This package provides a modular framework for standardized analysis of thermal imaging data in animal experimentation. The package integrates thermographic data import (FLIR, raw, CSV), automated region of interest (ROI) segmentation based on EBImage (Pau et al., 2010 <doi:10.1093/bioinformatics/btq046>), interactive ROI refinement, and high-throughput batch processing.

Bayesian optimal interval based on both efficacy and toxicity outcomes (BOIN-ET) design is a model-assisted oncology phase I/II trial design, aiming to establish an optimal biological dose accounting for efficacy and toxicity in the framework of dose-finding. Some extensions of BOIN-ET design are also available to allow for time-to-event efficacy and toxicity outcomes based on cumulative and pending data (time-to-event BOIN-ET: TITE-BOIN-ET), ordinal graded efficacy and toxicity outcomes (generalized BOIN-ET: gBOIN-ET), and their combination (TITE-gBOIN-ET). boinet is a package to implement the BOIN-ET design family and supports the conduct of simulation studies to assess operating characteristics of BOIN-ET, TITE-BOIN-ET, gBOIN-ET, and TITE-gBOIN-ET, where users can choose design parameters in flexible and straightforward ways depending on their own application.

This package implements a class and methods to work with sets, doing intersection, union, complementary sets, power sets, cartesian product and other set operations in a "tidy" way. These set operations are available for both classical sets and fuzzy sets. Import sets from several formats or from other several data structures.

Two practical tests are provided for assessing whether multiple covariates in a treatment group and a matched control group are balanced in observational studies.

This package provides the design of multi-group phase II clinical trials with binary outcomes using the hierarchical Bayesian classification and information sharing (BaCIS) model. Subgroups are classified into two clusters on the basis of their outcomes mimicking the hypothesis testing framework. Subsequently, information sharing takes place within subgroups in the same cluster, rather than across all subgroups. This method can be applied to the design and analysis of multi-group clinical trials with binary outcomes. Reference: Nan Chen and J. Jack Lee (2019) <doi:10.1002/bimj.201700275>.

This package provides tools for identifying subgroups within populations based on individual response patterns to specific interventions or treatments. Designed to support researchers and clinicians in exploring heterogeneous treatment effects and developing personalized therapeutic strategies. Offers functionality for analyzing and visualizing the interplay between two variables, thereby enhancing the interpretation of social sustainability metrics. The package focuses on bivariate discriminant analysis and aims to clarify relationships between indicator variables.

Write blog posts and web pages in R Markdown. This package supports the static site generator Hugo (<https://gohugo.io>) best, and it also supports Jekyll (<https://jekyllrb.com>) and Hexo (<https://hexo.io>).

Permutational method to incorporate taxonomic uncertainty and some functions to assess its effects on parameters of some widely used multivariate methods in ecology, as explained in Cayuela et al. (2011) <doi:10.1111/j.1600-0587.2009.05899.x>.

Enables quick calibration of radiocarbon dates under various calibration curves (including user generated ones); age-depth modelling as per the algorithm of Haslett and Parnell (2008) <DOI:10.1111/j.1467-9876.2008.00623.x>; Relative sea level rate estimation incorporating time uncertainty in polynomial regression models (Parnell and Gehrels 2015) <DOI:10.1002/9781118452547.ch32>; non-parametric phase modelling via Gaussian mixtures as a means to determine the activity of a site (and as an alternative to the Oxcal function SUM(); currently unpublished), and reverse calibration of dates from calibrated into 14C years (also unpublished).

Consider an at-most-K-stage group sequential design with only an upper bound for the last analysis and non-binding lower bounds.With binary endpoint, two kinds of test can be applied, asymptotic test based on normal distribution and exact test based on binomial distribution. This package supports the computation of boundaries and conditional power for single-arm group sequential test with binary endpoint, via either asymptotic or exact test. The package also provides functions to obtain boundary crossing probabilities given the design.

This package provides an Markov-Chain-Monte-Carlo algorithm for Bayesian t-tests on the effect size. The underlying Gibbs sampler is based on a two-component Gaussian mixture and approximates the posterior distributions of the effect size, the difference of means and difference of standard deviations. A posterior analysis of the effect size via the region of practical equivalence is provided, too. For more details about the Gibbs sampler see Kelter (2019) <arXiv:1906.07524>.

Fit Bayesian models using brms'/'Stan with parsnip'/'tidymodels via bayesian <doi:10.5281/zenodo.4426836>. tidymodels is a collection of packages for machine learning; see Kuhn and Wickham (2020) <https://www.tidymodels.org>). The technical details of brms and Stan are described in Bürkner (2017) <doi:10.18637/jss.v080.i01>, Bürkner (2018) <doi:10.32614/RJ-2018-017>, and Carpenter et al. (2017) <doi:10.18637/jss.v076.i01>.

This package provides a blind spike program provides samples to a laboratory in order to perform quality control (QC) checks. The samples provided are of a known quantity to the tester. The laboratory is typically uninformed of that the sample provided is a QC sample.

Extends blockr.core with interactive blocks for data visualization using ggplot2'. Users can build charts through a graphical interface without writing code directly. Includes common chart types (bar charts, line charts, pie charts, scatter plots) as well as statistical plots (boxplots, histograms, density plots, violin plots) with rich customization options and intuitive user interfaces.

This package implements regression models for binary data on the absolute risk scale. These models are applicable to cohort and population-based case-control data.

This package implements functions that calculate upper prediction bounds on the false discovery proportion (FDP) in the list of discoveries returned by competition-based setups, implementing Ebadi et al. (2022) <arXiv:2302.11837>. Such setups include target-decoy competition (TDC) in computational mass spectrometry and the knockoff construction in linear regression (note this package typically uses the terminology of TDC). Included is the standardized (TDC-SB) and uniform (TDC-UB) bound on TDC's FDP, and the simultaneous standardized and uniform bands. Requires pre-computed Monte Carlo statistics available at <https://github.com/uni-Arya/fdpbandsdata>. This data can be downloaded by running the command devtools::install_github("uni-Arya/fdpbandsdata") in R and restarting R after installation. The size of this data is roughly 81Mb.

Bayesian Mixture Survival Models using Additive Mixture-of-Weibull Hazards, with Lasso Shrinkage and Stratification. As a Bayesian dynamic survival model, it relaxes the proportional-hazard assumption. Lasso shrinkage controls overfitting, given the increase in the number of free parameters in the model due to presence of two Weibull components in the hazard function.

An implementation of Bayesian survival models with graph-structured selection priors for sparse identification of omics features predictive of survival (Madjar et al., 2021 <doi:10.1186/s12859-021-04483-z>) and its extension to use a fixed graph via a Markov Random Field (MRF) prior for capturing known structure of omics features, e.g. disease-specific pathways from the Kyoto Encyclopedia of Genes and Genomes database (Hermansen et al., 2025 <doi:10.48550/arXiv.2503.13078>).

Provide early termination phase II trial designs with a decreasingly informative prior (DIP) or a regular Bayesian prior chosen by the user. The program can determine the minimum planned sample size necessary to achieve the user-specified admissible designs. The program can also perform power and expected sample size calculations for the tests in early termination Phase II trials. See Wang C and Sabo RT (2022) <doi:10.18203/2349-3259.ijct20221110>; Sabo RT (2014) <doi:10.1080/10543406.2014.888441>.

This package provides some tools for developing and validating prediction models, estimate expected survival of patients and visualize them graphically. Most of the implemented methods are based on penalized regressions such as: the lasso (Tibshirani R (1996)), the elastic net (Zou H et al. (2005) <doi:10.1111/j.1467-9868.2005.00503.x>), the adaptive lasso (Zou H (2006) <doi:10.1198/016214506000000735>), the stability selection (Meinshausen N et al. (2010) <doi:10.1111/j.1467-9868.2010.00740.x>), some extensions of the lasso (Ternes et al. (2016) <doi:10.1002/sim.6927>), some methods for the interaction setting (Ternes N et al. (2016) <doi:10.1002/bimj.201500234>), or others. A function generating simulated survival data set is also provided.

This package performs change point detection on univariate and multivariate time series (Martà nez & Mena, 2014, <doi:10.1214/14-BA878> ; Corradin, Danese & Ongaro, 2022, <doi:10.1016/j.ijar.2021.12.019>) and clusters time-dependent data with common change points (Corradin, Danese, KhudaBukhsh & Ongaro, 2026, <doi:10.1007/s11222-025-10756-x>).

An aid for manipulating data associated with biomonitoring and bioassessment. Calculations include metric calculation, marking of excluded taxa, subsampling, and multimetric index calculation. Targeted communities are benthic macroinvertebrates, fish, periphyton, and coral. As described in the Revised Rapid Bioassessment Protocols (Barbour et al. 1999) <https://archive.epa.gov/water/archive/web/html/index-14.html>.

To visualize the execution data of the processes on BPMN (Business Process Model and Notation) diagrams, using overlays, style customization and interactions, with the bpmn-visualization TypeScript library.

Reading and writing BibTeX files using data frames in R sessions.