, the Pinilesâ and the minimal overlap rules, the random arrival and the Talmud rules. Besides, the Dominguez and Thomson and the average-of-awards rules are also included. All of them can be found in the book by W. Thomson (2019), How to divide when there isn't enough. From Aristotle, the Talmud, and Maimonides to the axiomatics of resource allocation', except for the average-of-awards rule, introduced by Mirás Calvo et al. (2022), <doi:10.1007/s00355-022-01414-6>. In addition, graphical diagrams allow the user to represent, among others, the set of awards, the paths of awards, the schedules of awards of a rule, and some indexes. A good understanding of the similarities and differences between the rules is useful for better decision-making. Therefore, this package could be helpful to students, researchers, and managers alike. For a more detailed explanation of the package, see Mirás Calvo et al. (2023), <doi:10.1016/j.dajour.2022.100160>.

Plots the coefficients from model objects. This very quickly shows the user the point estimates and confidence intervals for fitted models.

Design and evaluate choice-based conjoint survey experiments. Generate a variety of survey designs, including random designs, frequency-based designs, and D-optimal designs, as well as "labeled" designs (also known as "alternative-specific designs"), designs with "no choice" options, and designs with dominant alternatives removed. Conveniently inspect and compare designs using a variety of metrics, including design balance, overlap, and D-error, and simulate choice data for a survey design either randomly or according to a utility model defined by user-provided prior parameters. Conduct a power analysis for a given survey design by estimating the same model on different subsets of the data to simulate different sample sizes. Bayesian D-efficient designs using the cea and modfed methods are obtained using the idefix package by Traets et al (2020) <doi:10.18637/jss.v096.i03>. Choice simulation and model estimation in power analyses are handled using the logitr package by Helveston (2023) <doi:10.18637/jss.v105.i10>.

Original ctsem (continuous time structural equation modelling) functionality, based on the OpenMx software, as described in Driver, Oud, Voelkle (2017) <doi:10.18637/jss.v077.i05>, with updated details in vignette. Combines stochastic differential equations representing latent processes with structural equation measurement models. These functions were split off from the main package of ctsem', as the main package uses the rstan package as a backend now -- offering estimation options from max likelihood to Bayesian. There are nevertheless use cases for the wide format SEM style approach as offered here, particularly when there are no individual differences in observation timing and the number of individuals is large. For the main ctsem package, see <https://cran.r-project.org/package=ctsem>.

Extension of cmprsk to Stratified and Clustered data. A goodness of fit test for Fine-Gray model is also provided. Methods are detailed in the following articles: Zhou et al. (2011) <doi:10.1111/j.1541-0420.2010.01493.x>, Zhou et al. (2012) <doi:10.1093/biostatistics/kxr032>, Zhou et al. (2013) <doi: 10.1002/sim.5815>.

Provided data containing an outcome variable, compositional variables and additional covariates (optional); linearly regress the outcome variable on an isometric log ratio (ilr) transformation of the linearly dependent compositional variables. The package provides predictions (with confidence intervals) in the change (delta) in the outcome/response variable based on the multiple linear regression model and evenly spaced reallocations of the compositional values. The compositional data analysis approach implemented is outlined in Dumuid et al. (2017a) <doi:10.1177/0962280217710835> and Dumuid et al. (2017b) <doi:10.1177/0962280217737805>.