Calculate different glucose variability measures, including average measures of glycemia, measures of glycemic variability and measures of glycemic risk, from continuous glucose monitoring data. Boris P. Kovatchev, Erik Otto, Daniel Cox, Linda Gonder-Frederick, and William Clarke (2006) <doi:10.2337/dc06-1085>. Jean-Pierre Le Floch, Philippe Escuyer, Eric Baudin, Dominique Baudon, and Leon Perlemuter (1990) <doi:10.2337/diacare.13.2.172>. C.M. McDonnell, S.M. Donath, S.I. Vidmar, G.A. Werther, and F.J. Cameron (2005) <doi:10.1089/dia.2005.7.253>. Everitt, Brian (1998) <doi:10.1111/j.1751-5823.2011.00149_2.x>. Becker, R. A., Chambers, J. M. and Wilks, A. R. (1988) <doi:10.2307/2234167>. Dougherty, R. L., Edelman, A. and Hyman, J. M. (1989) <doi:10.1090/S0025-5718-1989-0962209-1>. Tukey, J. W. (1977) <doi:10.1016/0377-2217(86)90209-2>. F. John Service (2013) <doi:10.2337/db12-1396>. Edmond A. Ryan, Tami Shandro, Kristy Green, Breay W. Paty, Peter A. Senior, David Bigam, A.M. James Shapiro, and Marie-Christine Vantyghem (2004) <doi:10.2337/diabetes.53.4.955>. F. John Service, George D. Molnar, John W. Rosevear, Eugene Ackerman, Leal C. Gatewood, William F. Taylor (1970) <doi:10.2337/diab.19.9.644>. Sarah E. Siegelaar, Frits Holleman, Joost B. L. Hoekstra, and J. Hans DeVries (2010) <doi:10.1210/er.2009-0021>. Gabor Marics, Zsofia Lendvai, Csaba Lodi, Levente Koncz, David Zakarias, Gyorgy Schuster, Borbala Mikos, Csaba Hermann, Attila J. Szabo, and Peter Toth-Heyn (2015) <doi:10.1186/s12938-015-0035-3>. Thomas Danne, Revital Nimri, Tadej Battelino, Richard M. Bergenstal, Kelly L. Close, J. Hans DeVries, SatishGarg, Lutz Heinemann, Irl Hirsch, Stephanie A. Amiel, Roy Beck, Emanuele Bosi, Bruce Buckingham, ClaudioCobelli, Eyal Dassau, Francis J. Doyle, Simon Heller, Roman Hovorka, Weiping Jia, Tim Jones, Olga Kordonouri,Boris Kovatchev, Aaron Kowalski, Lori Laffel, David Maahs, Helen R. Murphy, Kirsten Nørgaard, Christopher G.Parkin, Eric Renard, Banshi Saboo, Mauro Scharf, William V. Tamborlane, Stuart A. Weinzimer, and Moshe Phillip.International consensus on use of continuous glucose monitoring.Diabetes Care, 2017 <doi:10.2337/dc17-1600>.

Turn arbitrary functions into binary operators.

This package provides methods to analyse experimental agriculture data, from data synthesis to model selection and visualisation. The package is named after W.S. Gosset aka â Studentâ , a pioneer of modern statistics in small sample experimental design and analysis.

This package provides a ggplot2 extension for drawing Hinton diagrams, a visualisation technique for numerical matrices in which the area of each square is proportional to the magnitude of the corresponding entry. For signed data, white squares indicate positive values and black squares indicate negative values on a grey background. Hinton diagrams are especially useful for visualising PCA weight matrices, correlation matrices, and transition matrices.

This package implements the generalized order-restricted information criterion approximation (GORICA), an AIC-like information criterion that can be utilized to evaluate informative hypotheses specifying directional relationships between model parameters in terms of (in)equality constraints (see Altinisik, Van Lissa, Hoijtink, Oldehinkel, & Kuiper, 2021), <doi:10.31234/osf.io/t3c8g>. The GORICA is applicable not only to normal linear models, but also to generalized linear models (GLMs), generalized linear mixed models (GLMMs), structural equation models (SEMs), and contingency tables. For contingency tables, restrictions on cell probabilities can be non-linear.

The gamma-Orthogonal Matching Pursuit (gamma-OMP) is a recently suggested modification of the OMP feature selection algorithm for a wide range of response variables. The package offers many alternative regression models, such linear, robust, survival, multivariate etc., including k-fold cross-validation. References: Tsagris M., Papadovasilakis Z., Lakiotaki K. and Tsamardinos I. (2018). "Efficient feature selection on gene expression data: Which algorithm to use?" BioRxiv. <doi:10.1101/431734>. Tsagris M., Papadovasilakis Z., Lakiotaki K. and Tsamardinos I. (2022). "The gamma-OMP algorithm for feature selection with application to gene expression data". IEEE/ACM Transactions on Computational Biology and Bioinformatics 19(2): 1214--1224. <doi:10.1109/TCBB.2020.3029952>.

This package provides a novel statistical model to detect the joint genetic and dynamic gene-environment (GxE) interaction with continuous traits in genetic association studies. It uses varying-coefficient models to account for different GxE trajectories, regardless whether the relationship is linear or not. The package includes one function, GxEtest(), to test a single genetic variant (e.g., a single nucleotide polymorphism or SNP), and another function, GxEscreen(), to test for a set of genetic variants. The method involves a likelihood ratio test described in Crainiceanu, C. M., and Ruppert, D. (2004) <doi:10.1111/j.1467-9868.2004.00438.x>.

Computes the probability density function (pdf), cumulative distribution function (cdf), quantile function (qf) and generates random values (rg) for the following general models : mixture models, composite models, folded models, skewed symmetric models and arc tan models.

Ridge regression due to Hoerl and Kennard (1970)<DOI:10.1080/00401706.1970.10488634> and generalized ridge regression due to Yang and Emura (2017)<DOI:10.1080/03610918.2016.1193195> with optimized tuning parameters. These ridge regression estimators (the HK estimator and the YE estimator) are computed by minimizing the cross-validated mean squared errors. Both the ridge and generalized ridge estimators are applicable for high-dimensional regressors (p>n), where p is the number of regressors, and n is the sample size.

These Rcpp'-based functions compute the efficient score statistics for grouped time-to-event data (Prentice and Gloeckler, 1978), with the optional inclusion of baseline covariates. Functions for estimating the parameter of interest and nuisance parameters, including baseline hazards, using maximum likelihood are also provided. A parallel set of functions allow for the incorporation of family structure of related individuals (e.g., trios). Note that the current implementation of the frailty model (Ripatti and Palmgren, 2000) is sensitive to departures from model assumptions, and should be considered experimental. For these data, the exact proportional-hazards-model-based likelihood is computed by evaluating multiple variable integration. The integration is accomplished using the Cuba library (Hahn, 2005), and the source files are included in this package. The maximization process is carried out using Brent's algorithm, with the C++ code file from John Burkardt and John Denker (Brent, 2002).

Efficient algorithms for fitting generalized linear and additive models with group elastic net penalties as described in Helwig (2025) <doi:10.1080/10618600.2024.2362232>. Implements group LASSO, group MCP, and group SCAD with an optional group ridge penalty. Computes the regularization path for linear regression (gaussian), multivariate regression (multigaussian), smoothed support vector machines (svm1), squared support vector machines (svm2), logistic regression (binomial), proportional odds logistic regression (ordinal), multinomial logistic regression (multinomial), log-linear count regression (poisson and negative.binomial), and log-linear continuous regression (gamma and inverse gaussian). Supports default and formula methods for model specification, k-fold cross-validation for tuning the regularization parameters, and nonparametric regression via tensor product reproducing kernel (smoothing spline) basis function expansion.

When comparing discrete data mini bubble plots allow displaying more information than traditional bubble plots via colour, shape or labels. Exact overlapping coordinates will be transformed so they surround the original point circularly without overlapping. This is implemented as a position_surround() function for ggplot2'.

Create correlation heatmaps with ggplot2 and customise them with flexible annotation and clustering. Symmetric heatmaps can use triangular or mixed layouts, removing redundant information or displaying complementary information in the two halves. There is also support for general heatmaps not displaying correlations.

This package provides a comprehensive suite of genome-wide association study (GWAS) methods specifically designed for biobank-scale data, including but not limited to, robust approaches for time-to-event traits (Li et al., 2025 <doi:10.1038/s43588-025-00864-z>) and ordinal categorical traits (Bi et al., 2021 <doi:10.1016/j.ajhg.2021.03.019>). The package also offers general frameworks for GWAS of any trait type (Bi et al., 2020 <doi:10.1016/j.ajhg.2020.06.003>), while accounting for sample relatedness (Xu et al., 2025 <doi:10.1038/s41467-025-56669-1>) or population structure (Ma et al., 2025 <doi:10.1186/s13059-025-03827-9>). By accurately approximating score statistic distributions using saddlepoint approximation (SPA), these methods can effectively control type I error rates for rare variants and in the presence of unbalanced phenotype distributions. Additionally, the package includes functions for simulating genotype and phenotype data to support research and method development.

This package provides a Bayesian statistical model for estimating child (under-five age group) and adult (15-60 age group) mortality. The main challenge is how to combine and integrate these different time series and how to produce unified estimates of mortality rates during a specified time span. GPR is a Bayesian statistical model for estimating child and adult mortality rates which its data likelihood is mortality rates from different data sources such as: Death Registration System, Censuses or surveys. There are also various hyper-parameters for completeness of DRS, mean, covariance functions and variances as priors. This function produces estimations and uncertainty (95% or any desirable percentiles) based on sampling and non-sampling errors due to variation in data sources. The GP model utilizes Bayesian inference to update predicted mortality rates as a posterior in Bayes rule by combining data and a prior probability distribution over parameters in mean, covariance function, and the regression model. This package uses Markov Chain Monte Carlo (MCMC) to sample from posterior probability distribution by rstan package in R. Details are given in Wang H, Dwyer-Lindgren L, Lofgren KT, et al. (2012) <doi:10.1016/S0140-6736(12)61719-X>, Wang H, Liddell CA, Coates MM, et al. (2014) <doi:10.1016/S0140-6736(14)60497-9> and Mohammadi, Parsaeian, Mehdipour et al. (2017) <doi:10.1016/S2214-109X(17)30105-5>.

This package provides convenient access to the official spatial datasets of Peru as sf objects in R. This package includes a wide range of geospatial data covering various aspects of Peruvian geography, such as: administrative divisions (Source: INEI <https://ide.inei.gob.pe/>), protected natural areas (Source: GEO ANP - SERNANP <https://geo.sernanp.gob.pe/visorsernanp/>). All datasets are harmonized in terms of attributes, projection, and topology, ensuring consistency and ease of use for spatial analysis and visualization.

The web service at <https://www.geonames.org/> provides a number of spatial data queries, including administrative area hierarchies, city locations and some country postal code queries. A (free) username is required and rate limits exist.

Generates (U,W) mixture graphs where U is a line graph graphon and W is a dense graphon. Graphons are graph limits and graphon U can be written as sequence of positive numbers adding to 1. Graphs are sampled from U and W and joined randomly to obtain the mixture graph. Given a mixture graph, U can be inferred. Kandanaarachchi and Ong (2025) <doi:10.48550/arXiv.2505.13864>.

This package provides an extension to ggplot2 (Wickham, 2016, <doi:10.1007/978-3-319-24277-4>) for creating two types of continuous confidence interval plots (Violin CI and Gradient CI plots), typically for the sample mean. These plots contain multiple user-defined confidence areas with varying colours, defined by the underlying t-distribution used to compute standard confidence intervals for the mean of the normal distribution when the variance is unknown. Two types of plots are available, a gradient plot with rectangular areas, and a violin plot where the shape (horizontal width) is defined by the probability density function of the t-distribution. These visualizations are studied in (Helske, Helske, Cooper, Ynnerman, and Besancon, 2021) <doi:10.1109/TVCG.2021.3073466>.

Computes the gravitational and magnetic anomalies generated by 3-D vertical rectangular prisms at specific observation points using the method of Plouff (1976) <doi:10.1190/1.1440645>.

Tool for import and process data from Lattes curriculum platform (<http://lattes.cnpq.br/>). The Brazilian government keeps an extensive base of curricula for academics from all over the country, with over 5 million registrations. The academic life of the Brazilian researcher, or related to Brazilian universities, is documented in Lattes'. Some information that can be obtained: professional formation, research area, publications, academics advisories, projects, etc. getLattes package allows work with Lattes data exported to XML format.

GPU'/CPU Benchmarking on Debian-package based systems This package benchmarks performance of a few standard linear algebra operations (such as a matrix product and QR, SVD and LU decompositions) across a number of different BLAS libraries as well as a GPU implementation. To do so, it takes advantage of the ability to plug and play different BLAS implementations easily on a Debian and/or Ubuntu system. The current version supports - Reference BLAS ('refblas') which are un-accelerated as a baseline - Atlas which are tuned but typically configure single-threaded - Atlas39 which are tuned and configured for multi-threaded mode - Goto Blas which are accelerated and multi-threaded - Intel MKL which is a commercial accelerated and multithreaded version. As for GPU computing, we use the CRAN package - gputools For Goto Blas', the gotoblas2-helper script from the ISM in Tokyo can be used. For Intel MKL we use the Revolution R packages from Ubuntu 9.10.

This package provides a genetic algorithm for finding variable subsets in high dimensional data with high prediction performance. The genetic algorithm can use ordinary least squares (OLS) regression models or partial least squares (PLS) regression models to evaluate the prediction power of variable subsets. By supporting different cross-validation schemes, the user can fine-tune the tradeoff between speed and quality of the solution.

This package provides tools for plotting gene clusters and transcripts by importing data from GenBank, FASTA, and GFF files. It performs BLASTP and MUMmer alignments [Altschul et al. (1990) <doi:10.1016/S0022-2836(05)80360-2>; Delcher et al. (1999) <doi:10.1093/nar/27.11.2369>] and displays results on gene arrow maps. Extensive customization options are available, including legends, labels, annotations, scales, colors, tooltips, and more.