This package provides statistical tools to analyze heterogeneous effects of rare variants within genes that are associated with multiple traits. The package implements methods for assessing pleiotropic effects and identifying allelic heterogeneity, which can be useful in large-scale genetic studies. Methods include likelihood-based statistical tests to assess these effects. For more details, see Lu et al. (2024) <doi:10.1101/2024.10.01.614806>.

Aster models are exponential family regression models for life history analysis. They are like generalized linear models except that elements of the response vector can have different families (e. g., some Bernoulli, some Poisson, some zero-truncated Poisson, some normal) and can be dependent, the dependence indicated by a graphical structure. Discrete time survival analysis, zero-inflated Poisson regression, and generalized linear models that are exponential family (e. g., logistic regression and Poisson regression with log link) are special cases. Main use is for data in which there is survival over discrete time periods and there is additional data about what happens conditional on survival (e. g., number of offspring). Uses the exponential family canonical parameterization (aster transform of usual parameterization). Unlike the aster package, this package does dependence groups (nodes of the graph need not be conditionally independent given their predecessor node), including multinomial and two-parameter normal as families. Thus this package also generalizes mark-capture-recapture analysis.

Read, manipulate and write voxel spaces. Voxel spaces are read from text-based output files of the AMAPVox software. AMAPVox is a LiDAR point cloud voxelisation software that aims at estimating leaf area through several theoretical/numerical approaches. See more in the article Vincent et al. (2017) <doi:10.23708/1AJNMP> and the technical note Vincent et al. (2021) <doi:10.23708/1AJNMP>.

Automatic normalisation of a data frame to third normal form, with the intention of easing the process of data cleaning. (Usage to design your actual database for you is not advised.) Originally inspired by the AutoNormalize library for Python by Alteryx (<https://github.com/alteryx/autonormalize>), with various changes and improvements. Automatic discovery of functional or approximate dependencies, normalisation based on those, and plotting of the resulting "database" via Graphviz', with options to exclude some attributes at discovery time, or remove discovered dependencies at normalisation time.

Datasets to be used primarily in conjunction with Ascent training materials but also for the book SAMS Teach Yourself R in 24 Hours (ISBN: 978-0-672-33848-9). Version 1.0-7 is largely for use with the book; however, version 1.1 has a much greater focus on use with training materials, whilst retaining compatibility with the book.

This package contains functions to implement automated covariate selection using methods described in the high-dimensional propensity score (HDPS) algorithm by Schneeweiss et.al. Covariate adjustment in real-world-observational-data (RWD) is important for for estimating adjusted outcomes and this can be done by using methods such as, but not limited to, propensity score matching, propensity score weighting and regression analysis. While these methods strive to statistically adjust for confounding, the major challenge is in selecting the potential covariates that can bias the outcomes comparison estimates in observational RWD (Real-World-Data). This is where the utility of automated covariate selection comes in. The functions in this package help to implement the three major steps of automated covariate selection as described by Schneeweiss et. al elsewhere. These three functions, in order of the steps required to execute automated covariate selection are, get_candidate_covariates(), get_recurrence_covariates() and get_prioritised_covariates(). In addition to these functions, a sample real-world-data from publicly available de-identified medical claims data is also available for running examples and also for further exploration. The original article where the algorithm is described by Schneeweiss et.al. (2009) <doi:10.1097/EDE.0b013e3181a663cc> .

Compute a tree level hierarchy, judgment matrix, consistency index and ratio, priority vectors, hierarchic synthesis and rank. Based on the book entitled "Models, Methods, Concepts and Applications of the Analytic Hierarchy Process" by Saaty and Vargas (2012, ISBN 978-1-4614-3597-6).

Generate spreadsheet publications that follow best practice guidance from the UK government's Analysis Function, available at <https://analysisfunction.civilservice.gov.uk/policy-store/releasing-statistics-in-spreadsheets/>, with a focus on accessibility. See also the Python package gptables'.

This package implements the scenario analysis proposed by Antolin-Diaz, Petrella and Rubio-Ramirez (2021) "Structural scenario analysis with SVARs" <doi:10.1016/j.jmoneco.2020.06.001>.

Colour palettes and a ggplot2 theme to follow the UK Government Analysis Function best practice guidance for producing data visualisations, available at <https://analysisfunction.civilservice.gov.uk/policy-store/data-visualisation-charts/>. Includes continuous and discrete colour and fill scales, as well as a ggplot2 theme.

Automatic fixed rank kriging for (irregularly located) spatial data using a class of basis functions with multi-resolution features and ordered in terms of their resolutions. The model parameters are estimated by maximum likelihood (ML) and the number of basis functions is determined by Akaike's information criterion (AIC). For spatial data with either one realization or independent replicates, the ML estimates and AIC are efficiently computed using their closed-form expressions when no missing value occurs. Details regarding the basis function construction, parameter estimation, and AIC calculation can be found in Tzeng and Huang (2018) <doi:10.1080/00401706.2017.1345701>. For data with missing values, the ML estimates are obtained using the expectation- maximization algorithm. Apart from the number of basis functions, there are no other tuning parameters, making the method fully automatic. Users can also include a stationary structure in the spatial covariance, which utilizes LatticeKrig package.

Create beautiful and interactive visualizations in a single function call. The data.table package is utilized to perform the data wrangling necessary to prepare your data for the plot types you wish to build, along with allowing fast processing for big data. There are two broad classes of plots available: standard plots and machine learning evaluation plots. There are lots of parameters available in each plot type function for customizing the plots (such as faceting) and data wrangling (such as variable transformations and aggregation).

Filters animal satellite tracking data obtained from the Argos system(<https://www.argos-system.org/>), following the algorithm described in Freitas et al (2008) <doi:10.1111/j.1748-7692.2007.00180.x>. It is especially indicated for telemetry studies of marine animals, where Argos locations are predominantly of low-quality.

This package provides a developer-facing interface to the Arrow Database Connectivity ('ADBC') SQLite driver for the purposes of building high-level database interfaces for users. ADBC <https://arrow.apache.org/adbc/> is an API standard for database access libraries that uses Arrow for result sets and query parameters.

Interactive graphical user interface (GUI) for the package AdhereR', allowing the user to access different data sources, to explore the patterns of medication use therein, and the computation of various measures of adherence. It is implemented using Shiny and HTML/CSS/JavaScript.

Utilities designed to make the analysis of field trials easier and more accessible for everyone working in plant breeding. It provides a simple and intuitive interface for conducting single and multi-environmental trial analysis, with minimal coding required. Whether you're a beginner or an experienced user, agriutilities will help you quickly and easily carry out complex analyses with confidence. With built-in functions for fitting Linear Mixed Models, agriutilities is the ideal choice for anyone who wants to save time and focus on interpreting their results. Some of the functions require the R package asreml for the ASReml software, this can be obtained upon purchase from VSN international <https://vsni.co.uk/software/asreml-r/>.

Developed for use by those tasked with the routine detection, characterisation and quantification of discrete changes in air quality time-series, such as identifying the impacts of air quality policy interventions. The main functions use signal isolation then break-point/segment (BP/S) methods based on strucchange and segmented methods to detect and quantify change events (Ropkins & Tate, 2021, <doi:10.1016/j.scitotenv.2020.142374>).

An unsupervised fully-automated pipeline for transcriptome analysis or a supervised option to identify characteristic genes from predefined subclasses. We rely on the pamr <http://www.bioconductor.org/packages//2.7/bioc/html/pamr.html> clustering algorithm to cluster the Data and then draw a heatmap of the clusters with the most significant genes and the least significant genes according to the pamr algorithm. This way we get easy to grasp heatmaps that show us for each cluster which are the clusters most defining genes.

Queries multiple resources authors HGNC (2019) <https://www.genenames.org>, authors limma (2015) <doi:10.1093/nar/gkv007> to find the correspondence between evolving nomenclature of human gene symbols, aliases, previous symbols or synonyms with stable, curated gene entrezID from NCBI database. This allows fast, accurate and up-to-date correspondence between human gene expression datasets from various date and platform (e.g: gene symbol: BRCA1 - ID: 672).

This package provides a Shiny application to access the functionalities and datasets of the archeofrag package for spatial analysis in archaeology from refitting data. Quick and seamless exploration of archaeological refitting datasets, focusing on physical refits only. Features include: built-in documentation and convenient workflow, plot generation and exports, exploration of spatial units merging solutions, simulation of archaeological site formation processes, support for parallel computing, R code generation to re-execute simulations and ensure reproducibility, code generation for the openMOLE model exploration software. A demonstration of the app is available at <https://analytics.huma-num.fr/Sebastien.Plutniak/archeofrag/>.

This package provides a wrapper for machine learning (ML) methods to select among a portfolio of algorithms based on the value of a key performance indicator (KPI). A number of features is used to adjust a model to predict the value of the KPI for each algorithm, then, for a new value of the features the KPI is estimated and the algorithm with the best one is chosen. To learn it can use the regression methods in caret package or a custom function defined by the user. Several graphics available to analyze the results obtained. This library has been used in Ghaddar et al. (2023) <doi:10.1287/ijoc.2022.0090>).

Automatic model selection for structural time series decomposition into trend, cycle, and seasonal components, plus optionality for structural interpolation, using the Kalman filter. Koopman, Siem Jan and Marius Ooms (2012) "Forecasting Economic Time Series Using Unobserved Components Time Series Models" <doi:10.1093/oxfordhb/9780195398649.013.0006>. Kim, Chang-Jin and Charles R. Nelson (1999) "State-Space Models with Regime Switching: Classical and Gibbs-Sampling Approaches with Applications" <doi:10.7551/mitpress/6444.001.0001><http://econ.korea.ac.kr/~cjkim/>.

This package performs requests to the Arctos API to download data. Provides a set of builder classes for performing complex requests, as well as a set of simple functions for automating many common requests and workflows. More information about Arctos can be found in Cicero et al. (2024) <doi:10.1371/journal.pone.0296478> or on their website <https://arctosdb.org/>.

Analysis of moderation (ANOMO) method conceptualizes the difference and equivalence tests as a moderation problem to test the difference and equivalence of two means (or two effects in two studies).