This package implements the Hierarchical Incremental GRAdient Descent (HiGrad) algorithm, a first-order algorithm for finding the minimizer of a function in online learning just like stochastic gradient descent (SGD). In addition, this method attaches a confidence interval to assess the uncertainty of its predictions. See Su and Zhu (2018) <arXiv:1802.04876> for details.

This package implements an efficient algorithm for fitting the entire regularization path of quantile regression models with elastic-net penalties using a generalized coordinate descent scheme. The framework also supports SCAD and MCP penalties. It is designed for high-dimensional datasets and emphasizes numerical accuracy and computational efficiency. This package implements the algorithms proposed in Tang, Q., Zhang, Y., & Wang, B. (2022) <https://openreview.net/pdf?id=RvwMTDYTOb>.

Univariate agglomerative hierarchical clustering with a comprehensive list of choices of a linkage function in O(n*log n) time. The better algorithmic time complexity is paired with an efficient C++ implementation.

By binding R functions and the Highmaps <https://www.highcharts.com.cn/products/highmaps> chart library, hchinamap package provides a simple way to map China and its provinces. The map of China drawn by this package contains complete Chinese territory, especially the Nine-dotted line, South Tibet, Hong Kong, Macao and Taiwan.

Historical borrowing in clinical trials can improve precision and operating characteristics. This package supports a hierarchical model and a mixture model to borrow historical control data from other studies to better characterize the control response of the current study. It also quantifies the amount of borrowing through benchmark models (independent and pooled). Some of the methods are discussed by Viele et al. (2013) <doi:10.1002/pst.1589>.

We provide a collection of various classical tests and latest normal-reference tests for comparing high-dimensional mean vectors including two-sample and general linear hypothesis testing (GLHT) problem. Some existing tests for two-sample problem [see Bai, Zhidong, and Hewa Saranadasa.(1996) <https://www.jstor.org/stable/24306018>; Chen, Song Xi, and Ying-Li Qin.(2010) <doi:10.1214/09-aos716>; Srivastava, Muni S., and Meng Du.(2008) <doi:10.1016/j.jmva.2006.11.002>; Srivastava, Muni S., Shota Katayama, and Yutaka Kano.(2013)<doi:10.1016/j.jmva.2012.08.014>]. Normal-reference tests for two-sample problem [see Zhang, Jin-Ting, Jia Guo, Bu Zhou, and Ming-Yen Cheng.(2020) <doi:10.1080/01621459.2019.1604366>; Zhang, Jin-Ting, Bu Zhou, Jia Guo, and Tianming Zhu.(2021) <doi:10.1016/j.jspi.2020.11.008>; Zhang, Liang, Tianming Zhu, and Jin-Ting Zhang.(2020) <doi:10.1016/j.ecosta.2019.12.002>; Zhang, Liang, Tianming Zhu, and Jin-Ting Zhang.(2023) <doi:10.1080/02664763.2020.1834516>; Zhang, Jin-Ting, and Tianming Zhu.(2022) <doi:10.1080/10485252.2021.2015768>; Zhang, Jin-Ting, and Tianming Zhu.(2022) <doi:10.1007/s42519-021-00232-w>; Zhu, Tianming, Pengfei Wang, and Jin-Ting Zhang.(2023) <doi:10.1007/s00180-023-01433-6>]. Some existing tests for GLHT problem [see Fujikoshi, Yasunori, Tetsuto Himeno, and Hirofumi Wakaki.(2004) <doi:10.14490/jjss.34.19>; Srivastava, Muni S., and Yasunori Fujikoshi.(2006) <doi:10.1016/j.jmva.2005.08.010>; Yamada, Takayuki, and Muni S. Srivastava.(2012) <doi:10.1080/03610926.2011.581786>; Schott, James R.(2007) <doi:10.1016/j.jmva.2006.11.007>; Zhou, Bu, Jia Guo, and Jin-Ting Zhang.(2017) <doi:10.1016/j.jspi.2017.03.005>]. Normal-reference tests for GLHT problem [see Zhang, Jin-Ting, Jia Guo, and Bu Zhou.(2017) <doi:10.1016/j.jmva.2017.01.002>; Zhang, Jin-Ting, Bu Zhou, and Jia Guo.(2022) <doi:10.1016/j.jmva.2021.104816>; Zhu, Tianming, Liang Zhang, and Jin-Ting Zhang.(2022) <doi:10.5705/ss.202020.0362>; Zhu, Tianming, and Jin-Ting Zhang.(2022) <doi:10.1007/s00180-021-01110-6>; Zhang, Jin-Ting, and Tianming Zhu.(2022) <doi:10.1016/j.csda.2021.107385>].

For supersonic aircraft, flying subsonic over land, find the best route between airports. Allow for coastal buffer and potentially closed regions. Use a minimal model of aircraft performance: the focus is on time saved versus subsonic flight, rather than on vertical flight profile. For modelling and forecasting, not for planning your flight!

Helper functions designed to make dynamically generating R Markdown documents easier by providing a simple and tidy way to create report pieces, shape them to your data, and combine them for exporting into a single R Markdown document.

Facilitates estimation of full univariate and bivariate probability density functions and cumulative distribution functions along with full quantile functions (univariate) and nonparametric correlation (bivariate) using Hermite series based estimators. These estimators are particularly useful in the sequential setting (both stationary and non-stationary) and one-pass batch estimation setting for large data sets. Based on: Stephanou, Michael, Varughese, Melvin and Macdonald, Iain. "Sequential quantiles via Hermite series density estimation." Electronic Journal of Statistics 11.1 (2017): 570-607 <doi:10.1214/17-EJS1245>, Stephanou, Michael and Varughese, Melvin. "On the properties of Hermite series based distribution function estimators." Metrika (2020) <doi:10.1007/s00184-020-00785-z> and Stephanou, Michael and Varughese, Melvin. "Sequential estimation of Spearman rank correlation using Hermite series estimators." Journal of Multivariate Analysis (2021) <doi:10.1016/j.jmva.2021.104783>.

Create compressed, interactive HTML (Hypertext Markup Language) reports with embedded Python code, custom JS ('JavaScript') and CSS (Cascading Style Sheets), and wrappers for CanvasXpress plots, networks and more. Based on <https://pypi.org/project/py-report-html/>, its sister project.

Enhance package testthat by allowing tests to be attached to the function/object they test. This allows to keep functional and unit test code together.

This package contains functions for fitting hierarchical versions of EVSD, UVSD, DPSD, DPSD with d restricted to be positive, and our gamma signal detection model to recognition memory confidence-ratings data.

Calculate expected relative risk and proportion protected assuming normally distributed log10 transformed antibody dose for a several component vaccine. Uses Hill models for each component which are combined under Bliss independence. See Saul and Fay, 2007 <DOI:10.1371/journal.pone.0000850>.

This package provides access to datasets published by Hlà daÄ státu <https://www.hlidacstatu.cz/>, a Czech watchdog, via their API.

Detection of haplotype patterns that include single nucleotide polymorphisms (SNPs) and non-contiguous haplotypes that are associated with a phenotype. Methods for implementing HTRX are described in Yang Y, Lawson DJ (2023) <doi:10.1093/bioadv/vbad038> and Barrie W, Yang Y, Irving-Pease E.K, et al (2024) <doi:10.1038/s41586-023-06618-z>.

An algorithm for time series analysis that leverages hidden Markov models, cluster analysis, and mixture distributions to segment data, detect patterns and predict future sequences.

Fitting hidden Markov models of learning under the cognitive diagnosis framework. The estimation of the hidden Markov diagnostic classification model, the first order hidden Markov model, the reduced-reparameterized unified learning model, and the joint learning model for responses and response times.

Cellular responses to perturbations are highly heterogeneous and depend largely on the initial state of cells. Connecting post-perturbation cells via cellular trajectories to untreated cells (e.g. by leveraging metabolic labeling information) enables exploitation of intercellular heterogeneity as a combined knock-down and overexpression screen to identify pathway modulators, termed Heterogeneity-seq (see Berg et al <doi:10.1101/2024.10.28.620481>). This package contains functions to generate cellular trajectories based on scSLAM-seq (single-cell, thiol-(SH)-linked alkylation of RNA for metabolic labelling sequencing) time courses, functions to identify pathway modulators and to visualize the results.

This package performs linear discriminant analysis in high dimensional problems based on reliable covariance estimators for problems with (many) more variables than observations. Includes routines for classifier training, prediction, cross-validation and variable selection.

Enables chat completion and text annotation with local and OpenAI <https://openai.com/> language models, supporting batch processing, multiple annotators, and consistent output formats.

This package provides a toolkit for the analysis and management of data for genes in the so-called "Human Leukocyte Antigen" (HLA) region. Functions extract reference data from the Anthony Nolan HLA Informatics Group/ImmunoGeneTics HLA GitHub repository (ANHIG/IMGTHLA) <https://github.com/ANHIG/IMGTHLA>, validate Genotype List (GL) Strings, convert between UNIFORMAT and GL String Code (GLSC) formats, translate HLA alleles and GLSCs across ImmunoPolymorphism Database (IPD) IMGT/HLA Database release versions, identify differences between pairs of alleles at a locus, generate customized, multi-position sequence alignments, trim and convert allele-names across nomenclature epochs, and extend existing data-analysis methods.

User-friendly and fast set of functions for estimating parameters of hierarchical Bayesian species distribution models (Latimer and others 2006 <doi:10.1890/04-0609>). Such models allow interpreting the observations (occurrence and abundance of a species) as a result of several hierarchical processes including ecological processes (habitat suitability, spatial dependence and anthropogenic disturbance) and observation processes (species detectability). Hierarchical species distribution models are essential for accurately characterizing the environmental response of species, predicting their probability of occurrence, and assessing uncertainty in the model results.

Datasets related to Hong Kong, including information on the 2019 elected District Councillors (<https://www.districtcouncils.gov.hk> and <https://dce2019.hk01.com/>) and traffic collision data from the Hong Kong Department of Transport (<https://www.td.gov.hk/>). All of the data in this package is available in the public domain.

R interface for H2O', the scalable open source machine learning platform that offers parallelized implementations of many supervised and unsupervised machine learning algorithms such as Generalized Linear Models (GLM), Gradient Boosting Machines (including XGBoost), Random Forests, Deep Neural Networks (Deep Learning), Stacked Ensembles, Naive Bayes, Generalized Additive Models (GAM), ANOVA GLM, Cox Proportional Hazards, K-Means, PCA, ModelSelection, Word2Vec, as well as a fully automatic machine learning algorithm (H2O AutoML).