Identifying spatially variable genes is critical in linking molecular cell functions with tissue phenotypes. This package utilizes a granularity-based dimension-agnostic tool, single-cell big-small patch (scBSP), implementing sparse matrix operation and KD tree methods for distance calculation, for the identification of spatially variable genes on large-scale data. The detailed description of this method is available at Wang, J. and Li, J. et al. 2023 (Wang, J. and Li, J. (2023), <doi:10.1038/s41467-023-43256-5>).

An implementation of a single-index regression for optimizing individualized dose rules from an observational study. To model interaction effects between baseline covariates and a treatment variable defined on a continuum, we employ two-dimensional penalized spline regression on an index-treatment domain, where the index is defined as a linear combination of the covariates (a single-index). An unspecified main effect for the covariates is allowed, which can also be modeled through a parametric model. A unique contribution of this work is in the parsimonious single-index parametrization specifically defined for the interaction effect term. We refer to Park, Petkova, Tarpey, and Ogden (2020) <doi:10.1111/biom.13320> (for the case of a discrete treatment) and Park, Petkova, Tarpey, and Ogden (2021) "A single-index model with a surface-link for optimizing individualized dose rules" <arXiv:2006.00267v2> for detail of the method. The model can take a member of the exponential family as a response variable and can also take an ordinal categorical response. The main function of this package is simsl().

Calculates (unconditional) post-selection confidence intervals and p-values for the coefficients of (generalized) linear models.

Implementations for two different Bayesian models of differential co-expression. scdeco.cop() fits the bivariate Gaussian copula model from Zichen Ma, Shannon W. Davis, Yen-Yi Ho (2023) <doi:10.1111/biom.13701>, while scdeco.pg() fits the bivariate Poisson-Gamma model from Zhen Yang, Yen-Yi Ho (2022) <doi:10.1111/biom.13457>.

Recent gcc and clang compiler versions provide functionality to test for memory violations and other undefined behaviour; this is often referred to as "Address Sanitizer" (or ASAN') and "Undefined Behaviour Sanitizer" ('UBSAN'). The Writing R Extension manual describes this in some detail in Section 4.3 title "Checking Memory Access". . This feature has to be enabled in the corresponding binary, eg in R, which is somewhat involved as it also required a current compiler toolchain which is not yet widely available, or in the case of Windows, not available at all (via the common Rtools mechanism). . As an alternative, pre-built Docker containers such as the Rocker container r-devel-san or the multi-purpose container r-debug can be used. . This package then provides a means of testing the compiler setup as the known code failures provides in the sample code here should be detected correctly, whereas a default build of R will let the package pass. . The code samples are based on the examples from the Address Sanitizer Wiki at <https://github.com/google/sanitizers/wiki>.

This package provides data frames that hold certain columns and attributes persistently for data processing in dplyr'.

Plots a QQ-Norm Plot with several Gaussian simulations.

This takes spatial single-cell-type RNA-seq data (specifically designed for Slide-seq v2) that calls copy number alterations (CNAs) using pseudo-spatial binning, clusters cellular units (e.g. beads) based on CNA profile, and visualizes spatial CNA patterns. Documentation about SlideCNA is included in the the pre-print by Zhang et al. (2022, <doi:10.1101/2022.11.25.517982>). The package enrichR (>= 3.0), conditionally used to annotate SlideCNA-determined clusters with gene ontology terms, can be installed at <https://github.com/wjawaid/enrichR> or with install_github("wjawaid/enrichR").

Routines to write, simulate, and validate stock-flow consistent (SFC) models. The accounting structure of SFC models are described in Godley and Lavoie (2007, ISBN:978-1-137-08599-3). The algorithms implemented to solve the models (Gauss-Seidel and Broyden) are described in Kinsella and O'Shea (2010) <doi:10.2139/ssrn.1729205> and Peressini and Sullivan (1988, ISBN:0-387-96614-5).

The strided iterator adapts multidimensional buffers to work with the C++ standard library and range-based for-loops. Given a pointer or iterator into a multidimensional data buffer, one can generate an iterator range using make_strided to construct strided versions of the standard library's begin and end. For constructing range-based for-loops, a strided_range class is provided. These help authors to avoid integer-based indexing, which in some cases can impede algorithm performance and introduce indexing errors. This library exists primarily to expose the header file to other R projects.

The main function is icweib(), which fits a stratified Weibull proportional hazards model for left censored, right censored, interval censored, and non-censored survival data. We parameterize the Weibull regression model so that it allows a stratum-specific baseline hazard function, but where the effects of other covariates are assumed to be constant across strata. Please refer to Xiangdong Gu, David Shapiro, Michael D. Hughes and Raji Balasubramanian (2014) <doi:10.32614/RJ-2014-003> for more details.

Calculate numerical agricultural soil management indicators from on a management timeline of an arable field. Currently, indicators for carbon (C) input into the soil system, soil tillage intensity rating (STIR), number of soil cover and living plant cover days, N fertilization and livestock intensity, and plant diversity are implemented. The functions can also be used independently of the management timeline to calculate some indicators. The package contains tables with reference information for the functions, as well as a *.xlsx template to collect the management data.

Fitting Cox proportional hazard model under dependent right censoring using copula and maximum penalised likelihood methods.

Perform sensitivity analysis in structural equation modeling using meta-heuristic optimization methods (e.g., ant colony optimization and others). The references for the proposed methods are: (1) Leite, W., & Shen, Z., Marcoulides, K., Fish, C., & Harring, J. (2022). <doi:10.1080/10705511.2021.1881786> (2) Harring, J. R., McNeish, D. M., & Hancock, G. R. (2017) <doi:10.1080/10705511.2018.1506925>; (3) Fisk, C., Harring, J., Shen, Z., Leite, W., Suen, K., & Marcoulides, K. (2022). <doi:10.1177/00131644211073121>; (4) Socha, K., & Dorigo, M. (2008) <doi:10.1016/j.ejor.2006.06.046>. We also thank Dr. Krzysztof Socha for sharing his research on ant colony optimization algorithm with continuous domains and associated R code, which provided the base for the development of this package.

This package implements the synthetic control group method for comparative case studies as described in Abadie and Gardeazabal (2003) and Abadie, Diamond, and Hainmueller (2010, 2011, 2014). The synthetic control method allows for effect estimation in settings where a single unit (a state, country, firm, etc.) is exposed to an event or intervention. It provides a data-driven procedure to construct synthetic control units based on a weighted combination of comparison units that approximates the characteristics of the unit that is exposed to the intervention. A combination of comparison units often provides a better comparison for the unit exposed to the intervention than any comparison unit alone.

Data visualization tours animates linear projection of multivariate data as its basis (ie. orientation) changes. The spinifex packages generates paths for manual tours by manipulating the contribution of a single variable at a time Cook & Buja (1997) <doi:10.1080/10618600.1997.10474754>. Other types of tours, such as grand (random walk) and guided (optimizing some objective function) are available in the tourr package Wickham et al. <doi:10.18637/jss.v040.i02>. spinifex builds on tourr and can render tours with gganimate and plotly graphics, and allows for exporting as an .html widget and as an .gif, respectively. This work is fully discussed in Spyrison & Cook (2020) <doi:10.32614/RJ-2020-027>.

This package provides a Shiny app allowing to compare and merge two files, with syntax highlighting for several coding languages.

SMART trial design, as described by He, J., McClish, D., Sabo, R. (2021) <doi:10.1080/19466315.2021.1883472>, includes multiple stages of randomization, where participants are randomized to an initial treatment in the first stage and then subsequently re-randomized between treatments in the following stage.

This package provides access to granular sub-national income data from the MCC-PIK Database Of Sub-national Economic Output (DOSE). The package downloads and processes the data from its open repository on Zenodo (<https://zenodo.org/records/13773040>). Functions are provided to fetch data at multiple geographic levels, match coordinates to administrative regions, and access associated geometries.

Offers classes and functions to contact web servers while enforcing scheduling rules required by the sites. The URL class makes it easy to construct a URL by providing parameters as a vector. The Request class allows to describes SOAP (Simple Object Access Protocol) or standard requests: URL, method (POST or GET), header, body. The Scheduler class controls the request frequency for each server address by mean of rules (Rule class). The RequestResult class permits to get the request status to handle error cases and the content.

Self-Consistent Field(SCF) calculation method is one of the most important steps in the calculation methods of quantum chemistry. Ehrenreich, H., & Cohen, M. H. (1959). <doi:10.1103/PhysRev.115.786> However, the most prevailing software in this area, Gaussian''s SCF convergence process is hard to monitor, especially while the job is still running, causing researchers difficulty in knowing whether the oscillation has started or not, wasting time and energy on useless configurations or abandoning the jobs that can actually work. M.J. Frisch, G.W. Trucks, H.B. Schlegel et al. (2016). <https://gaussian.com> SCFMonitor enables Gaussian quantum chemistry calculation software users to easily read the Gaussian .log files and monitor the SCF convergence and geometry optimization process with little effort and clear, beautiful, and clean outputs. It can generate graphs using tidyverse to let users check SCF convergence and geometry optimization processes in real-time. The software supports processing .log files remotely using with rbase::url(). This software is a suitcase for saving time and energy for the researchers, supporting multiple versions of Gaussian'.

This package provides tools for performing variable selection in three-way data using N-PLS in combination with L1 penalization, Selectivity Ratio and VIP scores. The N-PLS model (Rasmus Bro, 1996 <DOI:10.1002/(SICI)1099-128X(199601)10:1%3C47::AID-CEM400%3E3.0.CO;2-C>) is the natural extension of PLS (Partial Least Squares) to N-way structures, and tries to maximize the covariance between X and Y data arrays. The package also adds variable selection through L1 penalization, Selectivity Ratio and VIP scores.

This package creates D3 JavaScript scatterplots from R with interactive features : panning, zooming, tooltips, etc.

This package provides a collection of statistical hypothesis tests and other techniques for identifying certain spatial relationships/phenomena in DNA sequences. In particular, it provides tests and graphical methods for determining whether or not DNA sequences comply with Chargaff's second parity rule or exhibit purine-pyrimidine parity. In addition, there are functions for efficiently simulating discrete state space Markov chains and testing arbitrary symbolic sequences of symbols for the presence of first-order Markovianness. Also, it has functions for counting words/k-mers (and cylinder patterns) in arbitrary symbolic sequences. Functions which take a DNA sequence as input can handle sequences stored as SeqFastadna objects from the seqinr package.